JP2021181427A - Triglyceride detergent - Google Patents
Triglyceride detergent Download PDFInfo
- Publication number
- JP2021181427A JP2021181427A JP2021072230A JP2021072230A JP2021181427A JP 2021181427 A JP2021181427 A JP 2021181427A JP 2021072230 A JP2021072230 A JP 2021072230A JP 2021072230 A JP2021072230 A JP 2021072230A JP 2021181427 A JP2021181427 A JP 2021181427A
- Authority
- JP
- Japan
- Prior art keywords
- polyoxyethylene
- glyceryl
- detergent
- extract
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003599 detergent Substances 0.000 title claims abstract description 15
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- -1 polyoxyethylene Polymers 0.000 claims abstract description 67
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- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
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- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
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- 239000011732 tocopherol Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
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- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
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- 229920003169 water-soluble polymer Polymers 0.000 description 1
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Landscapes
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
Description
本発明は、トリグリセリドに対して優れた洗浄力を有する洗浄剤に関する。 The present invention relates to a detergent having excellent detergency against triglycerides.
ヒトの頭皮の皮脂はトリグリセリド、遊離脂肪酸、スクアレン、ワックスエステル等で構成されており、中でもトリグリセリドは主成分としておよそ40%程度を占めているとの報告がある（非特許文献１）。皮脂は皮膚表面を覆うことで、外部からの異物の侵入を防ぐ、体内からの水分漏出を防ぐなどの生理的役割を担っている。一方、過剰分泌された皮脂は様々な頭皮トラブル（悪臭、フケ、べたつき、炎症など）の一因となる可能性があり、近年の清潔志向の高まりから、皮脂洗浄力の優れた頭髪洗浄剤（シャンプーなど）による日常的なケアが求められている。 It has been reported that the sebum of the human scalp is composed of triglyceride, free fatty acid, squalene, wax ester and the like, and among them, triglyceride occupies about 40% as the main component (Non-Patent Document 1). By covering the surface of the skin, sebum plays a physiological role such as preventing the invasion of foreign substances from the outside and the leakage of water from the body. On the other hand, excessively secreted sebum may contribute to various scalp troubles (foul odor, dandruff, stickiness, inflammation, etc.). Daily care with shampoo etc.) is required.
頭髪洗浄剤が皮脂汚れへの洗浄作用を発揮する上で必要不可欠な成分は界面活性剤である。界面活性剤の洗浄機構の例としてローリングアップ、乳化、可溶化等が挙げられるが、シャンプーのような頭髪洗浄剤における洗浄機構には可溶化が関連し、他の機構の関与は不明であるとされている（非特許文献２）。したがって、皮脂汚れを効果的に除去するためには、皮脂成分を可溶化しうる十分な量の界面活性剤を添加する必要があるが、一方で、過剰な界面活性剤の使用によって肌本来のバリア機能を担う細胞間脂質等も流出し、健全な肌状態が損なわれる危険性もある。上記観点から、少量でも皮脂汚れを十分に除去できるよう、皮脂汚れ（特にその主成分であるトリグリセリド）に対して優れた洗浄力を有する洗浄剤の選択が求められるが、そのような検討はいまだ不十分であった。 A surfactant is an indispensable ingredient for a hair cleanser to exert a cleansing effect on sebum stains. Examples of the detergent cleaning mechanism include rolling-up, emulsification, solubilization, etc., but solubilization is related to the cleaning mechanism in hair cleaning agents such as shampoo, and the involvement of other mechanisms is unknown. (Non-Patent Document 2). Therefore, in order to effectively remove sebum stains, it is necessary to add a sufficient amount of surfactant that can solubilize the sebum component, but on the other hand, the use of excess surfactant is inherent in the skin. There is also a risk that the healthy skin condition will be impaired due to the outflow of intercellular lipids that have a barrier function. From the above viewpoint, it is required to select a detergent having excellent detergency against sebum stains (particularly triglyceride, which is the main component thereof) so that sebum stains can be sufficiently removed even in a small amount, but such studies are still conducted. It was inadequate.
本発明は、皮脂汚れの主成分であるトリグリセリドに対して優れた洗浄力を有する洗浄剤を提供することを課題とする。 An object of the present invention is to provide a cleaning agent having excellent detergency against triglyceride, which is a main component of sebum stains.
