JP2021512299A - 試料中の細胞および非細胞分析物の並行アッセイ法 - Google Patents

試料中の細胞および非細胞分析物の並行アッセイ法 Download PDF

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JP2021512299A
JP2021512299A JP2020540818A JP2020540818A JP2021512299A JP 2021512299 A JP2021512299 A JP 2021512299A JP 2020540818 A JP2020540818 A JP 2020540818A JP 2020540818 A JP2020540818 A JP 2020540818A JP 2021512299 A JP2021512299 A JP 2021512299A
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JPWO2019148054A5 (https=
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スティーブン ワイ. チョウ
スティーブン ワイ. チョウ
ウェイ ディン
ウェイ ディン
ジ リ
ジ リ
ユファン チャン
ユファン チャン
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エッセンリックス コーポレーション
エッセンリックス コーポレーション
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Publication of JP2021512299A publication Critical patent/JP2021512299A/ja
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Rigid containers without fluid transport within
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/29Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using visual detection
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0822Slides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2020540818A 2018-01-25 2019-01-25 試料中の細胞および非細胞分析物の並行アッセイ法 Pending JP2021512299A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862621761P 2018-01-25 2018-01-25
US62/621,761 2018-01-25
PCT/US2019/013388 WO2019140334A1 (en) 2018-01-11 2019-01-11 Homogeneous assay (ii)
USPCT/US2019/013388 2019-01-11
PCT/US2019/015309 WO2019148054A1 (en) 2018-01-25 2019-01-25 Assaying cells and non-cell analytes in a sample in parallel

Publications (3)

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JP2021512299A true JP2021512299A (ja) 2021-05-13
JPWO2019148054A5 JPWO2019148054A5 (https=) 2022-02-09
JP2021512299A5 JP2021512299A5 (https=) 2022-02-09

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US (2) US11940443B2 (https=)
EP (1) EP3743724A4 (https=)
JP (1) JP2021512299A (https=)
CN (2) CN120741847A (https=)
WO (1) WO2019148054A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230095630A (ko) * 2021-12-22 2023-06-29 한국재료연구원 신속 고감도 병원체 검출 장치 및 이를 이용한 병원체 분석 방법

