JP2020531412A - 抗微生物組成物 - Google Patents
抗微生物組成物 Download PDFInfo
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- JP2020531412A JP2020531412A JP2020506322A JP2020506322A JP2020531412A JP 2020531412 A JP2020531412 A JP 2020531412A JP 2020506322 A JP2020506322 A JP 2020506322A JP 2020506322 A JP2020506322 A JP 2020506322A JP 2020531412 A JP2020531412 A JP 2020531412A
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Abstract
Description
a.ポリビニルアルコールを含む水溶性ビニルポリマー0.01〜10重量%と、
b.4.5を超えるpKaを有するカルボン酸0.1〜20重量%と、
c.アニオン性界面活性剤1〜80重量%とを含む抗微生物組成物に関し、
組成物のpHは4.5〜6.5の範囲にある。
組成物は、ポリビニルアルコールを含む水溶性ビニルポリマーを含む。水溶性ビニルポリマーは、界面活性剤などの成分とともに使用される場合、増粘剤、粘度調整剤および複合体形成剤として使用されることが知られている。
本発明の組成物はまた、4.5を超えるpKa値を有するカルボン酸またはその誘導体を0.1〜20重量%、好ましくは0.1〜15重量%、さらに好ましくは0.2〜10重量%、最も好ましくは0.2〜5重量%含む。
pKaの値が高いほど、所与のpHでの解離の程度が低くなる。これは、周知のヘンダーソン・ハッセルバルヒ式によって支配される。
本発明の組成物はまた、アニオン性界面活性剤を含む。
溶媒、例えば、エチルアルコール、イソプロパノール、アセトン、エチレングリコールモノエチルエーテル、ジエチレングリコールモノブチルエーテル、ジエチレングリコールモノエチルエーテル;
固形石鹸の場合、乾燥した皮膚を取り除くのを助ける、平均直径が50μmを超える粒子を含有してもよい。理論に拘束されないが、剥離の程度は粒子の大きさおよび形態に依存する。大きくて粗い粒子は通常、非常に手触りが粗く、刺激性である。非常に小さな粒子は効果的なスクラブ剤として機能しない場合がある。当技術分野で使用されるこのようなスクラブ剤には、天然ミネラル、例えば、シリカ、タルク、方解石、軽石、リン酸三カルシウム;種子、例えば、イネ、アプリコットの種子など;砕いた殻、例えば、アーモンドおよびクルミの殻;オートミール;ポリマー、例えば、ポリエチレンおよびポリプロピレンのビーズ、花びらならびに葉;微結晶ワックスビーズ;ホホバエステルビーズなどが含まれる。これらのスクラブ剤には、ミクロンサイズから数mmの範囲の様々な粒径および形態がある。これらはまた、様々な硬さを有する。いくつかの例が、タルク、方解石、軽石、クルミの殻、ドロマイトおよびポリエチレンである。
プロトコル
以下の実施例に示される組成物はいずれも、以下のそれぞれの実施例および手順に示される量(重量パーセント単位)のポリマーおよびカルボン酸を使用して調製した。
(American Standard Test Method2783)に従って、抗微生物効果の評価を行った。トリプトソイ寒天(TAS)プレート上で試験生物を一晩(22±2時間)増殖させた。生物は、元の供給源から3回を超えて継代しなかった。必要な細胞数を達成するのに十分な好適な量の生理食塩水に再懸濁することにより、細胞の光学密度(OD)に基づいて細胞数を調整した。分光光度計を使用して、細胞の620nmでのODを各試験生物の細胞数に標準化した。コンタクトキルアッセイのために生理食塩水中でODを2.0に調整することにより、1×109コロニー形成単位(CFU)/mLの最小最終懸濁液を得た。
