JP2021508735A - ゴカヒ、ロコン、及びアカマツ抽出物を有効成分として含む前立腺疾患の予防、治療、又は改善用組成物 - Google Patents
ゴカヒ、ロコン、及びアカマツ抽出物を有効成分として含む前立腺疾患の予防、治療、又は改善用組成物 Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
【選択図】図1
Description
実施例1.ゴカヒ、ロコン、及びアカマツ複合抽出物の調製
乾燥したゴカヒ、ロコン、及びアカマツをそれぞれ溶媒に入れて加熱することでその抽出物を獲得し、前記抽出物を濃縮して各抽出物の濃縮抽出物を調製した。
結合相クロマトグラフィー(Bonded Phase Chromatography:BPC)は、各有効化合物と固定相及び移動相間の親和性によって分離される性質を用いる。
テストステロンの低下は、更年期男性に現われる最も重要な指標として、総テストステロン(Total Testosterone:TT)を測定した。
前立腺肥大症の改善に役立つ候補素材であるロコン、アカマツより分離した活性化合物(active compound)を基準に、それぞれの植物内含量及びバリデーション(validation)を評価して、機能性素材としての可能性を評価した。
HPLCを用いて複合抽出物のクロマトグラフィーを比較することで、アカントシドD及びp−クマル酸のピークが分離されるかどうかを確認した結果、図3及び図4に示したように、他の成分の干渉なしにアカントシドD及びp−クマル酸が分離されることを確認することができた。
図5から確認できるように、アカントシドDをHPLCで分析して作成した検量線の一次回帰式(Linear regression equation)は、y=22027 x−105709であり、検量線の相関係数(R2)は0.9998であって、良好な直線性を呈し、p−クマル酸をHPLCで分析して作成した検量線の一次回帰式は、y=46962 x−107117であり、検量線の相関係数(R2)は1であって、高い直線性を確認することができた。
図6に示したように、アカントシドDの正確性は、96.77〜101.46%以内であることを確認し、精密性は変動係数(C.V.:Coefficient Variation)で0.46〜1.13%であって、良好な値を示した。
アカントシドD及びp−クマル酸を効能指標にして、前記実施例1で調製した複合抽出物の指標成分の含量を評価した。
5アルファ還元酵素は、総3種類の亜型(I型、II型、III型)が明らかになっており、その中でもI型、III型は男性型脱毛やにきびなどのような疾患を対象にして研究されており、II型は前立腺肥大症と直接関連があるものと知られている。
Claims (7)
- ゴカヒ、ロコン、及びアカマツ抽出物を有効成分として含む、前立腺疾患の予防又は治療用薬学的組成物であって、
前記前立腺疾患は、前立腺癌又は前立腺肥大症であり、
前記組成物は、アカマツ抽出物1重量部に対してゴカヒ抽出物2〜5重量部を含み、ロコン抽出物1〜3重量部を含むことを特徴とする、薬学的組成物。 - 前記組成物は、5アルファ−還元酵素(5α-reductase)の活性を抑制することを特徴とする、請求項1記載の前立腺疾患の予防又は治療用薬学的組成物。
- 前記ゴカヒ、ロコン、及びアカマツ抽出物は、水、炭素数1〜4のアルコール、n−ヘキサン、エチルアセテート、アセトン、ブチルアセテート、1,3−ブチレングリコール、メチレンクロライド、及びこれらの混合溶媒からなる群より選択される1つ以上の溶媒で抽出されたことを特徴とする、請求項1記載の前立腺疾患の予防又は治療用薬学的組成物。
- 前記組成物は、アカマツ抽出物1重量部に対してゴカヒ抽出物4重量部及びロコン抽出物2重量部を含むことを特徴とする、請求項1記載の前立腺疾患の予防又は治療用薬学的組成物。
- ゴカヒ、ロコン、及びアカマツ抽出物を有効成分として含む、前立腺疾患の予防又は改善用健康機能食品組成物であって、
前記前立腺疾患は前立腺癌又は前立腺肥大症であり、
前記組成物は、アカマツ抽出物1重量部に対してゴカヒ抽出物2〜5重量部を含み、ロコン抽出物1〜3重量部を含むことを特徴とする、健康機能食品組成物。 - 前記組成物は、5アルファ−還元酵素の活性を抑制することを特徴とする、請求項5記載の前立腺疾患の予防又は改善用健康機能食品組成物。
- 前記ゴカヒ、ロコン、及びアカマツ抽出物は、水、炭素数1〜4のアルコール、n−ヘキサン、エチルアセテート、アセトン、ブチルアセテート、1,3−ブチレングリコール、メチレンクロライド、及びこれらの混合溶媒からなる群より選択される1つ以上の溶媒で抽出されたことを特徴とする、請求項5記載の前立腺疾患の予防又は改善用健康機能食品組成物。
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07278003A (ja) * | 1994-04-11 | 1995-10-24 | Narisu Keshohin:Kk | テストステロン−5α−レダクターゼ阻害剤 |
KR20060067255A (ko) * | 2004-12-14 | 2006-06-19 | 주식회사 케이티앤지 | 솔잎 추출물을 함유하는 테스토스테론 5-알파 환원효소저해제 |
