JP2021069317A - Deodorant composition - Google Patents

Abstract

To provide a deodorant composition that can maintain an excellent deodorizing effect for a long time, by using general plant extract having few problems in safety in oral ingestion and intraoral use as the source of a phenolic compound.SOLUTION: A deodorant composition contains at least one selected from the group consisting of a phenolic compound and a phenolic compound-containing plant extract, and an oxidase, the oxidase being powder containing at least one selected from the group consisting of saccharides and low saccharified reduced starch syrup as an excipient.SELECTED DRAWING: None

Description

The present invention relates to a novel deodorant composition containing a phenolic compound and an oxidase.

In recent years, with the awareness of cleanliness, consideration for customer service and surroundings, and heightened manners, many people are particularly concerned about bad breath. Halitosis is associated with the production of volatile sulfur compounds in the mouth that are involved in the breakdown of food by bacteria, and hydrogen sulfide and methyl mercaptan are believed to be the main causes.

For the purpose of suppressing bad breath, various plant extracts such as spices and herbs have been studied for their deodorizing effect on methyl mercaptan, and among the components contained in the plant extracts, catechins and the like have been studied. It is also known that phenolic compounds serve as deodorant active ingredients. It is also known that an oxidoreductase is used in combination in order to enhance the deodorizing effect of a plant extract or a phenolic compound (see Patent Documents 1 and 2).

Oxidoreductases are generally less stable in the composition. Therefore, even if an oxidoreductase is added to a deodorant composition containing a deodorant active ingredient, it is difficult to obtain a high deodorizing effect. As a method for improving this, for example, Patent Document 3 discloses a method for increasing the enzymatic activity of the oxidoreductase in the composition by blending plant-derived pulp or the like. In addition, Patent Document 4 describes that in a deodorizing composition containing a mint extraction residue and an oxidoreductase, the oxidoreductase is encapsulated in a capsule formed of a film such as gelatin for use. There is.

JP-A-63-309269 Japanese Unexamined Patent Publication No. 9-388183 Japanese Unexamined Patent Publication No. 2003-09784 International Publication No. 2007/097433

The invention relating to the deodorant composition described in Patent Document 4 is an extremely useful invention in that the mint extraction residue that is originally discarded is effectively utilized. However, the extraction residue generally contains a large amount of water, and there is a problem in terms of quality maintenance and storage. Therefore, it is required to provide a deodorant composition capable of maintaining an excellent deodorizing effect for a long time by using a general plant extract as a source of a phenolic compound.

An object of the present invention is to use a general plant extract as a source of phenolic compounds, which has few safety problems in oral ingestion and oral use, and to maintain an excellent deodorizing effect for a long period of time. To provide a composition.

In order to solve the above problems, the present inventor examined foods and drinks using deodorant compositions, oral hygiene agents, etc., and found that sorbitol and xylitol were found in deodorant compositions containing phenolic compounds and oxidases. It was found that the deodorant effect disappears quickly when is contained. Therefore, as a result of diligent studies on a method for stably maintaining the deodorizing effect even in the presence of sorbitol or xylitol, the stability of the oxidase is improved when the oxidase is pulverized, especially when the oxidase is pulverized by freeze-drying. The present invention has been completed by finding that a deodorant composition that can be kept in good condition and can maintain an excellent effect for a long period of time can be obtained.

