JP2021070656A - 認知症改善および/または予防剤 - Google Patents
認知症改善および/または予防剤 Download PDFInfo
- Publication number
- JP2021070656A JP2021070656A JP2019199014A JP2019199014A JP2021070656A JP 2021070656 A JP2021070656 A JP 2021070656A JP 2019199014 A JP2019199014 A JP 2019199014A JP 2019199014 A JP2019199014 A JP 2019199014A JP 2021070656 A JP2021070656 A JP 2021070656A
- Authority
- JP
- Japan
- Prior art keywords
- dementia
- agent
- fir
- present
- abies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010012289 Dementia Diseases 0.000 title claims abstract description 44
- 230000006872 improvement Effects 0.000 title description 5
- 230000003449 preventive effect Effects 0.000 title description 3
- 241000196324 Embryophyta Species 0.000 claims abstract description 23
- 241000218641 Pinaceae Species 0.000 claims abstract description 18
- 235000011613 Pinus brutia Nutrition 0.000 claims abstract description 18
- 239000000284 extract Substances 0.000 claims abstract description 17
- 239000004480 active ingredient Substances 0.000 claims abstract description 6
- 230000000069 prophylactic effect Effects 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 38
- 241001311472 Abies sachalinensis Species 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 15
- 238000001256 steam distillation Methods 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 7
- 239000007923 nasal drop Substances 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 238000000222 aromatherapy Methods 0.000 abstract description 9
- 239000002994 raw material Substances 0.000 abstract description 5
- 238000013138 pruning Methods 0.000 abstract description 4
- 241001311509 Abies firma Species 0.000 abstract 1
- 239000000341 volatile oil Substances 0.000 description 17
- 238000004821 distillation Methods 0.000 description 13
- 239000007788 liquid Substances 0.000 description 10
- 208000024891 symptom Diseases 0.000 description 10
- 229920000742 Cotton Polymers 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 230000003920 cognitive function Effects 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 241001311476 Abies veitchii Species 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000002386 air freshener Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- 230000008786 sensory perception of smell Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000005292 vacuum distillation Methods 0.000 description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
- 244000283070 Abies balsamea Species 0.000 description 2
- 235000007173 Abies balsamea Nutrition 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 241000723346 Cinnamomum camphora Species 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- 244000165082 Lavanda vera Species 0.000 description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 229960000846 camphor Drugs 0.000 description 2
- 229930008380 camphor Natural products 0.000 description 2
- 208000010877 cognitive disease Diseases 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- 230000008449 language Effects 0.000 description 2
- 239000001102 lavandula vera Substances 0.000 description 2
- 235000018219 lavender Nutrition 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 230000008450 motivation Effects 0.000 description 2
- 229940100662 nasal drops Drugs 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 230000003863 physical function Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- MFKRHJVUCZRDTF-UHFFFAOYSA-N 3-methoxy-3-methylbutan-1-ol Chemical compound COC(C)(C)CCO MFKRHJVUCZRDTF-UHFFFAOYSA-N 0.000 description 1
- 241000218642 Abies Species 0.000 description 1
- 241001261630 Abies cephalonica Species 0.000 description 1
- 241000379228 Abies concolor Species 0.000 description 1
- 235000004710 Abies lasiocarpa Nutrition 0.000 description 1
- 241000379219 Abies nebrodensis Species 0.000 description 1
- 241000379221 Abies nordmanniana Species 0.000 description 1
- 241000018645 Abies numidica Species 0.000 description 1
- 241000379225 Abies procera Species 0.000 description 1
- 241000379194 Abies sibirica Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 239000004857 Balsam Substances 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 240000003538 Chamaemelum nobile Species 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 240000002319 Citrus sinensis Species 0.000 description 1
