JP2020535845A5 - - Google Patents
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- Publication number
- JP2020535845A5 JP2020535845A5 JP2020537887A JP2020537887A JP2020535845A5 JP 2020535845 A5 JP2020535845 A5 JP 2020535845A5 JP 2020537887 A JP2020537887 A JP 2020537887A JP 2020537887 A JP2020537887 A JP 2020537887A JP 2020535845 A5 JP2020535845 A5 JP 2020535845A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- nucleic acid
- trans
- acid molecule
- functional nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108020004707 nucleic acids Proteins 0.000 description 18
- 102000039446 nucleic acids Human genes 0.000 description 18
- 150000007523 nucleic acids Chemical class 0.000 description 18
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 description 12
- 108020004414 DNA Proteins 0.000 description 6
- 102000053602 DNA Human genes 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 6
- 239000013604 expression vector Substances 0.000 description 5
- 108091026890 Coding region Proteins 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 230000014616 translation Effects 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 108020003589 5' Untranslated Regions Proteins 0.000 description 2
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000028782 Hereditary disease Diseases 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 208000024556 Mendelian disease Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102017000105372A IT201700105372A1 (it) | 2017-09-20 | 2017-09-20 | Molecola di acido nucleico funzionale e relativo uso |
| IT102017000105372 | 2017-09-20 | ||
| PCT/IB2018/057262 WO2019058304A1 (en) | 2017-09-20 | 2018-09-20 | FUNCTIONAL NUCLEIC ACID MOLECULE AND ASSOCIATED APPLICATIONS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535845A JP2020535845A (ja) | 2020-12-10 |
| JP2020535845A5 true JP2020535845A5 (https=) | 2021-09-09 |
| JP7258031B2 JP7258031B2 (ja) | 2023-04-14 |
Family
ID=61024873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020537887A Active JP7258031B2 (ja) | 2017-09-20 | 2018-09-20 | 機能性核酸分子及びその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11649456B2 (https=) |
| EP (1) | EP3684928A1 (https=) |
| JP (1) | JP7258031B2 (https=) |
| KR (1) | KR102677300B1 (https=) |
| CN (1) | CN111386344B (https=) |
| CA (1) | CA3076163A1 (https=) |
| IT (1) | IT201700105372A1 (https=) |
| WO (1) | WO2019058304A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201900011490A1 (it) * | 2019-07-11 | 2021-01-11 | Scuola Int Superiore Di Studi Avanzati Sissa | MOLECOLE DI ACIDO NUCLEICO FUNZIONALI CHE AUMENTANO LA TRADUZIONE DI UN mRNA DELLA FRATASSINA |
| CN110484563B (zh) * | 2019-07-25 | 2023-04-07 | 新乡医学院 | 哺乳动物细胞组合表达载体、表达系统、制备方法和应用 |
| CN116322791A (zh) | 2020-09-24 | 2023-06-23 | 意大利技术基金会 | 经修饰的功能性核酸分子 |
| CA3196633A1 (en) * | 2020-10-08 | 2022-04-14 | Scuola Internazionale Superiore Di Studi Avanzati | Functional nucleic acid molecules |
| EP3992289A1 (en) | 2020-10-30 | 2022-05-04 | Transine Therapeutics Limited | Functional nucleic acid molecules incorporating protein binding domain |
| CN112126644B (zh) * | 2020-11-25 | 2021-03-12 | 北京立康生命科技有限公司 | 一种非依赖帽结构下进行细胞外转录的mRNA、呈递细胞及应用 |
| EP4063505A1 (en) * | 2021-03-22 | 2022-09-28 | Fondazione Istituto Italiano di Tecnologia | Functional nucleic acid molecules directed to targets for nervous system disorders |
| GB202205423D0 (en) | 2022-04-12 | 2022-05-25 | Transine Therapeutics Ltd | Functional nucleic acid molecule |
| GB202207796D0 (en) | 2022-05-26 | 2022-07-13 | Fondazione St Italiano Tecnologia | Functional nucleic acid molecule |
| GB202207795D0 (en) | 2022-05-26 | 2022-07-13 | Fondazione St Italiano Tecnologia | Functional nucleic acid molecule |
| CN116004696B (zh) * | 2023-02-01 | 2024-03-29 | 郑州贝贝生物科技有限公司 | 可与IRES组合的3ˊUTR加茎环结构基因及其应用、mRNA表达系统 |
| KR20240132212A (ko) * | 2023-02-24 | 2024-09-03 | 서울시립대학교 산학협력단 | DNA 템플릿 및 이를 이용하여 제조된 mRNA 백신 |
| CN117947028A (zh) * | 2023-12-29 | 2024-04-30 | 北京衡昱生物科技有限公司 | Ires-w3-31序列及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6869779B1 (en) * | 1998-08-27 | 2005-03-22 | Fuso Pharmaceutical Industries, Ltd. | Nucleic acid sequence for potentiating the expression of useful gene and method therefor |
| US7468275B2 (en) * | 2000-01-28 | 2008-12-23 | The Scripps Research Institute | Synthetic internal ribosome entry sites and methods of identifying same |
| EP1579004B1 (en) | 2002-10-23 | 2010-06-16 | VIRxSYS Corporation | Screening methods for identification of efficient pre-trans-splicing molecules |
| US7696406B2 (en) | 2003-07-03 | 2010-04-13 | Board Of Trustees Operating Michigan State University | Expression of a recombinant transgene |
| TWI300441B (en) * | 2005-09-21 | 2008-09-01 | Univ Chung Yuan Christian | A polynucleotide with ires activity |
| KR101161622B1 (ko) * | 2009-08-31 | 2012-07-04 | 헬릭스 주식회사 | 번역 효율 증진용 ｄｎａ 단편 및 이를 포함하는 재조합 벡터 |
| EP3792359A1 (en) | 2011-03-30 | 2021-03-17 | Transine Therapeutics Limited | Functional nucleic acid molecule and use thereof |
| EP3241902B1 (en) * | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| WO2014081507A1 (en) | 2012-11-26 | 2014-05-30 | Moderna Therapeutics, Inc. | Terminally modified rna |
| CA2894684A1 (en) * | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of improved crispr-cas systems, methods and enzyme compositions for sequence manipulation in eukaryotes |
| CN105624156B (zh) * | 2014-11-04 | 2021-07-16 | 清华大学 | 含有反向sineb2重复序列的人工非编码rna及其在增强靶蛋白翻译中的用途 |
| DK3350327T3 (en) * | 2015-10-23 | 2019-01-21 | Caribou Biosciences Inc | CONSTRUCTED CRISPR CLASS-2-NUCLEIC ACID TARGETING-NUCLEIC ACID |
-
2017
- 2017-09-20 IT IT102017000105372A patent/IT201700105372A1/it unknown
-
2018
- 2018-09-20 CA CA3076163A patent/CA3076163A1/en active Pending
- 2018-09-20 CN CN201880074261.4A patent/CN111386344B/zh active Active
- 2018-09-20 EP EP18782521.1A patent/EP3684928A1/en active Pending
- 2018-09-20 KR KR1020207011322A patent/KR102677300B1/ko active Active
- 2018-09-20 JP JP2020537887A patent/JP7258031B2/ja active Active
- 2018-09-20 WO PCT/IB2018/057262 patent/WO2019058304A1/en not_active Ceased
- 2018-09-20 US US16/647,721 patent/US11649456B2/en active Active
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