JP2021512954A5 - - Google Patents
Info
- Publication number
- JP2021512954A5 JP2021512954A5 JP2020564046A JP2020564046A JP2021512954A5 JP 2021512954 A5 JP2021512954 A5 JP 2021512954A5 JP 2020564046 A JP2020564046 A JP 2020564046A JP 2020564046 A JP2020564046 A JP 2020564046A JP 2021512954 A5 JP2021512954 A5 JP 2021512954A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- trifluoromethyl
- phenyl
- quinazoline
- pyrazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862626739P | 2018-02-06 | 2018-02-06 | |
| US62/626,739 | 2018-02-06 | ||
| US201962793260P | 2019-01-16 | 2019-01-16 | |
| US62/793,260 | 2019-01-16 | ||
| PCT/US2019/016705 WO2019156987A1 (en) | 2018-02-06 | 2019-02-05 | AhR MODULATORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021512954A JP2021512954A (ja) | 2021-05-20 |
| JP2021512954A5 true JP2021512954A5 (enExample) | 2022-02-15 |
| JP7382348B2 JP7382348B2 (ja) | 2023-11-16 |
Family
ID=65494575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564046A Active JP7382348B2 (ja) | 2018-02-06 | 2019-02-05 | ＡｈＲモジュレータ |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10815250B2 (enExample) |
| EP (2) | EP4219495A1 (enExample) |
| JP (1) | JP7382348B2 (enExample) |
| CN (1) | CN111683950B (enExample) |
| CA (1) | CA3090150A1 (enExample) |
| DK (1) | DK3749669T6 (enExample) |
| ES (1) | ES2946632T7 (enExample) |
| FI (1) | FI3749669T6 (enExample) |
| TW (1) | TWI840343B (enExample) |
| WO (1) | WO2019156987A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11548867B2 (en) * | 2017-07-19 | 2023-01-10 | Idea Ya Biosciences, Inc. | Amido compounds as AhR modulators |
| JP7382348B2 (ja) | 2018-02-06 | 2023-11-16 | アイディアヤ バイオサイエンシーズ，インコーポレイティド | ＡｈＲモジュレータ |
| AU2020386967A1 (en) * | 2019-11-22 | 2022-07-07 | Sail Biomedicines, Inc. | Pyridopyrimidinone derivatives as AHR antagonists |
| BR112022020965A2 (pt) * | 2020-04-17 | 2022-12-06 | Dong A St Co Ltd | Derivados de piridopirimidinona e seu uso como moduladores de receptores de hidrocarboneto arila |
| US12570638B2 (en) | 2020-05-20 | 2026-03-10 | Sail Biomedicines, Inc. | Fused imidazole derivatives as AHR antagonists |
| CN114181212B (zh) * | 2020-09-15 | 2023-06-06 | 山东轩竹医药科技有限公司 | 哒嗪酮类AhR抑制剂 |
| CN116745622A (zh) * | 2020-10-13 | 2023-09-12 | 先达生物科技公司 | 与免疫检查点抑制剂疗法相关的生物标志物及其使用方法 |
| US20230381182A1 (en) * | 2020-10-13 | 2023-11-30 | Senda Biosciences, Inc. | Biomarkers Related to Immune Checkpoint Inhibitor Therapy and Methods of Using the Same |
| WO2023020512A1 (zh) * | 2021-08-16 | 2023-02-23 | 成都奥睿药业有限公司 | 取代的吡啶类似物、其制备方法及作为ahr调节剂的用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU72201A (sh) | 1999-04-28 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | Derivati di-aril kiseline kao ppar receptorski ligandi |
| JP2005504047A (ja) | 2001-08-13 | 2005-02-10 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | 紫外線吸収剤 |
| US20050256118A1 (en) | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| CR9465A (es) | 2005-03-25 | 2008-06-19 | Surface Logix Inc | Compuestos mejorados farmacocineticamente |
| US8410109B2 (en) | 2005-07-29 | 2013-04-02 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| WO2008054599A2 (en) | 2006-09-27 | 2008-05-08 | Surface Logix, Inc. | Rho kinase inhibitors |
