JP2021512898A - 複素環p2y14受容体拮抗薬 - Google Patents
複素環p2y14受容体拮抗薬 Download PDFInfo
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- JP2021512898A JP2021512898A JP2020542580A JP2020542580A JP2021512898A JP 2021512898 A JP2021512898 A JP 2021512898A JP 2020542580 A JP2020542580 A JP 2020542580A JP 2020542580 A JP2020542580 A JP 2020542580A JP 2021512898 A JP2021512898 A JP 2021512898A
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- compound
- esi
- mmol
- phenyl
- trifluoromethyl
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- 125000000623 heterocyclic group Chemical group 0.000 title description 12
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 189
- 241000124008 Mammalia Species 0.000 claims abstract description 15
- 208000006673 asthma Diseases 0.000 claims abstract description 8
- 206010061218 Inflammation Diseases 0.000 claims abstract description 7
- 230000004054 inflammatory process Effects 0.000 claims abstract description 7
- 210000003734 kidney Anatomy 0.000 claims abstract description 6
- 201000003883 Cystic fibrosis Diseases 0.000 claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims description 57
- 229910052799 carbon Inorganic materials 0.000 claims description 33
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 24
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 239000003937 drug carrier Substances 0.000 claims description 9
- 208000027866 inflammatory disease Diseases 0.000 claims description 9
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
- 229910052727 yttrium Inorganic materials 0.000 claims description 7
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 230000003042 antagnostic effect Effects 0.000 claims description 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 5
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims description 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 201000010099 disease Diseases 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 2
- 230000008485 antagonism Effects 0.000 abstract 1
- 238000010586 diagram Methods 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 249
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 108
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 93
- 235000019439 ethyl acetate Nutrition 0.000 description 84
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 81
- 239000000203 mixture Substances 0.000 description 74
- 238000000034 method Methods 0.000 description 73
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 69
- 125000004432 carbon atom Chemical group C* 0.000 description 65
- 239000007787 solid Substances 0.000 description 63
- -1 thiopheneyl Chemical group 0.000 description 57
- 239000011541 reaction mixture Substances 0.000 description 55
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 54
- 239000000243 solution Substances 0.000 description 52
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 51
- 230000002829 reductive effect Effects 0.000 description 49
- 238000010898 silica gel chromatography Methods 0.000 description 41
