JP2021505598A5 - - Google Patents
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- Publication number
- JP2021505598A5 JP2021505598A5 JP2020530969A JP2020530969A JP2021505598A5 JP 2021505598 A5 JP2021505598 A5 JP 2021505598A5 JP 2020530969 A JP2020530969 A JP 2020530969A JP 2020530969 A JP2020530969 A JP 2020530969A JP 2021505598 A5 JP2021505598 A5 JP 2021505598A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methyl
- dihydro
- pyridine
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **N(CC1)CCC1(C1)OCC1NCC(COc1cccc(S(N(*)*)(=O)=O)c1)O Chemical compound **N(CC1)CCC1(C1)OCC1NCC(COc1cccc(S(N(*)*)(=O)=O)c1)O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762595133P | 2017-12-06 | 2017-12-06 | |
| US62/595,133 | 2017-12-06 | ||
| PCT/US2018/064316 WO2019113359A1 (en) | 2017-12-06 | 2018-12-06 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021505598A JP2021505598A (ja) | 2021-02-18 |
| JP2021505598A5 true JP2021505598A5 (https=) | 2022-01-11 |
| JP7357617B2 JP7357617B2 (ja) | 2023-10-06 |
Family
ID=64744985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530969A Active JP7357617B2 (ja) | 2017-12-06 | 2018-12-06 | 心不全およびそれに関連する障害の治療または予防に有用なβ－３アドレナリン受容体のモジュレーター |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11339172B2 (https=) |
| EP (1) | EP3720858B1 (https=) |
| JP (1) | JP7357617B2 (https=) |
| CN (1) | CN111699189B (https=) |
| AR (1) | AR114156A1 (https=) |
| ES (1) | ES2953576T3 (https=) |
| MA (1) | MA51015A (https=) |
| TW (1) | TWI822713B (https=) |
| WO (1) | WO2019113359A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA44037B1 (fr) * | 2016-06-06 | 2020-03-31 | Arena Pharm Inc | Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci |
| LT3483164T (lt) | 2017-03-20 | 2020-05-11 | Forma Therapeutics, Inc. | Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai |
| CN111699189B (zh) | 2017-12-06 | 2025-02-18 | 艾尼纳制药公司 | 可用于治疗或预防与其相关的心力衰竭和障碍的β-3肾上腺素能受体的调节剂 |
| EP3852791B1 (en) | 2018-09-19 | 2024-07-03 | Novo Nordisk Health Care AG | Activating pyruvate kinase r |
| EP3853206B1 (en) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Treating sickle cell disease with a pyruvate kinase r activating compound |
| HRP20251148T1 (hr) | 2019-09-19 | 2025-11-21 | Novo Nordisk Health Care Ag | Pripravci koji aktiviraju piruvat-kinazu r (pkr) |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| US20250127773A1 (en) * | 2021-08-09 | 2025-04-24 | Arena Pharmaceuticals, Inc. | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure |
| WO2023026185A1 (en) * | 2021-08-26 | 2023-03-02 | Arena Pharmaceuticals, Inc. | Modulators of the beta-3 adrenergic receptor for the treatment or prevention of renal cystic disease and cardiorenal syndrome |
| EP4699606A3 (en) | 2021-10-06 | 2026-03-25 | Arena Pharmaceuticals, Inc. | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
| FR2755439B1 (fr) * | 1996-11-05 | 1998-12-24 | Virbac Sa | Derives aryloxypropanolamines, leur procede de preparation et leurs applications |
| AU2525801A (en) * | 1999-12-17 | 2001-06-25 | Sanofi-Synthelabo | Phenoxypropanolamines, method for producing them and pharmaceutical compositionscontaining them |
| CN1469876A (zh) * | 2000-10-20 | 2004-01-21 | �Ʒ� | α-芳基乙醇胺及其用作β-3肾上腺素能受体激动剂的用途 |
| EP1833480A2 (en) * | 2004-11-30 | 2007-09-19 | Artesian Therapeutics, Inc. | Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase |
| US20170231885A1 (en) | 2014-10-14 | 2017-08-17 | Sculpt B.V. | Body Sculpting |
| MA44037B1 (fr) * | 2016-06-06 | 2020-03-31 | Arena Pharm Inc | Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci |
| CN111699189B (zh) | 2017-12-06 | 2025-02-18 | 艾尼纳制药公司 | 可用于治疗或预防与其相关的心力衰竭和障碍的β-3肾上腺素能受体的调节剂 |
-
2018
- 2018-12-06 CN CN201880088219.8A patent/CN111699189B/zh active Active
- 2018-12-06 JP JP2020530969A patent/JP7357617B2/ja active Active
- 2018-12-06 US US16/769,507 patent/US11339172B2/en active Active
- 2018-12-06 AR ARP180103577A patent/AR114156A1/es unknown
- 2018-12-06 TW TW107143855A patent/TWI822713B/zh active
- 2018-12-06 EP EP18822236.8A patent/EP3720858B1/en active Active
- 2018-12-06 ES ES18822236T patent/ES2953576T3/es active Active
- 2018-12-06 MA MA051015A patent/MA51015A/fr unknown
- 2018-12-06 WO PCT/US2018/064316 patent/WO2019113359A1/en not_active Ceased
-
2022
- 2022-04-22 US US17/726,807 patent/US11987588B2/en active Active
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