JP2020533437A5 - - Google Patents
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- JP2020533437A5 JP2020533437A5 JP2020513530A JP2020513530A JP2020533437A5 JP 2020533437 A5 JP2020533437 A5 JP 2020533437A5 JP 2020513530 A JP2020513530 A JP 2020513530A JP 2020513530 A JP2020513530 A JP 2020513530A JP 2020533437 A5 JP2020533437 A5 JP 2020533437A5
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- streptococcus pneumoniae
- immunogenic composition
- unit
- serotype
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000004676 glycans Chemical class 0.000 claims 46
- 229920001282 polysaccharide Polymers 0.000 claims 31
- 239000005017 polysaccharide Substances 0.000 claims 31
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 18
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 18
- 230000002163 immunogen Effects 0.000 claims 16
- 150000004804 polysaccharides Polymers 0.000 claims 15
- 239000002671 adjuvant Substances 0.000 claims 7
- 102000014914 Carrier Proteins Human genes 0.000 claims 6
- 108010078791 Carrier Proteins Proteins 0.000 claims 6
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 230000004913 activation Effects 0.000 claims 6
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 4
- 101800002949 Diphtheria toxin fragment B Proteins 0.000 claims 3
- 229960002885 histidine Drugs 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 229960000814 tetanus toxoid Drugs 0.000 claims 3
- 208000034628 Celiac artery compression syndrome Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
- BBWBEZAMXFGUGK-UHFFFAOYSA-N bis(dodecylsulfanyl)-methylarsane Chemical compound CCCCCCCCCCCCS[As](C)SCCCCCCCCCCCC BBWBEZAMXFGUGK-UHFFFAOYSA-N 0.000 claims 2
- 229960003983 diphtheria toxoid Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000000569 multi-angle light scattering Methods 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 101710082714 Exotoxin A Proteins 0.000 claims 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 108010031071 cholera toxoid Proteins 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023096312A JP2023113922A (ja) | 2017-09-07 | 2023-06-12 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| JP2025087103A JP2025128174A (ja) | 2017-09-07 | 2025-05-26 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762555455P | 2017-09-07 | 2017-09-07 | |
| US62/555,455 | 2017-09-07 | ||
| PCT/US2018/049306 WO2019050814A1 (en) | 2017-09-07 | 2018-09-04 | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023096312A Division JP2023113922A (ja) | 2017-09-07 | 2023-06-12 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533437A JP2020533437A (ja) | 2020-11-19 |
| JP2020533437A5 true JP2020533437A5 (https=) | 2021-08-19 |
Family
ID=65635315
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513530A Pending JP2020533437A (ja) | 2017-09-07 | 2018-09-04 | 肺炎球菌多糖体および免疫原性多糖体−キャリアタンパク質コンジュゲートでのその使用 |
| JP2023096312A Pending JP2023113922A (ja) | 2017-09-07 | 2023-06-12 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| JP2025087103A Pending JP2025128174A (ja) | 2017-09-07 | 2025-05-26 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023096312A Pending JP2023113922A (ja) | 2017-09-07 | 2023-06-12 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| JP2025087103A Pending JP2025128174A (ja) | 2017-09-07 | 2025-05-26 | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US11491216B2 (https=) |
| EP (1) | EP3678655A4 (https=) |
| JP (3) | JP2020533437A (https=) |
| KR (2) | KR20250046326A (https=) |
| CN (2) | CN111065388A (https=) |
| AU (2) | AU2018328036B2 (https=) |
| BR (1) | BR112020004396A8 (https=) |
| CA (1) | CA3074706A1 (https=) |
| MX (2) | MX2020002559A (https=) |
| WO (1) | WO2019050814A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016015835B1 (pt) * | 2014-01-21 | 2023-12-26 | Pfizer Inc | Processo de preparação de conjugados compreendendo polissacarídeos capsulares de streptococcus pneumoniae |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN110366428B (zh) | 2016-12-30 | 2024-05-17 | Vaxcyte公司 | 具有非天然氨基酸的多肽-抗原缀合物 |
| CN110225757A (zh) * | 2017-01-31 | 2019-09-10 | 默沙东公司 | 由肺炎链球菌血清型19f生产荚膜多糖蛋白缀合物的方法 |
| EP4656208A3 (en) | 2017-01-31 | 2026-03-04 | Merck Sharp & Dohme LLC | Methods for making polysaccharide-protein conjugates |
| US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| JP7680185B2 (ja) * | 2017-02-24 | 2025-05-20 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| WO2019050814A1 (en) * | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| CN111093650B (zh) * | 2017-09-07 | 2024-03-01 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| MX2020002558A (es) | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Procesos para la formulacion de polisacaridos neumococicos para la conjugacion a una proteina transportadora. |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| MX394767B (es) | 2017-09-07 | 2025-03-24 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora. |
| MX394768B (es) | 2017-09-07 | 2025-03-21 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina. |
| WO2019070994A1 (en) * | 2017-10-04 | 2019-04-11 | Liffey Biotech Limited | SACCHARIDE-POLYPEPTIDE CONJUGATE COMPOSITIONS AND METHODS OF USE |
| ES3058336T3 (es) | 2017-12-06 | 2026-03-10 | Merck Sharp & Dohme Llc | Composiciones que comprenden conjugados polisacárido-proteína de Streptococcus pneumoniae y métodos de uso de los mismos |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| EP3788143B1 (en) | 2018-04-30 | 2023-06-28 | Merck Sharp & Dohme LLC | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| MX2021003358A (es) | 2018-09-23 | 2021-05-27 | Biological E Ltd | Polisacaridos capsulares purificados de streptococcus pneumoniae. |