That is, the present invention is as follows.
[1] Containing one or more selected from the group consisting of a phenolic compound and a plant extract containing a phenolic compound, and an oxidase.
A deodorant composition, wherein the oxidase is a powder containing at least one selected from the group consisting of sugars and low-saccharified reduced starch syrup as an excipient.
[2] The deodorant composition according to the above [1], wherein the saccharide is at least one selected from the group consisting of trehalose and maltotriose.
[3] The deodorant composition according to the above [1] or [2], wherein the oxidase is a freeze-dried powder or a spray-dried powder.
[4] The deodorant composition according to the above [2] or [3], wherein the oxidase is a freeze-dried powder containing a saccharide containing trehalose as an excipient.
[5] An oral composition containing the deodorant composition according to any one of the above [1] to [4] and at least one of sorbitol and xylitol.
[6] An oral hygiene composition containing the deodorant composition according to any one of [1] to [4] and at least one of sorbitol and xylitol.
[7] One or more selected from the group consisting of a phenolic compound and a plant extract containing a phenolic compound, and an oxidase which is a powder containing a saccharide or a low-saccharified reduced water candy as an excipient are used as raw materials. Or,
Using the deodorant composition according to any one of [1] to [4] as a raw material,
A composition containing at least one of sorbitol and xylitol was produced.
A method for producing a composition, wherein the composition is an oral composition or a composition for oral hygiene.
[8] In a deodorant composition containing one or more selected from the group consisting of a phenolic compound and a plant extract containing a phenolic compound, and an oxidase.
A method for improving the deodorizing power of a deodorant composition, wherein the oxidase is a powder containing at least one selected from the group consisting of sugars and low-saccharified reduced starch syrup as an excipient.

The deodorant composition according to the present invention can maintain the deodorizing effect for a relatively long period of time. Therefore, the deodorant composition can be used for foods and drinks such as gums, tablets and powdered beverages, and oral compositions used for oral hygiene products such as toothpaste, mouthwash and denture cleaning agents. It becomes possible to maintain the deodorizing ability of the product for a longer period of time.

<Phenolic compound>
In the present invention and the present specification, "phenolic compound" is a general term for compounds having a phenolic hydroxyl group. The phenolic compound used in the present invention can be used without particular limitation as long as it has a deodorizing effect. Examples of the phenolic compound contained in the deodorant composition according to the present invention include di, trihydroxybenzene and derivatives thereof such as catechol, resorcinol, hydroquinone, pyrogallol, protocatechuic acid, and gallic acid; kumalic acid and caffeic acid. , Eugenol, coniferyl alcohol, cinapyl alcohol, ferulic acid, lignan, lignin, chlorogenic acids and other phenylpropanoid phenolic compounds and their derivatives; Flavonoids such as hesperetin, apigenin, luteolin, eriodicthiol, eriocitrin, naringenin, catechin, morin, mylicetin, quercetin, isoflavone and their glycosides; and the like.

The phenolic compound contained in the deodorant composition according to the present invention may be one kind or two or more kinds. Further, the phenolic compound contained in the deodorant composition according to the present invention may be a synthetic product or an extract from a natural raw material containing the phenolic compound, and the extract may be purified. It may be the one that has been used. The synthetic product may be a chemically synthesized product, or may be a product synthesized in a microorganism by a genetically modified microorganism. The natural raw material containing the phenolic compound may be a microorganism or an animal, but is preferably a plant because it is widely used as a raw material for oral compositions. The extract containing a phenolic compound from a natural raw material such as a plant can be prepared by a conventional method such as the method described in Patent Document 1. Examples of plant extracts containing phenolic compounds include spearmint extract, tea extract, raw coffee bean extract, peppermint extract, sunflower seed extract, grape seed extract, blueberry leaf extract, and pepper extract. , Peppermint extract, Hosenka extract, Yamamomo extract, Eucalyptus leaf extract, Azuki whole plant extract, Enju extract, buckwheat whole plant extract, Rosemary extract, Lemon balm extract and the like.

<Oxidase>
The oxidase used in the present invention can be used without particular limitation as long as it can oxidize a phenolic compound. Examples of the oxidase include polyphenol oxidase (laccase, tyrosinase, etc.), peroxidase, and the like.

The deodorant composition according to the present invention may contain one type or two or more types of oxidase. Further, the oxidase contained in the deodorant composition according to the present invention may be a synthetic product, or may be an extract or a pulverized product from a natural raw material containing the oxidase, and the extract may be used. It may be purified. The natural raw material may be a microorganism, a plant such as a fruit, or an animal. The preparation of an extract containing an oxidase from a natural raw material and the purification from the extract can be carried out by a method generally used for extracting and purifying an enzyme from microorganisms, animals and plants, or an improved method thereof. Examples of the extract from a natural raw material containing an oxidase include wasabi extract containing peroxidase, mushroom extract containing tyrosinase, and burdock extract containing polyphenooxidase. Be done.