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 38
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 34
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 33
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 33
- 239000012044 organic layer Substances 0.000 description 32
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 30
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 28
- 239000011780 sodium chloride Substances 0.000 description 28
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 26
- 238000004128 high performance liquid chromatography Methods 0.000 description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 25
- 101150003085 Pdcl gene Proteins 0.000 description 24
- 239000010410 layer Substances 0.000 description 24
- 238000002360 preparation method Methods 0.000 description 24
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 21
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 18
- 239000002904 solvent Substances 0.000 description 18
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 16
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 16
- 239000003153 chemical reaction reagent Substances 0.000 description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 15
- 239000005557 antagonist Substances 0.000 description 14
- 238000009472 formulation Methods 0.000 description 14
- 235000019441 ethanol Nutrition 0.000 description 13
- 239000011734 sodium Substances 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 12
- 0 CCOC(C(CC(C1CC2)c(cc3)ccc3C3=CC*CC3)=CC1=CC2C1=CCC(*)C=C1)=O Chemical compound CCOC(C(CC(C1CC2)c(cc3)ccc3C3=CC*CC3)=CC1=CC2C1=CCC(*)C=C1)=O 0.000 description 11
- 125000003118 aryl group Chemical group 0.000 description 11
- 235000014113 dietary fatty acids Nutrition 0.000 description 11
- 239000000194 fatty acid Substances 0.000 description 11
- 229930195729 fatty acid Natural products 0.000 description 11
- 229940095102 methyl benzoate Drugs 0.000 description 11
- KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- 125000005843 halogen group Chemical group 0.000 description 9
- DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 description 9
- 229910000027 potassium carbonate Inorganic materials 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 8
- 239000002585 base Substances 0.000 description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 8
- 239000012453 solvate Substances 0.000 description 8
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 8
- 239000003981 vehicle Substances 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
- UDQTXCHQKHIQMH-KYGLGHNPSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NCC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2O UDQTXCHQKHIQMH-KYGLGHNPSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229940125936 compound 42 Drugs 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 6
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 6
- 239000007821 HATU Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 5
