JP2021511013A5 - - Google Patents
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- JP2021511013A5 JP2021511013A5 JP2020532877A JP2020532877A JP2021511013A5 JP 2021511013 A5 JP2021511013 A5 JP 2021511013A5 JP 2020532877 A JP2020532877 A JP 2020532877A JP 2020532877 A JP2020532877 A JP 2020532877A JP 2021511013 A5 JP2021511013 A5 JP 2021511013A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- group
- fusion protein
- acid sequence
- functional variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020001507 fusion proteins Proteins 0.000 claims 21
- 102000037865 fusion proteins Human genes 0.000 claims 21
- -1 A33 Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 102000000311 Cytosine Deaminase Human genes 0.000 claims 8
- 108010080611 Cytosine Deaminase Proteins 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 3
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 3
- 108010007712 Hepatitis A Virus Cellular Receptor 1 Proteins 0.000 claims 3
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims 3
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 3
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
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- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
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- 102100022662 Guanylyl cyclase C Human genes 0.000 claims 2
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- 101000899808 Homo sapiens Guanylyl cyclase C Proteins 0.000 claims 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 claims 2
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 2
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- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
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- JPSHPWJJSVEEAX-OWPBQMJCSA-N (2s)-2-amino-4-fluoranylpentanedioic acid Chemical compound OC(=O)[C@@H](N)CC([18F])C(O)=O JPSHPWJJSVEEAX-OWPBQMJCSA-N 0.000 claims 1
- SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 claims 1
- HXNBAOLVPAWYLT-NVNXTCNLSA-N (5z)-5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one Chemical compound S\1C(=S)NC(=O)C/1=C/C1=CC(Br)=CC=C1OCC1=CC=CC=C1Br HXNBAOLVPAWYLT-NVNXTCNLSA-N 0.000 claims 1
- 102220550021 3-ketoacyl-CoA thiolase, mitochondrial_T86D_mutation Human genes 0.000 claims 1
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 claims 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 108700020463 BRCA1 Proteins 0.000 claims 1
- 102000036365 BRCA1 Human genes 0.000 claims 1
- 101150072950 BRCA1 gene Proteins 0.000 claims 1
- 102000052609 BRCA2 Human genes 0.000 claims 1
- 108700020462 BRCA2 Proteins 0.000 claims 1
- 102000015735 Beta-catenin Human genes 0.000 claims 1
- 108060000903 Beta-catenin Proteins 0.000 claims 1
- 101150008921 Brca2 gene Proteins 0.000 claims 1
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 1
- 108700012439 CA9 Proteins 0.000 claims 1
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- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
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- 101150013553 CD40 gene Proteins 0.000 claims 1
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- 108010065524 CD52 Antigen Proteins 0.000 claims 1
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- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
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- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 1
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- 102100039496 Choline transporter-like protein 4 Human genes 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
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- 241000588724 Escherichia coli Species 0.000 claims 1
- 101100306202 Escherichia coli (strain K12) rpoB gene Proteins 0.000 claims 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 claims 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023111309A JP2023126935A (ja) | 2018-01-04 | 2023-07-06 | シングルドメイン抗体－シトシンデアミナーゼ融合タンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862613653P | 2018-01-04 | 2018-01-04 | |
| US62/613,653 | 2018-01-04 | ||
| PCT/IB2019/000013 WO2019135159A2 (en) | 2018-01-04 | 2019-01-04 | Single-domain antibody-cytosine deaminase fusion proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023111309A Division JP2023126935A (ja) | 2018-01-04 | 2023-07-06 | シングルドメイン抗体－シトシンデアミナーゼ融合タンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021511013A JP2021511013A (ja) | 2021-05-06 |