In recent years, advances in enzyme production technology have made it possible to easily obtain high-quality enzymes derived from microorganisms on the market. Also in the present invention, it is preferable to use a commercially available enzyme preparation. Examples of commercially available enzyme preparations contained in the deodorant composition according to the present invention include "laccase Y120" (laccase, manufactured by Amano Enzyme Co., Ltd.), "laccase M120" (laccase, manufactured by Amano Enzyme Co., Ltd.), and "laccase. "PEO-302" (Peroxidase, manufactured by Toyo Boseki Co., Ltd.), "Hyderase 15" (Glucose oxidase, manufactured by Amano Enzyme Co., Ltd.), "Optimase GO" (Glucose oxidase, manufactured by Danisco Japan Co., Ltd.), "Glucose oxidase 10000BG" (Glucose oxidase) , Novozymes Japan Co., Ltd.), "Sumiteam GOP" (glucose oxidase, manufactured by Shin Nihon Kagaku Kogyo Co., Ltd.), "Bakezyme GO1500" (glucose oxidase, manufactured by DSM Co., Ltd.), "Maxapearl GO4" (glucose oxidase, DSM) Co., Ltd.) and the like.

The oxidase contained in the deodorant composition according to the present invention is a powder (oxidase powder) containing at least one selected from the group consisting of saccharides and low-saccharified reduced starch syrup as an excipient. A conventional deodorant composition in which a phenolic compound or a plant extract containing a phenolic compound (hereinafter, may be referred to as "phenolic compound or the like") and an oxidizing enzyme are used in combination, and sorbitol or xylitol is contained. When added to foods and drinks, the deodorizing effect rapidly disappears. On the other hand, the deodorant composition according to the present invention is a deodorant composition in which an oxidase is powdered in advance together with a specific excipient and mixed with a phenolic compound or the like. Therefore, sorbitol Alternatively, the deodorant effect can be maintained for a longer period of time even when added to foods and drinks containing xylitol. That is, in a deodorant composition containing a phenolic compound or the like and an oxidase, the oxidase is powdered in advance together with a specific excipient, and by using this as a raw material, at least one of sorbitol and xylitol is present. The deodorant composition can be improved so that the deodorant effect can be stably maintained for a long period of time even under the condition. The reason why this deodorant effect can be maintained stably for a long period of time is not clear, but it is presumed that powdering with a specific excipient improves the stability of the oxidase in the composition. Will be done.

The powder formulation method generally includes a spray drying method, a freeze drying method, a fluidized bed method, a molecular inclusion method, a phase separation method and the like. The oxidase contained in the deodorant composition according to the present invention may be powdered by these general powdering methods, and in particular, a spray drying method generally used for powder formulation of the enzyme. , Pulverized using the freeze-drying method is preferable.

As the powdering of the oxidase by the spray drying method or the freeze drying method, a general spray drying or freeze drying method can be used without particular limitation. For example, when the enzyme is pulverized by the spray drying method, the solution prepared by dissolving the enzyme and the excipient in a solvent such as water or ethanol is sprayed into a gas by a spray dryer to separate the solid and the solvent. It is pulverized by separating. As the spray dryer, either a nozzle type or a disc type can be adopted. When the enzyme is pulverized by the freeze-drying method, for example, a solution in which the enzyme and the excipient are dissolved in a solvent is prepared, the solution is frozen in a container, and then only the solvent is sublimated under reduced pressure. Thereby, a lyophilized powder of the enzyme can be obtained. The spray drying method is excellent in that the enzyme can be pulverized in a short time, and the freeze drying method is excellent in that it can be pulverized without going through a heating step. The oxidase contained in the deodorant composition according to the present invention is particularly preferably powdered by a freeze-drying method.

