JP2021520831A5 - - Google Patents
Info
- Publication number
- JP2021520831A5 JP2021520831A5 JP2020556864A JP2020556864A JP2021520831A5 JP 2021520831 A5 JP2021520831 A5 JP 2021520831A5 JP 2020556864 A JP2020556864 A JP 2020556864A JP 2020556864 A JP2020556864 A JP 2020556864A JP 2021520831 A5 JP2021520831 A5 JP 2021520831A5
- Authority
- JP
- Japan
- Prior art keywords
- chain
- tcr
- seq
- treg
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1806331.3 | 2018-04-18 | ||
| GB1806330.5 | 2018-04-18 | ||
| GBGB1806331.3A GB201806331D0 (en) | 2018-04-18 | 2018-04-18 | Method |
| GBGB1806330.5A GB201806330D0 (en) | 2018-04-18 | 2018-04-18 | Engineered regulatory T cell |
| PCT/GB2019/051097 WO2019202322A1 (en) | 2018-04-18 | 2019-04-17 | Engineered regulatory t cell |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021520831A JP2021520831A (ja) | 2021-08-26 |
| JP2021520831A5 true JP2021520831A5 (enExample) | 2022-03-31 |
| JP7436383B2 JP7436383B2 (ja) | 2024-02-21 |
Family
ID=66286535
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020556883A Active JP7391038B2 (ja) | 2018-04-18 | 2019-04-17 | Ｔｒｅｇ細胞の抑制特性を増強するための方法 |
| JP2020556864A Active JP7436383B2 (ja) | 2018-04-18 | 2019-04-17 | 操作された調節性ｔ細胞 |
| JP2023197319A Active JP7839774B2 (ja) | 2018-04-18 | 2023-11-21 | Ｔｒｅｇ細胞の抑制特性を増強するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020556883A Active JP7391038B2 (ja) | 2018-04-18 | 2019-04-17 | Ｔｒｅｇ細胞の抑制特性を増強するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023197319A Active JP7839774B2 (ja) | 2018-04-18 | 2023-11-21 | Ｔｒｅｇ細胞の抑制特性を増強するための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US12227756B2 (enExample) |
| EP (2) | EP3781673A1 (enExample) |
| JP (3) | JP7391038B2 (enExample) |
| KR (1) | KR20210003810A (enExample) |
| CN (2) | CN112334571B (enExample) |
| AU (2) | AU2019256783A1 (enExample) |
| CA (2) | CA3105303A1 (enExample) |
| GB (3) | GB2587988B (enExample) |
| IL (1) | IL278016B2 (enExample) |
| SG (1) | SG11202010154UA (enExample) |
| WO (2) | WO2019202322A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12227756B2 (en) | 2018-04-18 | 2025-02-18 | Ucl Business Ltd | Engineered regulatory T cell |
| WO2020161122A1 (en) * | 2019-02-05 | 2020-08-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant vectors suitable for the treatment of ipex syndrome |
| GB201915359D0 (en) * | 2019-10-23 | 2019-12-04 | Ucl Business Ltd | Engineered regulatory t cell |
| AU2020370033A1 (en) | 2019-10-23 | 2022-06-02 | Ucl Business Ltd | Engineered regulatory T cell |
| PL241050B1 (pl) * | 2019-12-12 | 2022-07-25 | Gdanski Univ Medyczny | Zastosowanie limfocytów T regulatorowych jako leku w leczeniu stwardnienia rozsianego |
| IL302591A (en) * | 2020-11-09 | 2023-07-01 | Quell Therapeutics Ltd | Method for cryopreservation of transgenic regulatory T cells |
| WO2022103789A1 (en) | 2020-11-10 | 2022-05-19 | Kyverna Therapeutics, Inc. | A method for treating disease using foxp3+cd4+ t cells |
| WO2022165419A1 (en) | 2021-02-01 | 2022-08-04 | Kyverna Therapeutics, Inc. | Methods for increasing t-cell function |
| EP4410965A4 (en) * | 2021-09-27 | 2025-09-24 | Univ Kyoto | T LYMPHOCYTE PRODUCTION PROCESS |
| US20250017967A1 (en) | 2021-12-17 | 2025-01-16 | Quell Therapeutics Limited | Anti-thymocyte globulin for immunomodulation of a subject with regulatory t cells |
| US20230210900A1 (en) * | 2022-01-04 | 2023-07-06 | Kyverna Therapeutics, Inc. | Methods for treating autoimmune diseases |
| EP4496883A1 (en) | 2022-03-22 | 2025-01-29 | Quell Therapeutics Limited | Methods and products for culturing t cells and uses thereof |
| JP2025515116A (ja) * | 2022-05-05 | 2025-05-13 | クウェル セラピューティックス リミテッド | 制御性ｔ細胞の抑制活性を維持するための方法 |
| CN120091826A (zh) * | 2022-08-12 | 2025-06-03 | 阿巴塔治疗股份有限公司 | 多发性硬化症的细胞疗法 |
| CN116284447A (zh) * | 2023-02-20 | 2023-06-23 | 苏州大学 | 一种靶向pd1嵌合抗原受体修饰的调节性t细胞及其制备方法与应用 |
| WO2024194605A1 (en) | 2023-03-17 | 2024-09-26 | Quell Therapeutics Limited | Treg therapy |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| ATE139900T1 (de) | 1992-11-13 | 1996-07-15 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| CA2339409A1 (en) | 1998-08-11 | 2000-02-24 | Darwin Discovery Ltd. | Identification of the gene causing the mouse scurfy phenotype and its human ortholog |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| US7507542B2 (en) | 2001-05-08 | 2009-03-24 | Ucb Sa | Method for regulating immune function using the FOXP3 protein |
| FR2825261B1 (fr) | 2001-06-01 | 2003-09-12 | Maco Pharma Sa | Ligne de prelevement du sang placentaire comprenant une poche de rincage |
| CA2528595A1 (en) | 2003-06-13 | 2005-01-06 | Oncomax Acquisition Corp. | Preparation and application of anti-tumor bifunctional fusion proteins |
| US7700097B2 (en) | 2003-06-27 | 2010-04-20 | Biogen Idec Ma Inc. | Purification and preferential synthesis of binding molecules |
| CA2575604A1 (en) * | 2004-07-30 | 2006-02-02 | Oregon Health And Science University | Methods for detecting and treating autoimmune disorders |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| KR20080039844A (ko) | 2005-05-24 | 2008-05-07 | 아베스타 겐그레인 테크놀로지스 피브이티 리미티드 | Ｂ―세포 림프종 치료를 위한 ｃｄ20에 대한 모노클로날항체의 제조 방법 |
| PT2126054T (pt) | 2007-01-31 | 2016-10-12 | Yeda Res & Dev | Células t reguladoras geneticamente modificadas, redirecionadas e sua utilização na supressão de doenças inflamatórias e autoimunitárias |
| EP2050814A1 (en) | 2007-10-17 | 2009-04-22 | Txcell | Compositions for treating multiple sclerosis |
| JP5626164B2 (ja) | 2011-07-26 | 2014-11-19 | 日本精工株式会社 | ステアリングコラム用支持装置 |
| WO2013107413A1 (zh) | 2012-01-19 | 2013-07-25 | 中国科学院上海巴斯德研究所 | 磷酸化途径相关因子在调控调节性t细胞功能中的应用 |
| RU2523058C2 (ru) | 2012-06-29 | 2014-07-20 | Общество с ограниченной ответственностью "Регенекс" | Способ терапии ремиттирующего рассеянного склероза |
| US9693977B2 (en) | 2013-03-15 | 2017-07-04 | President And Fellows Of Harvard College | Method of increasing the quantity of colonic T regulatory cells via G-coupled protein receptor 43 |
| WO2014183056A1 (en) | 2013-05-10 | 2014-11-13 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Design and use of specific regulatory t-cells to induce immune tolerance |
| GB201322430D0 (en) * | 2013-12-18 | 2014-02-05 | Immunocore Ltd | T cell receptors |
| EP3234145B1 (en) | 2014-12-15 | 2019-06-05 | Bellicum Pharmaceuticals, Inc. | Methods for controlled activation or elimination of therapeutic cells |
| JP7013240B2 (ja) | 2015-02-16 | 2022-01-31 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Ｈｅｒ２／Ｎｅｕ （ＥＲＢＢ２）受容体タンパク質に由来する３６９～３７７位エピトープに特異的な完全ヒトＴ細胞受容体 |
| GB201507368D0 (en) * | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| US11365391B2 (en) | 2015-09-28 | 2022-06-21 | Trustees Of Dartmouth College | Chimeric antigen receptor anti-inflammatory cells and methods of use |
| US20190358258A1 (en) | 2015-10-09 | 2019-11-28 | Robert J. Deans | Methods for enhancing proliferation of t regulatory cells |
| US10604586B2 (en) | 2016-05-09 | 2020-03-31 | Industrial Technology Research Institute | Humanized monoclonal antibody and uses thereof |
| EP3714944A1 (en) | 2019-03-29 | 2020-09-30 | Medizinische Hochschule Hannover | Car for use in the treatment of hvg disease |
| EP3478722A1 (en) | 2016-06-30 | 2019-05-08 | F. Hoffmann-La Roche AG | Improved adoptive t-cell therapy |
| EP3263595A1 (en) | 2016-06-30 | 2018-01-03 | Medizinische Hochschule Hannover | Fusion protein for use in the treatment of hvg disease |
| US11241485B2 (en) | 2017-06-12 | 2022-02-08 | Obsidian Therapeutics, Inc. | PDE5 compositions and methods for immunotherapy |
| WO2018236909A1 (en) | 2017-06-20 | 2018-12-27 | La Jolla Institute For Allergy And Immunology | T-MODIFIED LYMPHOCYTE RECEPTORS AND METHODS OF USE IN INFLAMMATORY RESPONMS MODULATION AND ATHEROSCLEROSIS TREATMENT |
| WO2019079034A1 (en) | 2017-10-17 | 2019-04-25 | The General Hospital Corporation | METHODS AND COMPOSITIONS RELATING TO GENETICALLY MODIFIED REGULATORY T LYMPHOCYTES |
| US12227756B2 (en) | 2018-04-18 | 2025-02-18 | Ucl Business Ltd | Engineered regulatory T cell |
| WO2019241549A1 (en) | 2018-06-15 | 2019-12-19 | A2 Biotherapeutics, Inc. | Foxp3-expressing car-t regulatory cells |
| GB201814203D0 (en) | 2018-08-31 | 2018-10-17 | King S College London | Engineered regulatory t cell |
| JP2022533713A (ja) | 2019-05-21 | 2022-07-25 | サンガモ セラピューティクス， インコーポレイテッド | 調節性ｔ細胞における制御された導入遺伝子発現 |
| GB201915359D0 (en) * | 2019-10-23 | 2019-12-04 | Ucl Business Ltd | Engineered regulatory t cell |
| GB201915384D0 (en) | 2019-10-23 | 2019-12-04 | Ucl Business Ltd | Vector |
| GB202007842D0 (en) | 2020-05-26 | 2020-07-08 | Quell Therapeutics Ltd | Polypeptide useful in adoptive cell therapy |
-
2019
- 2019-04-17 US US17/048,587 patent/US12227756B2/en active Active
- 2019-04-17 AU AU2019256783A patent/AU2019256783A1/en not_active Abandoned
- 2019-04-17 CN CN201980041068.5A patent/CN112334571B/zh active Active
- 2019-04-17 CA CA3105303A patent/CA3105303A1/en active Pending
- 2019-04-17 SG SG11202010154UA patent/SG11202010154UA/en unknown
- 2019-04-17 JP JP2020556883A patent/JP7391038B2/ja active Active
- 2019-04-17 JP JP2020556864A patent/JP7436383B2/ja active Active
- 2019-04-17 WO PCT/GB2019/051097 patent/WO2019202322A1/en not_active Ceased
- 2019-04-17 IL IL278016A patent/IL278016B2/en unknown
- 2019-04-17 KR KR1020207032996A patent/KR20210003810A/ko active Pending
- 2019-04-17 CN CN201980026673.5A patent/CN112004924A/zh active Pending
- 2019-04-17 AU AU2019254824A patent/AU2019254824B2/en active Active
- 2019-04-17 US US17/048,239 patent/US12077774B2/en active Active
- 2019-04-17 GB GB2018103.8A patent/GB2587988B/en active Active
- 2019-04-17 EP EP19719600.9A patent/EP3781673A1/en active Pending
- 2019-04-17 GB GB2300916.0A patent/GB2611707A/en not_active Withdrawn
- 2019-04-17 CA CA3098128A patent/CA3098128A1/en active Pending
- 2019-04-17 EP EP19719599.3A patent/EP3781672B1/en active Active
- 2019-04-17 GB GB2300872.5A patent/GB2611498B/en active Active
- 2019-04-17 WO PCT/GB2019/051098 patent/WO2019202323A1/en not_active Ceased
-
2023
- 2023-11-21 JP JP2023197319A patent/JP7839774B2/ja active Active
-
2024
- 2024-08-02 US US18/792,799 patent/US20240384301A1/en active Pending
-
2025
- 2025-01-16 US US19/025,738 patent/US20250154532A1/en active Pending
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