CN111629746B - 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库 - Google Patents

具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库 Download PDF

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Publication number
CN111629746B
CN111629746B CN201880087087.7A CN201880087087A CN111629746B CN 111629746 B CN111629746 B CN 111629746B CN 201880087087 A CN201880087087 A CN 201880087087A CN 111629746 B CN111629746 B CN 111629746B
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insulin
composition
glucose
polymer
groups
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Expired - Fee Related
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CN201880087087.7A
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Chinese (zh)
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CN111629746A (zh
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顾臻
王金强
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North Carolina State University
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North Carolina State University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201880087087.7A 2017-11-21 2018-11-20 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库 Expired - Fee Related CN111629746B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762589091P 2017-11-21 2017-11-21
US62/589,091 2017-11-21
PCT/US2018/061953 WO2019104006A1 (en) 2017-11-21 2018-11-20 Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response

Publications (2)

Publication Number Publication Date
CN111629746A CN111629746A (zh) 2020-09-04
CN111629746B true CN111629746B (zh) 2024-04-16

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CN201880087087.7A Expired - Fee Related CN111629746B (zh) 2017-11-21 2018-11-20 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库

Country Status (6)

Country Link
US (1) US11813352B2 (https=)
EP (1) EP3713594A4 (https=)
JP (1) JP7479287B2 (https=)
CN (1) CN111629746B (https=)
MA (1) MA50815A (https=)
WO (1) WO2019104006A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11850285B2 (en) 2017-03-07 2023-12-26 North Carolina State University Insulin-responsive glucagon delivery patch
CN111629746B (zh) 2017-11-21 2024-04-16 北卡罗来纳州立大学 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库
CN112842333A (zh) * 2020-12-31 2021-05-28 华中科技大学 一种可视化葡萄糖浓度检测微针贴片、制备方法及应用
US20240108253A1 (en) * 2021-01-21 2024-04-04 The Regents Of The University Of California Colloidal crystal microneedle patch for glucose monitoring
CN113197838B (zh) * 2021-03-31 2022-08-23 浙江大学 一种无酶糖敏微针贴及其温和制备方法
US20250302737A1 (en) * 2022-07-26 2025-10-02 University Of Notre Dame Du Lac Polymeric microneedle arrays crosslinked by pba-diol complexes for glucose-responsive insulin delivery
CN118949061B (zh) * 2023-08-07 2026-04-17 浙江大学 一种糖响应鱼精蛋白胰岛素及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101273961A (zh) * 2007-03-30 2008-10-01 中国人民解放军总医院 葡萄糖敏感水凝胶
US20160067190A1 (en) * 2013-04-30 2016-03-10 The Children's Medical Center Corporation Injectable nano-network gels for diabetes treatment
WO2016173320A1 (zh) * 2015-04-28 2016-11-03 华为技术有限公司 一种视频质量评估的方法和装置

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US8137697B1 (en) 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof
US9101547B2 (en) 2011-08-04 2015-08-11 Nano And Advanced Materials Institute Limited Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery
RU2719584C2 (ru) 2015-04-21 2020-04-21 Норт Каролина Стейт Юниверсити Глюкозочувствительная система доставки инсулина с использованием чувствительных к гипоксии нанокомпозитов
JP6784352B2 (ja) * 2015-05-11 2020-11-11 国立大学法人 東京医科歯科大学 インスリン送達用デバイス
CN108366960B (zh) * 2015-10-23 2022-04-19 国立大学法人东京医科齿科大学 药物递送装置
CN111629746B (zh) 2017-11-21 2024-04-16 北卡罗来纳州立大学 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101273961A (zh) * 2007-03-30 2008-10-01 中国人民解放军总医院 葡萄糖敏感水凝胶
US20160067190A1 (en) * 2013-04-30 2016-03-10 The Children's Medical Center Corporation Injectable nano-network gels for diabetes treatment
WO2016173320A1 (zh) * 2015-04-28 2016-11-03 华为技术有限公司 一种视频质量评估的方法和装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Swelling properties of hydrogels containing phenylboronic acids;Kim A等;《Chemosensors》;第2卷(第1期);第1-12页 *

Also Published As

Publication number Publication date
MA50815A (fr) 2020-09-30
US11813352B2 (en) 2023-11-14
EP3713594A1 (en) 2020-09-30
JP7479287B2 (ja) 2024-05-08
US20200360269A1 (en) 2020-11-19
JP2021504448A (ja) 2021-02-15
CN111629746A (zh) 2020-09-04
EP3713594A4 (en) 2021-11-03
WO2019104006A1 (en) 2019-05-31

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