The oxidase powder contained in the deodorant composition according to the present invention is powdered with one or more excipients selected from the group consisting of sugars and low-saccharified reduced starch syrup. From the viewpoint of maintaining stable enzyme activity, the saccharide is preferably a sugar capable of maintaining an amorphous state after powder formulation for a long period of time, more preferably trehalose, maltotriose, or raffinose, and trehalose or maltotriose. Aus is more preferred, and trehalose is particularly preferred. The low-sugar reduced starch syrup is a reduced starch syrup (sugar alcohol) in which the content ratio of sugar alcohol of 5 sugar alcohols or more is 50% by mass or more per solid content. As the low-sugar reduced starch syrup used as an excipient, the content ratio of sugar alcohol of 5 sugar alcohol or more per solid content is preferably 50 to 85% by mass, more preferably 50 to 70% by mass.

The excipient used for powdering the oxidase powder contained in the deodorant composition according to the present invention may be one kind or two or more kinds. Further, the excipient is preferably composed of only one or more kinds selected from the group consisting of sugars and low saccharified reduced starch syrup, but contains other excipients as long as the present invention is not impaired. May be good. Examples of other excipients include polysaccharides, highly saccharified and reduced starch syrup, and the like.

When the excipient used for pulverizing the oxidase is used in combination with other excipients other than saccharides and low saccharified reduced water candy, per total solid content of the excipient used for pulverizing the oxidase. The content ratio of one or more selected from the group consisting of saccharides and low saccharified reduced water candy is preferably 60% by mass or more and less than 100% by mass, more preferably 70% by mass or more and less than 100% by mass, and 80% by mass or more and 100% by mass. It is more preferably less than mass%, and even more preferably 90% by mass or more and less than 100% by mass.

<Deodorant composition>
The deodorant composition according to the present invention is a composition containing the above-mentioned phenolic compound and the like and the above-mentioned oxidase powder. The composition can be prepared by mixing a phenolic compound or the like with an oxidase powder. The content of the phenolic compound or the like in the deodorant composition according to the present invention can be 0.1 to 50% by mass as the phenolic compound, although it depends on the type and form of the phenolic compound. It is preferably ~ 20% by mass. When a plant extract containing a phenolic compound is contained as a raw material instead of the phenolic compound itself, the plant in the deodorant composition according to the present invention depends on the type and composition of the plant extract used. The content of the extract can be 1 to 99% by mass as a dry weight, preferably 10 to 50% by mass.

The content of the oxidase powder in the deodorant composition according to the present invention can be 0.001 to 50% by mass, preferably 0.01 to 10% by mass, as the weight of the enzyme itself. ..

The deodorant composition according to the present invention may contain an enzyme other than an oxidase as long as the effect of the present invention is not impaired. Examples of the other enzyme include an enzyme using a substance other than a phenolic compound as a substrate. The deodorant composition according to the present invention preferably contains one or more selected from the group consisting of polyphenol oxidase and peroxidase, and contains polyphenol oxidase or peroxidase alone or in combination with glucose oxidase. It is preferable to contain it.

The deodorant composition according to the present invention may contain the above-mentioned phenolic compounds and other components other than enzymes as long as the effects of the present invention are not impaired. As the other components, various additives generally used in foods and drinks and oral hygiene products can also be added. Examples of such additives include antioxidants, antibacterial agents, emulsifiers, pH adjusters, colorants, natural flavors, synthetic flavors, sweeteners, acidulants and the like. As for natural and synthetic flavors, "Patent Office Gazette Well-known and Conventional Technology Collection (Fragrance) Part 2 Food Flavors" (Patent Office Edition, published in 2000), "Patent Office Gazette Well-known and Common Technology Collection (Fragrance) No. 3" "Fragrances for cosmetics" (JPO edition, published in 2001), "Synthetic fragrances Chemistry and product knowledge augmented new edition" (Synthetic fragrance editorial committee edition, Kagaku Kogyo Nihonsha, published in 2016), etc. It can be used as appropriate.

The deodorant composition according to the present invention can be blended in various products such as foods and drinks and oral hygiene products in the same manner as the conventional deodorant composition containing a phenolic compound or the like as an active ingredient. Various products containing the deodorant composition according to the present invention can be expected to provide a stable deodorizing effect for a relatively long period of time.