本発明者らは、トリグリセリドの一種であるトリオレインに対して、各種成分の可溶化限界濃度を測定することにより、トリグリセリド洗浄剤のスクリーニング評価を行った。その結果、ポリオキシエチレン脂肪酸グリセリルとアルキルグルコシドが、格段に優れたトリグリセリドに対する洗浄力を有するということを見出した。また、ポリオキシエチレン（カプリル／カプリン酸）グリセリルと特定の成分又は抽出物を組み合わせることでその洗浄力が飛躍的に向上するということを見出し、本発明を完成させた。 The present inventors conducted a screening evaluation of a triglyceride detergent by measuring the solubilization limit concentration of various components for triolein, which is a kind of triglyceride. As a result, it was found that the polyoxyethylene fatty acids glyceryl and alkyl glucoside have remarkably excellent detergency against triglycerides. Further, they have found that the detergency is dramatically improved by combining polyoxyethylene (caprylic / capric acid) glyceryl with a specific component or extract, and completed the present invention.
すなわち本発明は、
（１）ポリオキシエチレン脂肪酸グリセリル及び／又はアルキルグルコシドを含有し、頭皮用及び／又は毛髪用であることを特徴とするトリグリセリドに対する洗浄剤、
（２）トリグリセリドがトリオレインである（１）に記載の洗浄剤、
（３）ポリオキシエチレン脂肪酸グリセリドがポリオキシエチレンヤシ油脂肪酸グリセリル又はポリオキシエチレン（カプリル／カプリン酸）グリセリルである（１）又は（２）に記載の洗浄剤、
（４）アルキルグルコシドがアルキル（８〜１６）グルコシドである（１）〜（３）のいずれかに記載の洗浄剤、
（５）（ａ）ポリオキシエチレン（カプリル／カプリン酸）グリセリル、及び（ｂ）タウリン、オウレン抽出物、オウバク抽出物、及びテンチャ抽出物からなる群から選ばれる少なくとも１種を含有し、頭皮用及び／又は毛髪用であることを特徴とする洗浄剤、
である。
That is, the present invention
(1) A detergent for triglycerides containing the polyoxyethylene fatty acid glyceryl and / or alkyl glucoside, which is used for the scalp and / or hair.
(2) The cleaning agent according to (1), wherein the triglyceride is triolein.
(3) The cleaning agent according to (1) or (2), wherein the polyoxyethylene fatty acid glyceride is polyoxyethylene palm oil fatty acid glyceryl or polyoxyethylene (caprylic / capric acid) glyceryl.
(4) The cleaning agent according to any one of (1) to (3), wherein the alkyl glucoside is an alkyl (8 to 16) glucoside.
(5) Contains at least one selected from the group consisting of (a) polyoxyethylene (caprylic / capric acid) glyceryl and (b) taurine, Coptis chinensis extract, Coptis chinensis extract, and Tencha extract for the scalp. And / or a cleaning agent, characterized by being for hair.
Is.
本発明により、トリグリセリドに対して優れた洗浄力を有する洗浄剤を提供することが可能になった。 INDUSTRIAL APPLICABILITY According to the present invention, it has become possible to provide a detergent having excellent detergency against triglycerides.
本発明のトリグリセリド洗浄剤は、ポリオキシエチレン脂肪酸グリセリル及び／又はアルキルグルコシドを含有し、頭皮用及び／又は毛髪用として使用されるものである。また、本発明の洗浄剤は、ポリオキシエチレン（カプリル／カプリン酸）グリセリル、並びに、タウリン、オウレン抽出物、オウバク抽出物、及びテンチャ抽出物からなる群から選ばれる少なくとも１種を含有し、頭皮用及び／又は毛髪用として使用されるものである。上記各成分は、通常医薬品、医薬部外品、又は化粧品に用いられる品質のものを適宜使用することができる。 The triglyceride cleanser of the present invention contains the polyoxyethylene fatty acid glyceryl and / or alkyl glucoside and is used for the scalp and / or the hair. In addition, the cleaning agent of the present invention contains polyoxyethylene (caprylic / capric acid) glyceryl and at least one selected from the group consisting of taurine, Coptis chinensis extract, Coptis chinensis extract, and Tencha extract, and contains scalp. And / or for hair. As each of the above-mentioned components, those having a quality usually used for pharmaceuticals, quasi-drugs, or cosmetics can be appropriately used.
