JP2021517808A - 開口部付きの多孔性支持要素を備えた吸入器 - Google Patents
開口部付きの多孔性支持要素を備えた吸入器 Download PDFInfo
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- JP2021517808A JP2021517808A JP2020544613A JP2020544613A JP2021517808A JP 2021517808 A JP2021517808 A JP 2021517808A JP 2020544613 A JP2020544613 A JP 2020544613A JP 2020544613 A JP2020544613 A JP 2020544613A JP 2021517808 A JP2021517808 A JP 2021517808A
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Abstract
Description
Claims (18)
- 吸入器物品であって、
マウスピース端から遠位端に長軸方向軸に沿って延びる本体と、
前記遠位端にあるエンドピース要素と、
前記本体内に画定され、かつ前記長軸方向軸に沿って空洞の長さに延びるカプセル空洞と、
前記エンドピース要素と前記カプセル空洞との間の空気吸込み口領域であって、前記空気吸込み口領域が空気吸込み口および前記吸込み口から前記カプセル空洞に延びる空気通路を有し、前記空気通路が前記カプセル空洞の内径よりも小さい内径を含む、空気吸込み口領域と、
前記カプセル空洞の下流端を画定する多孔性支持要素であって、前記多孔性支持要素が多孔性材料で形成され、前記多孔性支持要素が長軸方向軸に沿って長さに延び、前記多孔性支持要素が前記多孔性支持要素の前記長さに延びる一つ以上の開口部を含む、多孔性支持要素と、
前記カプセル空洞から、前記多孔性要素を通って前記マウスピース端へと延びるマウスピース空気チャネルと、を備える、吸入器物品。 - 前記多孔性支持要素開口部が、前記支持要素の前記長さに沿ってらせん状の特徴を形成する、請求項1に記載の吸入器物品。
- 前記多孔性支持要素がポリ乳酸材料またはセルロースアセテート材料で形成される、請求項1または2に記載の吸入器物品。
- 前記多孔性支持要素が、二つの開口部、または三つの開口部、または四つの開口部、または五つの開口部、または六つの開口部、または七つの開口部を含む、請求項1〜3のいずれかに記載の吸入器物品。
- 前記多孔性支持要素が、前記多孔性支持要素の外径に沿った前記二つ以上の開口部を含む、請求項1〜4のいずれかに記載の吸入器物品。
- 前記多孔性支持要素が、前記長軸方向軸と一致する中央領域を有し、前記中央領域が開口部を含む、請求項1〜5のいずれかに記載の吸入器物品。
- 前記多孔性支持要素が、前記長軸方向軸と一致する中央領域を有し、前記中央領域が開口部を含まない、請求項1〜5のいずれか一項に記載の吸入器物品。
- 前記多孔性支持要素が、前記長軸方向軸と一致する中央領域を有し、前記中央領域が前記多孔性支持要素の外径に沿った一つの開口部および四つ以上の開口部を含む、請求項1〜6のいずれか一項に記載の吸入器物品。
- 前記二つ以上の開口部が、前記多孔性支持要素の外径に沿って相互から均等に間隙を介している、請求項4〜5のいずれか一項に記載の吸入器物品。
- 前記一つ以上の開口部が、前記多孔性支持要素の円形断面積の少なくとも約40%を画定する、または約15%〜約60%の範囲である、請求項1〜9のいずれかに記載の吸入器物品。
- 前記空気吸込み口領域が、前記カプセル空洞内に吸入気流の渦を誘発する渦トンネルを含む、請求項1〜10のいずれかに記載の吸入器物品。
- 請求項1〜11のいずれか一項に記載の吸入器物品と、前記吸入器物品の前記カプセル空洞内に配置されたカプセルとを備え、前記カプセルが医薬的に活性な粒子を含有し、前記医薬的に活性な粒子が、約5マイクロメートル以下、または約0.5マイクロメートル〜約4マイクロメートルの範囲、または約1マイクロメートル〜約3マイクロメートルの範囲の空気動力学的中央粒子径を有する、吸入器システム。
- 前記カプセルがニコチン含む医薬的に活性な粒子を含有する、請求項12に記載のシステム。
- 前記カプセルが、約20マイクロメートル以上、または約50マイクロメートル以上、または約50〜約200マイクロメートルの範囲、または約50〜約150マイクロメートルの範囲の空気動力学的中央粒子径を有する風味粒子の第二の集団をさらに含有する、請求項12または請求項13に記載のシステム。
- 前記システムが、前記カプセルを有効化するために前記吸入器物品と取り外し可能なように係合可能な貫通要素をさらに備え、前記エンドピース要素が、前記カプセルを有効化する時に前記貫通要素によって貫通されるように構成されている、請求項12〜14のいずれか一項に記載のシステム。
- 前記空気通路の前記内径が約2mm〜約4.5mmであり、前記カプセル空洞の内径よりも小さい、請求項1〜15のいずれかに記載の吸入器物品。
- 前記渦トンネルが、前記カプセル空洞の内径よりも小さい内径を含む、請求項11に記載の吸入器物品。
- 前記渦トンネルの前記内径が、前記カプセル空洞の内径よりも小さい約2mm〜約4.5mmである、請求項17に記載の吸入器物品。
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PCT/IB2019/052319 WO2019186337A1 (en) | 2018-03-26 | 2019-03-21 | Inhaler with aperatured porous support element |
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JP7350870B2 (ja) * | 2019-10-10 | 2023-09-26 | 日本たばこ産業株式会社 | 非燃焼加熱型香味吸引器具 |
JP7480287B2 (ja) * | 2019-10-25 | 2024-05-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 折り畳まれた遠位端を有する吸入器物品 |
KR20220087453A (ko) * | 2019-10-25 | 2022-06-24 | 필립모리스 프로덕츠 에스.에이. | 접선 방향 기류 단부 요소를 갖는 흡입기 물품 |
GB201919064D0 (en) * | 2019-12-20 | 2020-02-05 | Nicoventures Trading Ltd | Article for use in an aerosol provision system |
CN116137819A (zh) * | 2020-07-24 | 2023-05-19 | 菲利普莫里斯生产公司 | 吸入器制品 |
EP4210516A1 (en) * | 2020-09-07 | 2023-07-19 | JT International SA | An aerosol generating article and an aerosol generating system |
