JP2021522162A - 抗ｒｏｒ抗体構築物 - Google Patents

抗ｒｏｒ抗体構築物 Download PDF

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JP2021522162A
JP2021522162A JP2020556851A JP2020556851A JP2021522162A JP 2021522162 A JP2021522162 A JP 2021522162A JP 2020556851 A JP2020556851 A JP 2020556851A JP 2020556851 A JP2020556851 A JP 2020556851A JP 2021522162 A JP2021522162 A JP 2021522162A
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domain
antigen
amino acid
ror
binding molecule
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JP2021522162A5 (enExample
Inventor
ルーカス ベイリー，
ルーカス ベイリー，
チューフェイ リー，
チューフェイ リー，
マルゴルザータ アグニェシュカ ノキュラ−ルゴウスカ，
マルゴルザータ アグニェシュカ ノキュラ−ルゴウスカ，
ブライアン グレーザー，
ブライアン グレーザー，
Original Assignee
エグゼリクシス， インコーポレイテッド
エグゼリクシス， インコーポレイテッド
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Publication of JP2021522162A publication Critical patent/JP2021522162A/ja
Publication of JP2021522162A5 publication Critical patent/JP2021522162A5/ja
Priority to JP2023172867A priority Critical patent/JP2023168551A/ja
Priority to JP2025117193A priority patent/JP2025137618A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2020556851A 2018-04-18 2019-04-18 抗ｒｏｒ抗体構築物 Pending JP2021522162A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023172867A JP2023168551A (ja) 2018-04-18 2023-10-04 抗ｒｏｒ抗体構築物
JP2025117193A JP2025137618A (ja) 2018-04-18 2025-07-11 抗ｒｏｒ抗体構築物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862659635P 2018-04-18 2018-04-18
US62/659,635 2018-04-18
PCT/US2019/028051 WO2019204564A1 (en) 2018-04-18 2019-04-18 Anti-ror antibody constructs

Related Child Applications (1)

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JP2023172867A Division JP2023168551A (ja) 2018-04-18 2023-10-04 抗ｒｏｒ抗体構築物

Publications (2)

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JP2021522162A true JP2021522162A (ja) 2021-08-30
JP2021522162A5 JP2021522162A5 (enExample) 2022-04-25

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JP2020556851A Pending JP2021522162A (ja) 2018-04-18 2019-04-18 抗ｒｏｒ抗体構築物
JP2023172867A Withdrawn JP2023168551A (ja) 2018-04-18 2023-10-04 抗ｒｏｒ抗体構築物
JP2025117193A Pending JP2025137618A (ja) 2018-04-18 2025-07-11 抗ｒｏｒ抗体構築物

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JP2023172867A Withdrawn JP2023168551A (ja) 2018-04-18 2023-10-04 抗ｒｏｒ抗体構築物
JP2025117193A Pending JP2025137618A (ja) 2018-04-18 2025-07-11 抗ｒｏｒ抗体構築物

Country Status (15)

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US (2) US12084496B2 (enExample)
EP (1) EP3797122A4 (enExample)
JP (3) JP2021522162A (enExample)
KR (1) KR20200143470A (enExample)
CN (1) CN112384533A (enExample)
AU (2) AU2019256431B2 (enExample)
BR (1) BR112020021269A2 (enExample)
CA (1) CA3097704A1 (enExample)
EA (1) EA202092202A1 (enExample)
IL (2) IL316574A (enExample)
MX (4) MX2020010881A (enExample)
MY (1) MY207121A (enExample)
PH (1) PH12020551716A1 (enExample)
SG (1) SG11202010235QA (enExample)
WO (1) WO2019204564A1 (enExample)

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JP2025526427A (ja) * 2022-07-26 2025-08-13 エイムド バイオ インコーポレイテッド 抗ｒｏｒ１抗体及びその用途