ポリオキシエチレン脂肪酸グリセリルは、優れた乳化・分散作用をもつ安全性の高い非イオン性界面活性剤であり、化粧品分野において多目的に使用可能である。用いられるポリオキシエチレン脂肪酸グリセリルの具体例としては、ポリオキシエチレンヤシ油脂肪酸グリセリル、ポリオキシエチレン（カプリル／カプリン酸）グリセリル、ポリオキシエチレンカプリル酸グリセリル、ラウリン酸ポリオキシエチレングリセリル、ポリオキシエチレンオレイン酸グリセリル、ポリオキシエチレンモノヤシ油脂肪酸グリセリルなどを例示することができ、ポリオキシエチレンヤシ油脂肪酸グリセリル、ポリオキシエチレン（カプリル／カプリン酸）グリセリルを用いることがより好ましい。これらは、１種を単独で用いてもよく、２種以上を適宜組み合わせて用いることもできる。 The polyoxyethylene fatty acid glyceryl is a highly safe nonionic surfactant having an excellent emulsifying / dispersing action, and can be used for various purposes in the cosmetic field. Specific examples of the polyoxyethylene fatty acid glyceryl used include polyoxyethylene palm oil fatty acid glyceryl, polyoxyethylene (caprylic / capric acid) glyceryl, polyoxyethylene caprylate glyceryl, polyoxyethylene glyceryl laurate, and polyoxyethylene olein. Glyceryl acid, polyoxyethylene monococonut oil fatty acid glyceryl and the like can be exemplified, and polyoxyethylene coconut oil fatty acid glyceryl and polyoxyethylene (caprylic / capric acid) glyceryl are more preferable. One of these may be used alone, or two or more thereof may be used in combination as appropriate.
ポリオキシエチレン脂肪酸グリセリルの含有量は、所望の効果が充分に付与されるのであれば特に限定されないが、本発明の洗浄剤中、好ましくは０．０１〜２０質量％、より好ましくは０．１〜１０質量％である。 The content of the polyoxyethylene fatty acid glyceryl is not particularly limited as long as the desired effect is sufficiently imparted, but is preferably 0.01 to 20% by mass, more preferably 0.1 in the detergent of the present invention. It is 10% by mass.
アルキルグルコシドは、糖と高級アルコールがグリコシド結合した天然原料由来の非イオン性界面活性剤であり、起泡性や安全性に優れた洗浄成分として知られている。用いられるアルキルグルコシドの具体例としては、アルキル（８〜１６）グルコシドなどを例示することができ、炭素数８〜１０のアルキル基を有するものを用いることがより好ましい。これらは、１種を単独で用いてもよく、２種以上を適宜組み合わせて用いることもできる。 Alkyl glucoside is a nonionic surfactant derived from a natural raw material in which a sugar and a higher alcohol are glycosidic bonded, and is known as a cleaning component having excellent foaming properties and safety. Specific examples of the alkyl glucoside used include alkyl (8 to 16) glucosides, and it is more preferable to use one having an alkyl group having 8 to 10 carbon atoms. One of these may be used alone, or two or more thereof may be used in combination as appropriate.
アルキルグルコシドの含有量は、所望の効果が充分に付与されるのであれば特に限定されないが、本発明の洗浄剤中、好ましくは０．０１〜２０質量％、より好ましくは０．１〜１０質量％である。 The content of the alkyl glucoside is not particularly limited as long as the desired effect is sufficiently imparted, but is preferably 0.01 to 20% by mass, more preferably 0.1 to 10% by mass in the detergent of the present invention. %.
タウリン（別名アミノエチルスルホン酸、2-アミノエタンスルホン酸）は、Cas No.107-35-7で規定される化合物であり、一般的な化学合成法や、魚介類、特に軟体動物（タコ・イカ）などから抽出して製造することが可能である。また、種々の試薬・原料メーカーから購入したものを用いることも可能である。 Taurine (also known as aminoethyl sulfonic acid, 2-aminoethane sulfonic acid) is a compound defined by Cas No. 107-35-7, and is used for general chemical synthesis methods and fish and shellfish, especially mollusks (octopus). It can be manufactured by extracting from squid). It is also possible to use those purchased from various reagent / raw material manufacturers.
