MX2020002084A - Conjugados de peptido, proceso de conjugacion y usos de los mismos. - Google Patents

Conjugados de peptido, proceso de conjugacion y usos de los mismos.

Info

Publication number
MX2020002084A
MX2020002084A MX2020002084A MX2020002084A MX2020002084A MX 2020002084 A MX2020002084 A MX 2020002084A MX 2020002084 A MX2020002084 A MX 2020002084A MX 2020002084 A MX2020002084 A MX 2020002084A MX 2020002084 A MX2020002084 A MX 2020002084A
Authority
MX
Mexico
Prior art keywords
conjugates
methods
peptide conjugates
conjugation process
subject
Prior art date
Application number
MX2020002084A
Other languages
English (en)
Spanish (es)
Inventor
Anne Brimble Margaret
Roderick Dunbar Peter
Martyn Williams Geoffrey
Verdon Daniel
Original Assignee
Auckland Uniservices Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd
Publication of MX2020002084A publication Critical patent/MX2020002084A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018Lipids, e.g. in lipopeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MX2020002084A 2017-08-30 2018-08-30 Conjugados de peptido, proceso de conjugacion y usos de los mismos. MX2020002084A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ73500817 2017-08-30
PCT/IB2018/056611 WO2019043604A1 (en) 2017-08-30 2018-08-30 PEPTIDE CONJUGATES, CONJUGATION METHOD, AND USES THEREOF

Publications (1)

Publication Number Publication Date
MX2020002084A true MX2020002084A (es) 2020-03-24

Family

ID=65526296

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020002084A MX2020002084A (es) 2017-08-30 2018-08-30 Conjugados de peptido, proceso de conjugacion y usos de los mismos.

Country Status (14)

Country Link
US (1) US20200361864A1 (cg-RX-API-DMAC7.html)
EP (1) EP3676250A4 (cg-RX-API-DMAC7.html)
JP (1) JP2020532534A (cg-RX-API-DMAC7.html)
KR (1) KR20200058424A (cg-RX-API-DMAC7.html)
CN (1) CN111247123A (cg-RX-API-DMAC7.html)
AU (1) AU2018323043A1 (cg-RX-API-DMAC7.html)
BR (1) BR112020003907A2 (cg-RX-API-DMAC7.html)
CA (1) CA3073314A1 (cg-RX-API-DMAC7.html)
EA (1) EA202090319A1 (cg-RX-API-DMAC7.html)
IL (1) IL272931A (cg-RX-API-DMAC7.html)
MX (1) MX2020002084A (cg-RX-API-DMAC7.html)
SG (1) SG11202001602QA (cg-RX-API-DMAC7.html)
TW (1) TW201925240A (cg-RX-API-DMAC7.html)
WO (1) WO2019043604A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019119067A1 (en) 2017-12-21 2019-06-27 Ena Therapeutics Pty Ltd Optimised compounds
KR20220050873A (ko) * 2019-06-26 2022-04-25 악셀리아 온콜로지 피티와이 리미티드 신규한 분자
CN110681362B (zh) * 2019-09-26 2020-09-11 浙江大学 以羧基和吲哚基为功能基团的混合模式层析介质
CN111349054A (zh) * 2020-01-21 2020-06-30 青岛科技大学 一种防锈剂2-(1,3-苯并噻唑-2-硫基)丁二酸的制备方法
US20230278954A1 (en) * 2020-06-26 2023-09-07 Ena Respiratory Pty Ltd Branched lipid compouds
AU2022338350A1 (en) * 2021-09-02 2024-02-29 Ena Respiratory Pty Ltd Formulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1230261B1 (en) * 1999-11-15 2008-06-25 Ludwig Institute For Cancer Research Ny-eso-1 nonapeptide derivatives, and uses thereof
EP2334332A4 (en) * 2008-09-05 2013-01-09 Id Biomedical Corp Quebec NEW COMPOSITIONS AND NEW ADJUVANTS
JP2012523379A (ja) * 2009-04-09 2012-10-04 ザ ユニバーシティー オブ メルボルン 免疫原性組成物およびその使用
US10576144B2 (en) * 2013-06-28 2020-03-03 Auckland Uniservices Limited Amino acid and peptide conjugates and conjugation process
US11464853B2 (en) * 2016-02-26 2022-10-11 Auckland Uniservices Limited Amino acid and peptide conjugates and conjugation process

Also Published As

Publication number Publication date
CA3073314A1 (en) 2019-03-07
TW201925240A (zh) 2019-07-01
WO2019043604A1 (en) 2019-03-07
JP2020532534A (ja) 2020-11-12
EA202090319A1 (ru) 2020-10-16
EP3676250A4 (en) 2021-05-26
CN111247123A (zh) 2020-06-05
IL272931A (en) 2020-04-30
AU2018323043A1 (en) 2020-03-05
EP3676250A1 (en) 2020-07-08
KR20200058424A (ko) 2020-05-27
BR112020003907A2 (pt) 2020-09-08
SG11202001602QA (en) 2020-03-30
US20200361864A1 (en) 2020-11-19

Similar Documents

Publication Publication Date Title
MX2020002084A (es) Conjugados de peptido, proceso de conjugacion y usos de los mismos.
WO2014207708A3 (en) Amino acid and peptide conjugates and conjugation process
WO2017145097A3 (en) Amino acid and peptide conjugates and conjugation process
MX2016009469A (es) Polisacaridos capsulares de streptococcus pneumoniae y conjugados de los mismos.
MX2019000566A (es) Suministro mediado por ve de conjugados de proteína de enlace-molécula pequeña.
ZA201805853B (en) Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof
MX382438B (es) Polisacaridos capsulares de streptococcus pneumoniae y conjugados de los mismos
MX2019006043A (es) Proteína de unión de antígeno prostático específico de membrana.
NZ725480A (en) Anti-ptk7 antibody-drug conjugates
MX2017001638A (es) Molecula portadora para antigenos.
MX2020005170A (es) Formulaciones de proteinas de fusion vegfr-fc.
WO2014136064A3 (en) Immunogenic fusion polypeptides
MX2019009149A (es) Conjugado de material bioactivo que tiene sustentabilidad mejorada y uso del mismo.
MX2017008406A (es) Conjugados de aminoacidos y peptidos y sus usos.
IN2014DN09791A (cg-RX-API-DMAC7.html)
WO2014179184A8 (en) Compositions for inducing immune tolerance to coagulation factor proteins
TN2019000064A1 (en) Composition comprising multivalent capsular polysaccharide-transport protein and use thereof
MX2018014129A (es) Composiciones farmaceuticas de oligomero de morfolino fosforodiamidato.
IN2014DN09445A (cg-RX-API-DMAC7.html)
CY1125762T1 (el) Νεα απο του στοματος σκευασματα βελινοστατης
CA3010537A1 (en) Vaccine strains of brachyspira hyodysenteriae
MX2017016858A (es) Composiciones inmunogenicas.
HK1224187A1 (zh) 针对药物成瘾的疫苗组合物
PH12018500014A1 (en) Total synthesis of shishijimicin a and analogs thereof
ZA201905875B (en) Immunostimulating compositions and uses therefore