MA50815A - Dépôt polymère à changement de charge pour l'administration d'insuline déclenchée par le glucose avec une réponse ultra-rapide - Google Patents

Dépôt polymère à changement de charge pour l'administration d'insuline déclenchée par le glucose avec une réponse ultra-rapide

Info

Publication number
MA50815A
MA50815A MA050815A MA50815A MA50815A MA 50815 A MA50815 A MA 50815A MA 050815 A MA050815 A MA 050815A MA 50815 A MA50815 A MA 50815A MA 50815 A MA50815 A MA 50815A
Authority
MA
Morocco
Prior art keywords
glucose
ultra
delivery
load change
rapid response
Prior art date
Application number
MA050815A
Other languages
English (en)
French (fr)
Inventor
Zhen Gu
Jinqiang Wang
Original Assignee
Univ North Carolina State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina State filed Critical Univ North Carolina State
Publication of MA50815A publication Critical patent/MA50815A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
MA050815A 2017-11-21 2018-11-20 Dépôt polymère à changement de charge pour l'administration d'insuline déclenchée par le glucose avec une réponse ultra-rapide MA50815A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762589091P 2017-11-21 2017-11-21

Publications (1)

Publication Number Publication Date
MA50815A true MA50815A (fr) 2020-09-30

Family

ID=66632129

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050815A MA50815A (fr) 2017-11-21 2018-11-20 Dépôt polymère à changement de charge pour l'administration d'insuline déclenchée par le glucose avec une réponse ultra-rapide

Country Status (6)

Country Link
US (1) US11813352B2 (https=)
EP (1) EP3713594A4 (https=)
JP (1) JP7479287B2 (https=)
CN (1) CN111629746B (https=)
MA (1) MA50815A (https=)
WO (1) WO2019104006A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11850285B2 (en) 2017-03-07 2023-12-26 North Carolina State University Insulin-responsive glucagon delivery patch
CN111629746B (zh) 2017-11-21 2024-04-16 北卡罗来纳州立大学 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库
CN112842333A (zh) * 2020-12-31 2021-05-28 华中科技大学 一种可视化葡萄糖浓度检测微针贴片、制备方法及应用
US20240108253A1 (en) * 2021-01-21 2024-04-04 The Regents Of The University Of California Colloidal crystal microneedle patch for glucose monitoring
CN113197838B (zh) * 2021-03-31 2022-08-23 浙江大学 一种无酶糖敏微针贴及其温和制备方法
US20250302737A1 (en) * 2022-07-26 2025-10-02 University Of Notre Dame Du Lac Polymeric microneedle arrays crosslinked by pba-diol complexes for glucose-responsive insulin delivery
CN118949061B (zh) * 2023-08-07 2026-04-17 浙江大学 一种糖响应鱼精蛋白胰岛素及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8137697B1 (en) 2004-10-05 2012-03-20 Gp Medical, Inc. Nanoparticles for protein/peptide delivery and delivery means thereof
CN101273961A (zh) * 2007-03-30 2008-10-01 中国人民解放军总医院 葡萄糖敏感水凝胶
US9101547B2 (en) 2011-08-04 2015-08-11 Nano And Advanced Materials Institute Limited Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery
US20160067190A1 (en) 2013-04-30 2016-03-10 The Children's Medical Center Corporation Injectable nano-network gels for diabetes treatment
RU2719584C2 (ru) 2015-04-21 2020-04-21 Норт Каролина Стейт Юниверсити Глюкозочувствительная система доставки инсулина с использованием чувствительных к гипоксии нанокомпозитов
CN104811694B (zh) * 2015-04-28 2017-03-08 华为技术有限公司 一种视频数据质量评估的方法和装置
JP6784352B2 (ja) * 2015-05-11 2020-11-11 国立大学法人 東京医科歯科大学 インスリン送達用デバイス
CN108366960B (zh) * 2015-10-23 2022-04-19 国立大学法人东京医科齿科大学 药物递送装置
CN111629746B (zh) 2017-11-21 2024-04-16 北卡罗来纳州立大学 具有超快响应的用于葡萄糖触发胰岛素递送的电荷可切换聚合物储库

Also Published As

Publication number Publication date
US11813352B2 (en) 2023-11-14
EP3713594A1 (en) 2020-09-30
JP7479287B2 (ja) 2024-05-08
US20200360269A1 (en) 2020-11-19
JP2021504448A (ja) 2021-02-15
CN111629746B (zh) 2024-04-16
CN111629746A (zh) 2020-09-04
EP3713594A4 (en) 2021-11-03
WO2019104006A1 (en) 2019-05-31

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