JP7274478B2 - 置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 - Google Patents

置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 Download PDF

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JP7274478B2
JP7274478B2 JP2020527860A JP2020527860A JP7274478B2 JP 7274478 B2 JP7274478 B2 JP 7274478B2 JP 2020527860 A JP2020527860 A JP 2020527860A JP 2020527860 A JP2020527860 A JP 2020527860A JP 7274478 B2 JP7274478 B2 JP 7274478B2
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mmol
compound
chloro
acetamide
imidazo
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バンカヤラパティ，ハリプラサッド
リウ，シャオホイ
ラマムアシー，グルサンカー
シャルマ，スニル
カーディッジ，モハン・ラオ
ウェストン，アレクシス
トーデ，トラソン
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スティングレイ・セラピューティクス・インコーポレイテッド
ザ・ユニバーシティ・オブ・ユタ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020527860A 2017-07-27 2018-07-27 置換された－３Ｈ－イミダゾ［４，５－ｃ］ピリジン及び１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズの新規なエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）並びにがん免疫治療薬としてのインターフェロン遺伝子（ＳＴＩＮＧ）モジュレータのための刺激剤 Active JP7274478B2 (ja)

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US201762537758P 2017-07-27 2017-07-27
US62/537,758 2017-07-27
PCT/US2018/044183 WO2019023635A1 (en) 2017-07-27 2018-07-27 SUBSTITUTED 3 H-IMIDAZO (4,5-C) PYRIDINE AND 1H-PYRROLO (2,3-C) PYRIDINE SERIES OF A NOVEL ECTONUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE-1 (ENPP1) AND STIMULATOR FOR A GENE MODULATOR INTERFERON (STING) AS IMMUNOTHERAPEUTIC AGENTS AGAINST CANCER

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JP2020532578A5 JP2020532578A5 (cg-RX-API-DMAC10.html) 2021-09-16
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CN (1) CN111615388B (cg-RX-API-DMAC10.html)
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JP2021533110A (ja) * 2018-08-01 2021-12-02 スティングレイ・セラピューティクス・インコーポレイテッド 癌免疫療法剤としての新規エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ−１（ＥＮＰＰ１）の置換３Ｈ−イミダゾ［４，５−ｃ］ピリジンおよび１Ｈ−ピロロ［２，３−ｃ］ピリジンシリーズならびにインターフェロン遺伝子刺激因子（ＳＴＩＮＧ）調節剤

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EP3807264A1 (en) 2018-06-12 2021-04-21 Ryvu Therapeutics S.A. Modulators of stimulator of interferon genes (sting)
MX2021009269A (es) * 2019-02-01 2021-08-24 Univ Leland Stanford Junior Inhibidores de enpp1 y metodos para modular una respuesta inmunitaria.
ES3070946T3 (en) 2019-03-12 2026-06-18 Arcus Biosciences Inc Treatment of an oncogenene driven cancer having a kras or egfr mutation by decreasing adenosine production or antagonizing adenosine activation
KR20210146370A (ko) 2019-03-28 2021-12-03 루핀 리미티드 Sting 효능제로서의 매크로사이클릭 화합물
CA3135487A1 (en) 2019-03-29 2020-10-08 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
MX2021015188A (es) 2019-06-12 2022-01-18 Ryvu Therapeutics S A Moduladores de nueva generacion del estimulador de genes de interferon (sting).
DK4004002T3 (da) 2019-07-22 2024-09-30 Lupin Ltd Makrocykliske forbindelser som sting-agonister samt fremgangsmåder og anvendelser dermed
CA3151277A1 (en) 2019-09-16 2021-03-25 Aten Porus Lifesciences Pvt. Ltd. 2-amino-s6-substituted thiopurine compounds as inhibitors of the enpp1 protein
CN114787148A (zh) 2019-12-11 2022-07-22 雷沃医疗有限公司 官能化杂环化合物作为干扰素基因刺激物(sting)的调节剂
KR20260022465A (ko) * 2019-12-11 2026-02-19 리부 세라퓨틱스 에스.에이. 인터페론 유전자 자극제(sting)의 조절제인 헤테로사이클릭 화합물
GB202006382D0 (en) 2020-04-30 2020-06-17 Spermatech As Use
KR102682428B1 (ko) 2020-05-08 2024-07-05 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 프탈라진 유도체 및 이들의 용도
US20230159469A1 (en) 2020-05-08 2023-05-25 Txinno Bioscience Inc. Novel phthalazine derivative having ectonucloeotide pyrophosphatase/phosphodieste rase inhibitory activity, and use thereof
KR102720206B1 (ko) 2020-12-29 2024-10-21 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 나프티리딘온 유도체 및 이들의 용도
AU2021412688B2 (en) 2020-12-29 2025-06-12 Txinno Bioscience Inc. Novel naphthyridinone derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase and use thereof
CA3204409C (en) 2021-01-29 2026-04-28 Txinno Bioscience Inc. Benzotriazole derivative having inhibitory activity against ectonucleotide pyrophosphatase-phosphodiesterase, and use thereof
KR102686866B1 (ko) 2021-01-29 2024-07-19 주식회사 티씨노바이오사이언스 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 벤조트리아졸 유도체 및 이들의 용도
MX2024009216A (es) * 2022-01-28 2024-08-06 Insilico Medicine Ip Ltd Inhibidores de ectonucleotido pirofosfatasa-fosfodiesterasa 1 (enpp1) y usos de los mismos.
EP4514331A1 (en) 2022-04-29 2025-03-05 Petragen, Inc. Inhibitors of enpp1 and modulation of bone growth
WO2026006739A1 (en) * 2024-06-28 2026-01-02 Riboscience Llc Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors for the treatment of certain diseases
WO2026078593A1 (en) 2024-10-08 2026-04-16 Sun Pharma Advanced Research Company Limited Sting agonists and antibody drug conjugates thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021533110A (ja) * 2018-08-01 2021-12-02 スティングレイ・セラピューティクス・インコーポレイテッド 癌免疫療法剤としての新規エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ−１（ＥＮＰＰ１）の置換３Ｈ−イミダゾ［４，５−ｃ］ピリジンおよび１Ｈ−ピロロ［２，３−ｃ］ピリジンシリーズならびにインターフェロン遺伝子刺激因子（ＳＴＩＮＧ）調節剤
JP7461927B2 (ja) 2018-08-01 2024-04-04 スティングレイ・セラピューティクス・インコーポレイテッド 癌免疫療法剤としての新規エクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ－１（ＥＮＰＰ１）の置換３Ｈ－イミダゾ［４，５－ｃ］ピリジンおよび１Ｈ－ピロロ［２，３－ｃ］ピリジンシリーズならびにインターフェロン遺伝子刺激因子（ＳＴＩＮＧ）調節剤

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JP2020532578A (ja) 2020-11-12
EP3658138A1 (en) 2020-06-03
EP3658138A4 (en) 2021-03-31
EP3658138B1 (en) 2023-04-19
CN111615388B (zh) 2023-11-14
US20190031655A1 (en) 2019-01-31
US10689376B2 (en) 2020-06-23
WO2019023635A1 (en) 2019-01-31
WO2019023635A8 (en) 2020-02-20
CN111615388A (zh) 2020-09-01

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