- 229910001873 dinitrogen Inorganic materials 0.000 description 5
- 150000004665 fatty acids Chemical class 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 125000001072 heteroaryl group Chemical group 0.000 description 5
- CQVBKLLZAQYWQT-UHFFFAOYSA-N methyl 3-amino-5-(4-carbamoylphenyl)benzoate Chemical compound COC(=O)C1=CC(N)=CC(=C1)C1=CC=C(C=C1)C(N)=O CQVBKLLZAQYWQT-UHFFFAOYSA-N 0.000 description 5
- GFZITIUEBBDMMN-UHFFFAOYSA-N methyl 3-bromo-5-formylbenzoate Chemical compound COC(=O)C1=CC(Br)=CC(C=O)=C1 GFZITIUEBBDMMN-UHFFFAOYSA-N 0.000 description 5
- IOMMMLWIABWRKL-WUTDNEBXSA-N nazartinib Chemical compound C1N(C(=O)/C=C/CN(C)C)CCCC[C@H]1N1C2=C(Cl)C=CC=C2N=C1NC(=O)C1=CC=NC(C)=C1 IOMMMLWIABWRKL-WUTDNEBXSA-N 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 125000001424 substituent group Chemical group 0.000 description 5
- OOKAZRDERJMRCJ-KOUAFAAESA-N (3r)-7-[(1s,2s,4ar,6s,8s)-2,6-dimethyl-8-[(2s)-2-methylbutanoyl]oxy-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-3-hydroxy-5-oxoheptanoic acid Chemical compound C1=C[C@H](C)[C@H](CCC(=O)C[C@@H](O)CC(O)=O)C2[C@@H](OC(=O)[C@@H](C)CC)C[C@@H](C)C[C@@H]21 OOKAZRDERJMRCJ-KOUAFAAESA-N 0.000 description 4
- QNHZUKXPSZACNB-UHFFFAOYSA-N 1-azido-4-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=CC=C(N=[N+]=[N-])C=C1 QNHZUKXPSZACNB-UHFFFAOYSA-N 0.000 description 4
- XFJBGINZIMNZBW-CRAIPNDOSA-N 5-chloro-2-[4-[(1r,2s)-2-[2-(5-methylsulfonylpyridin-2-yl)oxyethyl]cyclopropyl]piperidin-1-yl]pyrimidine Chemical compound N1=CC(S(=O)(=O)C)=CC=C1OCC[C@H]1[C@@H](C2CCN(CC2)C=2N=CC(Cl)=CN=2)C1 XFJBGINZIMNZBW-CRAIPNDOSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 125000004429 atom Chemical group 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 4
- 125000004122 cyclic group Chemical group 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- KKLSSYPACNFMHI-UHFFFAOYSA-N ethyl 3-amino-5-(4-bromophenyl)-1H-pyrrole-2-carboxylate Chemical compound CCOC(=O)c1[nH]c(cc1N)-c1ccc(Br)cc1 KKLSSYPACNFMHI-UHFFFAOYSA-N 0.000 description 4
- 238000000684 flow cytometry Methods 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000011777 magnesium Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- LEWSRPWKDKGDFQ-UHFFFAOYSA-N methyl 3-(4-carbamoylphenyl)-5-[5-(trifluoromethyl)-1H-indol-2-yl]benzoate Chemical compound C(=O)(C1=CC=C(C2=CC(C3=CC4=CC(C(F)(F)F)=CC=C4N3)=CC(C(=O)OC)=C2)C=C1)N LEWSRPWKDKGDFQ-UHFFFAOYSA-N 0.000 description 4
- RSSSWAXLFLNWFE-UHFFFAOYSA-N methyl 3-(4-carbamoylphenyl)-5-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]benzoate Chemical compound C1=C(C(=O)N)C=CC(=C1)C1=CC(C2=NC3=CC(C(F)(F)F)=CC=C3N2)=CC(C(=O)OC)=C1 RSSSWAXLFLNWFE-UHFFFAOYSA-N 0.000 description 4
- IQJYFZSOYXTNKC-UHFFFAOYSA-N methyl 3-(4-carbamoylphenyl)-5-[6-(trifluoromethyl)-1H-indol-2-yl]benzoate Chemical compound O=C(C1=CC=C(C2=CC(C=3NC4=CC(C(F)(F)F)=CC=C4C=3)=CC(C(=O)OC)=C2)C=C1)N IQJYFZSOYXTNKC-UHFFFAOYSA-N 0.000 description 4
- MNXLJDUZJCMJCI-UHFFFAOYSA-N methyl 3-amino-5-bromobenzoate Chemical compound COC(=O)C1=CC(N)=CC(Br)=C1 MNXLJDUZJCMJCI-UHFFFAOYSA-N 0.000 description 4
