JP2021183586A - 複素環化合物 - Google Patents
複素環化合物 Download PDFInfo
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- JP2021183586A JP2021183586A JP2020090110A JP2020090110A JP2021183586A JP 2021183586 A JP2021183586 A JP 2021183586A JP 2020090110 A JP2020090110 A JP 2020090110A JP 2020090110 A JP2020090110 A JP 2020090110A JP 2021183586 A JP2021183586 A JP 2021183586A
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/36—Opioid-abuse
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020090110A JP2021183586A (ja) | 2020-05-22 | 2020-05-22 | 複素環化合物 |
| ES21737768T ES3001126T3 (es) | 2020-05-22 | 2021-05-20 | Derivados de 1-((1H-pirazol-4-il)metil)-3-(fenil)-1,3-dihidro-2H-imidazol-2-ona y compuestos relacionados como antagonistas de GPR139 para el tratamiento de la depresión |
| US17/999,505 US20230348435A1 (en) | 2020-05-22 | 2021-05-20 | 1-((1h-pyrazol-4-yl)methyl)-3-(phenyl)-1,3-dihydro-2h-imidazol-2-one derivatives and related compounds as gpr139 antagonists for the treatment of e.g. depression |
| TW110118331A TW202208349A (zh) | 2020-05-22 | 2021-05-20 | 雜環化合物 |
| JP2022570530A JP7734152B2 (ja) | 2020-05-22 | 2021-05-20 | 例えば、うつ病を治療するための、ｇｐｒ１３９拮抗薬としての１－（（１ｈ－ピラゾール－４－イル）メチル）－３－（フェニル）－１，３－ジヒドロ－２ｈ－イミダゾール－２－オン誘導体および関連化合物 |
| ARP210101386A AR122142A1 (es) | 2020-05-22 | 2021-05-20 | Compuestos heterocíclicos |
| EP21737768.8A EP4153583B1 (en) | 2020-05-22 | 2021-05-20 | 1-((1h-pyrazol-4-yl)methyl)-3-(phenyl)-1,3-dihydro-2h-imidazol-2-one derivatives and related compounds as gpr139 antagonists for the treatment of depression |
| PCT/IB2021/000336 WO2021234450A1 (en) | 2020-05-22 | 2021-05-20 | 1-((1h-pyrazol-4-yl)methyl)-3-(phenyl)-1,3-dihydro-2h-imidazol-2-one derivatives and related compounds as gpr139 antagonists for the treatment of e.g. depression |
| JP2025139598A JP2025168429A (ja) | 2020-05-22 | 2025-08-25 | 例えば、うつ病を治療するための、ｇｐｒ１３９拮抗薬としての１－（（１ｈ－ピラゾール－４－イル）メチル）－３－（フェニル）－１，３－ジヒドロ－２ｈ－イミダゾール－２－オン誘導体および関連化合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020090110A JP2021183586A (ja) | 2020-05-22 | 2020-05-22 | 複素環化合物 |
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|---|---|
| JP2021183586A true JP2021183586A (ja) | 2021-12-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020090110A Pending JP2021183586A (ja) | 2020-05-22 | 2020-05-22 | 複素環化合物 |
| JP2022570530A Active JP7734152B2 (ja) | 2020-05-22 | 2021-05-20 | 例えば、うつ病を治療するための、ｇｐｒ１３９拮抗薬としての１－（（１ｈ－ピラゾール－４－イル）メチル）－３－（フェニル）－１，３－ジヒドロ－２ｈ－イミダゾール－２－オン誘導体および関連化合物 |
| JP2025139598A Pending JP2025168429A (ja) | 2020-05-22 | 2025-08-25 | 例えば、うつ病を治療するための、ｇｐｒ１３９拮抗薬としての１－（（１ｈ－ピラゾール－４－イル）メチル）－３－（フェニル）－１，３－ジヒドロ－２ｈ－イミダゾール－２－オン誘導体および関連化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022570530A Active JP7734152B2 (ja) | 2020-05-22 | 2021-05-20 | 例えば、うつ病を治療するための、ｇｐｒ１３９拮抗薬としての１－（（１ｈ－ピラゾール－４－イル）メチル）－３－（フェニル）－１，３－ジヒドロ－２ｈ－イミダゾール－２－オン誘導体および関連化合物 |
