JP2020527156A5 - - Google Patents
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- Publication number
- JP2020527156A5 JP2020527156A5 JP2020502477A JP2020502477A JP2020527156A5 JP 2020527156 A5 JP2020527156 A5 JP 2020527156A5 JP 2020502477 A JP2020502477 A JP 2020502477A JP 2020502477 A JP2020502477 A JP 2020502477A JP 2020527156 A5 JP2020527156 A5 JP 2020527156A5
- Authority
- JP
- Japan
- Prior art keywords
- cladribine
- composition according
- amount
- effective
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 14
- 229960002436 cladribine Drugs 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 12
- 230000001186 cumulative effect Effects 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- 206010028417 myasthenia gravis Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 208000000209 Isaacs syndrome Diseases 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 206010028419 Myasthenia gravis neonatal Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 201000011396 Neonatal Myasthenia Gravis Diseases 0.000 claims 1
- 206010072359 Neuromyotonia Diseases 0.000 claims 1
- 208000030725 Transient neonatal myasthenia gravis Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 208000013315 neuromuscular junction disease Diseases 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001242 postsynaptic effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1711800.1 | 2017-07-21 | ||
| GB1711800.1A GB2564717A (en) | 2017-07-21 | 2017-07-21 | Use of cladribine for treating autoimmune neuromuscular disease |
| PCT/GB2018/051801 WO2019016505A1 (en) | 2017-07-21 | 2018-06-28 | USE OF CLADRIBINE FOR THE TREATMENT OF AUTOIMMUNE NEUROMUSCULAR DISEASE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527156A JP2020527156A (ja) | 2020-09-03 |
| JP2020527156A5 true JP2020527156A5 (enExample) | 2021-05-27 |
| JP7186214B2 JP7186214B2 (ja) | 2022-12-08 |
Family
ID=59771723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502477A Active JP7186214B2 (ja) | 2017-07-21 | 2018-06-28 | 自己免疫性神経筋疾患を処置するためのクラドリビンの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US12171775B2 (enExample) |
| EP (2) | EP4292663A3 (enExample) |
| JP (1) | JP7186214B2 (enExample) |
| CA (1) | CA3095893A1 (enExample) |
| DK (1) | DK3654989T3 (enExample) |
| ES (1) | ES2974423T3 (enExample) |
| FI (1) | FI3654989T3 (enExample) |
| GB (1) | GB2564717A (enExample) |
| HR (1) | HRP20240282T1 (enExample) |
| HU (1) | HUE066238T2 (enExample) |
| LT (1) | LT3654989T (enExample) |
| PL (1) | PL3654989T3 (enExample) |
| PT (1) | PT3654989T (enExample) |
| RS (1) | RS65246B1 (enExample) |
| SI (1) | SI3654989T1 (enExample) |
| WO (1) | WO2019016505A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2601786A (en) | 2020-12-10 | 2022-06-15 | Chord Therapeutics S A R L | Use of cladribine for treating immune brain disease |
| TW202541818A (zh) | 2023-12-14 | 2025-11-01 | 瑞士商亞利斯貿易公司 | 用於治療重症肌無力之克拉屈濱(cladribine)療程 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1269659A (en) | 1984-08-06 | 1990-05-29 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| US5310732A (en) | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| US5208327A (en) | 1991-12-18 | 1993-05-04 | Ortho Pharmaceutical Corporation | Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine |
| EP1200102A1 (en) * | 1999-07-22 | 2002-05-02 | Supergen, Inc. | Methods for treating autoimmune diseases |
| EP1556010A4 (en) * | 2002-10-31 | 2007-12-05 | Supergen Inc | PHARMACEUTICAL FORMULATIONS; WHICH ARE ADDRESSED TO CERTAIN REGIONS OF THE STOMACH-DARM TRAKTS |
| WO2004049195A2 (en) * | 2002-11-22 | 2004-06-10 | Transclick, Inc. | System and method for language translation via remote devices |
| KR20060011943A (ko) | 2003-03-28 | 2006-02-06 | 아이박스 코포레이션 | 향상된 경구 및 경점막 수송용 클라드리빈 제형 |
| DK2805723T3 (da) | 2004-12-22 | 2018-01-29 | Merck Serono Sa | Cladribin-regime til behandling af multipel sclerose |
| MX2008014971A (es) * | 2006-05-24 | 2008-12-05 | Serono Lab | Regimen de cladribine para tratar esclerosis multiple. |
-
2017
- 2017-07-21 GB GB1711800.1A patent/GB2564717A/en not_active Withdrawn
-
2018
- 2018-06-28 EP EP23205297.7A patent/EP4292663A3/en active Pending
- 2018-06-28 FI FIEP18739593.4T patent/FI3654989T3/fi active
- 2018-06-28 ES ES18739593T patent/ES2974423T3/es active Active
- 2018-06-28 WO PCT/GB2018/051801 patent/WO2019016505A1/en not_active Ceased
- 2018-06-28 JP JP2020502477A patent/JP7186214B2/ja active Active
- 2018-06-28 RS RS20240253A patent/RS65246B1/sr unknown
- 2018-06-28 US US16/632,245 patent/US12171775B2/en active Active
- 2018-06-28 HU HUE18739593A patent/HUE066238T2/hu unknown
- 2018-06-28 HR HRP20240282TT patent/HRP20240282T1/hr unknown
- 2018-06-28 PL PL18739593.4T patent/PL3654989T3/pl unknown
- 2018-06-28 DK DK18739593.4T patent/DK3654989T3/da active
- 2018-06-28 EP EP18739593.4A patent/EP3654989B1/en active Active
- 2018-06-28 SI SI201831074T patent/SI3654989T1/sl unknown
- 2018-06-28 LT LTEPPCT/GB2018/051801T patent/LT3654989T/lt unknown
- 2018-06-28 PT PT187395934T patent/PT3654989T/pt unknown
- 2018-06-28 CA CA3095893A patent/CA3095893A1/en active Pending
-
2024
- 2024-11-14 US US18/948,158 patent/US20250302858A1/en active Pending
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