JP2020524181A5 - - Google Patents
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- Publication number
- JP2020524181A5 JP2020524181A5 JP2020519025A JP2020519025A JP2020524181A5 JP 2020524181 A5 JP2020524181 A5 JP 2020524181A5 JP 2020519025 A JP2020519025 A JP 2020519025A JP 2020519025 A JP2020519025 A JP 2020519025A JP 2020524181 A5 JP2020524181 A5 JP 2020524181A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- compound
- nafld
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229940125904 compound 1 Drugs 0.000 claims description 43
- 150000003839 salts Chemical class 0.000 claims description 30
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 29
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 claims description 17
- 108010082126 Alanine transaminase Proteins 0.000 claims description 17
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims description 17
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims description 17
- 206010016654 Fibrosis Diseases 0.000 claims description 12
- 102000003929 Transaminases Human genes 0.000 claims description 12
- 108090000340 Transaminases Proteins 0.000 claims description 12
- 230000002440 hepatic effect Effects 0.000 claims description 12
- 230000004761 fibrosis Effects 0.000 claims description 11
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 9
- 210000004185 liver Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 208000004930 Fatty Liver Diseases 0.000 claims description 6
- 239000012453 solvate Substances 0.000 claims description 5
- 206010019708 Hepatic steatosis Diseases 0.000 claims description 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 3
- WPDCHTSXOPUOII-UHFFFAOYSA-N propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate Chemical compound N1=CN=C(OC2CCN(CC2)C(=O)OC(C)C)C(OC)=C1NC1=CC=C(S(C)(=O)=O)N=C1C WPDCHTSXOPUOII-UHFFFAOYSA-N 0.000 claims description 3
- 231100000240 steatosis hepatitis Toxicity 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000010706 fatty liver disease Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 102000004896 Sulfotransferases Human genes 0.000 claims 1
- 108090001033 Sulfotransferases Proteins 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 46
- 238000000034 method Methods 0.000 description 44
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000012317 liver biopsy Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000007863 steatosis Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762522045P | 2017-06-19 | 2017-06-19 | |
| US62/522,045 | 2017-06-19 | ||
| PCT/US2018/038319 WO2018236896A1 (en) | 2017-06-19 | 2018-06-19 | Compounds and methods for treatment of nafld and nash |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020524181A JP2020524181A (ja) | 2020-08-13 |
| JP2020524181A5 true JP2020524181A5 (enExample) | 2021-07-29 |
Family
ID=62875321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020519025A Withdrawn JP2020524181A (ja) | 2017-06-19 | 2018-06-19 | Ｎａｆｌｄおよびｎａｓｈの治療のための化合物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20200129511A1 (enExample) |
| EP (1) | EP3641887A1 (enExample) |
| JP (1) | JP2020524181A (enExample) |
| MA (1) | MA49456A (enExample) |
| WO (1) | WO2018236896A1 (enExample) |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1133559E (pt) | 1998-11-20 | 2005-10-31 | Arena Pharm Inc | Receptor acoplato a proteina g orfao humano, rup3 |
| HRP20050696B1 (en) | 2003-01-14 | 2008-10-31 | Arena Pharmaceuticals Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
| ES2316964T3 (es) | 2003-02-24 | 2009-04-16 | Arena Pharmaceuticals, Inc. | Fenil-y piridilpipereidinia-derivados como moduladores del metabolismo de la glucosa. |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| US7132426B2 (en) | 2003-07-14 | 2006-11-07 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
| UA92150C2 (ru) | 2004-06-04 | 2010-10-11 | Арена Фармасьютикалз, Инк. | Замещенные производные арила и гетероарила как модуляторы метаболизма и для профилактики и лечения связанных с ним расстройств |
| DOP2006000008A (es) | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
| DE602007010420D1 (de) | 2006-04-11 | 2010-12-23 | Arena Pharm Inc | Verfahren zur verwendung des gpr119-rezeptors zur identifizierung von verbindungen zur erhöhung der knochenmasse bei einer person |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| WO2010059385A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidne derivatives useful as gdir agonists |
| WO2010059384A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives useful as gdir agonists |
| WO2010135506A1 (en) | 2009-05-20 | 2010-11-25 | Janssen Pharmaceutica Nv | Process for the preparation of 4- [6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino) -5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester |
| WO2010135505A2 (en) | 2009-05-20 | 2010-11-25 | Janssen Pharmaceutica Nv | Crystalline forms of 4-[6-(6-methanesulfonyl-2-methylpyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester |
| BR112017014341A2 (pt) * | 2015-01-09 | 2018-03-27 | Gilead Apollo, Llc | método e sistema para tratamento, estabilização, ou redução da gravidade ou progressão de uma doença de fígado gorduroso não alcoólica, e, composição. |
-
2018
- 2018-06-19 WO PCT/US2018/038319 patent/WO2018236896A1/en not_active Ceased
- 2018-06-19 US US16/624,198 patent/US20200129511A1/en not_active Abandoned
- 2018-06-19 MA MA049456A patent/MA49456A/fr unknown
- 2018-06-19 EP EP18740023.9A patent/EP3641887A1/en not_active Withdrawn
- 2018-06-19 JP JP2020519025A patent/JP2020524181A/ja not_active Withdrawn
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