- 235000005976 Citrus sinensis Nutrition 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 240000005109 Cryptomeria japonica Species 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- 240000004784 Cymbopogon citratus Species 0.000 description 1
- 235000017897 Cymbopogon citratus Nutrition 0.000 description 1
- 206010012239 Delusion Diseases 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 201000011240 Frontotemporal dementia Diseases 0.000 description 1
- 208000004547 Hallucinations Diseases 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010049976 Impatience Diseases 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 241000499917 Milla Species 0.000 description 1
- 244000179970 Monarda didyma Species 0.000 description 1
- 235000010672 Monarda didyma Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 241001482237 Pica Species 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 240000003889 Piper guineense Species 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 235000011751 Pogostemon cablin Nutrition 0.000 description 1
- 240000002505 Pogostemon cablin Species 0.000 description 1
- 235000009984 Pterocarpus indicus Nutrition 0.000 description 1
- 244000086363 Pterocarpus indicus Species 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 240000000513 Santalum album Species 0.000 description 1
- 235000008632 Santalum album Nutrition 0.000 description 1
- 244000028419 Styrax benzoin Species 0.000 description 1
- 235000000126 Styrax benzoin Nutrition 0.000 description 1
- 235000008411 Sumatra benzointree Nutrition 0.000 description 1
- 241000736892 Thujopsis dolabrata Species 0.000 description 1
- 201000004810 Vascular dementia Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 229960002130 benzoin Drugs 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 239000000544 cholinesterase inhibitor Substances 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011257 definitive treatment Methods 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 231100000868 delusion Toxicity 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 235000019382 gum benzoic Nutrition 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 235000015092 herbal tea Nutrition 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 208000027061 mild cognitive impairment Diseases 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 235000015927 pasta Nutrition 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- -1 troches Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
(1)マツ科モミ属に属する植物の圧搾液、抽出物または蒸留物を有効成分として含有する認知症改善および/または予防剤。
(2)マツ科モミ属に属する植物がトドマツである(1)記載の剤。
(3)蒸留物がマイクロ波減圧水蒸気蒸留法にて得られたものである(1)または(2)記載の剤。
(4)吸入剤、噴霧剤または点鼻剤である(1)〜(3)のいずれか記載の剤。
(5)医薬組成物である(1)〜(4)のいずれか記載の剤。
また、95キロパスカル以上では、原料の温度が高くなるため、エネルギーロスが大きく、原料の酸化も促進されてしまうという点で好ましくない。また、蒸留時間は、0.2ないし8時間程度、好ましくは、0.4ないし6時間程度とすれば良い。0.2時間以下では植物中の未抽出成分が多く残存してしまい、8時間以上では原料が乾固に近い状態となってしまうため、抽出効率が低下するという点で好ましくない。
更に、蒸留槽内に導入する気体としては、空気でもかまわないが、窒素ガス、ヘリウムガス、アルゴンガス等の不活性ガスが好ましく、その流量としては、1分当たりの流量が、蒸留槽の0.001ないし0.1容量倍程度とすれば良い。マイクロ波減圧水蒸気蒸留法を用いると、変性の少ない精油を得ることができるとともに濃縮、精製等の手間をかけなくても、さわやかな香気を有し、香りの嗜好性が高いため認知症の芳香療法を、広く、継続的に利用できるため好ましい。
釧路産のトドマツの枝葉を圧搾式粉砕機で粉砕し、粉砕物をマイクロ波減圧水蒸気蒸留装置の蒸留槽に投入し、蒸留槽内の圧力を、約10KPaの減圧条件下に保持し、(蒸気温度は約60℃)1時間マイクロ波照射して蒸留し、その油性画分として精油を得た。
(a)試験方法
100%トドマツおよび30%トドマツを用いて、実験を行った。対象は、認知機能障害を認める高齢者17名(アルツハイマー型認知症:7名、軽度認知障害:10名)であった。対象者に対して、午前中はペンダントを用い、午後はディフューザーを用いて芳香療法を行った。午前中(12時までに)、アロマペンダントに100%トドマツまたは30%トドマツ0.8mlを含浸させた綿を入れ、対象者に2時間使用させた。2時間後にペンダントを外し、トドマツ精油を含浸させた綿が入ったまま放置した。午後(20時以降に)、ペンダント内の綿をタイマー式ディフューザーに移し、ディフューザーを室内に設置して、対象者に2時間使用させた。2時間後、ディフューザー内のカートリッジを捨てた。翌日の試験では新しい綿を使用した。介入時間は4週間とし、介入開始前、介入終了時、介入終了4週間後の計3回検査を行った。検査内容は、1)TDASによる認知機能検査、2)においスティックを用いた嗅覚検査、3)肝機能や腎機能を評価するための血液検査、4)生活に関するアンケートであった。試験デザインは、並行群間比較、ランダム化、二重盲検、用量対照とした。
100%トドマツ使用群のTDAS解析結果を図1に、30%トドマツ使用群のTDAS解析結果を図2に示す。100%トドマツ使用群では77.8%の人が認知機能の改善を示し(TDASが平均2.7点改善)、30%トドマツ使用群では57.1%の人が認知機能の改善を示した(TDASが平均1.7点改善)。100%トドマツ使用群のほうが認知機能の改善率が高かったことより、濃度の違いによる差があることが示唆され、トドマツ精油を使用した芳香療法が認知機能改善に作用したと考えられた。また、トドマツ精油を用いた芳香療法による嗅覚刺激が、他の経路を介さずダイレクトに脳へのシグナル伝達を増強している可能性が考えられた。一方、嗅覚検査、血液検査および生活に関するアンケートの結果には変動が見られなかった。
Claims (5)
- マツ科モミ属に属する植物の圧搾液、抽出物または蒸留物を有効成分として含有する認知症改善および/または予防剤。
- マツ科モミ属に属する植物がトドマツである請求項1記載の剤。
- 蒸留物がマイクロ波減圧水蒸気蒸留法にて得られたものである請求項1または2記載の剤。
- 吸入剤、噴霧剤または点鼻剤である請求項1〜3のいずれか1項記載の剤。
