JP2021042193A5 - - Google Patents
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- JP2021042193A5 JP2021042193A5 JP2020122939A JP2020122939A JP2021042193A5 JP 2021042193 A5 JP2021042193 A5 JP 2021042193A5 JP 2020122939 A JP2020122939 A JP 2020122939A JP 2020122939 A JP2020122939 A JP 2020122939A JP 2021042193 A5 JP2021042193 A5 JP 2021042193A5
- Authority
- JP
- Japan
- Prior art keywords
- hsn
- tumor
- neoantigen
- silica
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 30
- 230000000975 bioactive effect Effects 0.000 claims 17
- 239000000377 silicon dioxide Substances 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 6
- 238000002296 dynamic light scattering Methods 0.000 claims 6
- 239000002953 phosphate buffered saline Substances 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 239000003966 growth inhibitor Substances 0.000 claims 5
- 239000004615 ingredient Substances 0.000 claims 5
- 230000004614 tumor growth Effects 0.000 claims 5
- 230000028993 immune response Effects 0.000 claims 4
- 239000004530 micro-emulsion Substances 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 229940124447 delivery agent Drugs 0.000 claims 3
- 239000011796 hollow space material Substances 0.000 claims 3
- 239000000411 inducer Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- 239000002077 nanosphere Substances 0.000 claims 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000012071 phase Substances 0.000 claims 2
- 238000007910 systemic administration Methods 0.000 claims 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000010936 aqueous wash Methods 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001687 destabilization Effects 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 125000005702 oxyalkylene group Chemical group 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962875842P | 2019-07-18 | 2019-07-18 | |
| US62/875,842 | 2019-07-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021042193A JP2021042193A (ja) | 2021-03-18 |
| JP2021042193A5 true JP2021042193A5 (enExample) | 2023-07-24 |
Family
ID=71670078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020122939A Pending JP2021042193A (ja) | 2019-07-18 | 2020-07-17 | 免疫療法用シリカナノスフェア |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12274755B2 (enExample) |
| EP (1) | EP3766515A1 (enExample) |
| JP (1) | JP2021042193A (enExample) |
| CN (1) | CN112237627A (enExample) |
| CA (1) | CA3087227A1 (enExample) |
| TW (1) | TWI829949B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114377120B (zh) * | 2022-01-10 | 2023-09-22 | 大连理工大学 | 一种以病毒样颗粒为模板的二氧化硅疫苗递送系统的构建及其应用 |
| CN114601817B (zh) * | 2022-02-11 | 2023-01-10 | 国家纳米科学中心 | 一种可降解中空有机硅纳米粒子及其制备方法和应用 |
| CN116999581B (zh) * | 2023-08-08 | 2025-06-13 | 中南大学湘雅医院 | 一种靶向治疗乳腺癌的核素纳米药物及其制备方法与应用 |
| CN120590491A (zh) * | 2025-05-28 | 2025-09-05 | 中科中山药物创新研究院 | 基于二氧化硅载体的hiv病毒mper多肽纳米疫苗及其制备方法与应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009023697A2 (en) * | 2007-08-14 | 2009-02-19 | The Regents Of The University Of California | Hollow silica nanospheres and methods of making same |
| US20160038608A1 (en) * | 2014-08-07 | 2016-02-11 | National Taiwan University | Silica-based mesoporous carrier and delivery method of using the same |
| JP6868862B2 (ja) * | 2015-08-31 | 2021-05-12 | 国立研究開発法人産業技術総合研究所 | メソポーラスシリカ粒子 |
| IL254053B (en) * | 2016-08-19 | 2021-03-25 | Univ Nat Taiwan | Nanoparticles of hollow silica with thermalized biologically active components, a process for their preparation and their applications |
-
2020
- 2020-07-17 US US16/932,380 patent/US12274755B2/en active Active
- 2020-07-17 CN CN202010693282.3A patent/CN112237627A/zh active Pending
- 2020-07-17 TW TW109124259A patent/TWI829949B/zh active
- 2020-07-17 EP EP20186407.1A patent/EP3766515A1/en active Pending
- 2020-07-17 JP JP2020122939A patent/JP2021042193A/ja active Pending
- 2020-07-17 CA CA3087227A patent/CA3087227A1/en active Pending
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