JP2021510692A - ガレクチンの新規なガラクトシド阻害剤 - Google Patents
ガレクチンの新規なガラクトシド阻害剤 Download PDFInfo
- Publication number
- JP2021510692A JP2021510692A JP2020538084A JP2020538084A JP2021510692A JP 2021510692 A JP2021510692 A JP 2021510692A JP 2020538084 A JP2020538084 A JP 2020538084A JP 2020538084 A JP2020538084 A JP 2020538084A JP 2021510692 A JP2021510692 A JP 2021510692A
- Authority
- JP
- Japan
- Prior art keywords
- deoxy
- thio
- triazole
- galactopyranoside
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *c(c(Cl)c1)ncc1S[C@](C(C1[n]2nnc(-c3c[s]c(O)n3)c2)O)OC(CO)[C@@]1O Chemical compound *c(c(Cl)c1)ncc1S[C@](C(C1[n]2nnc(-c3c[s]c(O)n3)c2)O)OC(CO)[C@@]1O 0.000 description 5
- RSOFYKRANCNBKS-TXIHYXHLSA-N CC(OCC([C@@H](C(C1OC(C)=O)N)OC(C)=O)O[C@H]1Cl)=O Chemical compound CC(OCC([C@@H](C(C1OC(C)=O)N)OC(C)=O)O[C@H]1Cl)=O RSOFYKRANCNBKS-TXIHYXHLSA-N 0.000 description 1
- AXTAJSAIDGDYDB-PYLPIWIQSA-O CC(OCC([C@@H](C1N/C=C(/C(N)=S)\N=[NH2+])OC(C)=O)OC(Sc(cc2)cc(Cl)c2Cl)=C1OC(C)=O)=O Chemical compound CC(OCC([C@@H](C1N/C=C(/C(N)=S)\N=[NH2+])OC(C)=O)OC(Sc(cc2)cc(Cl)c2Cl)=C1OC(C)=O)=O AXTAJSAIDGDYDB-PYLPIWIQSA-O 0.000 description 1
- QWVPDDBXICKWPZ-CPEFVRJUSA-N CC([C@H](C(COC(C)=O)O[C@@H]1Sc2ccc(C)c(Cl)c2)OC(C)=O)C1OC(C)=O Chemical compound CC([C@H](C(COC(C)=O)O[C@@H]1Sc2ccc(C)c(Cl)c2)OC(C)=O)C1OC(C)=O QWVPDDBXICKWPZ-CPEFVRJUSA-N 0.000 description 1
- BGOGGQHKWUJJFX-UHFFFAOYSA-N C[Si](C)(C)C#Cc1nc(Cl)c[s]1 Chemical compound C[Si](C)(C)C#Cc1nc(Cl)c[s]1 BGOGGQHKWUJJFX-UHFFFAOYSA-N 0.000 description 1
- PNHGFDCNABQFPZ-NUVPSNFDSA-N N=N/C(/c1c[s]c(O)n1)=C\NC(C([C@H](OC1CO)Sc(cc2)cc(Br)c2C#N)O)=C1O Chemical compound N=N/C(/c1c[s]c(O)n1)=C\NC(C([C@H](OC1CO)Sc(cc2)cc(Br)c2C#N)O)=C1O PNHGFDCNABQFPZ-NUVPSNFDSA-N 0.000 description 1
- OPRCEDOIBGQMPP-KUPQVICFSA-N NC(c(ncc(Cl)c1)c1S[C@H](C(C1N/C=C(/c2nc(Cl)c[s]2)\N=N)O)OC(CO)[C@@H]1O)=O Chemical compound NC(c(ncc(Cl)c1)c1S[C@H](C(C1N/C=C(/c2nc(Cl)c[s]2)\N=N)O)OC(CO)[C@@H]1O)=O OPRCEDOIBGQMPP-KUPQVICFSA-N 0.000 description 1
- MEHIVLLXQCWEFJ-UHFFFAOYSA-O OCC(C(C(C1O)N2[NH2+]NC(c3nc(F)c[s]3)=C2)O)OC1Sc(cc1Cl)ccc1Cl Chemical compound OCC(C(C(C1O)N2[NH2+]NC(c3nc(F)c[s]3)=C2)O)OC1Sc(cc1Cl)ccc1Cl MEHIVLLXQCWEFJ-UHFFFAOYSA-O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18150959.7 | 2018-01-10 | ||
| EP18150959 | 2018-01-10 | ||
| PCT/EP2019/050467 WO2019137971A1 (en) | 2018-01-10 | 2019-01-09 | Novel galactoside inhibitor of galectins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021510692A true JP2021510692A (ja) | 2021-04-30 |
| JP2021510692A5 JP2021510692A5 (https=) | 2022-01-13 |
| JPWO2019137971A5 JPWO2019137971A5 (https=) | 2022-01-13 |
Family
ID=60953765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538084A Pending JP2021510692A (ja) | 2018-01-10 | 2019-01-09 | ガレクチンの新規なガラクトシド阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11046725B2 (https=) |
| EP (1) | EP3737686A1 (https=) |
| JP (1) | JP2021510692A (https=) |
| KR (1) | KR20200108303A (https=) |
| CN (1) | CN111699193A (https=) |
| BR (1) | BR112020013647A2 (https=) |
| CA (1) | CA3086092A1 (https=) |
| EA (1) | EA202091684A1 (https=) |
| MX (1) | MX2020007391A (https=) |
| WO (1) | WO2019137971A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022538635A (ja) * | 2019-07-03 | 2022-09-05 | ガレクト バイオテック エービー | ガレクチンの新規なガラクトシド阻害剤 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6904906B2 (ja) * | 2015-01-30 | 2021-07-21 | ガレクト・バイオテック・エイビイ | ガレクチンの新規なガラクトシド阻害剤 |
| US11046725B2 (en) * | 2018-01-10 | 2021-06-29 | Galecto Biotech Ab | Galactoside inhibitor of galectins |
| CN113366007A (zh) * | 2018-10-15 | 2021-09-07 | 格莱克特生物技术公司 | 半乳糖凝集素的半乳糖苷抑制剂 |
| EP3983423A4 (en) | 2019-06-14 | 2023-07-19 | Université Laval | SYNTHESIS OF 3-AZIDO-3-DEOXY-D-GALACTOPYRANOSE |