The deodorant composition according to the present invention is particularly excellent in sustainability of deodorant power when sorbitol or xylitol coexists, and by incorporating it in a composition containing sorbitol or xylitol, etc. Demonstrates an extremely high deodorant lasting effect. Therefore, the deodorant composition according to the present invention is preferably blended in an oral composition or an oral hygiene composition containing at least one of sorbitol and xylitol.

The oral composition is a composition that is orally ingested like foods and drinks and medicines for oral administration, and the oral hygiene composition is for keeping the oral cavity hygienic, suppressing tooth decay and bad breath, and in the oral cavity. It is a composition used to give a refreshing feeling to the mouth. Examples of the oral composition include foods and drinks such as chewing gum, candy, tablets, and troches. Examples of the oral hygiene composition include oral hygiene agents such as toothpaste, mouthwash, mouth refreshing agent and halitosis inhibitor, and hygiene products used outside the oral cavity such as toothpaste cleaning agents.

The shape of the oral composition or the oral hygiene composition containing the deodorant composition according to the present invention is not particularly limited, and may be solid, paste-like, or liquid. It may be. Since the long-term stabilizing effect of the deodorant effect of the oxidase powder can be more sufficiently exhibited, the oral composition or the like containing the deodorant composition according to the present invention is more like a tablet, a candy, or a troche than a liquid composition. It is preferable to use it for solid foods such as.

By separately adding the phenolic compound or the like and the oxidase powder to the oral composition or the composition for oral hygiene, the phenolic compound or the like, the oxidase powder, and sorbitol can be added. A composition containing at least one of xylitol can be produced. The composition thus obtained can stably maintain the deodorizing effect of the above-mentioned phenolic compound or the like for a longer period of time even in the presence of at least one of sorbitol and xylitol.

The content of the deodorant composition according to the present invention in the oral composition or the composition for oral hygiene can be 0.01 to 50% by mass with respect to the oral composition or the like, and is 0.1 to 10% by mass. It is preferably%. When the phenolic compound or the like and the oxidase powder are separately added to the oral composition or the like and the phenolic compound itself is used as a raw material, the phenolic compound itself is contained in the oral composition or the like. The content can be 0.001 to 1% by mass, preferably 0.01 to 0.1% by mass, based on the oral composition or the like. When a plant extract containing a phenolic compound is used as a raw material, the content of the plant extract in the oral composition or the like is 0.01 to 10% by mass as a dry weight with respect to the total amount of the oral composition or the like. It can be%, preferably 0.1 to 1% by mass. The content of the oxidase powder in the oral composition or the like can be 0.1 to 10000 ppm with respect to the total amount of the oral composition or the like as the weight of the enzyme itself, and is preferably 1 to 1000 ppm.

Hereinafter, the present invention will be specifically described with reference to Examples, but the present invention is not limited thereto.

<Stability evaluation test of deodorant power of deodorant composition>
In the subsequent experiments, the deodorizing power of each deodorant composition with respect to methyl mercaptan was examined as follows.

(I) Evaluation of stability of deodorant power in the presence of various components The following experiments were conducted to see the effect of the types of coexisting components such as sugar on the stability of the deodorant effect of the deodorant composition. Was done. A mixed powder was prepared by mixing the test components after leaving them to absorb moisture at a relative humidity of 70% and 40 ° C. for 2 hours with the deodorant composition to be evaluated at a weight ratio of 1: 1. The obtained mixed powder was stored at 40 ° C. for 1 week, and then the deodorizing effect on methyl mercaptan was measured.

The deodorizing effect on methyl mercaptan was carried out as follows using the mixed powder of the test component / deodorant composition after storage mixed with dextrin at a weight ratio of 1:99 as a sample. First, 108 μL of 15 mass% methyl mercaptan sodium (manufactured by Tokyo Chemical Industry Co., Ltd., specific gravity 1.08) is dissolved in 18 mL of 0.1 M phosphate buffer (pH 7.0) to dissolve a methyl mercaptan solution (methyl mercaptan concentration 663 mg / L). ) Was prepared. Next, 150 mg of the sample, 100 mg of the glucose / dextrin mixture (containing 6 mg of glucose), and 2 mL of 0.1 M phosphate buffer (pH 7.0) were added to a 20 mL volume headspace analysis vial, and the mixture was sealed. 4 μL of methyl mercaptan solution was injected and shaken at 37 ° C. for 5 minutes. After shaking, the concentration of methyl mercaptan in the gas phase in the vial was measured by a gas chromatograph mass spectrometer. Using the measurement results of the control prepared in the same manner by adding dextrin powder instead of the sample, the deodorizing rate of each deodorant composition was determined by the following formula.

