JP2021504448A5 - - Google Patents
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- Publication number
- JP2021504448A5 JP2021504448A5 JP2020545067A JP2020545067A JP2021504448A5 JP 2021504448 A5 JP2021504448 A5 JP 2021504448A5 JP 2020545067 A JP2020545067 A JP 2020545067A JP 2020545067 A JP2020545067 A JP 2020545067A JP 2021504448 A5 JP2021504448 A5 JP 2021504448A5
- Authority
- JP
- Japan
- Prior art keywords
- skin patch
- pharmaceutical preparation
- group
- polymer
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000825 pharmaceutical preparation Substances 0.000 claims 15
- 239000007933 dermal patch Substances 0.000 claims 12
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 10
- 102000004877 Insulin Human genes 0.000 claims 5
- 108090001061 Insulin Proteins 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 229940125396 insulin Drugs 0.000 claims 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 150000001543 aryl boronic acids Chemical group 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- 239000011859 microparticle Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000002105 nanoparticle Substances 0.000 claims 4
- 229940127557 pharmaceutical product Drugs 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 3
- 230000000975 bioactive effect Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 229920002401 polyacrylamide Polymers 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000005620 boronic acid group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical group OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 claims 1
- 0 CCC(*)(C*(C)CC(*)(C(C)(C)C)C(NINC(c1ccc(B(O)O)cc1)=O)=O)C(NIN)=O Chemical compound CCC(*)(C*(C)CC(*)(C(C)(C)C)C(NINC(c1ccc(B(O)O)cc1)=O)=O)C(NIN)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762589091P | 2017-11-21 | 2017-11-21 | |
| US62/589,091 | 2017-11-21 | ||
| PCT/US2018/061953 WO2019104006A1 (en) | 2017-11-21 | 2018-11-20 | Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021504448A JP2021504448A (ja) | 2021-02-15 |
| JP2021504448A5 true JP2021504448A5 (https=) | 2022-01-04 |
| JP7479287B2 JP7479287B2 (ja) | 2024-05-08 |
Family
ID=66632129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545067A Active JP7479287B2 (ja) | 2017-11-21 | 2018-11-20 | 超高速応答を伴うグルコース誘発性インスリン送達のための電荷切り替え可能な高分子デポ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11813352B2 (https=) |
| EP (1) | EP3713594A4 (https=) |
| JP (1) | JP7479287B2 (https=) |
| CN (1) | CN111629746B (https=) |
| MA (1) | MA50815A (https=) |
| WO (1) | WO2019104006A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11850285B2 (en) | 2017-03-07 | 2023-12-26 | North Carolina State University | Insulin-responsive glucagon delivery patch |
| CN111629746B (zh) | 2017-11-21 | 2024-04-16 | 北卡罗来纳州立大学 | 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库 |
| CN112842333A (zh) * | 2020-12-31 | 2021-05-28 | 华中科技大学 | 一种可视化葡萄糖浓度检测微针贴片、制备方法及应用 |
| US20240108253A1 (en) * | 2021-01-21 | 2024-04-04 | The Regents Of The University Of California | Colloidal crystal microneedle patch for glucose monitoring |
| CN113197838B (zh) * | 2021-03-31 | 2022-08-23 | 浙江大学 | 一种无酶糖敏微针贴及其温和制备方法 |
| US20250302737A1 (en) * | 2022-07-26 | 2025-10-02 | University Of Notre Dame Du Lac | Polymeric microneedle arrays crosslinked by pba-diol complexes for glucose-responsive insulin delivery |
| CN118949061B (zh) * | 2023-08-07 | 2026-04-17 | 浙江大学 | 一种糖响应鱼精蛋白胰岛素及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8137697B1 (en) | 2004-10-05 | 2012-03-20 | Gp Medical, Inc. | Nanoparticles for protein/peptide delivery and delivery means thereof |
| CN101273961A (zh) * | 2007-03-30 | 2008-10-01 | 中国人民解放军总医院 | 葡萄糖敏感水凝胶 |
| US9101547B2 (en) | 2011-08-04 | 2015-08-11 | Nano And Advanced Materials Institute Limited | Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery |
| US20160067190A1 (en) | 2013-04-30 | 2016-03-10 | The Children's Medical Center Corporation | Injectable nano-network gels for diabetes treatment |
| RU2719584C2 (ru) | 2015-04-21 | 2020-04-21 | Норт Каролина Стейт Юниверсити | Глюкозочувствительная система доставки инсулина с использованием чувствительных к гипоксии нанокомпозитов |
| CN104811694B (zh) * | 2015-04-28 | 2017-03-08 | 华为技术有限公司 | 一种视频数据质量评估的方法和装置 |
| JP6784352B2 (ja) * | 2015-05-11 | 2020-11-11 | 国立大学法人 東京医科歯科大学 | インスリン送達用デバイス |
| CN108366960B (zh) * | 2015-10-23 | 2022-04-19 | 国立大学法人东京医科齿科大学 | 药物递送装置 |
| CN111629746B (zh) | 2017-11-21 | 2024-04-16 | 北卡罗来纳州立大学 | 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库 |
-
2018
- 2018-11-20 CN CN201880087087.7A patent/CN111629746B/zh not_active Expired - Fee Related
- 2018-11-20 MA MA050815A patent/MA50815A/fr unknown
- 2018-11-20 WO PCT/US2018/061953 patent/WO2019104006A1/en not_active Ceased
- 2018-11-20 US US16/765,064 patent/US11813352B2/en active Active
- 2018-11-20 JP JP2020545067A patent/JP7479287B2/ja active Active
- 2018-11-20 EP EP18882215.9A patent/EP3713594A4/en not_active Withdrawn
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