JP2020527146A5 - - Google Patents
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- Publication number
- JP2020527146A5 JP2020527146A5 JP2020501509A JP2020501509A JP2020527146A5 JP 2020527146 A5 JP2020527146 A5 JP 2020527146A5 JP 2020501509 A JP2020501509 A JP 2020501509A JP 2020501509 A JP2020501509 A JP 2020501509A JP 2020527146 A5 JP2020527146 A5 JP 2020527146A5
- Authority
- JP
- Japan
- Prior art keywords
- range
- alopecia
- hair loss
- hair
- minoxidil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000004384 Alopecia Diseases 0.000 claims 32
- 230000003676 hair loss Effects 0.000 claims 18
- 208000024963 hair loss Diseases 0.000 claims 16
- 231100000360 alopecia Toxicity 0.000 claims 12
- 229940079593 drug Drugs 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims 10
- 229960003632 minoxidil Drugs 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 230000003779 hair growth Effects 0.000 claims 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 230000012010 growth Effects 0.000 claims 4
- 239000007937 lozenge Substances 0.000 claims 4
- 239000008188 pellet Substances 0.000 claims 4
- 229960002256 spironolactone Drugs 0.000 claims 4
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims 4
- 239000003826 tablet Substances 0.000 claims 4
- 239000002775 capsule Substances 0.000 claims 3
- 210000004209 hair Anatomy 0.000 claims 3
- 210000004877 mucosa Anatomy 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- 210000003296 saliva Anatomy 0.000 claims 3
- 239000007921 spray Substances 0.000 claims 3
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 claims 2
- 108010037003 Buserelin Proteins 0.000 claims 2
- 206010016936 Folliculitis Diseases 0.000 claims 2
- 208000002720 Malnutrition Diseases 0.000 claims 2
- 201000002996 androgenic alopecia Diseases 0.000 claims 2
- 208000007502 anemia Diseases 0.000 claims 2
- 229960000997 bicalutamide Drugs 0.000 claims 2
- CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 claims 2
- 229960002719 buserelin Drugs 0.000 claims 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 208000034557 congenital alopecia Diseases 0.000 claims 2
- 229960000978 cyproterone acetate Drugs 0.000 claims 2
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 claims 2
- 239000006196 drop Substances 0.000 claims 2
- 229960004199 dutasteride Drugs 0.000 claims 2
- JWJOTENAMICLJG-QWBYCMEYSA-N dutasteride Chemical compound O=C([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)N[C@@H]4CC3)C)CC[C@@]21C)NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F JWJOTENAMICLJG-QWBYCMEYSA-N 0.000 claims 2
- 229960004671 enzalutamide Drugs 0.000 claims 2
- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 claims 2
- 239000010408 film Substances 0.000 claims 2
- 229960004039 finasteride Drugs 0.000 claims 2
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 claims 2
- 229960002074 flutamide Drugs 0.000 claims 2
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 210000003780 hair follicle Anatomy 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000001071 malnutrition Effects 0.000 claims 2
- 235000000824 malnutrition Nutrition 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 210000002200 mouth mucosa Anatomy 0.000 claims 2
- 210000002850 nasal mucosa Anatomy 0.000 claims 2
- 229960002653 nilutamide Drugs 0.000 claims 2
- XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 claims 2
- 208000015380 nutritional deficiency disease Diseases 0.000 claims 2
- 239000006187 pill Substances 0.000 claims 2
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 240000004670 Glycyrrhiza echinata Species 0.000 claims 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 229940083712 aldosterone antagonist Drugs 0.000 claims 1
- 239000002170 aldosterone antagonist Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000003698 anagen phase Effects 0.000 claims 1
- 230000002280 anti-androgenic effect Effects 0.000 claims 1
- 239000000051 antiandrogen Substances 0.000 claims 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000005178 buccal mucosa Anatomy 0.000 claims 1
- 229960001948 caffeine Drugs 0.000 claims 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229940010454 licorice Drugs 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 239000003956 nonsteroidal anti androgen Substances 0.000 claims 1
- 230000000284 resting effect Effects 0.000 claims 1
- 239000011669 selenium Substances 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022195386A JP2023016964A (ja) | 2017-07-12 | 2022-12-07 | 育毛促進及び脱毛または過剰な毛髪脱落の治療 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017902722A AU2017902722A0 (en) | 2017-07-12 | Promoting hair growth and treatment of hair loss or excessive hair shedding | |
| AU2017902722 | 2017-07-12 | ||
| PCT/AU2018/050719 WO2019010535A1 (en) | 2017-07-12 | 2018-07-12 | STIMULATION OF HAIR GROWTH AND TREATMENT OF HAIR FALL OR EXCESSIVE ALOPECIA |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022195386A Division JP2023016964A (ja) | 2017-07-12 | 2022-12-07 | 育毛促進及び脱毛または過剰な毛髪脱落の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020527146A JP2020527146A (ja) | 2020-09-03 |