GB202108939D0 (en) * | 2021-06-22 | 2021-08-04 | Nicoventures Trading Ltd | An article for use with a non-combustible aerosol provision device |
WO2024008817A1 (en) * | 2022-07-05 | 2024-01-11 | Philip Morris Products S.A. | Inhaler article with powder leak protection |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015530106A (ja) * | 2012-09-28 | 2015-10-15 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 吸口端汚損を低減した喫煙物品 |
WO2017109626A1 (en) * | 2015-12-24 | 2017-06-29 | Philip Morris Products S.A. | Nicotine powder delivery system |
WO2017109678A1 (en) * | 2015-12-24 | 2017-06-29 | Philip Morris Products S.A. | Nicotine particle capsule |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4069819A (en) * | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
IT1228459B (it) * | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
SE466684B (sv) * | 1989-03-07 | 1992-03-23 | Draco Ab | Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator |
PT1610850E (pt) * | 2003-04-09 | 2012-06-15 | Novartis Ag | Dispositivo para gerar um aerossol com protecção da entrada de ar |
DE112005001366A5 (de) * | 2004-07-01 | 2007-05-24 | Heribert Schwarz | Rauchlose Zigarette |
CN100431634C (zh) * | 2005-04-04 | 2008-11-12 | 陈庆堂 | 干粉气溶胶化吸入器 |
GB201110863D0 (en) | 2011-06-27 | 2011-08-10 | British American Tobacco Co | Smoking article filter and insertable filter unit thereof |
US10821240B2 (en) * | 2014-02-11 | 2020-11-03 | Vapor Cartridge Technology Llc | Methods and drug delivery devices using cannabis |
UA122124C2 (uk) | 2014-06-20 | 2020-09-25 | Філіп Морріс Продактс С.А. | Система доставки нікотинового порошку із засобами керування потоком повітря |
TWI693031B (zh) | 2015-04-30 | 2020-05-11 | 瑞士商菲利浦莫里斯製品股份有限公司 | 包含具高通氣度之可卸式清新劑遞送元件的氣溶膠產生物件 |
MX2018015620A (es) * | 2016-07-07 | 2019-04-11 | Philip Morris Products Sa | Producto consumible de suministro de particulas de nicotina. |
JP2021509297A (ja) * | 2017-12-28 | 2021-03-25 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 渦トンネルを備えた吸入器 |
-
2019
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015530106A (ja) * | 2012-09-28 | 2015-10-15 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 吸口端汚損を低減した喫煙物品 |
WO2017109626A1 (en) * | 2015-12-24 | 2017-06-29 | Philip Morris Products S.A. | Nicotine powder delivery system |
WO2017109678A1 (en) * | 2015-12-24 | 2017-06-29 | Philip Morris Products S.A. | Nicotine particle capsule |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7212326B1 (ja) | 2021-10-02 | 2023-01-25 | 梅爾斯特(広東)生物科技有限公司 | ドローレジスタンスレギュレーター及びそのドローレジスタンスレギュレーターの電子タバコのシガレットボム |
JP2023053843A (ja) * | 2021-10-02 | 2023-04-13 | 梅爾斯特(広東)生物科技有限公司 | ドローレジスタンスレギュレーター及びそのドローレジスタンスレギュレーターの電子タバコのシガレットボム |
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WO2019186337A1 (en) | 2019-10-03 |
KR20200133335A (ko) | 2020-11-27 |
EP3772252A1 (en) | 2021-02-10 |
BR112020016528A2 (pt) | 2020-12-15 |
US11925751B2 (en) | 2024-03-12 |
EP3772252B1 (en) | 2022-05-04 |
CN111801026B (zh) | 2024-04-19 |
JP7249354B2 (ja) | 2023-03-30 |
CN111801026A (zh) | 2020-10-20 |
RU2020128329A (ru) | 2022-04-26 |
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