KR102922730B1 - 표적화된 crispr 전달 플랫폼 - Google Patents

표적화된 crispr 전달 플랫폼

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Publication number
KR102922730B1
KR102922730B1 KR1020207016690A KR20207016690A KR102922730B1 KR 102922730 B1 KR102922730 B1 KR 102922730B1 KR 1020207016690 A KR1020207016690 A KR 1020207016690A KR 20207016690 A KR20207016690 A KR 20207016690A KR 102922730 B1 KR102922730 B1 KR 102922730B1
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nucleotides
sgrna
nme2cas9
cas9
sequence
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KR20200080314A (ko
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에릭 죠셉 손테머
라에드 이브라하임
웬 크슈
아아미르 미르
알리레자 에드라키
가이넷디노브 일다르
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유니버시티 오브 매사추세츠
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KR1020207016690A 2017-11-10 2018-11-09 표적화된 crispr 전달 플랫폼 Active KR102922730B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267003248A KR20260023096A (ko) 2017-11-10 2018-11-09 표적화된 crispr 전달 플랫폼

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762584310P 2017-11-10 2017-11-10
US62/584,310 2017-11-10
US201762596375P 2017-12-08 2017-12-08
US62/596,375 2017-12-08
US201862667084P 2018-05-04 2018-05-04
US62/667,084 2018-05-04
PCT/US2018/060126 WO2019094791A2 (en) 2017-11-10 2018-11-09 Targeted crispr delivery platforms

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KR102922730B1 true KR102922730B1 (ko) 2026-02-03

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US (3) US20220389447A9 (https=)
EP (1) EP3707254A4 (https=)
JP (2) JP2021502097A (https=)
KR (2) KR102922730B1 (https=)
CN (1) CN111868240A (https=)
AU (2) AU2018364993B2 (https=)
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CN113661392B (zh) 2019-02-05 2025-05-27 卡蒂亚生物公司 有效靶向基因组操纵剂的增强选择
US20220298494A1 (en) * 2019-02-14 2022-09-22 Metagenomi Ip Technologies, Llc Enzymes with ruvc domains
CN110257406B (zh) * 2019-06-21 2022-07-22 安徽省农业科学院水稻研究所 密码子植物化改造的Plant Nme2Cas9基因及其应用
US12297426B2 (en) 2019-10-01 2025-05-13 The Broad Institute, Inc. DNA damage response signature guided rational design of CRISPR-based systems and therapies
WO2021122944A1 (en) 2019-12-18 2021-06-24 Alia Therapeutics Srl Compositions and methods for treating retinitis pigmentosa
CN113652411B (zh) * 2021-07-30 2025-01-10 复旦大学 Cas9蛋白、含有Cas9蛋白的基因编辑系统及应用
CA3225082A1 (en) 2021-08-27 2023-03-02 Brian C. Thomas Enzymes with ruvc domains
US20230183687A1 (en) * 2021-10-13 2023-06-15 University Of Massachusetts Modified guide rnas for neisseria meningitidis cas9
WO2023081687A1 (en) * 2021-11-03 2023-05-11 Intellia Therapeutics, Inc. Modified guide rnas for gene editing
EP4426822A2 (en) 2021-11-03 2024-09-11 Intellia Therapeutics, Inc. Polynucleotides, compositions, and methods for genome editing
WO2023240076A1 (en) 2022-06-07 2023-12-14 Scribe Therapeutics Inc. Compositions and methods for the targeting of pcsk9
WO2024137766A2 (en) 2022-12-21 2024-06-27 Intellia Therapeutics, Inc. Compositions and methods for proprotein convertase subtilisin kexin 9 (pcsk9) editing
WO2024186890A1 (en) 2023-03-06 2024-09-12 Intellia Therapeutics, Inc. Compositions and methods for hepatitis b virus (hbv) genome editing
TW202515994A (zh) 2023-08-14 2025-04-16 美商英特利亞醫療公司 用於對ｃｄ７０進行基因修飾之組合物及方法
WO2025038637A1 (en) 2023-08-14 2025-02-20 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
TW202521564A (zh) 2023-08-14 2025-06-01 美商英特利亞醫療公司 用於基於細胞之療法的ｃｄ７０ ｃａｒ－ｔ組合物及方法
AU2024324870A1 (en) 2023-08-14 2026-02-12 Intellia Therapeutics, Inc. Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
WO2025255308A1 (en) 2024-06-07 2025-12-11 Intellia Therapeutics, Inc. Cd8 co-receptor chimeric polypeptides in tcr cell therapy

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WO2015089473A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation

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AU2023200084B2 (en) 2025-10-16
IL274526B1 (en) 2025-01-01
CO2020007046A2 (es) 2020-08-31
US20190338308A1 (en) 2019-11-07
US20220389447A9 (en) 2022-12-08
CN111868240A (zh) 2020-10-30
IL317505A (en) 2025-02-01
AU2023200084A1 (en) 2023-02-09
EP3707254A4 (en) 2021-08-18
JP2024019727A (ja) 2024-02-09
SG11202005103RA (en) 2020-06-29
IL274526B2 (en) 2025-05-01
EP3707254A2 (en) 2020-09-16
US20250223611A1 (en) 2025-07-10
AU2018364993A1 (en) 2020-06-11
JP2021502097A (ja) 2021-01-28
KR20200080314A (ko) 2020-07-06
WO2019094791A2 (en) 2019-05-16
AU2018364993B2 (en) 2022-10-06
WO2019094791A3 (en) 2019-06-20
CA3082370A1 (en) 2019-05-16
KR20260023096A (ko) 2026-02-20
BR112020009268A2 (pt) 2020-11-17
US20250197889A1 (en) 2025-06-19
IL274526A (en) 2020-06-30
MX2020004777A (es) 2020-10-08

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