[Methyl mercaptan deodorant rate (%)] = (AB) / A × 100
A: Control methyl mercaptan concentration B: Methyl mercaptan concentration when the sample is added

(Ii) Evaluation of Deodorant Power Stability in the Presence of Sorbitol The stability of the deodorant power of each deodorant composition in the presence of sorbitol was evaluated by the following method. First, the deodorant composition of Examples and sorbitol were powder-mixed at a weight ratio of 99.35: 0.65. Further, the deodorant composition of Comparative Example 1 and sorbitol were powder-mixed at a weight ratio of 99.5: 0.5. Next, each mixed powder was stored at 40 ° C. for 1 or 2 weeks, and then the deodorizing effect on methyl mercaptan was measured. The deodorizing effect on methyl mercaptan was evaluated by the same method as described above using the sorbitol / deodorant composition mixed powder after storage as a sample.

[Comparative Example 1] Peroxidase Adsorbed Powder Formulation-Containing Deodorant Composition Peroxidase (Toyo Boseki Co., Ltd. "PEO-302") 0.036 g is dissolved in 0.26 g of distilled water, and then microcrystalline cellulose (Meidai Kako Co., Ltd.) 5.9 g of an adsorbed powder formulation of peroxidase was prepared by adding 5.7 g of (trade name "Compressell S101") manufactured by Co., Ltd. and mixing them. The obtained peroxidase adsorption powder formulation 5.9 g, glucose oxidase (manufactured by Shin Nihon Kagaku Kogyo Co., Ltd., trade name "Sumiteam PGO", containing 10% glucose oxidase) 63.4 g, and peppermint hot water extract (Ogawa Fragrance Co., Ltd.) 31.6 g of the product, trade name "mint polyphenol powder 50", extract component 50% by mass, polyphenol content 9.5% by mass or more) was mixed to prepare 100.0 g of a deodorant composition.

[Reference Example 1] Evaluation of stability of deodorant effect When a deodorant composition and foods and drinks using the deodorant composition, oral hygiene agents, etc. were examined, the sustainability of the deodorant effect was found in the types of foods and drinks, etc. It was found that the deodorant effect disappears more rapidly than other foods and drinks. In order to clarify the cause, the components contained in foods and drinks whose deodorant effect rapidly disappeared were investigated in detail.

In order to investigate the effect of the type of sugar or sugar alcohol on the stability of the deodorant effect of the deodorant composition, deodorization of methyl mercaptan in the coexistence of various components of the deodorant composition of Comparative Example 1 The force was measured (n = 3).

The measurement results are shown in Table 1. As a result, the deodorant rate of methyl mercaptan of the deodorant composition of Comparative Example 1 after storage at 40 ° C. for 1 week was significantly reduced when sorbitol or xylitol was contained. It was speculated that this was because the storage stability of the oxidase was significantly impaired in the coexistence of sorbitol and xylitol.

[Example 1] Peroxidase freeze-dried powder-containing deodorant composition Peroxidase (manufactured by Toyo Boseki Co., Ltd., trade name "Peroxidase PEO-302") 0.1 g, trehalose (manufactured by Hayashihara Co., Ltd., trade name "Treha") 99 After mixing and dissolving 9.9 g and 900 g of distilled water, the peroxidase freeze-dried powder preparation 95 g was prepared by freeze-drying. 32 g of the obtained peroxidase lyophilized powder formulation, 61.4 g of glucose oxidase (manufactured by Shin Nihon Kagaku Kogyo Co., Ltd., trade name "Sumiteam PGO", containing 10% glucose oxidase), and peppermint (Mentha x piperita) as a phenolic compound. Mix 31.6 g of hot water extract (manufactured by Ogawa Fragrance Co., Ltd., trade name "Mint polyphenol powder 50", extract component 50% by mass, polyphenol content 9.5% by mass or more) to prepare 125 g of deodorant composition. did.