| CR20210333A (es) | 2018-12-19 | 2021-08-18 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso |
| CN119371566A (zh) * | 2020-02-21 | 2025-01-28 | 辉瑞公司 | 糖类的纯化 |
| EP4288106A4 (en) * | 2021-02-04 | 2025-06-04 | Merck Sharp & Dohme LLC | Lipid DNANOparticle adjuvant composition for pneumococcal conjugate vaccines |
| EP4622665A2 (en) | 2022-11-22 | 2025-10-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2023403045A1 (en) | 2022-12-01 | 2025-06-12 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
| TW202527906A (zh) | 2023-09-14 | 2025-07-16 | 美商輝瑞股份有限公司 | 包含經結合之肺炎鏈球菌莢膜醣抗原之佐劑化致免疫性組成物及其用途 |
| WO2025219908A2 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Media and fermentation methods for polysaccharide production in bacterial cell culture |
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| CN110859957B (zh) * | 2014-01-21 | 2024-04-12 | 辉瑞公司 | 包含缀合荚膜糖抗原的免疫原性组合物及其用途 |
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| EP3436061A4 (en) | 2016-03-31 | 2019-12-04 | Liffey Biotech Limited | Saccharide-polypeptide-conjugate compositions and methods of use thereof |
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| EP4656208A3 (en) | 2017-01-31 | 2026-03-04 | Merck Sharp & Dohme LLC | Methods for making polysaccharide-protein conjugates |
| US11400162B2 (en) * | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US11219680B2 (en) * | 2017-02-24 | 2022-01-11 | Merck Sharp & Dohme Corp. | Polysaccharide-protein conjugates utilizing diphtheria toxin fragment B as a carrier |
| EP3585427A4 (en) | 2017-02-24 | 2020-12-30 | Merck Sharp & Dohme Corp. | METHODS FOR IMPROVING THE FILTRABILITY OF POLYSACCHARIDE CONJUGATE WITH PROTEIN REACTIONS |
| JP7680185B2 (ja) | 2017-02-24 | 2025-05-20 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| MX2019009869A (es) | 2017-02-24 | 2019-10-02 | Merck Sharp & Dohme | Formulaciones de vacunas de conjugado de neumococos. |
| US11739356B2 (en) * | 2017-05-05 | 2023-08-29 | Serum Institute Of India Private Limited | Method for removal of impurities from bacterial capsular polysaccharide based preparations |
| GB201711635D0 (en) * | 2017-07-19 | 2017-08-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
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| WO2019050814A1 (en) * | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| MX394768B (es) | 2017-09-07 | 2025-03-21 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina. |
| MX394767B (es) * | 2017-09-07 | 2025-03-24 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora. |
| MX2020002558A (es) | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Procesos para la formulacion de polisacaridos neumococicos para la conjugacion a una proteina transportadora. |
| CN111093650B (zh) | 2017-09-07 | 2024-03-01 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| US11524076B2 (en) * | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| KR20200077538A (ko) | 2017-10-25 | 2020-06-30 | 머크 샤프 앤드 돔 코포레이션 | 아주반트 첨가된 백신 |
| ES3058336T3 (es) * | 2017-12-06 | 2026-03-10 | Merck Sharp & Dohme Llc | Composiciones que comprenden conjugados polisacárido-proteína de Streptococcus pneumoniae y métodos de uso de los mismos |
| US12144855B2 (en) * | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| CR20210333A (es) * | 2018-12-19 | 2021-08-18 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso |
| MY207971A (en) * | 2019-07-18 | 2025-03-31 | Celltrion Inc | Immunogenic composition comprising multivalent streptococcus pneumoniae polysaccharide-protein conjugates |
| WO2022035816A1 (en) * | 2020-08-10 | 2022-02-17 | Inventprise, Llc | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
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2018
- 2018-09-04 WO PCT/US2018/049306 patent/WO2019050814A1/en not_active Ceased
- 2018-09-04 US US16/645,048 patent/US11491216B2/en active Active
- 2018-09-04 EP EP18854598.2A patent/EP3678655A4/en active Pending
- 2018-09-04 CN CN201880058250.7A patent/CN111065388A/zh active Pending
- 2018-09-04 CA CA3074706A patent/CA3074706A1/en active Pending
- 2018-09-04 CN CN202311711412.1A patent/CN117736348A/zh active Pending
- 2018-09-04 KR KR1020257008384A patent/KR20250046326A/ko active Pending
- 2018-09-04 BR BR112020004396A patent/BR112020004396A8/pt unknown
- 2018-09-04 MX MX2020002559A patent/MX2020002559A/es unknown
- 2018-09-04 JP JP2020513530A patent/JP2020533437A/ja active Pending
- 2018-09-04 KR KR1020207009613A patent/KR102783492B1/ko active Active
- 2018-09-04 AU AU2018328036A patent/AU2018328036B2/en active Active
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2020
- 2020-03-05 MX MX2022014850A patent/MX2022014850A/es unknown
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2022
- 2022-09-22 US US17/934,396 patent/US20230107713A1/en active Pending
- 2022-09-22 US US17/934,379 patent/US20230075760A1/en active Pending
- 2022-09-27 US US17/935,864 patent/US20230041441A1/en active Pending
- 2022-09-27 US US17/935,871 patent/US20230029424A1/en active Pending
- 2022-09-27 US US17/935,856 patent/US20230094548A1/en active Pending
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2023
- 2023-06-12 JP JP2023096312A patent/JP2023113922A/ja active Pending
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2024
- 2024-03-06 AU AU2024201479A patent/AU2024201479A1/en not_active Abandoned
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2025
- 2025-05-26 JP JP2025087103A patent/JP2025128174A/ja active Pending
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