| JP2025139598A Pending JP2025168429A (ja) | 2020-05-22 | 2025-08-25 | 例えば、うつ病を治療するための、ｇｐｒ１３９拮抗薬としての１－（（１ｈ－ピラゾール－４－イル）メチル）－３－（フェニル）－１，３－ジヒドロ－２ｈ－イミダゾール－２－オン誘導体および関連化合物 |
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| US (1) | US20230348435A1 (https=) |
| EP (1) | EP4153583B1 (https=) |
| JP (3) | JP2021183586A (https=) |
| AR (1) | AR122142A1 (https=) |
| ES (1) | ES3001126T3 (https=) |
| TW (1) | TW202208349A (https=) |
| WO (1) | WO2021234450A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2021183587A (ja) | 2020-05-22 | 2021-12-02 | 武田薬品工業株式会社 | 複素環化合物 |
| TW202400588A (zh) * | 2022-02-28 | 2024-01-01 | 香港商維泰瑞隆（香港）生物科技有限公司 | Ｒｉｐ１調製劑、其製備及用途 |
| CN121159462A (zh) * | 2025-11-19 | 2025-12-19 | 杭州市第七人民医院(杭州市心理危机研究与干预中心) | 喹唑啉酮类化合物及其在制备神经系统疾病药物中的应用 |
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| CA2374610A1 (en) | 1999-06-28 | 2001-01-04 | Jordan J. N. Tang | Catalytically active recombinant memapsin and methods of use thereof |
| AR052342A1 (es) * | 2004-12-21 | 2007-03-14 | Janssen Pharmaceutica Nv | Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores |
| US8148367B2 (en) | 2007-01-12 | 2012-04-03 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
| WO2008094556A2 (en) | 2007-01-30 | 2008-08-07 | Biogen Idec Ma Inc. | Imidazolone compounds as tgf-beta family type i receptors, alk5 and/or alk4 antagonists |
| WO2011145735A1 (ja) * | 2010-05-21 | 2011-11-24 | 武田薬品工業株式会社 | チアゾール誘導体 |
| AR103990A1 (es) * | 2015-01-09 | 2017-06-21 | Bristol Myers Squibb Co | Ureas cíclicas como inhibidoras de rock |
| WO2020097609A1 (en) * | 2018-11-09 | 2020-05-14 | Blackthorn Therapeutics, Inc. | Gpr139 receptor modulators |
| JP7199940B2 (ja) | 2018-12-03 | 2023-01-06 | 川崎重工業株式会社 | 複合材料製航空機用部品およびその製造方法 |
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- 2021-05-20 WO PCT/IB2021/000336 patent/WO2021234450A1/en not_active Ceased
- 2021-05-20 TW TW110118331A patent/TW202208349A/zh unknown
- 2021-05-20 EP EP21737768.8A patent/EP4153583B1/en active Active
- 2021-05-20 US US17/999,505 patent/US20230348435A1/en active Pending
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| Publication number | Publication date |
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| AR122142A1 (es) | 2022-08-17 |
| JP7734152B2 (ja) | 2025-09-04 |
| TW202208349A (zh) | 2022-03-01 |
| WO2021234450A1 (en) | 2021-11-25 |
| JP2023528280A (ja) | 2023-07-04 |
| EP4153583C0 (en) | 2024-10-30 |
| JP2025168429A (ja) | 2025-11-07 |
| ES3001126T3 (es) | 2025-03-04 |
| US20230348435A1 (en) | 2023-11-02 |
| EP4153583B1 (en) | 2024-10-30 |
| EP4153583A1 (en) | 2023-03-29 |
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