タウリンの含有量は、所望の効果が充分に付与されるのであれば特に限定されないが、本発明の洗浄剤中、好ましくは０．００１〜１０質量％、より好ましくは０．０１〜５質量％である。 The content of taurine is not particularly limited as long as the desired effect is sufficiently imparted, but is preferably 0.001 to 10% by mass, more preferably 0.01 to 5% by mass in the detergent of the present invention. Is.
オウレン抽出物は、オウレン(学名Coptis japonica Makino)又はその他同属植物の根茎から得られる抽出物である。オウバク抽出物は、キハダ（学名Phellodendron amurense Ruprecht）又はその他同属植物の周皮を除いた樹皮から得られる抽出物である。テンチャ抽出物は、バラ科に属する植物名甜茶（学名Rubus suavissimus）の葉から得られる抽出物である。上記抽出物の抽出方法は特に限定されず、常法に従って行うことができる。抽出に用いられる抽出溶媒としては、極性溶媒、非極性溶媒のいずれも使用することができ、例えば水、エタノール、プロピレングリコール、１，３−ブチレングリコール、及びこれらの混液を用いることができる。上記抽出物は、抽出した溶液のまま用いても良く、必要に応じて、濃縮、希釈、濾過、活性炭等による脱色、脱臭、エタノール沈殿等の処理したものを用いても良い。さらには、抽出した溶液を濃縮乾固、噴霧乾燥、凍結乾燥等の処理を行い、乾燥物としたものとして用いても良い。また市販品を用いることもできる。 Coptis chinensis extract is an extract obtained from the rhizome of Coptis japonica (scientific name) or other plants of the same genus. Oubaku extract is an extract obtained from the bark of Phellodendron amurense Ruprecht (scientific name: Phellodendron amurense Ruprecht) or other plants of the same genus, excluding the periderm. Tencha extract is an extract obtained from the leaves of the plant name Rubus suavissimus, which belongs to the Rosaceae family. The extraction method of the above extract is not particularly limited and can be carried out according to a conventional method. As the extraction solvent used for extraction, either a polar solvent or a non-polar solvent can be used, and for example, water, ethanol, propylene glycol, 1,3-butylene glycol, and a mixed solution thereof can be used. The above-mentioned extract may be used as it is, or may be concentrated, diluted, filtered, decolorized with activated carbon, deodorized, ethanol precipitation or the like, if necessary. Further, the extracted solution may be subjected to treatments such as concentrated drying, spray drying, freeze-drying and the like to be used as a dried product. A commercially available product can also be used.
オウレン抽出物、オウバク抽出物又はテンチャ抽出物の含有量は、所望の効果が充分に付与されるのであれば特に限定されないが、本発明の洗浄剤中、好ましくは０．０００１〜５質量％、より好ましくは０．００１〜３質量％である。 The content of Coptis chinensis extract, Coptis chinensis extract or Tencha extract is not particularly limited as long as the desired effect is sufficiently imparted, but is preferably 0.0001 to 5% by mass in the cleaning agent of the present invention. More preferably, it is 0.001 to 3% by mass.