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3655809B1 (en) * 2017-07-20 2025-01-08 Viventis Microscopy Sàrl Microscope, method of operating a microscope and method of imaging a sample
CN112236451A (zh) * 2017-10-26 2021-01-15 Essenlix公司 引起性传播疾病的细菌和免疫t细胞检测
WO2019140334A1 (en) 2018-01-11 2019-07-18 Essenlix Corporation Homogeneous assay (ii)
CN120801147A (zh) * 2018-08-16 2025-10-17 上海宜晟生物科技有限公司 体液,特别是血液中的细胞分析
CN114026422A (zh) * 2018-11-20 2022-02-08 Essenlix 公司 用于快速检测急性期反应物和白细胞的设备和方法
CN114270178A (zh) 2019-02-26 2022-04-01 特鲁维安科学公司 测定装置及其使用方法
US20220276235A1 (en) * 2019-07-18 2022-09-01 Essenlix Corporation Imaging based homogeneous assay
CN115605752A (zh) * 2019-12-20 2023-01-13 Essenlix 公司(Us) 快速细胞内测定
US11308616B2 (en) * 2020-08-04 2022-04-19 PAIGE.AI, Inc. Systems and methods to process electronic images to provide image-based cell group targeting
WO2022081863A2 (en) 2020-10-16 2022-04-21 Life Technologies Corporation Systems and methods for autofocus and automated cell count using artificial intelligence
CN113759129A (zh) * 2021-09-26 2021-12-07 北京倍肯恒业科技发展股份有限公司 一种白细胞结合c反应蛋白快速检测卡及其制备方法
EP4562401A1 (en) 2022-07-27 2025-06-04 The Johns Hopkins University Capturing multi-spectral images
USD1116151S1 (en) 2023-05-03 2026-03-03 Truvian Sciences, Inc. Monolayer
WO2025042839A1 (en) * 2023-08-21 2025-02-27 Truvian Sciences, Inc. Assay device and method of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112277A1 (en) * 2003-06-12 2005-05-26 Sukanta Banerjee Immobilization of bead-displayed ligands on substrate surfaces
US20130105200A1 (en) * 2010-07-01 2013-05-02 Sumitomo Bakelite Co., Ltd. Prepreg, wiring board, and semiconductor device
US20140323330A1 (en) * 2013-04-25 2014-10-30 Vladislav B. Bergo Microarray compositions and methods of their use
WO2017048871A1 (en) * 2015-09-14 2017-03-23 Essenlix Corp. Device and system for analyzing a sample, particularly blood, as well as methods of using the same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1022521A (en) 1911-11-28 1912-04-09 Ralston Steel Car Co Dumping-car.
US4022521A (en) * 1974-02-19 1977-05-10 Honeywell Inc. Microscope slide
US6083761A (en) 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US6358475B1 (en) * 1998-05-27 2002-03-19 Becton, Dickinson And Company Device for preparing thin liquid for microscopic analysis
ES2548567T3 (es) 2004-04-07 2015-10-19 Levine, Robert Aaron Cámara desechable para analizar fluidos biológicos
WO2007076023A2 (en) 2005-12-21 2007-07-05 Meso Scale Technologies, Llc Assay modules having assay reagents and methods of making and using same
US20120108787A1 (en) * 2009-02-26 2012-05-03 Nubiome, Inc. Immobilization Particles for Removal of Microorganisms and/or Chemicals
EP2536818B1 (en) * 2010-02-18 2018-10-03 Bima Limited Immobilised-bead immunomultiplex assay
WO2011149526A2 (en) * 2010-05-25 2011-12-01 Arryx, Inc. Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics
WO2012016136A2 (en) * 2010-07-30 2012-02-02 The General Hospital Corporation Microscale and nanoscale structures for manipulating particles
US10656149B2 (en) * 2013-03-15 2020-05-19 The Trustees Of Princeton University Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis
CN111426822B (zh) * 2015-09-14 2022-12-13 艾森利克斯公司 采集分析蒸汽凝析,特别是呼出气凝析的装置与系统,以及使用方法
WO2017112957A1 (en) 2015-12-23 2017-06-29 VOR, Inc. Dual-image based bioimaging devices and techniques
CN108956241B (zh) * 2017-05-26 2021-04-30 深圳大学 组织芯片的多重染色方法
EP3638421A4 (en) 2017-06-12 2021-04-07 Essenlix Corporation HOMOGENOUS ASSAY

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112277A1 (en) * 2003-06-12 2005-05-26 Sukanta Banerjee Immobilization of bead-displayed ligands on substrate surfaces
US20130105200A1 (en) * 2010-07-01 2013-05-02 Sumitomo Bakelite Co., Ltd. Prepreg, wiring board, and semiconductor device
US20140323330A1 (en) * 2013-04-25 2014-10-30 Vladislav B. Bergo Microarray compositions and methods of their use
WO2017048871A1 (en) * 2015-09-14 2017-03-23 Essenlix Corp. Device and system for analyzing a sample, particularly blood, as well as methods of using the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230095630A (ko) * 2021-12-22 2023-06-29 한국재료연구원 신속 고감도 병원체 검출 장치 및 이를 이용한 병원체 분석 방법
KR102819088B1 (ko) 2021-12-22 2025-06-12 한국재료연구원 신속 고감도 병원체 검출 장치 및 이를 이용한 병원체 분석 방법

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CN120741847A (zh) 2025-10-03
CN112673255B (zh) 2025-03-18
CN112673255A (zh) 2021-04-16
US11940443B2 (en) 2024-03-26
EP3743724A1 (en) 2020-12-02
EP3743724A4 (en) 2021-11-10
US20210011001A1 (en) 2021-01-14
US20240377389A1 (en) 2024-11-14
WO2019148054A1 (en) 2019-08-01

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