| JP2020527146A5 true JP2020527146A5 (cg-RX-API-DMAC7.html) | 2021-08-19 |
| JP7191927B2 JP7191927B2 (ja) | 2022-12-19 |
Family
ID=65001077
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020501509A Active JP7191927B2 (ja) | 2017-07-12 | 2018-07-12 | 育毛促進及び脱毛または過剰な毛髪脱落の治療 |
| JP2022195386A Withdrawn JP2023016964A (ja) | 2017-07-12 | 2022-12-07 | 育毛促進及び脱毛または過剰な毛髪脱落の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022195386A Withdrawn JP2023016964A (ja) | 2017-07-12 | 2022-12-07 | 育毛促進及び脱毛または過剰な毛髪脱落の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20190269684A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3651769B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7191927B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20240064747A (cg-RX-API-DMAC7.html) |
| CN (1) | CN111065396A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2018250398B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3069336A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2909395T3 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11202000124PA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2019010535A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ732075A (en) | 2014-10-29 | 2022-09-30 | Samson Clinical Pty Ltd | Detection and treatment of excessive hair shedding |
| GB2596942B (en) | 2019-02-27 | 2023-05-10 | Samson Clinical Pty Ltd | Tofacitinib via oral mucosa for use in treatment of autoimmune hair loss or excessing hair shedding |
| WO2021178871A1 (en) | 2020-03-05 | 2021-09-10 | University Of Miami | Cannabidiol nanodrug formulations and methods for use the same |
| CN112691187B (zh) * | 2020-12-30 | 2021-12-21 | 深圳新发源植物科技发展有限公司 | 一种用于防止额前脱发的缓释膜及其制备方法 |
| CN113248501B (zh) * | 2021-06-17 | 2021-10-08 | 南京韦尔优众医药有限公司 | Cly系列化合物及其制备方法和制备药物的用途 |
| KR20250100660A (ko) | 2022-10-25 | 2025-07-03 | 베라더믹스 인코포레이티드 | 변형 방출 미녹시딜의 조성물 및 사용 방법 |
| EP4539816A4 (en) * | 2023-09-01 | 2025-07-23 | Follea Int | COMPOSITIONS AND METHODS FOR AN ORALLY ADMINISTERED MINOXIDIL SUPPLEMENT FOR THE TREATMENT OF ALOPECIA |
| KR20260065905A (ko) * | 2023-09-08 | 2026-05-11 | 수조우 킨터 제약회사(주) | 안드로겐 수용체 억제제/길항제를 함유하는 약학 조성물, 방법 및 용도 |
| GB2638418A (en) * | 2024-02-21 | 2025-08-27 | Novumgen Ltd | An orodispersible tablet of spironolactone and its process of preparation |
| WO2026062695A1 (en) * | 2024-09-17 | 2026-03-26 | Shah Atul K | Toothpaste for body disorders |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4997643A (en) * | 1989-07-12 | 1991-03-05 | Union Carbide Chemicals And Plastics Company Inc. | Polymeric salt delivery systems |
| GB2314019B (en) * | 1996-06-10 | 2000-03-15 | Bio Scient Ltd | The use of L-Lysine in the treatment of hair loss |
| WO1999040898A2 (en) * | 1998-02-12 | 1999-08-19 | Centrapharm Inc. | Sublingual drug formulations having combined rapid onset of action and long lasting therapeutic effect |
| US20050271596A1 (en) * | 2002-10-25 | 2005-12-08 | Foamix Ltd. | Vasoactive kit and composition and uses thereof |
| CN1838969A (zh) * | 2004-10-07 | 2006-09-27 | 三仪股份有限公司 | 经皮和经粘膜制剂 |
| JP2009091325A (ja) * | 2007-10-11 | 2009-04-30 | Rohto Pharmaceut Co Ltd | 育毛剤 |
| EP2344198B1 (en) * | 2008-09-27 | 2020-11-04 | Jina Pharmaceuticals Inc. | Lipid based pharmaceutical preparations for topical application |
| EP2510930A1 (en) * | 2011-04-15 | 2012-10-17 | Bionanoplus, S.L. | Nanoparticles comprising half esters of poly (methyl vinyl ether-co-maleic anhydride) and uses thereof |
| AU2011100917B4 (en) * | 2011-07-26 | 2013-05-02 | Sinclair, Rodney Daniel Professor | Treatment of male and female androgenetic alopecia with oral minoxidil either alone or in combination with antiandrogens |
| WO2013181487A2 (en) * | 2012-05-31 | 2013-12-05 | Stiefel Laboratories, Inc. | Method of treating |
| NZ732075A (en) * | 2014-10-29 | 2022-09-30 | Samson Clinical Pty Ltd | Detection and treatment of excessive hair shedding |
| US9561224B1 (en) * | 2015-05-27 | 2017-02-07 | Moshe Rogosnitzky | Methods and compositions for treating androgenetic alopecia |
-
2018
- 2018-07-12 KR KR1020247014382A patent/KR20240064747A/ko not_active Ceased
- 2018-07-12 CN CN201880057079.8A patent/CN111065396A/zh active Pending
- 2018-07-12 AU AU2018250398A patent/AU2018250398B2/en active Active
- 2018-07-12 SG SG11202000124PA patent/SG11202000124PA/en unknown
- 2018-07-12 US US16/344,288 patent/US20190269684A1/en not_active Abandoned
- 2018-07-12 EP EP18832869.4A patent/EP3651769B1/en active Active
- 2018-07-12 KR KR1020207002802A patent/KR102663164B1/ko active Active
- 2018-07-12 ES ES18832869T patent/ES2909395T3/es active Active
- 2018-07-12 JP JP2020501509A patent/JP7191927B2/ja active Active
- 2018-07-12 CA CA3069336A patent/CA3069336A1/en active Pending
- 2018-07-12 WO PCT/AU2018/050719 patent/WO2019010535A1/en not_active Ceased
-
2019
- 2019-05-16 AU AU2019203438A patent/AU2019203438A1/en not_active Abandoned
-
2022
- 2022-12-07 JP JP2022195386A patent/JP2023016964A/ja not_active Withdrawn
-
2024
- 2024-11-08 US US18/942,149 patent/US20250064807A1/en active Pending
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