[Test Example 1] Evaluation of stability of deodorant power in the presence of sorbitol Various excipients are used to investigate the effect of the type of excipient on the stability of the deodorant effect of the deodorant composition in the presence of sorbitol. The stability of the deodorant power of the deodorant composition prepared using sorbitol in the presence of sorbitol was evaluated (n = 3).

Each deodorant composition was prepared in the same manner as the deodorant composition of Example 1 except that the excipients shown in Table 2 were used. The deodorant composition using trehalose as an excipient was prepared by the same method as the deodorant composition of Example 1.

In Table 2, trehalose is "Treha" (manufactured by Hayashihara Co., Ltd.), maltotriose is "Fujioligo # 360" (manufactured by Nippon Shokuhin Kako Co., Ltd.), maltosyl trehalose is "Hellodex" (manufactured by Hayashihara Co., Ltd.), and low sugar. The chemical-reduced starch syrup is "SE 30" (manufactured by Bussan Food Science Co., Ltd., the content of sugar alcohol of 5 sugar alcohol or more in the total solid content is 51 to 68% by mass), and the reduced starch syrup (multi-tall syrup) is "SE". 20 ”(manufactured by Bussan Food Science Co., Ltd.),“ Oligotrehalose H70 ”for maltotriose sugar alcohol,“ Instant gum BA ”(manufactured by Nexira) for Arabic gum (seiyal type), resistant glucan Is "Fit Fiber # 80" (manufactured by Nippon Shokuhin Kako Co., Ltd.), polydextrose is "Starlight III" (manufactured by Koyo Shokai Co., Ltd.), and hydrolyzed collagen is "collagen peptide SCP5000" (manufactured by Nitta Gelatin Co., Ltd.). is there.

Then, sorbitol was powder-mixed with each deodorant composition at a weight ratio of 99.35: 0.65, and the deodorizing power for methyl mercaptan after storage at 40 ° C. for 1 week or 2 weeks was measured. Table 2 shows the results of examining the stability of the deodorizing power of each deodorant composition in the presence of sorbitol.

As a result, when trehalose, maltotriose, and low-saccharified reduced starch syrup were used as excipients, the deodorization rate of methyl mercaptan was maintained at 40 ° C. even after storage for 2 weeks. It was speculated that this was because the stability of the oxidase in the composition was improved by powdering it with a specific excipient.

[Example 2] Deodorant composition containing peroxidase spray-dried powder formulation A deodorant composition is prepared in the same manner as in Example 1 except that a peroxidase spray-dry powder formulation is used instead of the peroxidase freeze-dried powder formulation. did. The peroxidase spray-dried powder preparation was prepared as follows. 0.2 g of peroxidase (manufactured by Toyo Boseki Co., Ltd., trade name "Peroxidase PEO-302"), 199.8 g of trehalose (manufactured by Hayashibara Co., Ltd., trade name "Treha"), and 270 g of distilled water are mixed and dissolved, and then spray-dried. To prepare 159.7 g of a peroxidase spray-dried powder preparation.

[Test Example 2] Evaluation of stability of deodorant power in the presence of sorbitol The oxidase powder contained in the deodorant composition with respect to the deodorant power of the deodorant composition after long-term storage in the presence of sorbitol. The effect of the powdered state on the stability of deodorant power in the presence of sorbitol was investigated.

Specifically, various components and sorbitol are blended in the deodorant compositions of Example 1, Example 2, and Comparative Example 1, respectively, and deodorized for methyl mercaptan after storage at 40 ° C. for 1 week or 2 weeks. The force was measured.

The measurement results are shown in Table 3. The deodorant compositions of Examples 1 and 2 have a higher deodorizing effect after storage for one week than the deodorant compositions of Comparative Example 1, and the deodorant composition of Example 1 has 2 The deodorant effect was maintained even after a week, and it became clear that it was particularly stable.

