JP2020532578A5 - - Google Patents
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- JP2020532578A5 JP2020532578A5 JP2020527860A JP2020527860A JP2020532578A5 JP 2020532578 A5 JP2020532578 A5 JP 2020532578A5 JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020532578 A5 JP2020532578 A5 JP 2020532578A5
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- JP
- Japan
- Prior art keywords
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- compound
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- pharmaceutically acceptable
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- 150000001875 compounds Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 0 CCC[C@](C)CNS(C)(CSC(*(C)*C)=CCCC)O Chemical compound CCC[C@](C)CNS(C)(CSC(*(C)*C)=CCCC)O 0.000 description 3
- ULMKNGVHAZDIEL-OLNZRHPYSA-O C/C=N\C/C=C(\NCCN(C)C[SH2+])/Cl Chemical compound C/C=N\C/C=C(\NCCN(C)C[SH2+])/Cl ULMKNGVHAZDIEL-OLNZRHPYSA-O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762537758P | 2017-07-27 | 2017-07-27 | |
| US62/537,758 | 2017-07-27 | ||
| PCT/US2018/044183 WO2019023635A1 (en) | 2017-07-27 | 2018-07-27 | SUBSTITUTED 3 H-IMIDAZO (4,5-C) PYRIDINE AND 1H-PYRROLO (2,3-C) PYRIDINE SERIES OF A NOVEL ECTONUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE-1 (ENPP1) AND STIMULATOR FOR A GENE MODULATOR INTERFERON (STING) AS IMMUNOTHERAPEUTIC AGENTS AGAINST CANCER |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532578A JP2020532578A (ja) | 2020-11-12 |
| JP2020532578A5 true JP2020532578A5 (cg-RX-API-DMAC10.html) | 2021-09-16 |
| JP7274478B2 JP7274478B2 (ja) | 2023-05-16 |
Family
ID=65040330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527860A Active JP7274478B2 (ja) | 2017-07-27 | 2018-07-27 | 置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10689376B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3658138B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP7274478B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN111615388B (cg-RX-API-DMAC10.html) |
| WO (1) | WO2019023635A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3807264A1 (en) | 2018-06-12 | 2021-04-21 | Ryvu Therapeutics S.A. | Modulators of stimulator of interferon genes (sting) |
| JP7461927B2 (ja) * | 2018-08-01 | 2024-04-04 | スティングレイ・セラピューティクス・インコーポレイテッド | 癌免疫療法剤としての新規エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）の置換３Ｈ－イミダゾ［４，５－ｃ］ピリジンおよび１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズならびにインターフェロン遺伝子刺激因子（ＳＴＩＮＧ）調節剤 |
| MX2021009269A (es) * | 2019-02-01 | 2021-08-24 | Univ Leland Stanford Junior | Inhibidores de enpp1 y metodos para modular una respuesta inmunitaria. |
| ES3070946T3 (en) | 2019-03-12 | 2026-06-18 | Arcus Biosciences Inc | Treatment of an oncogenene driven cancer having a kras or egfr mutation by decreasing adenosine production or antagonizing adenosine activation |
| KR20210146370A (ko) | 2019-03-28 | 2021-12-03 | 루핀 리미티드 | Sting 효능제로서의 매크로사이클릭 화합물 |
| CA3135487A1 (en) | 2019-03-29 | 2020-10-08 | Arcus Biosciences, Inc. | Treatment of cancer utilizing an identified adenosine fingerprint |
| MX2021015188A (es) | 2019-06-12 | 2022-01-18 | Ryvu Therapeutics S A | Moduladores de nueva generacion del estimulador de genes de interferon (sting). |
| DK4004002T3 (da) | 2019-07-22 | 2024-09-30 | Lupin Ltd | Makrocykliske forbindelser som sting-agonister samt fremgangsmåder og anvendelser dermed |
| CA3151277A1 (en) | 2019-09-16 | 2021-03-25 | Aten Porus Lifesciences Pvt. Ltd. | 2-amino-s6-substituted thiopurine compounds as inhibitors of the enpp1 protein |
| CN114787148A (zh) | 2019-12-11 | 2022-07-22 | 雷沃医疗有限公司 | 官能化杂环化合物作为干扰素基因刺激物(sting)的调节剂 |
| KR20260022465A (ko) * | 2019-12-11 | 2026-02-19 | 리부 세라퓨틱스 에스.에이. | 인터페론 유전자 자극제(sting)의 조절제인 헤테로사이클릭 화합물 |
| GB202006382D0 (en) | 2020-04-30 | 2020-06-17 | Spermatech As | Use |
| KR102682428B1 (ko) | 2020-05-08 | 2024-07-05 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도 |
| US20230159469A1 (en) | 2020-05-08 | 2023-05-25 | Txinno Bioscience Inc. | Novel phthalazine derivative having ectonucloeotide pyrophosphatase/phosphodieste rase inhibitory activity, and use thereof |
| KR102720206B1 (ko) | 2020-12-29 | 2024-10-21 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도 |
| AU2021412688B2 (en) | 2020-12-29 | 2025-06-12 | Txinno Bioscience Inc. | Novel naphthyridinone derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase and use thereof |
| CA3204409C (en) | 2021-01-29 | 2026-04-28 | Txinno Bioscience Inc. | Benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof |
| KR102686866B1 (ko) | 2021-01-29 | 2024-07-19 | 주식회사 티씨노바이오사이언스 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도 |
| MX2024009216A (es) * | 2022-01-28 | 2024-08-06 | Insilico Medicine Ip Ltd | Inhibidores de ectonucleotido pirofosfatasa-fosfodiesterasa 1 (enpp1) y usos de los mismos. |
| EP4514331A1 (en) | 2022-04-29 | 2025-03-05 | Petragen, Inc. | Inhibitors of enpp1 and modulation of bone growth |
| WO2026006739A1 (en) * | 2024-06-28 | 2026-01-02 | Riboscience Llc | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors for the treatment of certain diseases |
| WO2026078593A1 (en) | 2024-10-08 | 2026-04-16 | Sun Pharma Advanced Research Company Limited | Sting agonists and antibody drug conjugates thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5081253A (en) * | 1989-12-21 | 1992-01-14 | American Home Products Corporation | Imidazo(4,5-c)pyridines as antiosteoporotic agents |
| JP4647726B2 (ja) * | 1997-03-25 | 2011-03-09 | 興和株式会社 | 新規なアニリド化合物及びこれを含有する医薬 |
| WO2014176258A1 (en) * | 2013-04-23 | 2014-10-30 | The General Hospital Corporation | Compounds useful as antibiotic tolerance inhibitors |
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2018
- 2018-07-27 WO PCT/US2018/044183 patent/WO2019023635A1/en not_active Ceased
- 2018-07-27 CN CN201880063421.5A patent/CN111615388B/zh active Active
- 2018-07-27 EP EP18837593.5A patent/EP3658138B1/en active Active
- 2018-07-27 US US16/047,915 patent/US10689376B2/en active Active
- 2018-07-27 JP JP2020527860A patent/JP7274478B2/ja active Active