5を超えるログ減少はCFUの数が99.99%減少することを意味し、0.5未満のログ減少はCFUの数が減少しないことを意味し、これは、抗微生物効果がないことを意味する。また、5を超えるログ減少は、完全な死滅を意味する。
4−メチルオクタン酸−(pKa=4.93;Aldrich製、カタログ番号W357502)
ヘキサン酸−(pKa=4.88;Aldrich製、カタログ番号153745)
2−エチルヘキサン酸−(pKa=4.72;Aldrich製、カタログ番号538701)
シクロヘキサン酸−(pKa=4.92;Aldrich製、カタログ番号101834)
サリチル酸−(pKa=2.97、Sigma Aldrich製、カタログ番号247588)
クエン酸−(pKa=3.13、Sigma Aldrich製、カタログ番号C83155)
乳酸−(pKa=3.86、Sigma Aldrich製、カタログ番号252476)
リンゴ酸−(pKa=3.4、Sigma Aldrich製、カタログ番号M8304)
グリコール酸−(pKa=3.6、Sigma Aldrich製、カタログ番号V900017)
PVA−ALDRICH、カタログ番号363170、
PVP−SIGMA−ALDRICH製、名称PVP10
PAA−ALDRICH製、カタログ番号523925、
ポリスチレンスルホネート(PSS)−AkzoNobel製、名称FLEXAN(登録商標)IIの下に販売、
カルボキシメチルセルロースナトリウム(SCMC)−ALDRICH製、カタログ番号419273、
ヒドロキシエチルセルロース(HEC)−SIGMA製、カタログ番号09368、および
アルギン酸ナトリウム−Thomas Baker製、カタログ番号142582。
ラウリル硫酸ナトリウム(SLS)、カタログ番号62862、Sigma−Aldrich製。
Claims (15)
- 抗微生物組成物であって、
a.ポリビニルアルコールを含む水溶性ビニルポリマー0.01〜10重量%と、
b.4.5を超えるpKaを有するカルボン酸0.1〜20重量%と、
c.アニオン性界面活性剤1〜80重量%と
を含み、
前記組成物のpHが4.5〜6.5の範囲にある抗微生物組成物。 - 前記ビニルポリマーがポリビニルアルコールである、請求項1に記載の組成物。
- 前記カルボン酸が、鎖長C4〜C16を有する脂肪族カルボン酸から選択される、請求項1または2に記載の組成物。
- 前記脂肪族カルボン酸が、直鎖または分岐脂肪族カルボン酸、環状脂肪族カルボン酸およびそれらの混合物から選択される、請求項3に記載の組成物。
- 前記脂肪族カルボン酸が、ヘキサン酸、シクロヘキサン酸、2−エチルヘキサン酸、オクタン酸、4−メチルオクタン酸およびそれらの混合物から選択される、請求項4に記載の組成物。
- 化粧品として許容される基剤をさらに含む、請求項1から5のいずれか一項に記載の組成物。
- 前記組成物の前記pHが4.5〜6の範囲にある、請求項1から6のいずれか一項に記載の組成物。
- 前記組成物の前記pHが5〜6の範囲にある、請求項1から6のいずれか一項に記載の組成物。
- 前記界面活性剤が石鹸以外である、請求項8に記載の組成物。
- 請求項1から9のいずれか一項に記載の組成物を表面に適用する工程を含む、表面を洗浄または消毒する方法。
- 前記組成物がウォッシュオフ組成物の形態であり、前記適用された組成物を少なくとも部分的に除去する追加の工程がある、請求項10に記載の方法。
- 前記組成物を少なくとも部分的に除去する前記工程が、前記基材上に前記組成物を適用する工程の後5分未満以内に実行される、請求項11に記載の方法。
- 抗微生物効果のための、請求項1から9のいずれか一項に記載の組成物の使用。
- 手指衛生の改善のための、請求項1から9のいずれか一項に記載の組成物の使用。
- (a)ポリビニルアルコールを含む水溶性ビニルポリマー0.01〜10重量%と、(b)4.5を超えるpKaを有するカルボン酸またはその誘導体0.1〜20重量%と、(c)アニオン性界面活性剤1〜80重量%との組合せの使用であって、改善された抗微生物効果のための組成物では、前記組成物のpHが4.5〜6.5の範囲にある使用。
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