JP2020532534A5 - - Google Patents

Info

Publication number

JP2020532534A5

JP2020532534A5 JP2020512441A JP2020512441A JP2020532534A5 JP 2020532534 A5 JP2020532534 A5 JP 2020532534A5 JP 2020512441 A JP2020512441 A JP 2020512441A JP 2020512441 A JP2020512441 A JP 2020512441A JP 2020532534 A5 JP2020532534 A5 JP 2020532534A5

Authority

JP

Japan

Prior art keywords

amino acid

xaa

sequence

compound

hydrogen

Prior art date

2018-08-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 25
• 229910052739 hydrogen Inorganic materials 0.000 claims 20
• 239000001257 hydrogen Substances 0.000 claims 20
• 150000002431 hydrogen Chemical group 0.000 claims 14
• 150000001413 amino acids Chemical class 0.000 claims 13
• 108090000765 processed proteins & peptides Proteins 0.000 claims 10
• 125000000539 amino acid group Chemical group 0.000 claims 9
• 125000001931 aliphatic group Chemical group 0.000 claims 7
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
• 125000000217 alkyl group Chemical group 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 239000000863 peptide conjugate Substances 0.000 claims 4
• 125000006239 protecting group Chemical group 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000012453 solvate Substances 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 2
• 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims 2
• 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
• 102100024333 Toll-like receptor 2 Human genes 0.000 claims 2
• 230000003213 activating effect Effects 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 230000001939 inductive effect Effects 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102100034411 H/ACA ribonucleoprotein complex subunit 2 Human genes 0.000 claims 1
• 101000994912 Homo sapiens H/ACA ribonucleoprotein complex subunit 2 Proteins 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 244000144980 herd Species 0.000 claims 1
• 125000003473 lipid group Chemical group 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 238000002255 vaccination Methods 0.000 claims 1