- RMNWWMXKJSSAKE-UHFFFAOYSA-N methyl 3-bromo-5-ethynyl-2-methylbenzoate Chemical compound BrC=1C(=C(C(=O)OC)C=C(C=1)C#C)C RMNWWMXKJSSAKE-UHFFFAOYSA-N 0.000 description 4
- PLEFRXUXCLZJGC-UHFFFAOYSA-N methyl 3-bromo-5-ethynylbenzoate Chemical compound COC(=O)c1cc(Br)cc(c1)C#C PLEFRXUXCLZJGC-UHFFFAOYSA-N 0.000 description 4
- LJPMCOSCYIDQLI-UHFFFAOYSA-N methyl 7-bromo-2-[4-(trifluoromethyl)phenyl]-3H-benzimidazole-5-carboxylate Chemical compound C1=2C(=CC(=CC=2NC(=N1)C1=CC=C(C(F)(F)F)C=C1)C(=O)OC)Br LJPMCOSCYIDQLI-UHFFFAOYSA-N 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
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- 108020003175 receptors Proteins 0.000 description 4
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 4
- 235000010378 sodium ascorbate Nutrition 0.000 description 4
- 229960005055 sodium ascorbate Drugs 0.000 description 4
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
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- KKHFRAFPESRGGD-UHFFFAOYSA-N 1,3-dimethyl-7-[3-(n-methylanilino)propyl]purine-2,6-dione Chemical compound C1=NC=2N(C)C(=O)N(C)C(=O)C=2N1CCCN(C)C1=CC=CC=C1 KKHFRAFPESRGGD-UHFFFAOYSA-N 0.000 description 3
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 description 3
- NKBWMBRPILTCRD-UHFFFAOYSA-N 2-Methylheptanoic acid Chemical compound CCCCCC(C)C(O)=O NKBWMBRPILTCRD-UHFFFAOYSA-N 0.000 description 3
- OBETXYAYXDNJHR-UHFFFAOYSA-M 2-ethylhexanoate Chemical compound CCCCC(CC)C([O-])=O OBETXYAYXDNJHR-UHFFFAOYSA-M 0.000 description 3
- VKIGAWAEXPTIOL-UHFFFAOYSA-N 2-hydroxyhexanenitrile Chemical compound CCCCC(O)C#N VKIGAWAEXPTIOL-UHFFFAOYSA-N 0.000 description 3
- YSEQNZOXHCKLOG-UHFFFAOYSA-N 2-methyl-octanoic acid Chemical compound CCCCCCC(C)C(O)=O YSEQNZOXHCKLOG-UHFFFAOYSA-N 0.000 description 3
- DVQSZLXOELHQNJ-UHFFFAOYSA-N 3-(4-carbamoylphenyl)-5-[5-(trifluoromethyl)-1H-indol-2-yl]benzoic acid Chemical compound C1=C(C=CC(=C1)C1=CC(C(=O)O)=CC(C2=CC3=CC(C(F)(F)F)=CC=C3N2)=C1)C(=O)N DVQSZLXOELHQNJ-UHFFFAOYSA-N 0.000 description 3
- GSFZEBQEWYYWBC-UHFFFAOYSA-N 3-(4-piperazin-1-ylphenyl)-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid Chemical compound N1CCN(CC1)C1=CC=C(C2=CC(=CC(N3C=C(C4=CC=C(C(F)(F)F)C=C4)N=N3)=C2)C(=O)O)C=C1 GSFZEBQEWYYWBC-UHFFFAOYSA-N 0.000 description 3
- OXMXKYKVKGAURA-UHFFFAOYSA-N 3-[4-(2-benzyl-2-azabicyclo[3.1.1]heptan-5-yl)phenyl]-5-[4-[4-(trifluoromethyl)phenyl]triazol-1-yl]benzoic acid Chemical compound C1(=CC=CC=C1)CN1C2CC(C3=CC=C(C4=CC(=CC(N5C=C(N=N5)C5=CC=C(C(F)(F)F)C=C5)=C4)C(=O)O)C=C3)(CC1)C2 OXMXKYKVKGAURA-UHFFFAOYSA-N 0.000 description 3
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract
Description
本出願は、2018年2月9日に出願された米国仮特許出願第62/628,699号の利益を主張し、その開示は、全ての目的についてその全体が本明細書に参考として援用される。
本発明は、NIDDK校内調査プログラムによって授与された許可番号ZIA DK031116-29下および米国国立精神保健研究所の精神活性薬スクリーニングプログラムによって授与された契約# HHSN-271-2008-00025-C下での政府支援でなされた。政府はこの発明においてある一定の権利を有する。
