JP2020536056A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020536056A5 JP2020536056A5 JP2020517421A JP2020517421A JP2020536056A5 JP 2020536056 A5 JP2020536056 A5 JP 2020536056A5 JP 2020517421 A JP2020517421 A JP 2020517421A JP 2020517421 A JP2020517421 A JP 2020517421A JP 2020536056 A5 JP2020536056 A5 JP 2020536056A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- solid oral
- oral dosage
- opioid analgesic
- gelling agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007787 solid Substances 0.000 claims 26
- 239000006186 oral dosage form Substances 0.000 claims 25
- 239000000203 mixture Substances 0.000 claims 19
- 239000000014 opioid analgesic Substances 0.000 claims 16
- 239000003349 gelling agent Substances 0.000 claims 12
- 239000002245 particle Substances 0.000 claims 10
- 230000003111 delayed effect Effects 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 4
- 229920002125 Sokalan® Polymers 0.000 claims 3
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000012730 sustained-release form Substances 0.000 claims 3
- 235000010418 carrageenan Nutrition 0.000 claims 2
- 239000000679 carrageenan Substances 0.000 claims 2
- 229920001525 carrageenan Polymers 0.000 claims 2
- 229940113118 carrageenan Drugs 0.000 claims 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 2
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 229940005483 opioid analgesics Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims 1
- XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 1
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 230000036592 analgesia Effects 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- -1 attaparghite Substances 0.000 claims 1
- 239000000440 bentonite Substances 0.000 claims 1
- 229910000278 bentonite Inorganic materials 0.000 claims 1
- 235000012216 bentonite Nutrition 0.000 claims 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 229960004126 codeine Drugs 0.000 claims 1
- 239000007891 compressed tablet Substances 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 claims 1
- 229960000920 dihydrocodeine Drugs 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960002428 fentanyl Drugs 0.000 claims 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims 1
- 229960000240 hydrocodone Drugs 0.000 claims 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 1
- 229960001410 hydromorphone Drugs 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 229960002085 oxycodone Drugs 0.000 claims 1
- 229960005118 oxymorphone Drugs 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 229960000482 pethidine Drugs 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023176374A JP7736755B2 (ja) | 2017-10-02 | 2023-10-12 | 遅延放出ゲル化剤組成物を含む医薬組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762566989P | 2017-10-02 | 2017-10-02 | |
| US62/566,989 | 2017-10-02 | ||
| PCT/US2018/053755 WO2019070581A1 (en) | 2017-10-02 | 2018-10-01 | PHARMACEUTICAL COMPOSITIONS COMPRISING GELIFYING AGENT COMPOSITIONS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023176374A Division JP7736755B2 (ja) | 2017-10-02 | 2023-10-12 | 遅延放出ゲル化剤組成物を含む医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020536056A JP2020536056A (ja) | 2020-12-10 |
| JP2020536056A5 true JP2020536056A5 (enExample) | 2021-11-04 |
Family
ID=65995217
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517421A Pending JP2020536056A (ja) | 2017-10-02 | 2018-10-01 | 遅延放出ゲル化剤組成物を含む医薬組成物 |
| JP2023176374A Active JP7736755B2 (ja) | 2017-10-02 | 2023-10-12 | 遅延放出ゲル化剤組成物を含む医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023176374A Active JP7736755B2 (ja) | 2017-10-02 | 2023-10-12 | 遅延放出ゲル化剤組成物を含む医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20200289424A1 (enExample) |
| EP (1) | EP3691645A4 (enExample) |
| JP (2) | JP2020536056A (enExample) |
| CA (1) | CA3074694A1 (enExample) |
| WO (1) | WO2019070581A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4039252A1 (en) * | 2021-02-09 | 2022-08-10 | Sanovel Ilac Sanayi Ve Ticaret A.S. | A film coated tablet comprising naltrexone hydrochloride |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
| US20090022786A1 (en) * | 2007-07-16 | 2009-01-22 | Yung Shin Pharm. Ind. Co., Ltd. | Oral pharmaceutical dosage form and manufacturing method thereof |
| FR2960775A1 (fr) * | 2010-06-07 | 2011-12-09 | Ethypharm Sa | Microgranules resistants au detournement |
| ES2703688T3 (es) * | 2011-09-16 | 2019-03-12 | Purdue Pharma Lp | Formulaciones de liberación inmediata resistentes a alteración |
| WO2014123899A1 (en) * | 2013-02-05 | 2014-08-14 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| US10632113B2 (en) | 2014-02-05 | 2020-04-28 | Kashiv Biosciences, Llc | Abuse-resistant drug formulations with built-in overdose protection |
| US9132096B1 (en) * | 2014-09-12 | 2015-09-15 | Alkermes Pharma Ireland Limited | Abuse resistant pharmaceutical compositions |
-
2018
- 2018-10-01 JP JP2020517421A patent/JP2020536056A/ja active Pending
- 2018-10-01 EP EP18864793.7A patent/EP3691645A4/en not_active Withdrawn
- 2018-10-01 US US16/647,927 patent/US20200289424A1/en active Pending
- 2018-10-01 WO PCT/US2018/053755 patent/WO2019070581A1/en not_active Ceased
- 2018-10-01 CA CA3074694A patent/CA3074694A1/en active Pending
-
2023
- 2023-10-12 JP JP2023176374A patent/JP7736755B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5566102B2 (ja) | 医薬組成物 | |
| JP2016535773A5 (enExample) | ||
| US7374781B2 (en) | Sustained release formulations containing acetaminophen and tramadol | |
| EP1557179B2 (en) | Analgesic dosage forms that are unable to be inhaled or injected | |
| JP5937068B2 (ja) | 転用防止微粒剤および微小錠剤 | |
| JP2018012711A5 (enExample) | ||
| JP2015511953A5 (enExample) | ||
| JP6138798B2 (ja) | 不正改変抵抗性即時放出性製剤 | |
| JP2008540419A5 (enExample) | ||
| JP2016006108A5 (enExample) | ||
| RU2010129907A (ru) | Лекарственная форма с контролируемым высвобождением, предотвращающая неправильное употребление | |
| JP2014530185A5 (enExample) | ||
| JP2014526497A5 (enExample) | ||
| JP2010506833A (ja) | 医薬組成物 | |
| CN107106503B (zh) | 抗滥用药物组合物 | |
| JP2010195807A (ja) | 乱用の可能性が低減したオピオイド製剤 | |
| JP2009545560A5 (enExample) | ||
| CN113908153B (zh) | 一种布瓦西坦药物组合物、其制备方法及应用 | |
| BR112015021403B1 (pt) | Composição oral sólida antitussígena de liberação modificada compreendendo enzonatato em uma matriz | |
| CN106714782A (zh) | 具有滥用遏制性质的药物组合物 | |
| CN102210688B (zh) | 复方甲氧那明的速释-缓释制剂 | |
| JP5973347B2 (ja) | 口腔内崩壊錠 | |
| JP2020536056A5 (enExample) | ||
| CN110381926A (zh) | 新型剂型 | |
| JP6815109B2 (ja) | デュロキセチンまたは薬学的に許容されるその塩を有効成分とする医薬組成物 |