JP2021046394A5 - - Google Patents
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- Publication number
- JP2021046394A5 JP2021046394A5 JP2020153876A JP2020153876A JP2021046394A5 JP 2021046394 A5 JP2021046394 A5 JP 2021046394A5 JP 2020153876 A JP2020153876 A JP 2020153876A JP 2020153876 A JP2020153876 A JP 2020153876A JP 2021046394 A5 JP2021046394 A5 JP 2021046394A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- intraocular pressure
- pharmaceutically acceptable
- acceptable salt
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 58
- 230000004410 intraocular pressure Effects 0.000 claims 23
- 150000003839 salts Chemical class 0.000 claims 20
- 230000000007 visual effect Effects 0.000 claims 15
- 230000005856 abnormality Effects 0.000 claims 14
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims 10
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 10
- 208000010412 Glaucoma Diseases 0.000 claims 10
- 229960003679 brimonidine Drugs 0.000 claims 10
- 229960004605 timolol Drugs 0.000 claims 10
- 230000004493 normal intraocular pressure Effects 0.000 claims 9
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims 5
- 229960001724 brimonidine tartrate Drugs 0.000 claims 5
- WLRMANUAADYWEA-NWASOUNVSA-N (S)-timolol maleate Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 WLRMANUAADYWEA-NWASOUNVSA-N 0.000 claims 3
- 229960005221 timolol maleate Drugs 0.000 claims 3
- 206010067013 Normal tension glaucoma Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003889 eye drop Substances 0.000 claims 2
- 201000002978 low tension glaucoma Diseases 0.000 claims 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- LVXHNCUCBXIIPE-UHFFFAOYSA-L disodium;hydrogen phosphate;hydrate Chemical compound O.[Na+].[Na+].OP([O-])([O-])=O LVXHNCUCBXIIPE-UHFFFAOYSA-L 0.000 claims 1
- 239000006196 drop Substances 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 claims 1
- 229940037001 sodium edetate Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 239000012929 tonicity agent Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025017822A JP2025069397A (ja) | 2019-09-12 | 2025-02-05 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019166276 | 2019-09-12 | ||
| JP2019166276 | 2019-09-12 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017822A Division JP2025069397A (ja) | 2019-09-12 | 2025-02-05 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021046394A JP2021046394A (ja) | 2021-03-25 |
| JP2021046394A5 true JP2021046394A5 (enExample) | 2023-09-25 |
| JP7630944B2 JP7630944B2 (ja) | 2025-02-18 |
Family
ID=74877765
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020153876A Active JP7630944B2 (ja) | 2019-09-12 | 2020-09-14 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
| JP2025017822A Pending JP2025069397A (ja) | 2019-09-12 | 2025-02-05 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017822A Pending JP2025069397A (ja) | 2019-09-12 | 2025-02-05 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP7630944B2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021090883A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
| JP2021090879A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
| JP2021090884A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
| JP2021090881A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
| JP2021090880A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107427460A (zh) | 2015-03-19 | 2017-12-01 | 阿勒根公司 | 溴莫尼定和噻吗洛尔的固定剂量组合 |
-
2020
- 2020-09-14 JP JP2020153876A patent/JP7630944B2/ja active Active
-
2025
- 2025-02-05 JP JP2025017822A patent/JP2025069397A/ja active Pending
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