本発明の洗浄剤は、上記した各成分の他に、本発明の効果を損なわない範囲で、通常の化粧品、医薬部外品、医薬品などに用いられる各種成分を加えることができる。例えば、アニオン性界面活性剤（Ｎ−アシルメチルアラニン塩、Ｎ−アシルグルタミン酸塩、Ｎ−アシルアスパラギン酸塩、Ｎ−アシルタウリン塩などのアミノ酸系、α−オレフィンスルホン酸塩、脂肪酸塩、スルホコハク酸塩、アルキルエーテルカルボン酸塩、アシル乳酸塩、アルキル硫酸塩、アルキルエーテル硫酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレンアルキルエーテル酢酸塩、高級脂肪酸アルカノールアミド硫酸塩等）、両性界面活性剤（アルキルベタイン型、アルキルアミドベタイン型、アミドスルホベタイン型、アミノ酸型、イミダゾリン型、アミンオキサイド型等）、ノニオン性界面活性剤（ポリオキシエチレンアルキルエーテル、ポリオキシプロピレンアルキルエーテル、ポリエチレングリコール脂肪酸エステル、ポリエチレングリコール脂肪酸ジエステル、グリセリンエステル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、脂肪酸アルカノールアミド、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、プロピレングリコール脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタンモノ脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油等）、カチオン性高分子（カチオン化セルロース、カチオン化グアーガム、カチオン化キサンタンガム、ポリ塩化ジメチルメチレンピペリジニウム、塩化ジメチルジアリルアンモニウム・アクリルアミド共重合体、アクリルアミド・アクリル酸・塩化ジメチルジアリルアンモニウム共重合体等）、賦形剤、香料、清涼化剤（メントール、ハッカ油、カンフル等）、抗炎症剤（グアイアズレン、サリチル酸、グリチルリチン酸塩、グリチルレチン酸等）、殺菌剤（グルコン酸クロルヘキシジン、イソプロピルメチルフェノール、第４級アンモニウム塩、ピロクトンオラミン等）、防腐剤（パラベン類（メチルパラベン、エチルパラベン、ブチルパラベン、プロピルパラベン等）、安息香酸又はその塩、デヒドロ酢酸ナトリウム、フェノキシエタノール、ヒノキチオール等、保湿剤（ヒアルロン酸又はその塩、コンドロイチン硫酸等）、各種動植物の抽出物、ビタミン類（酢酸レチノール、アスコルビン酸、硝酸チアミン、シアノコバラミン、ビオチン、リボフラビン等）、抗酸化剤（ジブチルヒドロキシトルエン、ピロ亜硫酸ナトリウム、トコフェロール、エデト酸ナトリウム、アスコルビン酸、イソプロピルガレート等）、溶解補助剤（各種植物油、各種動物油、アルキルグリセリルエーテル、炭化水素類等）、代謝賦活剤、ゲル化剤（水溶性高分子等）、粘着剤などを目的に応じて適宜配合することができる。 In addition to the above-mentioned components, the cleaning agent of the present invention can contain various components used in ordinary cosmetics, quasi-drugs, pharmaceuticals, etc., as long as the effects of the present invention are not impaired. For example, anionic surfactants (amino acid systems such as N-acylmethylalanine salt, N-acylglutamate, N-acylaspartate, N-acyltaurine salt, α-olefin sulfonate, fatty acid salt, sulfosuccinic acid. Salts, alkyl ether carboxylates, acyl lactates, alkyl sulfates, alkyl ether sulfates, polyoxyethylene alkyl ether sulfates, polyoxyethylene alkyl ether acetates, higher fatty acids alkanolamide sulfates, etc.), amphoteric surfactants (Alkylbetaine type, Alkylamide betaine type, Amidosulfobetaine type, Amino acid type, Imidazoline type, Aminoxide type, etc.), Nonionic surfactant (Polyoxyethylene alkyl ether, Polyoxypropylene alkyl ether, Polyethylene glycol fatty acid ester, etc. Polyethylene glycol fatty acid diester, glycerin ester, polyoxyethylene polyoxypropylene alkyl ether, fatty acid alkanolamide, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan mono fatty acid Esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbit fatty acid esters, polyoxyethylene hydrogenated castor oil, etc.), cationic polymers (cationized cellulose, cationized guar gum, cationized xanthan gum, polydimethylmethylene piperidinium, Dimethyldialylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid, dimethyldiallylammonium chloride copolymer, etc.), excipients, fragrances, cooling agents (menthol, peppermint oil, camphor, etc.), anti-inflammatory agents (guiazulen, etc.) Salicylic acid, glycyrrhizinate, glycyrrhetinic acid, etc.), bactericides (chlorhexidine gluconate, isopropylmethylphenol, quaternary ammonium salt, pyrocton olamine, etc.), preservatives (parabens (methylparaben, ethylparaben, butylparaben, propyl, etc.)) Paraben, etc.), benzoic acid or its salt, sodium dehydroacetate, phenoxyethanol, hinokithiol, etc., moisturizer (hyaluronic acid or its salt, chondroitin sulfate, etc.), extracts of various animals and plants, vitamins (retinol acetate, ascorbic acid, thiamine nitrate, etc.) , Cyanocobalamine, biotin, riboflavin Etc.), Antioxidants (dibutylhydroxytoluene, sodium pyrosulfite, tocopherol, sodium edetate, ascorbic acid, isopropyl gallate, etc.), lysis aids (various vegetable oils, various animal oils, alkylglyceryl ethers, hydrocarbons, etc.), metabolism An activator, a gelling agent (water-soluble polymer, etc.), a pressure-sensitive adhesive, and the like can be appropriately blended depending on the purpose.