ストレスまたは損傷の間に組織および臓器によって放出される細胞外ヌクレオチドは、細胞-表面受容体(P2Rs)のクラスを活性化して先天性および適応免疫応答を増加させる(1-3)。このメカニズムは、抗炎症性アデノシン受容体(ARs、P1受容体とも呼ばれる)と共に、シグナル伝達プリノームの時間依存成分として作用し、種々の障害のある状況において有機体を保護する。P2Y14受容体(P2Y14R)は、内因性アゴニストであるウリジン-5’-ジホスホグルコースおよびウリジン-5’-ジフォスフェートに応答し一部分において好中球の運動性を活性化することによって炎症性活性を媒介する(4-6)。構造的に、P2Y14Rはロードポシン(rhodoposin)様G蛋白質-共役受容体(GPCRs)のδ部門に属する。P2YRsの3つのサブタイプは、グアニンヌクレオチド阻害(Gi)蛋白質によってアデニル酸シクラーゼの阻害に選択的に結合する: P2Y12R、P2Y13RおよびP2Y14R。選択的P2Y14R拮抗薬は、喘息、腎臓の無菌性炎症、糖尿病および神経変性の治療のための可能性のある薬剤として探求されている(7-12)。しかしながら、少数のクラスの拮抗薬しか知られておらず、従ってより多様な競合P2Y14R拮抗薬の明らかな要求がある。一般にP2YRファミリーの他のサブタイプ、例えばP2Y2RおよびP2Y6Rもまた、炎症誘発効果に関連しており、そしてそれらの拮抗薬はそれらの抗炎症活性が望まれている(13、14)。
本発明は、式(I)の化合物:
R1はハロまたはトリフルオロメチルであり、
R2はCOOH、CN、CONH2、または
Aは、
またはその薬理学的に許容し得る塩を提供する。
R7はCOOH、CONH2、CN、
R8はC1-C10アルキル、-CONHR12R13、-CONH(CH2)m-NHR14R15、
R10はハロまたはCF3であり、
R11はハロ、OH、またはC1-C6アルコキシであり、
R12およびR13は独立してHまたはC1-C6アルキルであり、
R14およびR15は独立してHまたはC1-C6アルキルであり、
R16はH、C1-C10、アルキル、またはC3-C10アルキニルであり、および
R17およびR18は両方ともHであるか、または両方ともFであり、
mは1〜約10の整数であり、
(i) XはNであり、YはCHであり、およびZはCHであり、(ii) XはCHであり、YはNであり、およびZはCHであり、もしくは(iii) XはCHであり、YはCHであり、およびZはNであり、
X’およびY’はCまたはNであり、および
Z’はNまたはCR9(式中、R9はHまたはC1-C6アルキルである。)である。)
またはその医薬上許容し得る塩を提供する。
態様において、本発明は式(I)の化合物:
R1はハロまたはトリフルオロメチルであり、
R2はCOOH、CN、CONH2、または
Aは、
またはその薬理学的に許容し得る塩を提供する。
R7はCOOH、CONH2、CN、
R8はC1-C10アルキル、-CONHR12R13、-CONH(CH2)m-NHR14R15、
R10はハロまたはCF3であり、
R11はハロ、OH、またはC1-C6アルコキシであり、
R12およびR13は独立してHまたはC1-C6アルキルであり、
R14およびR15は独立してHまたはC1-C6アルキルであり、
R16はH、C1-C10、アルキル、またはC3-C10アルキニルであり、および
R17およびR18は両方ともHであるか、または両方ともFであり、
mは1〜約10の整数であり、
(i) XはNであり、YはCHであり、およびZはCHであり、(ii) XはCHであり、YはNであり、およびZはCHであり、もしくは(iii) XはCHであり、YはCHであり、およびZはNであり、
X’およびY’はCまたはNであり、および
Z’はNまたはCR9(式中、R9はHまたはC1-C6アルキルである。)である。)
またはその医薬上許容し得る塩を提供する。
スキーム1A〜1D、2、3A〜3D、4A〜4C、および5は、本発明の化合物態様の例示的合成を示す。
スキーム1A
細胞培: hP2Y14-R(CHO-hP2Y14R)を安定に発現するチャイニーズハムスター卵巣細胞を、10% FBS、100ユニット/mLペニシリン、100 mg/mLストレプトマイシン、2mM L-グルタミンおよび0.500 mg/mL G418サルフェート(Geneticin)を補充したダルベッコ改変イーグル培地(DMEM)/Ham’s F12(F12) 1:1中で増殖させた。細胞を、37℃および5% CO2(g)で保持した加湿雰囲気および無菌性インキュベーション条件中で維持した。
本実施例は、本発明の態様に従って、化合物の合成を説明する。
一般的手順: 脱保護反応
方法A: メタノール:水(2:1)中の化合物 (1 eq) および水酸化カリウム (5 eq)の混合物を50℃で撹拌した。この混合物をpHが5-6まで1N HClで中和した。わずかに酸性の混合物を減圧下でエバポレートし、そしてシリカゲルカラムクロマトグラフィー(ジクロロメタン:メタノール:酢酸=95:5:0.1)またはセミ分取用HPLC(10 mM 酢酸トリエチルアンモニウム緩衝液:アセトニトリル=80:20〜20:80で40分)により精製し、化合物を白色固体として得た。
この実施例は、本発明の態様に従って、固定濃度(20 nM)の3aの存在下、全hP2Y14R-CHO細胞のフローサイトメトリーを用いて決定した、hP2Y14R拮抗薬結合の阻害を説明する(平均± SEM, n = 3-6)。式(I)の化合物についての結果を表1に示す。式(II)、(III)、(IV)、(V)、および(VI)の化合物についての結果を表2に示す。
b IC50値は、Junker et al.および Yu et al.8,9からのものであった。
c 化合物による阻害は最高濃度で判別できず、従ってIC50>100 μM。
d ALOGPS 2.1プログラム(www.vcclab.org/lab/alogps/)24を用いて計算したcLogP。
b IC50値は、Junker et al.および Yu et al.8,9からのものであった。
c 化合物による阻害は最高濃度で判別できず、従ってIC50>100 μM。
d ALOGPS 2.1プログラム(www.vcclab.org/lab/alogps/)24を用いて計算したcLogP。
この実施例は、蛍光結合法を用いて、HEK293細胞において発現されたhP2Y14Rに対するmP2Y14Rでの拮抗薬の阻害能力を比較する。結果を表3に示す。
この実施例は、本発明の態様に従って、喘息のプロテアーゼ-媒介マウスモデルにおける本発明の化合物の薬効を説明する。
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9. Xu, J.; Morinaga, H.; Oh, D.; Li, P.; Chen, A.; Talukdar, S.; Lazarowski, E.; Olefsky, J. M.; Kim, J. J. GPR105 J. Immunol. 2012, 189, 1992-1999.