[Example 3] Sorbitol-containing tablet To 100 g of sorbitol, 1.5 g of sucrose fatty acid ester and 0.8 g of alpartame are mixed, and 0.67 g of the deodorant composition of Example 1 is added thereto for homogenization. Tablet confectionery was prepared by tableting.

[Comparative Example 2] Sorbitol-containing tablet A tablet was prepared in the same manner as in Example 3 except that 0.51 g of the deodorant composition of Comparative Example 1 was blended in place of the deodorant composition of Example 1.

[Test Example 3] Evaluation of Stability of Deodorant Power of Sorbitol-Containing Tablets Methyl mercaptan after storing the sorbitol-containing tablets of Example 3 and Comparative Example 2 at 40 ° C., before storage, after storage for 1 week, and after storage for 2 weeks. The deodorant power against the tablet was measured. The deodorizing power for methyl mercaptan was evaluated by the same method as in Test Example 2 except that one tablet (about 150 mg) was used as a sample and the shaking time at 37 ° C. was set to 10 minutes.

The measurement results are shown in Table 4. The tablet containing the deodorant composition of Example 3 showed excellent storage stability as compared with the case of using the tablet containing the deodorant composition of Comparative Example 2.

[Example 4] Xylitol-containing chewing gum Xylitol-containing chewing gum by mixing 25 g of gum base, 40 g of xylitol, 16 g of reduced palatinose, 13 g of maltitol powder, 6 g of maltitol syrup, and 1.3 g of the deodorant composition of Example 1. Gum was made.

[Comparative Example 3] Xylitol-containing chewing gum A chewing gum was prepared in the same manner as in Example 4 except that 1.0 g of the deodorant composition of Comparative Example 1 was blended in place of the deodorant composition of Example 1.

[Test Example 4] Evaluation of stability of deodorant power of xylitol-containing chewing gum The xylitol-containing chewing gums of Example 4 and Comparative Example 3 were stored at 40 ° C., respectively, before storage, after storage for 1 week, and after storage for 2 weeks. The deodorizing power for methyl mercaptan was measured. The deodorizing power for methyl mercaptan was evaluated by the same method as in Test Example 2 except that an equal amount of pulverized mixture of chewing gum and dexstone (250 mg) was used as a sample and the shaking time at 37 ° C. was 30 minutes. ..

The measurement results are shown in Table 5. The chewing gum containing the deodorant composition of Example 4 showed excellent storage stability as compared with the chewing gum containing the deodorant composition of Comparative Example 3.

Claims (8)

It contains one or more selected from the group consisting of phenolic compounds and plant extracts containing phenolic compounds, and oxidases.
A deodorant composition, wherein the oxidase is a powder containing at least one selected from the group consisting of sugars and low-saccharified reduced starch syrup as an excipient. The deodorant composition according to claim 1, wherein the saccharide is at least one selected from the group consisting of trehalose and maltotriose. The deodorant composition according to claim 1 or 2, wherein the oxidase is a freeze-dried powder or a spray-dried powder. The deodorant composition according to claim 2 or 3, wherein the oxidase is a freeze-dried powder containing a saccharide containing trehalose as an excipient. An oral composition containing the deodorant composition according to any one of claims 1 to 4 and at least one of sorbitol and xylitol. An oral hygiene composition containing the deodorant composition according to any one of claims 1 to 4 and at least one of sorbitol and xylitol. One or more selected from the group consisting of phenolic compounds and plant extracts containing phenolic compounds, and oxidase, which is a powder containing saccharides or low-saccharified reduced water candy as an excipient, is used as a raw material, or
Using the deodorant composition according to any one of claims 1 to 4 as a raw material,
A composition containing at least one of sorbitol and xylitol was produced.
A method for producing a composition, wherein the composition is an oral composition or a composition for oral hygiene. In a deodorant composition containing one or more selected from the group consisting of a phenolic compound and a plant extract containing a phenolic compound, and an oxidase.
A method for improving the deodorizing power of a deodorant composition, wherein the oxidase is a powder containing at least one selected from the group consisting of sugars and low-saccharified reduced starch syrup as an excipient.