| JP2021511013A5 true JP2021511013A5 (OSRAM) | 2021-12-23 |
Family
ID=67058005
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020532877A Pending JP2021511013A (ja) | 2018-01-04 | 2019-01-04 | シングルドメイン抗体−シトシンデアミナーゼ融合タンパク質 |
| JP2023111309A Withdrawn JP2023126935A (ja) | 2018-01-04 | 2023-07-06 | シングルドメイン抗体－シトシンデアミナーゼ融合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023111309A Withdrawn JP2023126935A (ja) | 2018-01-04 | 2023-07-06 | シングルドメイン抗体－シトシンデアミナーゼ融合タンパク質 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20190202931A1 (OSRAM) |
| EP (1) | EP3735420A4 (OSRAM) |
| JP (2) | JP2021511013A (OSRAM) |
| KR (1) | KR20200106032A (OSRAM) |
| CN (1) | CN112272673A (OSRAM) |
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| WO (1) | WO2019135159A2 (OSRAM) |
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Families Citing this family (10)
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| CN113527496B (zh) * | 2020-04-16 | 2022-03-04 | 上海洛启生物医药技术有限公司 | 抗Trop2纳米抗体及其应用 |
| EP4135733A4 (en) * | 2020-04-17 | 2024-06-26 | University of Cincinnati | MODIFIED PROBIOTICS FOR TREATMENT AND IMMUNITY AGAINST VIRUSES |
| CA3205007A1 (en) * | 2020-12-17 | 2022-06-23 | Parasol Biotech Ltd. | Gucy2c binding molecules and uses thereof |
| WO2022152862A1 (en) * | 2021-01-14 | 2022-07-21 | Institut Curie | Her2 single domain antibodies variants and cars thereof |
| CN118215685A (zh) * | 2021-12-27 | 2024-06-18 | 山东先声生物制药有限公司 | 抗gucy2c抗体及其应用 |
| WO2023198008A1 (en) * | 2022-04-11 | 2023-10-19 | Bj Bioscience Inc. | Compositions and methods for treating cancer |
| WO2023198007A1 (en) * | 2022-04-11 | 2023-10-19 | Bj Bioscience Inc. | Anti-nectin-4 antibodies and bispecific antibodies |
| CN116063498A (zh) * | 2022-04-27 | 2023-05-05 | 博际生物医药科技(杭州)有限公司 | 单域抗Nectin-4抗体 |
| CN119604536A (zh) * | 2022-05-23 | 2025-03-11 | 塞雷乌斯股份有限公司 | Her2结合剂及其用途 |
| CN116655806B (zh) * | 2023-05-31 | 2024-01-05 | 四川大学华西医院 | 包含shp2 c-sh2结构域的靶向her2阳性肿瘤的car-t及制备方法和应用 |
Family Cites Families (8)
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| NZ225599A (en) * | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
| DE4314556A1 (de) * | 1993-05-04 | 1994-11-10 | Behringwerke Ag | Modifizierte Antikörperenzymkonjugate und Fusionsproteine sowie ihre Anwendung zur tumorselektiven Therapie |
| US7109304B2 (en) * | 2003-07-31 | 2006-09-19 | Immunomedics, Inc. | Humanized anti-CD19 antibodies |
| AR059900A1 (es) * | 2006-03-17 | 2008-05-07 | Genentech Inc | Anticuerpos anti-tat226 e inmunoconjugados |
| ES2528922T3 (es) * | 2007-07-16 | 2015-02-13 | Genentech, Inc. | Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso |
| WO2009068631A1 (en) * | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| CA2757382A1 (en) * | 2009-04-01 | 2010-10-21 | Kristi Elkins | Anti-fcrh5 antibodies and immunoconjugates |
| GB201010389D0 (en) * | 2010-06-21 | 2010-08-04 | Ist Superiore Sanita | Antibody derivatives |
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2019
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- 2019-01-04 AU AU2019205128A patent/AU2019205128A1/en not_active Abandoned
- 2019-01-04 CA CA3087135A patent/CA3087135A1/en active Pending
- 2019-01-04 RU RU2020116541A patent/RU2020116541A/ru unknown
- 2019-01-04 US US16/239,887 patent/US20190202931A1/en not_active Abandoned
- 2019-01-04 TW TW108100438A patent/TW201932487A/zh unknown
- 2019-01-04 BR BR112020013244-6A patent/BR112020013244A2/pt not_active IP Right Cessation
- 2019-01-04 EP EP19736000.1A patent/EP3735420A4/en not_active Withdrawn
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- 2019-01-04 CN CN201980007078.7A patent/CN112272673A/zh active Pending
- 2019-01-04 WO PCT/IB2019/000013 patent/WO2019135159A2/en not_active Ceased
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2020
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- 2020-06-28 IL IL275691A patent/IL275691A/en unknown
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2021
- 2021-09-03 US US17/446,950 patent/US20220056149A1/en not_active Abandoned
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2023
- 2023-07-06 JP JP2023111309A patent/JP2023126935A/ja not_active Withdrawn
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