本発明の洗浄剤は化粧品、医薬部外品、医薬品などの用途に使用できる。また、本発明の洗浄剤は、シャンプー、頭皮洗浄剤として使用することが好ましい。 The cleaning agent of the present invention can be used for cosmetics, quasi-drugs, pharmaceuticals and the like. Moreover, it is preferable to use the cleaning agent of the present invention as a shampoo and a scalp cleaning agent.
以下に、実施例、比較例及び試験例を記載し、本発明をさらに具体的に説明するが、本発明はこれら実施例等により何ら制約されるものではない。尚、濃度は、特記しない限り「質量％」を表す。 Hereinafter, the present invention will be described in more detail with reference to Examples, Comparative Examples and Test Examples, but the present invention is not limited to these Examples and the like. The concentration represents "mass%" unless otherwise specified.
（試験例１）
トリグリセリドの一種であるトリオレインに対して、各種成分の可溶化限界濃度を測定することで、洗浄力の評価を行った。
(Test Example 1)
The detergency of triolein, which is a kind of triglyceride, was evaluated by measuring the solubilization limit concentration of various components.
精製水、トリオレイン及び表１に記載の各種成分を、最終濃度１％、トリオレイン最終濃度０．１〜０．００１％となるように秤量し、種々の濃度の混合水溶液１０ｇを調製した。室温にて１時間振とうし、その後室温にて一晩静置した。転倒混和してさらに１時間以上静置（脱泡）し、紫外可視分光光度計（ＵＶ−２４５０、島津製作所）にて、各界面活性剤／トリオレイン混合水溶液の６００ｎｍでの吸光度を濁度として測定した。トリオレイン濃度に対する濁度の値をプロットし、濁度が急激に増加し始める点（屈折点）におけるトリオレイン濃度をトリオレイン可溶化限界濃度として算出した。 Purified water, triolein and various components shown in Table 1 were weighed so as to have a final concentration of 1% and a final concentration of triolein of 0.1 to 0.001% to prepare 10 g of a mixed aqueous solution having various concentrations. It was shaken at room temperature for 1 hour and then allowed to stand overnight at room temperature. After mixing by inversion and allowing to stand for 1 hour or more (defoaming), the absorbance of each surfactant / triolein mixed aqueous solution at 600 nm is defined as the turbidity in an ultraviolet-visible spectrophotometer (UV-2450, Shimadzu Corporation). It was measured. The value of turbidity with respect to the triolein concentration was plotted, and the triolein concentration at the point where the turbidity began to increase rapidly (refraction point) was calculated as the triolein solubilization limit concentration.
（試験結果）
トリオレイン可溶化限界濃度が０．００１％以上のものを洗浄力が優れている（○）とし、０．００１％以下のものを洗浄力が不十分である（×）とした。評価結果を表１に示す。
(Test results)
Those having a triolein solubilization limit concentration of 0.001% or more were regarded as having excellent detergency (◯), and those having a triolein solubilization limit concentration of 0.001% or less were regarded as having insufficient detergency (×). The evaluation results are shown in Table 1.
ポリオキシエチレン脂肪酸グリセリル又はアルキルグルコシドからなる実施例１〜３は、トリオレイン可溶化限界濃度が高く、トリオレインに対する洗浄力に優れていることが明らかとなった。一方、その他成分を用いた比較例１〜１６は、トリオレイン可溶化限界濃度が低く、トリオレインに対する洗浄力が不十分であることが明らかとなった。 It was revealed that Examples 1 to 3 composed of the polyoxyethylene fatty acid glyceryl or the alkyl glucoside had a high triolein solubilization limit concentration and were excellent in detergency against triolein. On the other hand, in Comparative Examples 1 to 16 using other components, it was clarified that the triolein solubilization limit concentration was low and the detergency against triolein was insufficient.
