JP2021507689A5 - - Google Patents
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- JP2021507689A5 JP2021507689A5 JP2020530617A JP2020530617A JP2021507689A5 JP 2021507689 A5 JP2021507689 A5 JP 2021507689A5 JP 2020530617 A JP2020530617 A JP 2020530617A JP 2020530617 A JP2020530617 A JP 2020530617A JP 2021507689 A5 JP2021507689 A5 JP 2021507689A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cells
- item
- cell
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 170
- 210000004027 cell Anatomy 0.000 claims description 63
- 150000001875 compounds Chemical class 0.000 claims description 52
- 208000031481 Pathologic Constriction Diseases 0.000 claims description 34
- 230000036262 stenosis Effects 0.000 claims description 34
- 208000037804 stenosis Diseases 0.000 claims description 34
- 239000006285 cell suspension Substances 0.000 claims description 33
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 28
- 108020004707 nucleic acids Proteins 0.000 claims description 19
- 102000039446 nucleic acids Human genes 0.000 claims description 19
- 150000007523 nucleic acids Chemical class 0.000 claims description 19
- 230000016784 immunoglobulin production Effects 0.000 claims description 17
- 210000000628 antibody-producing cell Anatomy 0.000 claims description 16
- 241000700605 Viruses Species 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 239000002243 precursor Substances 0.000 claims description 9
- 108091033409 CRISPR Proteins 0.000 claims description 8
- 108020005004 Guide RNA Proteins 0.000 claims description 8
- 241000702421 Dependoparvovirus Species 0.000 claims description 7
- 108020004414 DNA Proteins 0.000 claims description 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 6
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 6
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 210000000234 capsid Anatomy 0.000 claims description 6
- 210000002865 immune cell Anatomy 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 239000003981 vehicle Substances 0.000 claims description 6
- 210000004962 mammalian cell Anatomy 0.000 claims description 5
- 210000001185 bone marrow Anatomy 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 108091008875 B cell receptors Proteins 0.000 claims description 3
- 102000016605 B-Cell Activating Factor Human genes 0.000 claims description 3
- 108010028006 B-Cell Activating Factor Proteins 0.000 claims description 3
- 108010051219 Cre recombinase Proteins 0.000 claims description 3
- 102100034343 Integrase Human genes 0.000 claims description 3
- 108010061833 Integrases Proteins 0.000 claims description 3
- 108020005198 Long Noncoding RNA Proteins 0.000 claims description 3
- 108091093037 Peptide nucleic acid Proteins 0.000 claims description 3
- 108091029810 SaRNA Proteins 0.000 claims description 3
- 108091027967 Small hairpin RNA Proteins 0.000 claims description 3
- 108020004459 Small interfering RNA Proteins 0.000 claims description 3
- 108010043645 Transcription Activator-Like Effector Nucleases Proteins 0.000 claims description 3
- 108091023040 Transcription factor Proteins 0.000 claims description 3
- 102000040945 Transcription factor Human genes 0.000 claims description 3
- 108020004566 Transfer RNA Proteins 0.000 claims description 3
- 102000008579 Transposases Human genes 0.000 claims description 3
- 108010020764 Transposases Proteins 0.000 claims description 3
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims description 3
- 239000012190 activator Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 230000024245 cell differentiation Effects 0.000 claims description 3
- 230000003325 follicular Effects 0.000 claims description 3
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- 108020001507 fusion proteins Proteins 0.000 claims description 3
- 102000037865 fusion proteins Human genes 0.000 claims description 3
- 210000005260 human cell Anatomy 0.000 claims description 3
- 239000003446 ligand Substances 0.000 claims description 3
- 239000002502 liposome Substances 0.000 claims description 3
- 210000003826 marginal zone b cell Anatomy 0.000 claims description 3
- 210000001806 memory b lymphocyte Anatomy 0.000 claims description 3
- 108020004999 messenger RNA Proteins 0.000 claims description 3
- 108091070501 miRNA Proteins 0.000 claims description 3
- 239000002679 microRNA Substances 0.000 claims description 3
- 239000002105 nanoparticle Substances 0.000 claims description 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 3