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CA3172530A1 (en) 2021-02-25 2022-09-01 Spencer PARK Ror1 targeting chimeric antigen receptor
WO2023019121A2 (en) * 2021-08-09 2023-02-16 Merck Patent Gmbh Proteins that decouple t cell-mediated tumor cytotoxicity from release of pro-inflammatory cytokines
WO2023077026A1 (en) 2021-10-28 2023-05-04 Lyell Immunopharma, Inc. Methods for culturing cells expressing ror1-binding protein
TW202346330A (zh) * 2022-03-18 2023-12-01 美商長典生物晶片股份有限公司 抗豬繁殖與呼吸道綜合症病毒的抗體及其用途
TW202408589A (zh) 2022-06-30 2024-03-01 美商舒卓生物製藥公司 抗ror1抗體及抗體結合物、包含抗ror1抗體或抗體結合物之組合物，及製造及使用抗ror1抗體及抗體結合物之方法
WO2024207177A1 (en) * 2023-04-04 2024-10-10 Genequantum Healthcare (Suzhou) Co., Ltd. Antibody, linkers, payload, conjugates and applications thereof
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
GB202216284D0 (en) * 2022-11-02 2022-12-14 Ucl Business Ltd Self-regulation
EP4638506A1 (en) * 2022-12-20 2025-10-29 Oncternal Therapeutics, Inc. Combination therapies for the treatment of cancer
KR20260056331A (ko) * 2023-07-20 2026-04-24 엑셀리시스, 인코포레이티드 활성화 가능한 티로신-단백질 키나제 막 수용체(ror) 항체-약물 접합체 및 이의 용도
CN121752598A (zh) * 2023-07-20 2026-03-27 埃克塞里艾克西斯公司 酪氨酸蛋白激酶膜受体1 (ror1)抗体-药物缀合物和其用途
CN121843961A (zh) * 2023-07-20 2026-04-10 埃克塞里艾克西斯公司 可活化的ror结合剂和其用途
WO2025132812A1 (en) * 2023-12-20 2025-06-26 Antalgenics, S.L. Phospholipase c inhibitor peptides and uses thereof
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WO2011159847A2 (en) * 2010-06-15 2011-12-22 The Regents Of The University Of California Receptor tyrosine kinase-like orphan receptor 1 (ror1) single chain fv antibody fragment conjugates and methods of use thereof
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JP2017536341A (ja) * 2014-10-09 2017-12-07 エンクマフ アーゲー 卵巣がんの処置における使用のためのＣＤ３εおよびＲＯＲ１に対する二特異性抗体
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JP2018503380A (ja) * 2015-01-16 2018-02-08 ジュノー セラピューティクス インコーポレイテッド Ｒｏｒ１に特異的な抗体およびキメラ抗原受容体
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025526427A (ja) * 2022-07-26 2025-08-13 エイムド バイオ インコーポレイテッド 抗ｒｏｒ１抗体及びその用途

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WO2019204564A9 (en) 2019-12-12
EA202092202A1 (ru) 2021-07-23
IL278061A (en) 2020-11-30
US20210155692A1 (en) 2021-05-27
WO2019204564A1 (en) 2019-10-24
IL316574A (en) 2024-12-01
JP2025137618A (ja) 2025-09-19
AU2026202585A1 (en) 2026-04-30
AU2019256431B2 (en) 2026-01-15
MX2025001900A (es) 2025-04-02
US12084496B2 (en) 2024-09-10
BR112020021269A2 (pt) 2021-03-16
MY207121A (en) 2025-01-31
MX2025001906A (es) 2025-04-02
EP3797122A1 (en) 2021-03-31
MX2020010881A (es) 2020-11-09
KR20200143470A (ko) 2020-12-23
PH12020551716A1 (en) 2021-07-26
JP2023168551A (ja) 2023-11-24
SG11202010235QA (en) 2020-11-27
CA3097704A1 (en) 2019-10-24
US20240392002A1 (en) 2024-11-28
MX2025001902A (es) 2025-04-02
EP3797122A4 (en) 2022-04-20
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