JP2021502097A5 - - Google Patents

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Publication number
JP2021502097A5
JP2021502097A5 JP2020525971A JP2020525971A JP2021502097A5 JP 2021502097 A5 JP2021502097 A5 JP 2021502097A5 JP 2020525971 A JP2020525971 A JP 2020525971A JP 2020525971 A JP2020525971 A JP 2020525971A JP 2021502097 A5 JP2021502097 A5 JP 2021502097A5
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JP
Japan
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nucleotides
sgrna
sequence
composition
shortened
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JP2020525971A
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English (en)
Japanese (ja)
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JP2021502097A (ja
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Priority claimed from PCT/US2018/060126 external-priority patent/WO2019094791A2/en
Publication of JP2021502097A publication Critical patent/JP2021502097A/ja
Publication of JP2021502097A5 publication Critical patent/JP2021502097A5/ja
Priority to JP2023223638A priority Critical patent/JP2024019727A/ja
Withdrawn legal-status Critical Current

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JP2020525971A 2017-11-10 2018-11-09 標的化ｃｒｉｓｐｒ送達プラットフォーム Withdrawn JP2021502097A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023223638A JP2024019727A (ja) 2017-11-10 2023-12-28 標的化ｃｒｉｓｐｒ送達プラットフォーム

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762584310P 2017-11-10 2017-11-10
US62/584,310 2017-11-10
US201762596375P 2017-12-08 2017-12-08
US62/596,375 2017-12-08
US201862667084P 2018-05-04 2018-05-04
US62/667,084 2018-05-04
PCT/US2018/060126 WO2019094791A2 (en) 2017-11-10 2018-11-09 Targeted crispr delivery platforms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023223638A Division JP2024019727A (ja) 2017-11-10 2023-12-28 標的化ｃｒｉｓｐｒ送達プラットフォーム

Publications (2)

Publication Number Publication Date
JP2021502097A JP2021502097A (ja) 2021-01-28
JP2021502097A5 true JP2021502097A5 (https=) 2021-12-02

Family

ID=66438139

Family Applications (2)

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JP2020525971A Withdrawn JP2021502097A (ja) 2017-11-10 2018-11-09 標的化ｃｒｉｓｐｒ送達プラットフォーム
JP2023223638A Pending JP2024019727A (ja) 2017-11-10 2023-12-28 標的化ｃｒｉｓｐｒ送達プラットフォーム

Family Applications After (1)

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JP2023223638A Pending JP2024019727A (ja) 2017-11-10 2023-12-28 標的化ｃｒｉｓｐｒ送達プラットフォーム

Country Status (13)

Country Link
US (3) US20220389447A9 (https=)
EP (1) EP3707254A4 (https=)
JP (2) JP2021502097A (https=)
KR (2) KR102922730B1 (https=)
CN (1) CN111868240A (https=)
AU (2) AU2018364993B2 (https=)
BR (1) BR112020009268A2 (https=)
CA (1) CA3082370A1 (https=)
CO (1) CO2020007046A2 (https=)
IL (2) IL317505A (https=)
MX (1) MX2020004777A (https=)
SG (1) SG11202005103RA (https=)
WO (1) WO2019094791A2 (https=)

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JP7250031B2 (ja) * 2018-09-25 2023-03-31 公益財団法人微生物化学研究会 新規ウイルスベクターおよびその製造方法と使用方法
EP3921638A4 (en) 2019-02-05 2022-08-24 AMMR Joint Venture EXPANDED CHOICE OF EFFICIENT TARGETED GENE MANIPULATORS
US20220298494A1 (en) * 2019-02-14 2022-09-22 Metagenomi Ip Technologies, Llc Enzymes with ruvc domains
CN110257406B (zh) * 2019-06-21 2022-07-22 安徽省农业科学院水稻研究所 密码子植物化改造的Plant Nme2Cas9基因及其应用
US12297426B2 (en) 2019-10-01 2025-05-13 The Broad Institute, Inc. DNA damage response signature guided rational design of CRISPR-based systems and therapies
WO2021122944A1 (en) 2019-12-18 2021-06-24 Alia Therapeutics Srl Compositions and methods for treating retinitis pigmentosa
CN113652411B (zh) * 2021-07-30 2025-01-10 复旦大学 Cas9蛋白、含有Cas9蛋白的基因编辑系统及应用
AU2022335499A1 (en) 2021-08-27 2024-02-22 Metagenomi Therapeutics, Inc. Enzymes with ruvc domains
WO2023064813A2 (en) * 2021-10-13 2023-04-20 University Of Massachusetts Modified guide rnas for neisseria meningitidis cas9
CA3237303A1 (en) 2021-11-03 2023-05-11 Intellia Therapeutics, Inc. Polynucleotides, compositions, and methods for genome editing
IL312507A (en) * 2021-11-03 2024-07-01 Intellia Therapeutics Inc Modified guide rnas for gene editing
GB2634837A (en) 2022-06-07 2025-04-23 Scribe Therapeutics Inc Compositions and methods for the targeting of PCSK9
KR20250124819A (ko) 2022-12-21 2025-08-20 인텔리아 테라퓨틱스, 인크. 프로단백질 전환효소 서브틸리신 켁신 9(pcsk9) 편집을 위한 조성물 및 방법
TW202436622A (zh) 2023-03-06 2024-09-16 美商英特利亞醫療公司 用於ｂ型肝炎病毒（ｈｂｖ）基因體編輯之組合物及方法
WO2025038646A1 (en) 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Cd70 car-t compositions and methods for cell-based therapy
WO2025038642A1 (en) 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying cd70
WO2025038637A1 (en) 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
IL326191A (en) 2023-08-14 2026-03-01 Intellia Therapeutics Inc Compositions and methods for genetic modification of transforming growth factor beta receptor type 2 (tgfβr2)
WO2025255308A1 (en) 2024-06-07 2025-12-11 Intellia Therapeutics, Inc. Cd8 co-receptor chimeric polypeptides in tcr cell therapy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013266968B2 (en) * 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
RU2716420C2 (ru) * 2013-06-17 2020-03-11 Те Брод Инститьют Инк. Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени
EP3666892A1 (en) * 2013-07-10 2020-06-17 President and Fellows of Harvard College Orthogonal cas9 proteins for rna-guided gene regulation and editing
CA2930877A1 (en) * 2013-11-18 2015-05-21 Crispr Therapeutics Ag Crispr-cas system materials and methods
JP2016538001A (ja) * 2013-11-28 2016-12-08 ホライズン・ジェノミクス・ゲーエムベーハー 体細胞半数体ヒト細胞株
JP6793547B2 (ja) * 2013-12-12 2020-12-02 ザ・ブロード・インスティテュート・インコーポレイテッド 最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
EP3080259B1 (en) * 2013-12-12 2023-02-01 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
WO2016049258A2 (en) * 2014-09-25 2016-03-31 The Broad Institute Inc. Functional screening with optimized functional crispr-cas systems
US10190106B2 (en) * 2014-12-22 2019-01-29 Univesity Of Massachusetts Cas9-DNA targeting unit chimeras
WO2016179038A1 (en) * 2015-05-01 2016-11-10 Spark Therapeutics, Inc. ADENO-ASSOCIATED VIRUS-MEDIATED CRISPR-Cas9 TREATMENT OF OCULAR DISEASE
US11732258B2 (en) * 2016-11-02 2023-08-22 President And Fellows Of Harvard College Engineered guide RNA sequences for in situ detection and sequencing
BR112019028146A2 (pt) * 2017-07-31 2020-07-07 Sigma-Aldrich Co. Llc rna guia sintético para sistemas ativadores de crispr/cas

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