| CA2714181C (en) | 2008-02-04 | 2013-12-24 | Mercury Therapeutics, Inc. | Ampk modulators |
| ES2586459T3 (es) | 2008-05-01 | 2016-10-14 | Glaxosmithkline Llc | Quinolinas y análogos relacionados como moduladores de sirtuina |
| JP2011521958A (ja) * | 2008-05-27 | 2011-07-28 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | Ｗｎｔタンパク質シグナル伝達阻害剤 |
| MX2011009568A (es) | 2009-03-09 | 2011-12-06 | Surface Logix Inc | Inhibidores de la rho cinasa. |
| WO2010148350A1 (en) * | 2009-06-18 | 2010-12-23 | Cornell University | Photoproducts of tryptophan, their synthesis and uses thereof |
| AU2011282776B2 (en) * | 2010-07-27 | 2014-06-12 | Boston Medical Center Corporation | Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics |
| WO2012050500A1 (en) | 2010-10-14 | 2012-04-19 | Lars Pettersson | 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as ahr activators. |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環化合物及びその使用 |
| AU2012212323A1 (en) | 2011-02-01 | 2013-09-12 | The Board Of Trustees Of The University Of Illinois | HDAC inhibitors and therapeutic methods using the same |
| EP2788476B1 (en) | 2011-12-08 | 2019-05-22 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| MX388871B (es) * | 2014-06-27 | 2025-03-20 | Nogra Pharma Ltd | Moduladores del receptor arilo y metodos para elaborar y usar los mismos. |
| US10669528B2 (en) | 2015-06-25 | 2020-06-02 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| WO2017184547A1 (en) | 2016-04-18 | 2017-10-26 | New York University | Quinoline compounds as modulators of rage activity and uses thereof |
| TWI674260B (zh) | 2017-02-01 | 2019-10-11 | 德商菲尼克斯製藥股份有限公司 | 芳基烴受體(AhR)調節劑化合物 |
| TWI752155B (zh) | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| TW201835070A (zh) | 2017-02-21 | 2018-10-01 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| MX2019012431A (es) | 2017-04-21 | 2020-08-03 | Ikena Oncology Inc | Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos. |
| US11548867B2 (en) | 2017-07-19 | 2023-01-10 | Idea Ya Biosciences, Inc. | Amido compounds as AhR modulators |
| JP7382348B2 (ja) | 2018-02-06 | 2023-11-16 | アイディアヤ バイオサイエンシーズ，インコーポレイティド | ＡｈＲモジュレータ |
| US20210254006A1 (en) | 2018-06-06 | 2021-08-19 | Ideaya Biosciences, Inc. | Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds |
-
2019
- 2019-02-05 JP JP2020564046A patent/JP7382348B2/ja active Active
- 2019-02-05 EP EP23160174.1A patent/EP4219495A1/en not_active Withdrawn
- 2019-02-05 FI FIEP19706135.1T patent/FI3749669T6/fi active
- 2019-02-05 DK DK19706135.1T patent/DK3749669T6/da active
- 2019-02-05 EP EP19706135.1A patent/EP3749669B3/en active Active
- 2019-02-05 US US16/268,444 patent/US10815250B2/en active Active
- 2019-02-05 CN CN201980011943.5A patent/CN111683950B/zh active Active
- 2019-02-05 WO PCT/US2019/016705 patent/WO2019156987A1/en not_active Ceased
- 2019-02-05 CA CA3090150A patent/CA3090150A1/en active Pending
- 2019-02-05 ES ES19706135T patent/ES2946632T7/es active Active
- 2019-02-11 TW TW108104425A patent/TWI840343B/zh active
-
2020
- 2020-09-17 US US17/023,980 patent/US11407764B2/en active Active
-
2022
- 2022-06-29 US US17/853,647 patent/US12258354B2/en active Active
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