JP2021504448A5 - - Google Patents
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- Publication number
- JP2021504448A5 JP2021504448A5 JP2020545067A JP2020545067A JP2021504448A5 JP 2021504448 A5 JP2021504448 A5 JP 2021504448A5 JP 2020545067 A JP2020545067 A JP 2020545067A JP 2020545067 A JP2020545067 A JP 2020545067A JP 2021504448 A5 JP2021504448 A5 JP 2021504448A5
- Authority
- JP
- Japan
- Prior art keywords
- skin patch
- pharmaceutical preparation
- group
- polymer
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000825 pharmaceutical preparation Substances 0.000 claims 15
- 239000007933 dermal patch Substances 0.000 claims 12
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 10
- 102000004877 Insulin Human genes 0.000 claims 5
- 108090001061 Insulin Proteins 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 229940125396 insulin Drugs 0.000 claims 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 150000001543 aryl boronic acids Chemical group 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- 239000011859 microparticle Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000002105 nanoparticle Substances 0.000 claims 4
- 229940127557 pharmaceutical product Drugs 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 3
- 230000000975 bioactive effect Effects 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 229920002401 polyacrylamide Polymers 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 125000005620 boronic acid group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- HXITXNWTGFUOAU-UHFFFAOYSA-N phenylboronic acid Chemical group OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 claims 1
- 0 CCC(*)(C*(C)CC(*)(C(C)(C)C)C(NINC(c1ccc(B(O)O)cc1)=O)=O)C(NIN)=O Chemical compound CCC(*)(C*(C)CC(*)(C(C)(C)C)C(NINC(c1ccc(B(O)O)cc1)=O)=O)C(NIN)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762589091P | 2017-11-21 | 2017-11-21 | |
| US62/589,091 | 2017-11-21 | ||
| PCT/US2018/061953 WO2019104006A1 (en) | 2017-11-21 | 2018-11-20 | Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021504448A JP2021504448A (ja) | 2021-02-15 |
| JP2021504448A5 true JP2021504448A5 (https=) | 2022-01-04 |
| JP7479287B2 JP7479287B2 (ja) | 2024-05-08 |
Family
ID=66632129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020545067A Active JP7479287B2 (ja) | 2017-11-21 | 2018-11-20 | 超高速応答を伴うグルコース誘発性インスリン送達のための電荷切り替え可能な高分子デポ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11813352B2 (https=) |
| EP (1) | EP3713594A4 (https=) |
| JP (1) | JP7479287B2 (https=) |
| CN (1) | CN111629746B (https=) |
| MA (1) | MA50815A (https=) |
| WO (1) | WO2019104006A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018165294A1 (en) | 2017-03-07 | 2018-09-13 | North Carolina State University | Insulin-responsive glucagon delivery patch |
| US11813352B2 (en) | 2017-11-21 | 2023-11-14 | North Carolina State University | Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response |
| CN112842333A (zh) * | 2020-12-31 | 2021-05-28 | 华中科技大学 | 一种可视化葡萄糖浓度检测微针贴片、制备方法及应用 |
| US20240108253A1 (en) * | 2021-01-21 | 2024-04-04 | The Regents Of The University Of California | Colloidal crystal microneedle patch for glucose monitoring |
| CN113197838B (zh) * | 2021-03-31 | 2022-08-23 | 浙江大学 | 一种无酶糖敏微针贴及其温和制备方法 |
| WO2024026280A1 (en) * | 2022-07-26 | 2024-02-01 | University Of Notre Dame Du Lac | Polymeric microneedle arrays crosslinked by pba-diol complexes for glucose-responsive insulin delivery |
| WO2025031391A1 (zh) * | 2023-08-07 | 2025-02-13 | 浙江大学 | 一种糖响应鱼精蛋白胰岛素及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8137697B1 (en) * | 2004-10-05 | 2012-03-20 | Gp Medical, Inc. | Nanoparticles for protein/peptide delivery and delivery means thereof |
| CN101273961A (zh) * | 2007-03-30 | 2008-10-01 | 中国人民解放军总医院 | 葡萄糖敏感水凝胶 |
| US9101547B2 (en) | 2011-08-04 | 2015-08-11 | Nano And Advanced Materials Institute Limited | Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery |
| US20160067190A1 (en) * | 2013-04-30 | 2016-03-10 | The Children's Medical Center Corporation | Injectable nano-network gels for diabetes treatment |
| TN2017000439A1 (en) | 2015-04-21 | 2019-04-12 | Univ North Carolina State | Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites |
| CN104811694B (zh) * | 2015-04-28 | 2017-03-08 | 华为技术有限公司 | 一种视频数据质量评估的方法和装置 |
| JP6784352B2 (ja) | 2015-05-11 | 2020-11-11 | 国立大学法人 東京医科歯科大学 | インスリン送達用デバイス |
| US11141486B2 (en) | 2015-10-23 | 2021-10-12 | National University Corporation Tokyo Medical And Dental University | Drug delivery device |
| US11813352B2 (en) | 2017-11-21 | 2023-11-14 | North Carolina State University | Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response |
-
2018
- 2018-11-20 US US16/765,064 patent/US11813352B2/en active Active
- 2018-11-20 JP JP2020545067A patent/JP7479287B2/ja active Active
- 2018-11-20 CN CN201880087087.7A patent/CN111629746B/zh not_active Expired - Fee Related
- 2018-11-20 WO PCT/US2018/061953 patent/WO2019104006A1/en not_active Ceased
- 2018-11-20 MA MA050815A patent/MA50815A/fr unknown
- 2018-11-20 EP EP18882215.9A patent/EP3713594A4/en not_active Withdrawn
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