JP2020529845A5 - - Google Patents
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- Publication number
- JP2020529845A5 JP2020529845A5 JP2020505248A JP2020505248A JP2020529845A5 JP 2020529845 A5 JP2020529845 A5 JP 2020529845A5 JP 2020505248 A JP2020505248 A JP 2020505248A JP 2020505248 A JP2020505248 A JP 2020505248A JP 2020529845 A5 JP2020529845 A5 JP 2020529845A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- pharmaceutical composition
- wnt3a
- seq
- wnt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000013814 Wnt Human genes 0.000 claims 11
- 108050003627 Wnt Proteins 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 102000044880 Wnt3A Human genes 0.000 claims 9
- 108700013515 Wnt3A Proteins 0.000 claims 9
- 101710140933 Frizzled-8 Proteins 0.000 claims 4
- 102100028466 Frizzled-8 Human genes 0.000 claims 4
- 108010006519 Molecular Chaperones Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 239000002502 liposome Substances 0.000 claims 3
- 238000003776 cleavage reaction Methods 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000005698 Frizzled receptors Human genes 0.000 claims 1
- 108010045438 Frizzled receptors Proteins 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- -1 sulfonated polycyclic aromatic compound Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024075397A JP2024120178A (ja) | 2017-08-01 | 2024-05-07 | Ｗｎｔ組成物および無血清培養条件からの処理の方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762539960P | 2017-08-01 | 2017-08-01 | |
| US62/539,960 | 2017-08-01 | ||
| US201862630448P | 2018-02-14 | 2018-02-14 | |
| US62/630,448 | 2018-02-14 | ||
| PCT/US2018/044886 WO2019028186A1 (en) | 2017-08-01 | 2018-08-01 | WNT COMPOSITIONS AND METHODS OF TREATMENT FROM SERUM-FREE CULTURE CONDITIONS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024075397A Division JP2024120178A (ja) | 2017-08-01 | 2024-05-07 | Ｗｎｔ組成物および無血清培養条件からの処理の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020529845A JP2020529845A (ja) | 2020-10-15 |
| JP2020529845A5 true JP2020529845A5 (enExample) | 2021-09-09 |
Family
ID=65234165
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505248A Pending JP2020529845A (ja) | 2017-08-01 | 2018-08-01 | Ｗｎｔ組成物および無血清培養条件からの処理の方法 |
| JP2024075397A Pending JP2024120178A (ja) | 2017-08-01 | 2024-05-07 | Ｗｎｔ組成物および無血清培養条件からの処理の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024075397A Pending JP2024120178A (ja) | 2017-08-01 | 2024-05-07 | Ｗｎｔ組成物および無血清培養条件からの処理の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20200399588A1 (enExample) |
| EP (1) | EP3661475A4 (enExample) |
| JP (2) | JP2020529845A (enExample) |
| CN (1) | CN111182880B (enExample) |
| AU (1) | AU2018309026A1 (enExample) |
| CA (1) | CA3071638A1 (enExample) |
| GB (2) | GB2610090B (enExample) |
| WO (1) | WO2019028186A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019121846A1 (en) * | 2017-12-19 | 2019-06-27 | CSL Behring Lengnau AG | Protein purification and virus inactivation with alkyl glycosides |
| CN115702242A (zh) * | 2020-04-20 | 2023-02-14 | 医药控股公司 | 一种改性的细菌透明质酸酶多肽、生产方法、药物组合物及其用途 |
| CN116359367B (zh) * | 2022-12-27 | 2023-08-25 | 绍兴市食品药品检验研究院 | 一种同位素内标高效液相色谱串联质谱法检测食品中γ-氨基丁酸的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0707472B1 (en) * | 1993-07-08 | 2001-03-14 | The Liposome Company, Inc. | Method of controlling the size of liposomes |
| US6610316B2 (en) * | 1997-05-30 | 2003-08-26 | Shanbrom Technologies, Llc | Disinfection by particle-bound and insolubilized detergents |
| WO2006036175A2 (en) * | 2004-09-21 | 2006-04-06 | Rhode Island Hospital, A Lifespan-Partner | Wnt proteins and detection and treatment of cancer |
| US20070072239A1 (en) * | 2005-09-26 | 2007-03-29 | Wyeth | Pharmaceutical compositions and methods of using secreted frizzled related protein |
| US8431532B2 (en) * | 2010-06-28 | 2013-04-30 | Five Prime Therepeutics, Inc. | FZD8 extracellular domains and FZD8 extracellular domain fusion molecules and treatments using same |
| US9873722B2 (en) * | 2011-09-16 | 2018-01-23 | Fate Therapeutics, Inc. | Wnt compositions and therapeutic uses of such compositions |
| HK1212216A1 (en) * | 2012-10-23 | 2016-06-10 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
| AU2014329547B2 (en) * | 2013-10-02 | 2019-05-16 | The Board Of Trustees Of The Leland Stanford Junior University | Wnt compositions and methods for purification |
| JP7150604B2 (ja) * | 2016-01-28 | 2022-10-11 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 無血清合成のためのｗｎｔ組成物及び方法 |
-
2018
- 2018-08-01 GB GB2216232.5A patent/GB2610090B/en not_active Expired - Fee Related
- 2018-08-01 CN CN201880064338.XA patent/CN111182880B/zh not_active Expired - Fee Related
- 2018-08-01 CA CA3071638A patent/CA3071638A1/en active Pending
- 2018-08-01 JP JP2020505248A patent/JP2020529845A/ja active Pending
- 2018-08-01 WO PCT/US2018/044886 patent/WO2019028186A1/en not_active Ceased
- 2018-08-01 EP EP18840842.1A patent/EP3661475A4/en not_active Withdrawn
- 2018-08-01 AU AU2018309026A patent/AU2018309026A1/en not_active Abandoned
- 2018-08-01 GB GB2001567.3A patent/GB2581882B/en not_active Expired - Fee Related
-
2020
- 2020-08-18 US US16/996,676 patent/US20200399588A1/en not_active Abandoned
-
2024
- 2024-05-07 JP JP2024075397A patent/JP2024120178A/ja active Pending
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