JP2021501589A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021501589A5 JP2021501589A5 JP2020524434A JP2020524434A JP2021501589A5 JP 2021501589 A5 JP2021501589 A5 JP 2021501589A5 JP 2020524434 A JP2020524434 A JP 2020524434A JP 2020524434 A JP2020524434 A JP 2020524434A JP 2021501589 A5 JP2021501589 A5 JP 2021501589A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen recognition
- recognition construct
- construct
- host cell
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 26
- 108091007433 antigens Proteins 0.000 claims 26
- 102000036639 antigens Human genes 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 102100024338 Collagen alpha-3(VI) chain Human genes 0.000 claims 5
- 101000909506 Homo sapiens Collagen alpha-3(VI) chain Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 108091008874 T cell receptors Proteins 0.000 claims 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024101016A JP2024156654A (ja) | 2017-11-06 | 2024-06-24 | 新規操作ｔ細胞受容体およびそれを使用した免疫療法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762582202P | 2017-11-06 | 2017-11-06 | |
| DE102017125888.4 | 2017-11-06 | ||
| DE102017125888.4A DE102017125888A1 (de) | 2017-11-06 | 2017-11-06 | Neue konstruierte T-Zell-Rezeptoren und deren Verwendung in Immuntherapie |
| US62/582,202 | 2017-11-06 | ||
| PCT/EP2018/080176 WO2019086665A1 (en) | 2017-11-06 | 2018-11-05 | Novel engineered t cell receptors and immune therapy using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024101016A Division JP2024156654A (ja) | 2017-11-06 | 2024-06-24 | 新規操作ｔ細胞受容体およびそれを使用した免疫療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021501589A JP2021501589A (ja) | 2021-01-21 |
| JP2021501589A5 true JP2021501589A5 (https=) | 2021-12-16 |
| JP7510873B2 JP7510873B2 (ja) | 2024-07-04 |
Family
ID=66336165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524434A Active JP7510873B2 (ja) | 2017-11-06 | 2018-11-05 | 新規操作ｔ細胞受容体およびそれを使用した免疫療法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP3707159B1 (https=) |
| JP (1) | JP7510873B2 (https=) |
| KR (1) | KR102793492B1 (https=) |
| CN (1) | CN111448209B (https=) |
| AR (1) | AR113834A1 (https=) |
| AU (1) | AU2018358085B2 (https=) |
| BR (1) | BR112020008943A2 (https=) |
| CA (1) | CA3081780A1 (https=) |
| DE (1) | DE102017125888A1 (https=) |
| MA (1) | MA50562A (https=) |
| PE (1) | PE20211452A1 (https=) |
| SG (1) | SG11202003404UA (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102020111571A1 (de) * | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| CN120718134B (zh) * | 2025-08-25 | 2025-12-26 | 北京立康生命科技有限公司 | 靶向col6a3肽的t细胞受体及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| WO2001058479A1 (en) | 2000-02-08 | 2001-08-16 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| WO2006023382A2 (en) * | 2004-08-23 | 2006-03-02 | Albert Einstein College Of Medicine Of Yeshiva University | Collagen vi and cancer |
| GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| AU2015289644A1 (en) | 2014-07-15 | 2017-02-02 | Juno Therapeutics, Inc. | Engineered cells for adoptive cell therapy |
| GB201505305D0 (en) * | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| DE102016115246C5 (de) | 2016-08-17 | 2018-12-20 | Immatics Biotechnologies Gmbh | Neue t-zellrezeptoren und deren verwendung in immuntherapie |
| DE102016121899A1 (de) | 2016-11-15 | 2018-05-17 | Immatics Biotechnologies Gmbh | Verfahren zur Herstellung von elektrokompetenten Hefezellen und Verfahren zur Verwendung dieser Zellen |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
-
2017
- 2017-11-06 DE DE102017125888.4A patent/DE102017125888A1/de active Pending
-
2018
- 2018-11-05 CN CN201880066776.XA patent/CN111448209B/zh active Active
- 2018-11-05 JP JP2020524434A patent/JP7510873B2/ja active Active
- 2018-11-05 BR BR112020008943-5A patent/BR112020008943A2/pt unknown
- 2018-11-05 SG SG11202003404UA patent/SG11202003404UA/en unknown
- 2018-11-05 EP EP18803349.2A patent/EP3707159B1/en active Active
- 2018-11-05 AU AU2018358085A patent/AU2018358085B2/en active Active
- 2018-11-05 KR KR1020207010945A patent/KR102793492B1/ko active Active
- 2018-11-05 CA CA3081780A patent/CA3081780A1/en active Pending
- 2018-11-05 PE PE2020000470A patent/PE20211452A1/es unknown
- 2018-11-05 MA MA050562A patent/MA50562A/fr unknown
- 2018-11-06 AR ARP180103228A patent/AR113834A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020500523A5 (https=) | ||
| JP2020529830A5 (https=) | ||
| JP2024164002A (ja) | キメラ抗原受容体を使用する癌の処置 | |
| JP2020511152A5 (https=) | ||
| US20200339651A1 (en) | Methods for b cell preconditioning in car therapy | |
| JP2020511936A5 (https=) | ||
| AU2014228962B2 (en) | Multimerization technologies | |
| HRP20241228T1 (hr) | T stanični receptori i imunološka terapija uporabom istih protiv pram pozitivnih karcinoma | |
| US20170274014A1 (en) | Combinations of low, immune enhancing, doses of mtor inhibitors and cars | |
| AU2019256431A1 (en) | Anti-ror antibody constructs | |
| HRP20220131T1 (hr) | Nova terapija s t-staničnim receptorima i imunološka terapija koja koristi iste | |
| JP2019511222A5 (https=) | ||
| EP3423482A1 (en) | Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore | |
| JP2012518425A5 (https=) | ||
| FI3430030T3 (fi) | Transfektoituja t-soluja ja t-solureseptoreita käytettäviksi syöpien immunoterapiassa | |
| JP2020500510A5 (https=) | ||
| JP2017528433A (ja) | 低い免疫増強用量のｍＴＯＲ阻害剤とＣＡＲの組み合わせ | |
| JP2018166506A5 (https=) | ||
| CN117069842B (zh) | 具有特定等电点的抗人bcma纳米抗体及car-t和应用 | |
| JP2021501589A5 (https=) | ||
| US20250276064A1 (en) | Engineered chimeric fusion protein compositions and methods of use thereof | |
| CN116997572A (zh) | 小细胞肺癌的分类与治疗的方法和系统 | |
| HRP20211677T1 (hr) | T-stanični receptori i imunološka terapija koja koristi iste | |
| CN113929767A (zh) | 具有高亲和力的t细胞受体及其用途 | |
| US20250049848A1 (en) | Methods and compositions for altering a tumor microbiome |