- 239000013612 plasmid Substances 0.000 claims description 3
- 210000002707 regulatory b cell Anatomy 0.000 claims description 3
- 229940078677 sarna Drugs 0.000 claims description 3
- 230000011664 signaling Effects 0.000 claims description 3
- 239000004055 small Interfering RNA Substances 0.000 claims description 3
- 150000003384 small molecules Chemical class 0.000 claims description 3
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 claims description 2
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 claims description 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims description 2
- 210000004180 plasmocyte Anatomy 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000005684 electric field Effects 0.000 description 4
- 210000000130 stem cell Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
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- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
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- 238000002965 ELISA Methods 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
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- 210000004443 dendritic cell Anatomy 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 210000002064 heart cell Anatomy 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000000581 natural killer T-cell Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762594981P | 2017-12-05 | 2017-12-05 | |
| US62/594,981 | 2017-12-05 | ||
| PCT/US2018/063931 WO2019113125A1 (en) | 2017-12-05 | 2018-12-04 | Intracellular delivery of biomolecules to modulate antibody production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021507689A JP2021507689A (ja) | 2021-02-25 |
| JP2021507689A5 true JP2021507689A5 (https=) | 2022-01-11 |
Family
ID=65409454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530617A Pending JP2021507689A (ja) | 2017-12-05 | 2018-12-04 | 抗体産生をモジュレートするための生体分子の細胞内送達 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210317187A1 (https=) |
| EP (1) | EP3720878A1 (https=) |
| JP (1) | JP2021507689A (https=) |
| CN (1) | CN111683964A (https=) |
| WO (1) | WO2019113125A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3344575B1 (en) | 2015-09-04 | 2020-04-15 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| CA3023092A1 (en) | 2016-05-03 | 2017-11-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| AU2019234549B2 (en) | 2018-03-12 | 2026-02-12 | Sqz Biotechnologies Company | Methods for treating HPV-associated diseases |
| CA3131701A1 (en) | 2019-02-28 | 2020-09-03 | Sqz Biotechnologies Company | Delivery of biomolecules to pbmcs to modify an immune response |
| KR20210149791A (ko) | 2019-04-08 | 2021-12-09 | 에스큐지 바이오테크놀로지스 컴퍼니 | 페이로드를 세포 내로 전달하기 위한 시스템에서 이용하기 위한 카트리지 |
| CN115427579A (zh) * | 2019-12-17 | 2022-12-02 | 阿瑞迪思医药公司 | 增强和加速抗体表达的方法 |
| EP4127195A4 (en) * | 2020-03-26 | 2024-12-11 | Agency for Science, Technology and Research | A method and system for introducing one or more exogenous substances into an immune cell |
| JP7524928B2 (ja) * | 2022-07-15 | 2024-07-30 | トヨタ自動車株式会社 | 電池および電池の製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9005974B2 (en) * | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| NZ592159A (en) * | 2005-12-09 | 2012-12-21 | Amc Amsterdam | Means and methods for influencing the stability of antibody producing cells |
| US9018245B2 (en) * | 2006-12-26 | 2015-04-28 | Japan Science And Technology | Method for promoting immune response comprising inhibiting CD22 function in B cells |
| PT2768942T (pt) | 2011-10-17 | 2020-01-21 | Massachusetts Inst Technology | Entrega intracelular |
| KR102243597B1 (ko) | 2013-08-16 | 2021-04-26 | 메사추세츠 인스티튜트 오브 테크놀로지 | 세포로의 선택적 물질 전달 |
| KR20170074235A (ko) * | 2014-10-31 | 2017-06-29 | 메사추세츠 인스티튜트 오브 테크놀로지 | 면역 세포로의 생체분자의 전달 |
| CA2981077A1 (en) * | 2015-04-03 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
| JP7033535B2 (ja) * | 2016-01-12 | 2022-03-10 | スクイーズ バイオテクノロジーズ カンパニー | 複合体の細胞内送達 |
| AU2017259988B2 (en) * | 2016-05-03 | 2023-04-27 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
-
2018
- 2018-12-04 EP EP18847162.7A patent/EP3720878A1/en not_active Withdrawn
- 2018-12-04 JP JP2020530617A patent/JP2021507689A/ja active Pending
- 2018-12-04 WO PCT/US2018/063931 patent/WO2019113125A1/en not_active Ceased
- 2018-12-04 CN CN201880088328.XA patent/CN111683964A/zh active Pending
- 2018-12-04 US US16/769,993 patent/US20210317187A1/en not_active Abandoned
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