JP2010100601A (ja) * | 2008-10-27 | 2010-05-06 | Shonan Institute For Medical & Preventive Science | バナナの皮を有効成分とする5αリダクターゼ阻害剤 |
KR20130081131A (ko) * | 2012-01-06 | 2013-07-16 | 강원대학교산학협력단 | 민들레 추출물, 가시오가피 추출물, 홍삼 추출물, 금앵자 추출물, 애엽 추출물 및 은행잎 추출물이 첨가된 조성물 및 건강주 |
KR20140015199A (ko) * | 2012-07-24 | 2014-02-06 | 현대약품 주식회사 | 천연추출물을 유효성분으로 포함하는 모발 및 두피 상태 개선용 조성물 및 이의 제조방법 |
KR20160084175A (ko) * | 2015-01-05 | 2016-07-13 | 권영아 | 식물유래 루테리온의 암 줄기세포의 성장 및/또는 분화 억제 용도 |
KR20160125090A (ko) * | 2015-04-21 | 2016-10-31 | 대한민국(농촌진흥청장) | 오가피 열매 유래 물질이 포함된 혈관노화 예방 또는 억제용 약학적 조성물 및 그의 제조방법 |
JP2017137290A (ja) * | 2016-02-01 | 2017-08-10 | 株式会社日本健康食品研究所 | 5α−リダクターゼ阻害剤及び泌尿器系疾患治療・予防用組成物ならびにこれらの製造方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6790464B2 (en) * | 2003-01-16 | 2004-09-14 | Healthaid Enterprise Pte. Ltd. | Herbal compositions for prostate conditions |
CN100569233C (zh) * | 2008-02-21 | 2009-12-16 | 上海麟翔生物技术有限公司 | 可预防前列腺癌的组合物 |
CN103461540B (zh) * | 2013-09-24 | 2015-03-11 | 中国农业科学院油料作物研究所 | 一种具有预防前列腺疾病作用的功能性油脂及其制备方法 |
KR101917733B1 (ko) * | 2017-12-19 | 2018-11-13 | 게놈앤메디신(주) | 오가피, 노근, 및 적송 추출물을 유효성분으로 포함하는 전립선 질환 예방, 치료, 또는 개선용 조성물 |
-
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Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07278003A (ja) * | 1994-04-11 | 1995-10-24 | Narisu Keshohin:Kk | テストステロン−5α−レダクターゼ阻害剤 |
KR20060067255A (ko) * | 2004-12-14 | 2006-06-19 | 주식회사 케이티앤지 | 솔잎 추출물을 함유하는 테스토스테론 5-알파 환원효소저해제 |
JP2010100601A (ja) * | 2008-10-27 | 2010-05-06 | Shonan Institute For Medical & Preventive Science | バナナの皮を有効成分とする5αリダクターゼ阻害剤 |
KR20130081131A (ko) * | 2012-01-06 | 2013-07-16 | 강원대학교산학협력단 | 민들레 추출물, 가시오가피 추출물, 홍삼 추출물, 금앵자 추출물, 애엽 추출물 및 은행잎 추출물이 첨가된 조성물 및 건강주 |
KR20140015199A (ko) * | 2012-07-24 | 2014-02-06 | 현대약품 주식회사 | 천연추출물을 유효성분으로 포함하는 모발 및 두피 상태 개선용 조성물 및 이의 제조방법 |
KR20160084175A (ko) * | 2015-01-05 | 2016-07-13 | 권영아 | 식물유래 루테리온의 암 줄기세포의 성장 및/또는 분화 억제 용도 |
KR20160125090A (ko) * | 2015-04-21 | 2016-10-31 | 대한민국(농촌진흥청장) | 오가피 열매 유래 물질이 포함된 혈관노화 예방 또는 억제용 약학적 조성물 및 그의 제조방법 |
JP2017137290A (ja) * | 2016-02-01 | 2017-08-10 | 株式会社日本健康食品研究所 | 5α−リダクターゼ阻害剤及び泌尿器系疾患治療・予防用組成物ならびにこれらの製造方法 |
Non-Patent Citations (1)
Title |
---|
PROSTATE CANCER PREVENTION TRIAL(PCPT):QUESTIONS AND ANSWERS, [ONLINE], (2013.08.14), NIH NATIONAL C, JPN6021020282, ISSN: 0004520178 * |
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