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14. Idzko, M.; Ferrari, D.; Eltzschig, H. K. Nature 2014, 509, 310-317, doi:10.1038/nature13085
Claims (26)
- 式(I)の化合物:
(式中、(i) XはNであり、YはCHであり、およびZはCHであり、(ii) XはCHであり、YはNであり、およびZはCHであり、もしくは(iii) XはCHであり、YはCHであり、およびZはNであり、
R1はハロまたはトリフルオロメチルであり、
R2はCOOH、CN、CONH2、または
であり、
Aは、
(式中、R3は、存在ごとに、H、C1-C10アルキル、C3-C10アルキニル、ベンジル、C1-C6アルコキシカルボニル、-CO(CH2)2O)o(CH2)pQ、または-(CH2)q(CH2)2O)o(CH2)pQ(式中、QはH、C1-C6アルキル、またはNR28R29(式中、R27およびR28は独立してH、C1-C6アルキル、C1-C6アルキルカルボニル、またはC1-C6アルコキシカルボニルである)であり、ならびにR4およびR5はそれぞれHまたはFである)からなる群より選ばれる。)
またはその薬理学的に許容し得る塩。 - X、Y、およびZが全てCHである、請求項1記載の化合物または塩。
- R1がトリフルオロメチルである、請求項1または2記載の化合物または塩。
- 請求項1〜6のいずれか1項記載の化合物または塩および医薬上許容し得る担体を含有する医薬組成物。
- それを必要とする哺乳動物においてP2Y14R受容体を拮抗するのに使用するための請求項1〜6のいずれか1項記載の化合物または塩。
- それを必要とする哺乳動物において炎症性疾患を治療または予防するのに使用するための請求項1〜6のいずれか1項記載の化合物または塩。
- 炎症性疾患が喘息、嚢胞性線維症、および腎臓の無菌性炎症からなる群より選ばれる、請求項8記載の使用するための化合物。
- 式(II)、(III)、(IV)、または(V)の化合物:
からなる群より選ばれ、
R7はCOOH、CONH2、CN、
またはCOCH2NMe2であり、
R8はC1-C10アルキル、-CONHR12R13、-CONH(CH2)m-NHR14R15、
からなる群より選ばれ、
R10はハロまたはCF3であり、
R11はハロ、OH、またはC1-C6アルコキシであり、
R12およびR13は独立してHまたはC1-C6アルキルであり、
R14およびR15は独立してHまたはC1-C6アルキルであり、
R16はH、C1-C10、アルキル、またはC3-C10アルキニルであり、および
R17およびR18は両方ともHであるか、または両方ともFであり、
mは1〜約10の整数であり、
(i) XはNであり、YはCHであり、およびZはCHであり、(ii) XはCHであり、YはNであり、およびZはCHであり、もしくは(iii) XはCHであり、YはCHであり、およびZはNであり、
X’およびY’はCまたはNであり、および
Z’はNまたはCR9(式中、R9はHまたはC1-C6アルキルである。)である。)
またはその医薬上許容し得る塩。 - R7がCOOHである、請求項10記載の化合物または塩。
- 請求項10〜22のいずれか1項記載の化合物または塩および医薬上許容し得る担体を含有する医薬組成物。
- それを必要とする哺乳動物においてP2Y14R受容体を拮抗するのに使用するための請求項10〜22のいずれか1項記載の化合物または塩。
- それを必要とする哺乳動物において炎症性疾患を治療または予防するのに使用するための請求項10〜22のいずれか1項記載の化合物または塩。
- 炎症性疾患が喘息、嚢胞性線維症、および腎臓の無菌性炎症からなる群より選ばれる、請求項25記載の使用するための化合物。
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US8580961B2 (en) | 2010-12-13 | 2013-11-12 | National Tsing Hua University | 2-phenyl-6-azolylpyridine-based ligand and group VIII transition metal complex |
US8882486B2 (en) | 2011-08-01 | 2014-11-11 | Mitsubishi Electric Corporation | Control device for an injection molding machine |
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US11938114B2 (en) | 2017-03-10 | 2024-03-26 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
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JP2011505389A (ja) * | 2007-12-04 | 2011-02-24 | メルク フロスト カナダ リミテツド | Gpr105活性のアンタゴニストとしての置換2−ナフトエ酸 |
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US20210047293A1 (en) | 2021-02-18 |
US11584736B2 (en) | 2023-02-21 |
CN111868036A (zh) | 2020-10-30 |
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