（試験例２）
各種成分を組み合わせた際の可溶化限界濃度を測定することで、洗浄力向上効果の評価を行った。
(Test Example 2)
The detergency improving effect was evaluated by measuring the solubilization limit concentration when various components were combined.
精製水、トリオレイン、ポリオキシエチレン（カプリル／カプリン酸）グリセリル及び表２に記載の各種成分を、表２記載の最終濃度で、トリオレイン最終濃度０．０７〜０．００１％となるように秤量し、種々の濃度の混合水溶液１０ｇを調製した。室温にて１時間振とうし、その後室温にて一晩静置した。転倒混和してさらに１時間以上静置（脱泡）し、紫外可視分光光度計（ＵＶ−２４５０、島津製作所）にて、ポリオキシエチレン（カプリル／カプリン酸）グリセリル／トリオレイン混合水溶液の６００ｎｍでの吸光度を濁度として測定した。トリオレイン濃度に対する濁度の値をプロットし、濁度が急激に増加し始める点（屈折点）におけるトリオレイン濃度をトリオレイン可溶化限界濃度として算出した。 Purified water, triolein, polyoxyethylene (capryl / capric acid) glyceryl and various components shown in Table 2 should be added to the final concentration shown in Table 2 so that the final concentration of triolein is 0.07 to 0.001%. Weighed to prepare 10 g of mixed aqueous solutions of various concentrations. It was shaken at room temperature for 1 hour and then allowed to stand overnight at room temperature. After mixing by inversion and allowing to stand for 1 hour or more (defoaming), use an ultraviolet-visible spectrophotometer (UV-2450, Shimadzu Corporation) at 600 nm of a mixed aqueous solution of polyoxyethylene (capril / capric acid) glyceryl / triolein. The absorbance of the sample was measured as turbidity. The value of turbidity with respect to the triolein concentration was plotted, and the triolein concentration at the point where the turbidity began to increase rapidly (refraction point) was calculated as the triolein solubilization limit concentration.
（試験結果）
実施例２と比較して、トリオレイン可溶化限界濃度の向上率が１０％以上であったものを洗浄力向上効果が優れた組合せ（○）、向上率が０〜１０％未満であったものを洗浄力向上効果が不十分な組合せ（△）、向上率が負の値となったものを洗浄力向上効果がない組合せ（×）とした。評価結果を表２に示す。
(Test results)
A combination in which the improvement rate of the triolein solubilization limit concentration was 10% or more as compared with Example 2 was excellent in the detergency improving effect (◯), and the improvement rate was less than 0 to 10%. Was defined as a combination having an insufficient detergency improving effect (Δ), and a combination having a negative improvement rate was defined as a combination having no detergency improving effect (×). The evaluation results are shown in Table 2.
実施例４〜７は、実施例２と比較してトリオレイン可溶化限界濃度が劇的に向上し、洗浄力が優れた組合せであることが明らかとなった。一方、その他成分を組み合わせた比較例１７〜２０は、トリオレイン可溶化限界濃度が向上せず、洗浄力向上効果が不十分な組合せであることが明らかとなった。したがって、ポリオキシエチレン（カプリル／カプリン酸）グリセリル、並びに、タウリン、オウレン抽出物、オウバク抽出物、及びテンチャ抽出物から選ばれる成分の組み合わせが、頭皮又は毛髪用の洗浄剤として優れることが明らかとなった。 It was revealed that Examples 4 to 7 were a combination in which the triolein solubilization limit concentration was dramatically improved as compared with Example 2 and the detergency was excellent. On the other hand, it was clarified that Comparative Examples 17 to 20 in which other components were combined were combinations in which the triolein solubilization limit concentration was not improved and the detergency improving effect was insufficient. Therefore, it is clear that the combination of polyoxyethylene (caprylic / capric acid) glyceryl and the components selected from taurine, Coptis chinensis extract, Phellodendron amur extract, and Tencha extract is excellent as a cleaning agent for scalp or hair. became.
本発明により、頭皮の皮脂汚れの主成分であるトリグリセリドに対して優れた洗浄力を有する洗浄剤を提供することが可能になった。 INDUSTRIAL APPLICABILITY According to the present invention, it has become possible to provide a detergent having excellent detergency against triglyceride, which is a main component of sebum stains on the scalp.
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