CN120741847A - 并行测定样品中细胞和非细胞分析物 - Google Patents

并行测定样品中细胞和非细胞分析物

Info

Publication number
CN120741847A
CN120741847A CN202510216744.5A CN202510216744A CN120741847A CN 120741847 A CN120741847 A CN 120741847A CN 202510216744 A CN202510216744 A CN 202510216744A CN 120741847 A CN120741847 A CN 120741847A
Authority
CN
China
Prior art keywords
sample
plate
certain embodiments
cellular
plates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510216744.5A
Other languages
English (en)
Chinese (zh)
Inventor
斯蒂芬·Y·周
丁惟
李骥
张玙璠
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Yisheng Biotechnology Co ltd
Original Assignee
Shanghai Yisheng Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2019/013388 external-priority patent/WO2019140334A1/en
Application filed by Shanghai Yisheng Biotechnology Co ltd filed Critical Shanghai Yisheng Biotechnology Co ltd
Publication of CN120741847A publication Critical patent/CN120741847A/zh
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/29—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using visual detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202510216744.5A 2018-01-25 2019-01-25 并行测定样品中细胞和非细胞分析物 Pending CN120741847A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862621761P 2018-01-25 2018-01-25
US62/621,761 2018-01-25
PCT/US2019/013388 WO2019140334A1 (en) 2018-01-11 2019-01-11 Homogeneous assay (ii)
USPCT/US2019/013388 2019-01-11
CN201980021703.3A CN112673255B (zh) 2018-01-25 2019-01-25 并行测定样品中细胞和非细胞分析物
PCT/US2019/015309 WO2019148054A1 (en) 2018-01-25 2019-01-25 Assaying cells and non-cell analytes in a sample in parallel

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201980021703.3A Division CN112673255B (zh) 2018-01-25 2019-01-25 并行测定样品中细胞和非细胞分析物

Publications (1)

Publication Number Publication Date
CN120741847A true CN120741847A (zh) 2025-10-03

Family

ID=67395062

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202510216744.5A Pending CN120741847A (zh) 2018-01-25 2019-01-25 并行测定样品中细胞和非细胞分析物
CN201980021703.3A Active CN112673255B (zh) 2018-01-25 2019-01-25 并行测定样品中细胞和非细胞分析物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201980021703.3A Active CN112673255B (zh) 2018-01-25 2019-01-25 并行测定样品中细胞和非细胞分析物

Country Status (5)

Country Link
US (2) US11940443B2 (https=)
EP (1) EP3743724A4 (https=)
JP (1) JP2021512299A (https=)
CN (2) CN120741847A (https=)
WO (1) WO2019148054A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3655809B1 (en) * 2017-07-20 2025-01-08 Viventis Microscopy Sàrl Microscope, method of operating a microscope and method of imaging a sample
CN112236451A (zh) * 2017-10-26 2021-01-15 Essenlix公司 引起性传播疾病的细菌和免疫t细胞检测
WO2019140334A1 (en) 2018-01-11 2019-07-18 Essenlix Corporation Homogeneous assay (ii)
CN120801147A (zh) * 2018-08-16 2025-10-17 上海宜晟生物科技有限公司 体液，特别是血液中的细胞分析
CN114026422A (zh) * 2018-11-20 2022-02-08 Essenlix 公司 用于快速检测急性期反应物和白细胞的设备和方法
CN114270178A (zh) 2019-02-26 2022-04-01 特鲁维安科学公司 测定装置及其使用方法
US20220276235A1 (en) * 2019-07-18 2022-09-01 Essenlix Corporation Imaging based homogeneous assay
CN115605752A (zh) * 2019-12-20 2023-01-13 Essenlix 公司（Us） 快速细胞内测定
US11308616B2 (en) * 2020-08-04 2022-04-19 PAIGE.AI, Inc. Systems and methods to process electronic images to provide image-based cell group targeting
WO2022081863A2 (en) 2020-10-16 2022-04-21 Life Technologies Corporation Systems and methods for autofocus and automated cell count using artificial intelligence
KR102819088B1 (ko) * 2021-12-22 2025-06-12 한국재료연구원 신속 고감도 병원체 검출 장치 및 이를 이용한 병원체 분석 방법
CN113759129A (zh) * 2021-09-26 2021-12-07 北京倍肯恒业科技发展股份有限公司 一种白细胞结合c反应蛋白快速检测卡及其制备方法
EP4562401A1 (en) 2022-07-27 2025-06-04 The Johns Hopkins University Capturing multi-spectral images
USD1116151S1 (en) 2023-05-03 2026-03-03 Truvian Sciences, Inc. Monolayer
WO2025042839A1 (en) * 2023-08-21 2025-02-27 Truvian Sciences, Inc. Assay device and method of use thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1022521A (en) 1911-11-28 1912-04-09 Ralston Steel Car Co Dumping-car.
US4022521A (en) * 1974-02-19 1977-05-10 Honeywell Inc. Microscope slide
US6083761A (en) 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
US6358475B1 (en) * 1998-05-27 2002-03-19 Becton, Dickinson And Company Device for preparing thin liquid for microscopic analysis
US7452565B2 (en) 2003-06-12 2008-11-18 Sukanta Banerjee Immobilization of bead-displayed ligands on substrate surfaces
ES2548567T3 (es) 2004-04-07 2015-10-19 Levine, Robert Aaron Cámara desechable para analizar fluidos biológicos
WO2007076023A2 (en) 2005-12-21 2007-07-05 Meso Scale Technologies, Llc Assay modules having assay reagents and methods of making and using same
US20120108787A1 (en) * 2009-02-26 2012-05-03 Nubiome, Inc. Immobilization Particles for Removal of Microorganisms and/or Chemicals
EP2536818B1 (en) * 2010-02-18 2018-10-03 Bima Limited Immobilised-bead immunomultiplex assay
WO2011149526A2 (en) * 2010-05-25 2011-12-01 Arryx, Inc. Methods and apparatuses for detection of positional freedom of particles in biological and chemical analyses and applications in immunodiagnostics
TW201220977A (en) 2010-07-01 2012-05-16 Sumitomo Bakelite Co Preppreg, circuit board, and semiconductor device
WO2012016136A2 (en) * 2010-07-30 2012-02-02 The General Hospital Corporation Microscale and nanoscale structures for manipulating particles
US10656149B2 (en) * 2013-03-15 2020-05-19 The Trustees Of Princeton University Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis
WO2014176435A2 (en) * 2013-04-25 2014-10-30 Bergo Vladislav B Microarray compositions and methods of their use
WO2017048871A1 (en) * 2015-09-14 2017-03-23 Essenlix Corp. Device and system for analyzing a sample, particularly blood, as well as methods of using the same
CN111426822B (zh) * 2015-09-14 2022-12-13 艾森利克斯公司 采集分析蒸汽凝析，特别是呼出气凝析的装置与系统，以及使用方法
WO2017112957A1 (en) 2015-12-23 2017-06-29 VOR, Inc. Dual-image based bioimaging devices and techniques
CN108956241B (zh) * 2017-05-26 2021-04-30 深圳大学 组织芯片的多重染色方法
EP3638421A4 (en) 2017-06-12 2021-04-07 Essenlix Corporation HOMOGENOUS ASSAY

Also Published As

Publication number Publication date
CN112673255B (zh) 2025-03-18
CN112673255A (zh) 2021-04-16
US11940443B2 (en) 2024-03-26
EP3743724A1 (en) 2020-12-02
EP3743724A4 (en) 2021-11-10
US20210011001A1 (en) 2021-01-14
US20240377389A1 (en) 2024-11-14
JP2021512299A (ja) 2021-05-13
WO2019148054A1 (en) 2019-08-01

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