| TW202134214A (zh) * | 2020-03-04 | 2021-09-16 | 瑞士商先正達農作物保護公司 | 用於製備具有3-含硫取代基的5-氯-吡啶-2-甲酸醯胺以及甲酸鹽之方法 |
| WO2025180907A1 (en) * | 2024-02-26 | 2025-09-04 | Galecto Biotech Ab | Specific galactoside inhibitor of galectin-1 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016120403A1 (en) * | 2015-01-30 | 2016-08-04 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| JP7038099B2 (ja) * | 2016-07-12 | 2022-03-17 | ガレクト バイオテック エービー | ガレクチンのα－Ｄ－ガラクトシド阻害剤 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6849607B2 (en) | 2001-05-09 | 2005-02-01 | Health Research, Inc. | Galectin recognized photosensitizers for photodynamic therapy |
| SE0401301D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel 3-triazolyl-galactoside inhibitors of galectins |
| SE0401300D0 (sv) | 2004-05-21 | 2004-05-21 | Forskarpatent I Syd Ab | Novel Galactoside Inhibitors of Galectins |
| CN102439021B (zh) | 2009-04-28 | 2015-09-02 | 格莱克特生物技术公司 | 半乳凝素的新型半乳糖苷抑制剂 |
| US8828971B2 (en) | 2012-10-10 | 2014-09-09 | Galectin Therapeutics, Inc. | Galactose-pronged carbohydrate compounds for the treatment of diabetic nephropathy and associated disorders |
| JP2015535233A (ja) | 2012-10-31 | 2015-12-10 | ガレクト・バイオテック・エイビイ | ガレクチン−３のガラクトシド阻害剤及び肺線維症のためのその使用 |
| EP3245216B1 (en) * | 2015-01-16 | 2019-12-11 | Galecto Biotech AB | Novel galactoside inhibitor of galectins |
| CA3025867A1 (en) * | 2016-07-12 | 2018-01-18 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| US11046725B2 (en) * | 2018-01-10 | 2021-06-29 | Galecto Biotech Ab | Galactoside inhibitor of galectins |
-
2019
- 2019-01-09 US US16/960,996 patent/US11046725B2/en active Active
- 2019-01-09 CN CN201980007910.3A patent/CN111699193A/zh active Pending
- 2019-01-09 JP JP2020538084A patent/JP2021510692A/ja active Pending
- 2019-01-09 EA EA202091684A patent/EA202091684A1/ru unknown
- 2019-01-09 MX MX2020007391A patent/MX2020007391A/es unknown
- 2019-01-09 KR KR1020207022591A patent/KR20200108303A/ko not_active Withdrawn
- 2019-01-09 BR BR112020013647-6A patent/BR112020013647A2/pt not_active Application Discontinuation
- 2019-01-09 CA CA3086092A patent/CA3086092A1/en active Pending
- 2019-01-09 WO PCT/EP2019/050467 patent/WO2019137971A1/en not_active Ceased
- 2019-01-09 EP EP19700281.9A patent/EP3737686A1/en not_active Withdrawn
-
2021
- 2021-05-24 US US17/327,954 patent/US11827666B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016120403A1 (en) * | 2015-01-30 | 2016-08-04 | Galecto Biotech Ab | Alpha-d-galactoside inhibitors of galectins |
| JP7038099B2 (ja) * | 2016-07-12 | 2022-03-17 | ガレクト バイオテック エービー | ガレクチンのα－Ｄ－ガラクトシド阻害剤 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022538635A (ja) * | 2019-07-03 | 2022-09-05 | ガレクト バイオテック エービー | ガレクチンの新規なガラクトシド阻害剤 |
| JP7674276B2 (ja) | 2019-07-03 | 2025-05-09 | ガレクト バイオテック エービー | ガレクチンの新規なガラクトシド阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020013647A2 (pt) | 2020-12-01 |
| MX2020007391A (es) | 2020-09-03 |
| WO2019137971A1 (en) | 2019-07-18 |
| EA202091684A1 (ru) | 2020-12-04 |
| KR20200108303A (ko) | 2020-09-17 |
| US20200347089A1 (en) | 2020-11-05 |
| US11827666B2 (en) | 2023-11-28 |
| CN111699193A (zh) | 2020-09-22 |
| EP3737686A1 (en) | 2020-11-18 |
| US11046725B2 (en) | 2021-06-29 |
| US20210284678A1 (en) | 2021-09-16 |
| CA3086092A1 (en) | 2019-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
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| A621 | Written request for application examination |
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| A131 | Notification of reasons for refusal |
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| A601 | Written request for extension of time |
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