- 医薬組成物である請求項1〜4のいずれか1項記載の剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019199014A JP7334104B2 (ja) | 2019-10-31 | 2019-10-31 | 認知症改善および/または予防剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019199014A JP7334104B2 (ja) | 2019-10-31 | 2019-10-31 | 認知症改善および/または予防剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021070656A true JP2021070656A (ja) | 2021-05-06 |
JP7334104B2 JP7334104B2 (ja) | 2023-08-28 |
Family
ID=75712422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019199014A Active JP7334104B2 (ja) | 2019-10-31 | 2019-10-31 | 認知症改善および/または予防剤 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP7334104B2 (ja) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004103988A1 (ja) * | 2003-05-26 | 2004-12-02 | Amino Up Chemical Co., Ltd. | 含硫プロアントシアニジンオリゴマー組成物及びその製造方法 |
JP2006131589A (ja) * | 2004-11-09 | 2006-05-25 | Univ Kinki | アセチルコリンエステラーゼ阻害剤 |
JP2015117197A (ja) * | 2013-12-18 | 2015-06-25 | エステー株式会社 | 鼻症状改善剤 |
KR20180083468A (ko) * | 2017-01-12 | 2018-07-23 | 가천대학교 산학협력단 | 전나무 메탄올 추출물, 이의 분획물 또는 이들로부터 분리한 화합물을 포함하는 최종당화산물 관련 질환의 예방 또는 치료용 조성물 |
-
2019
- 2019-10-31 JP JP2019199014A patent/JP7334104B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004103988A1 (ja) * | 2003-05-26 | 2004-12-02 | Amino Up Chemical Co., Ltd. | 含硫プロアントシアニジンオリゴマー組成物及びその製造方法 |
JP2006131589A (ja) * | 2004-11-09 | 2006-05-25 | Univ Kinki | アセチルコリンエステラーゼ阻害剤 |
JP2015117197A (ja) * | 2013-12-18 | 2015-06-25 | エステー株式会社 | 鼻症状改善剤 |
KR20180083468A (ko) * | 2017-01-12 | 2018-07-23 | 가천대학교 산학협력단 | 전나무 메탄올 추출물, 이의 분획물 또는 이들로부터 분리한 화합물을 포함하는 최종당화산물 관련 질환의 예방 또는 치료용 조성물 |
Non-Patent Citations (1)
Title |
---|
"トドマツから抽出した精油を用いた芳香療法が認知機能に与える影響についての検討", UMIN-CTR臨床試験登録情報,UMIN試験ID:UMIN000027692, JPN6023011092, 2017, ISSN: 0005016519 * |
Also Published As
Publication number | Publication date |
---|---|
JP7334104B2 (ja) | 2023-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Ali et al. | Essential oils used in aromatherapy: A systemic review | |
JP5697126B2 (ja) | 抗ウィルス剤 | |
KR101729919B1 (ko) | 천연 정유 및 천연 하이드로졸을 함유하는 아로마테라피 효과가 있는 바디오일 조성물 | |
JPH04149136A (ja) | 鎮静用香料組成物および香粧品 | |
Ishfaq et al. | Biochemical and pharmacological applications of essential oils in human health especially in cancer prevention | |
JPH0757733B2 (ja) | 覚醒用香料組成物および香粧品 | |
Liang et al. | Essential oils: Chemical constituents, potential neuropharmacological effects and aromatherapy-A review | |
US20200268824A1 (en) | Crocus sativus inhalation apparatus | |
Aswandi et al. | Ethnopharmacological properties of essential oils from natural forests in Northern Sumatra | |
KR102316168B1 (ko) | 프랑킨센스오일을 포함하는 아로마 오일세럼 조성물 | |
Burlec et al. | Essential oils in wellness centers: overview on european union legislation, potential therapeutic effects and toxicity | |
Cho et al. | Fragrant chemicals in the supercritical carbon dioxide extract of Magnolia kobus DC. Flower buds increase the concentration state of brain function | |
KR101729921B1 (ko) | 천연 정유 및 천연 하이드로졸을 포함하는 아로마테라피 미스트 조성물 | |
KR101729920B1 (ko) | 천연 정유 및 천연 하이드로졸을 포함하는 아로마테라피 세럼 조성물 | |
JP7334104B2 (ja) | 認知症改善および/または予防剤 | |
KR101597782B1 (ko) | 천연 정유 및 천연 하이드로졸을 함유하는 아로마테라피 효과가 있는 마스크 시트 조성물 | |
JP2015117197A (ja) | 鼻症状改善剤 | |
CA2357106A1 (en) | Aromatherapeutic environmental system | |
KR20150006243A (ko) | 피톤치드를 함유하는 향료 조성물 | |
JP3659665B2 (ja) | 発想促進剤 | |
WO2021080535A2 (en) | Memory booster essential oil mixture | |
Patel et al. | Extraction of herbal aroma oils from solid surface | |
JPH01254629A (ja) | 意識水準を高揚させる効果をもつ室内用芳香剤 | |
Sobhy et al. | Role of Egyptian Essential Oils in Health Care and Industry | |
KR20070059775A (ko) | 한방 방향제 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A80 | Written request to apply exceptions to lack of novelty of invention |
Free format text: JAPANESE INTERMEDIATE CODE: A80 Effective date: 20191121 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20200306 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20200407 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20200408 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220524 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20220607 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20230320 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230322 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230517 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230726 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230816 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7334104 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |