JP2020523293A - Surface germicide with residual germicidal properties - Google Patents

Abstract

There is provided a fungicide formulation comprising poly(2-ethyl-2-oxazoline) and a quaternary ammonium compound or a combination of quaternary ammonium compounds. Wipes having residual bactericidal properties are also provided. Wipe formulations include substrates comprised of fibrous material and formulations present on or in the substrate. The formulation comprises poly(2-ethyl-2-oxazoline), a quaternary ammonium compound or a combination of quaternary ammonium compounds, a surfactant, water, and an optional perfume. [Selection diagram] None

Description

CROSS REFERENCE TO RELATED APPLICATIONS This application is a US Provisional Patent Application Serial No. No. 62/084917 filed on Mar. 2, 2015, US provisional patent application serial no. U.S. Provisional Patent Application Serial No. No. 62/127,075 filed on May 26, 2015. US Patent Application No. 14/948,962 filed November 23, 2015, claiming priority from 62/166403, US Partial Continuation Patent Application 15 filed May 23, 2016, claiming priority from US patent application 14/948,962 /162068 claiming priority from U.S. continuation application 15/625612 filed June 16, 2017, which is a continuation-in-part application claiming priority. The disclosures of which are incorporated herein by reference in their entireties.

FIELD OF THE INVENTION The present invention relates to the field of fungicide formulations, and more particularly to the field of fungicide formulations that impart residual bactericidal properties.

Microbes exist everywhere in the modern world. Some are beneficial to humans and the environment, while others can have significantly negative consequences for contaminated articles and the human, animal, and ecological elements that come in contact with them. There are numerous industries and environments in which such microorganisms are particularly widespread.

Health care

Nosocomial infections (HAIs; or "nosocomial infections") are infections whose spread is favored by the hospital or health care environment. Such diseases are fungal or bacterial infections and can afflict the victim locally or systemically. Nosocomial infections can cause severe pneumonia and infections of the urinary tract, blood, and other parts of the body.

Nosocomial infections have serious medical implications for patients and caregivers. In the United States, data show that approximately 1.7 million hospital-acquired infections occur each year, resulting in almost 100,000 deaths. European data and surveys indicate that infections by Gram-negative bacteria alone account for 8,000 to 10,000 people each year.

Several exacerbating factors contribute to the high HAI rate. Hospitals, first aid centers, nursing homes, and similar facilities are focused on treating people with serious illness and injury. As a result, these facilities accommodate an abnormally concentrated population of patients with a weakened immune system.

Three pathogens are commonly found in medical settings and are responsible for about one-third of nosocomial infections: coagulase-negative staphylococci (15%), Candida spp. (11%), and E. coli (10%).

To make matters worse, there are pathogenic bacteria that exist in these environments and cause stubborn disease. Six so-called “ESKAPE” pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannini, all of which are infectious, and Pseudomonas aeruginosa, and most of them are infected with Pseudomonas aeruginosa. Their resistance to one or more fungicides makes such infections particularly dangerous.

In particular, the wide nutritional diversity of Pseudomonas allows its survival in extreme environments, including survival on strongly uncleaned and unsterilized surfaces. The ubiquity of this pathogen in a hospital setting creates a major cause of nosocomial Gram-negative infections. Particularly vulnerable are patients with compromised immunity (eg, patients with cystic fibrosis, cancer, or burns).

The most common means of HAI is by direct or indirect contact transmission. Direct contact transmission involves patients who come into contact with either contaminated patients or workers. As caregivers move within the health care agency, they come in contact with many of their patients. These workers unintentionally "pollize" rooms and hospital rooms in a manner similar to garden bees when caring for residents.

Indirect contact transmission occurs when a patient contacts a contaminated object or surface. The healthcare environment provides an array of articles that can passively carry pathogens.

Nosocomial infections further severely impact the quantity, quality, and cost of health care provided by hospitals or other facilities. In addition to the roughly 100,000 HAI-related deaths occurring each year in the United States, an estimated more than 2 million casualties are associated with the physical and mental distress associated with these serious and avoidable illnesses. Forced to endure.

The facility is responding by creating policies that impose stricter clean and sanitize conditions on staff and patient environments. These programs typically include frequent handwashes and frequent surface disinfection. Despite the implementation of programs to control nosocomial infections, infections still occur at unacceptably high rates.

Home care and home

The home environment also faces microbes. The main drawback associated with disinfectants and fungicides for consumption is that they may be effective when they first kill the microorganisms, but they are easy due to surface contact, floating microorganisms, and residual microorganisms that have not been killed prior to treatment. And to be recontaminated quickly. Some of the disinfectant, if only left on the surface, remains somewhat under control, which results in a greasy or sticky residue that is easily overwhelmed by accidental contact with the surface. .. Therefore, there is a need for home care and household cleaners that, upon contact, quickly kill microbes and then act as a residual bactericide, but do not have this undesirable sticky or tacky effect. Such cleaners may be useful for general purpose household cleaning, bathroom cleaning, and spray protectants.

The difference between hospital and home care cleaners and household products is the acceptable VOC (volatile organic content). The regulation for household consuming disinfectants that do not use most CFCs is up to 1% VOC.

Provision of food and drink

The food service industry also faces epidemics of pathogen contamination in the workplace and the spread of disease to consumers. Even though food manufacturers have adopted robust sanitation plans and have followed strict governmental sanitary regulations, microbial pandemics are still sometimes reported to cause serious illness among consumers. Fungicides with residual activity should effectively alleviate the problem.

Bio film

A biofilm is generally defined as a layer of microorganisms attached to the surface of a structure, which can be organic or inorganic, which secretes a protective coating of biological origin. Biofilms pose a major problem to public health due to the increased resistance of biofilm-related organisms to antimicrobial agents and to the potential of biofilm-bearing organisms to cause infections. Therefore, there is a need for sterilization solutions for biofilms. Current biocides do not have the ability to kill biofilms or seal or immobilize biofilms on surfaces to prevent cross-contamination or growth. There are limited solutions for the surface biofilm problem. For example, there is evidence that surface biofilms pose problems with the health care set for the reasons mentioned above. In addition, biofilms are a recognized problem of possible contamination within the food industry. Other industries face similar problems. Therefore, there is a need for solutions directed to potential biofilm problem areas that can be used to eradicate biofilms.

In summary, there remains a need for formulations that can provide residual bactericidal activity to the treated surface. It would be further advantageous if the formulation was combined with a surface bactericide to allow one-time cleaning to sterilize and impart a residual bactericidal effect.

Further, it would be advantageous if the residual bactericidal activity was permanently associated with the treated surface and continued to provide microbial reduction for extended periods of time after application.

Furthermore, it would be advantageous if there were formulations that were effective over a wide range of industries and applications.

The present invention relates to fungicide formulations that impart residual bactericidal properties. The bactericide formulation comprises a polymeric binder and a bactericidal compound, the polymeric binder being an oxazoline homopolymer or an extended or modified polymer based on the oxazoline homopolymer. The fungicide formulation further comprises a carrier.

但し、Ｒ_１は、水素、アルキル、アルケニル、アルコキシ、アルキルアミノ、アルキニル、アリル、アミノ、アニリノ、アリール、ベンジル、カルボキシル、カルボキシアルキル、カルボキシアルケニル、シアノ、グリコシル、ハロ、ヒドロキシル、オキサゾリニウムメシレート、オキサゾリニウムトシレート、オキサゾリニウムトリフレート、シリルオキサゾリニウム、フェノール、ポリアルコキシ、４級アンモニウム、チオール、又はチオエーテル基であり、
Ｒ_２は、水素、アルキル、アルケニル、アルコキシ、アルキルアミノ、アルキニル、アリル、アミノ、アニリノ、アリール、ベンジル、カルボキシル、カルボキシアルキル、カルボキシアルケニル、シアノ、グリコシル、ハロ、ヒドロキシル、オキサゾリニウムメシレート、オキサゾリニウムトシレート、オキサゾリニウムトリフレート、シリルオキサゾリニウム、フェノール、ポリアルコキシ、４級アンモニウム、チオール、又はチオエーテル基又は大環状構造であり、
Ｒ_３は、水素、アルキル、アルケニル、アルコキシ、アリール、ベンジル、ヒドロキシアルキル、又はパーフルオロアルキル基であり、
ｎは、１〜１００００００の範囲である。 In one aspect of the invention, the oxazoline homopolymer has the structure:

However, R ₁ is hydrogen, alkyl, alkenyl, alkoxy, alkylamino, alkynyl, allyl, amino, anilino, aryl, benzyl, carboxyl, carboxyalkyl, carboxyalkenyl, cyano, glycosyl, halo, hydroxyl, oxazolinium mesylate. , Oxazolinium tosylate, oxazolinium triflate, silyloxazolinium, phenol, polyalkoxy, quaternary ammonium, thiol, or thioether group,
R ₂ is hydrogen, alkyl, alkenyl, alkoxy, alkylamino, alkynyl, allyl, amino, anilino, aryl, benzyl, carboxyl, carboxyalkyl, carboxyalkenyl, cyano, glycosyl, halo, hydroxyl, oxazolinium mesylate, oxa Zolinium tosylate, oxazolinium triflate, silyloxazolinium, phenol, polyalkoxy, quaternary ammonium, thiol, or thioether group or a macrocyclic structure,
R ₃ is hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxyalkyl, or perfluoroalkyl group,
n is in the range of 1 to 1,000,000.

In another aspect of the invention, other features of the germicide formulation are provided.

In yet another aspect of the invention, an article having a fungicide formulation of the invention is provided, along with a method of making, using and applying a fungicide formulation.

Further areas of applicability of the present invention will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating preferred embodiments of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.

The following description of embodiments of the invention is merely exemplary in nature and is not intended to limit the invention, its application, or uses in any manner. The present invention has broad potential application and utility, which is believed to be adaptable across a wide range of industries. The following description is given herein by way of example only for the purpose of providing a feasible disclosure of the present invention, and does not limit the scope or substance of the present invention.

As used herein, fungus ("microbe" or "microbial") is taken to indicate any of the microorganisms studied by microbiologists or found in the environment of use of the treated article. Should be. Such microorganisms include, but are not limited to, bacteria and fungi, and other unicellular organisms such as molds, powdery mildews and algae. Viral particles and other infectious agents are also included in the term "microorganism".

It is to be understood that "antimicrobial" further includes both microbicidal and bacteriostatic properties. That is, the term embraces microbial killing leading to the loss of a large number of microorganisms, as well as the retarding effect of microbial growth (keeping the numbers more or less constant (still allowing a slight increase/decrease)).

For ease of explanation, this specification uses the term antimicrobial to indicate broad spectrum activity (eg, against bacteria and fungi). A more focused term will be used when talking about efficacy against a particular microbial or biological class (eg, "antifungal" to indicate efficacy against fungal growth in particular).

It should be understood that using the above examples, efficacy against fungi never excludes the possibility that the same antimicrobial composition may be effective against different types of microorganisms.

For example, a description of the strong bacterial efficacy exhibited by a disclosed embodiment should not be read as excluding that embodiment from exhibiting antifungal activity. This method of presentation should not be construed as limiting the scope of the invention in any way.

Fungicide formulation

The present invention is directed to fungicide formulations. In one aspect of the invention, the germicide formulation is in liquid form. The composition of the germicide formulation comprises a germicidal compound and a polymeric binder. The composition may further comprise, among other ingredients, solvents (eg water or low molecular weight alcohols), surfactants, colorants, fragrances, among others.

The liquid composition is formulated with surface and residual bactericidal properties. The formulation can be applied to the surface by spraying, rolling, fogging, wiping, or other means. The formulation acts as a surface germicide that kills infectious microorganisms present on the surface.

Once dried, the liquid formulation leaves a residual protective film on the surface. The residual film has bactericidal properties, which allows it to maintain its surface protection against microbial contamination for a long time after its application.

In a preferred embodiment, the surface germicide formulation imparts to the film the ability to rapidly kill bacteria and other microorganisms for at least 24 hours after depositing the film on the treated surface. In one aspect of the invention, rapid killing generally refers to a time period of about 30 seconds to about 5 minutes. The thin film will remain on the surface and will be resistant to multiple contacts and abrasions of the surface.

In another embodiment of the invention, the germicide formulation is a liquid composition that includes a polymeric binder, a germicidal compound, a carrier such as a solvent, and other optional ingredients such as perfumes.

Biofilm sealant

In one embodiment of the invention, the germicide formulation is a biofilm sealant. The biofilm sealant forms a polymer film once applied to the surface. The polymer film is applied wet and dried as a film layer to anchor biofilm microorganisms and prevent subsequent growth. The biofilm sealant is preferably in liquid form, but can take other forms such as gels. Once the biofilm sealant is in place, the biofilm microorganisms have limited access to oxygen and external nutrients. Biofilm sealants have the ability to seal bacteria, but also to kill microbes in biofilms by increasing the release of antimicrobial agents into the biofilm.

In one embodiment of the invention, the biofilm sealant comprises a polymeric binder and a germicidal compound. The bactericidal compound can include, but is not limited to, any of the bactericidal compounds described herein.

In one embodiment of the invention, the biofilm sealant comprises an oxazoline homopolymer as the polymeric binder. The oxazoline homopolymer can have any of the structures described herein.

In one embodiment of the invention, the biofilm sealant comprises a polymeric binder, a germicidal compound, and an enzyme. Enzymes help break down biofilms, enhance antimicrobial penetration by bactericides, and ultimately remove biofilms. Examples of enzymes include, but are not limited to, proteinases, DNases, RNases, and enzymes specific for carbohydrates that can degrade the extracellular matrix associated with biofilms.

In one embodiment of the invention, the biofilm sealant comprises a polymeric binder and an antibody as the biological material for slow release into the film. The antibody functionality will bind to biofilm microorganisms and prevent cross-contamination.

In one embodiment of the invention, the biofilm sealant comprises a polymeric binder and a bacteriophage or mixture of bacteriophages as biological material for slow release into the film. Bacteriophages act as antimicrobial agents for the purpose of killing biofilm-related organisms.

In one embodiment of the invention, the biofilm sealant comprises a polymer binder and a mixture of bacteriophage, antibacterial agents, enzymes and antibodies as biological material for slow release into the film.

Polymer binder

但し、Ｒ_１及びＲ_２は、オキサゾリンホモポリマーを合成するために使用される重合技術によって決定される末端基である。Ｒ_１及びＲ_２は、独立して選択され、水素、アルキル、アルケニル、アルコキシ、アルキルアミノ、アルキニル、アリル、アミノ、アニリノ、アリール、ベンジル、カルボキシル、カルボキシアルキル、カルボキシアルケニル、シアノ、グリコシル、ハロ、ヒドロキシル、オキサゾリニウムメシレート、オキサゾリニウムトシレート、オキサゾリニウムトリフレート、シリルオキサゾリニウム、フェノール、ポリアルコキシ、４級アンモニウム、チオール、又はチオエーテル基を含むが、これらに限定されない。あるいは、Ｒ_２は、分子内攻撃の結果として合成時に形成された大環状構造を含むことができる。 In one aspect of the invention, the polymeric binder is an oxazoline homopolymer. In another aspect of the invention, the oxazoline homopolymer has the structure:

However, R ₁ and R ₂ are end groups determined by the polymerization technique used to synthesize the oxazoline homopolymer. R ₁ and R ₂ are independently selected and are hydrogen, alkyl, alkenyl, alkoxy, alkylamino, alkynyl, allyl, amino, anilino, aryl, benzyl, carboxyl, carboxyalkyl, carboxyalkenyl, cyano, glycosyl, halo, It includes but is not limited to hydroxyl, oxazolinium mesylate, oxazolinium tosylate, oxazolinium triflate, silyl oxazolinium, phenol, polyalkoxy, quaternary ammonium, thiol, or thioether groups. Alternatively, R ₂ can include macrocycles formed synthetically as a result of intramolecular attack.

For example, R ₁ is a methyl group and R ₂ is oxazolinium tosylate if methyl tosylate is used as an initiator in the cationically initiated polymerization of oxazoline.

R ₃ is an end group determined by the type of oxazoline used to make the polymeric binder of the present invention. R ₃ includes, but is not limited to, hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxyalkyl, or perfluoroalkyl. For example, R ₃ is an ethyl group if ethyloxazoline is the monomer used to prepare the polymeric binder for the present invention.

n is the degree of polymerization of oxazoline in the homopolymer. n is in the range of 1 to 1,000,000. Preferably, n is in the range 500-250,000. Most preferably n is in the range 2500-100,000.

但し、Ｒ_１及びＲ_３は、上記オキサゾリンホモポリマーで与えたものと同じ定義を有する。 As with oxazoline homopolymers, extended or modified polymers with some modifications based on oxazoline homopolymers are also suitable for the present invention. One of skill in the art would be familiar with techniques and options for performing chemical or molecular structural changes or modifications to oxazolines. A class of extended or modified polymers based on oxazoline homopolymers can be represented by the following molecular structure:

Provided that R ₁ and R ₃ have the same definition as given for the oxazoline homopolymer.

B is an additional monomer repeat unit attached to the oxazoline in the copolymer. The type of arrangement of repeating units between the oxazoline and B in the copolymer can include, but is not limited to, block, alternating, periodic, or a combination thereof. There is no limitation as to the type of B that can be used to copolymerize with or modify the oxazolines of the present invention.

n is the degree of polymerisation for the oxazoline repeat unit; n in the copolymer is in the range 1-1,000,000 and the degree of polymerisation m for the B repeat unit in the copolymer is simultaneously in the range 0-500000. Preferably, n is in the range 500 to 250,000, m is in the range 20 to 10000, most preferably n is in the range 2500 to 100000 and m is in the range 50 to 5000. .. In addition to linking B to ethyloxazoline by copolymerization, B also binds to oxazoline as a terminal group in cationic polymerization by using B as a cationic initiator if B itself is already a quaternary ammonium compound. Can be done.

但し、Ｒ_１及びＲ_２末端基は、オキサゾリンホモポリマーについて説明したものと同じ定義を持つ。 Although not intended to be all inclusive, B can be, for example, ethyleneimine having the following molecular structure:

However, the R ₁ and R ₂ terminal groups have the same definition as described for the oxazoline homopolymer.

R ₃ includes, but is not limited to, hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxyalkyl, or perfluoroalkyl.

R ₄ includes, but is not limited to, hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxyalkyl, or perfluoroalkyl.

m is in the range of 0 to 500,000, preferably in the range of 20 to 10,000, and most preferably in the range of 50 to 5,000.

n is in the range of 0 to 1,000,000, preferably in the range of 500 to 250,000, and most preferably in the range of 2500 to 100,000.

The synthesis of a copolymer of oxazoline and ethyleneimine can be carried out stepwise, for example in two steps. In the first step, cationic ring-opening polymerization techniques can be used to make polyoxazoline homopolymers. In the second step, the polyoxazoline produced in the first step can be hydrolyzed to convert some of the polyoxazoline repeat units to polyethyleneimine. Alternatively, the oxazoline-ethyleneimine copolymer can be made with each suitable monomer, oxazoline and aziridine. The result would be a cationic polymer with the above structure.

The degree of polymerization n for the oxazoline repeating units in the copolymer is in the range of 1 to 1,000,000, and the degree of polymerization m for the ethyleneimine repeating units in the copolymer is in the range of 0 to 500,000 at the same time. Preferably, n is in the range 500 to 250,000, m is in the range 20 to 10000, most preferably n is in the range 2500 to 100000 and m is in the range 50 to 5000. ..

Alternatively, the nitrogen in the ethyleneimine repeat unit can be further quaternized to produce the following cationic copolymer:

Any quaternization technique familiar to those skilled in the art can be used to quaternize the polymer of this example. R ₁ , R ₂ , R ₃ and R ₄ have the same meanings as given above for the oxazoline-ethyleneimine copolymer. R ₅ includes, but is not limited to, hydrogen, methyl, ethyl, propyl, or other types of alkyl groups. The corresponding anion X ⁻ is halogen, sulfonate, sulfate, phosphonate, phosphate, carbonate/bicarbonate, hydroxy, or carboxylate.

The ranges for n and m are also the same as described for the oxazoline-ethyleneimine copolymer.

但し、Ｒ_１及びＲ_４は、４級化されたオキサゾリン−エチレンイミンコポリマーについての前の例に記載されたものと同じ意味を有する。 Another example of B that can be used for the present invention is polydiallyldimethylammonium chloride. Polyethyloxazoline modified with polydiallyldimethylammonium chloride has the following structure:

However, R ₁ and R ₄ have the same meaning as described in the previous example for the quaternized oxazoline-ethyleneimine copolymer.

R ₂ and R ₃ independently include, but are not limited to, short chain alkyl groups such as C ₁ -C ₆ . The corresponding anion X ⁻ is halogen, sulfonate, sulfate, phosphonate, phosphate, carbonate/bicarbonate, hydroxy, or carboxylate.

n and m are defined and numerically determined as in the previous example.

B can be other olefins, including but not limited to diallyldimethylammonium chloride, styrene, methoxystyrene, and methoxyethene. Ethyloxazoline can also be copolymerized with heterocyclic monomers such as oxirane, thietane, 1,3-dioxepane, oxetane-2-one, and tetrahydrofuran to enhance the performance of polymers for the present invention. The binder used in the present invention can also use pendant oxazoline groups on the polymer backbone, such as acrylic or styrene based polymers, or copolymers containing acrylic or styrene.

An example of a commercially available polyethyloxazoline includes, but is not limited to, Aquazol 500 from Polymer Chemistry Innovations, Inc.

The amount of polymeric binder that can be used in the liquid formulation can vary somewhat depending on the desired length of residual activity of the composition and the nature of all other ingredients in the composition. .. Preferably, the amount of polymeric binder in the liquid formulation ranges from 0.1% to 20% based on the weight of the liquid formulation. In liquid formulations for health care applications, the amount of polymeric binder in the liquid formulation is more preferably in the range 0.5% to 10%, most preferably in the range 0.8% to 5%. is there. In liquid formulations for all purposes and bathroom cleaning agents, the amount of polymeric binder in the liquid formulation more preferably ranges from 0.1% to 10%, most preferably 0.1% to 5%. % Range.

The polymeric binder is preferably water soluble and can be easily removed from the surface if aggregation is noticed. When present in small amounts, it can nevertheless provide a durable bond between the germicidal compound and the treated surface to promote residual effects.

Bactericidal compound

但し、Ｒ_１，Ｒ_２，Ｒ_３及びＲ_４は、独立してアルキル、アルコキシ、又はアリールから選択されるが、これらに限定されず、ヘテロ原子を有していても有さなくてもよく、また置換されても置換されなくてもよい。官能基の一部又は全ては、同じであることができる。 The bactericidal compound can be a quaternary ammonium compound (QAC) having the following molecular structure:

However, R ₁ , R ₂ , R ₃ and R ₄ are independently selected from alkyl, alkoxy, or aryl, but are not limited thereto, and may or may not have a hetero atom. , And may or may not be substituted. Some or all of the functional groups can be the same.

Corresponding anion X ^- is a halogen, sulfonate, sulfate, phosphonate, phosphate, carbonate / bicarbonate, hydroxy, or including carboxylates, and the like.

QACs include n-alkyldimethylbenzylammonium chloride, di-n-octyldimethylammonium chloride, dodecyldimethylammonium chloride, n-alkyldimethylbenzylammonium saccharinate, and 3-(trimethoxysilyl)propyldimethyloctadecylammonium chloride. However, it is not limited to these.

A combination of monomeric QACs is preferably used for the present invention. Specific examples of QAC combinations are N-alkyldimethylbenzylammonium chloride (40%); N-octyldecyldimethylammonium chloride (30%); di-n-decyldimethylammonium chloride (15%); and di-n. -Dioctyldimethylammonium chloride (15%). Percentage percentages are the weight percentages of individual QACs based on the total weight of the blended QAC composition.

但し、Ｒ_１，Ｒ_２，Ｒ_５及びＲ_６は、独立して水素、メチル、エチル、プロピル、又は他のより長い炭素アルキル基を含むが、これらに限定されない。 Polymeric forms of QAC having the following structure can also be used for the present invention.

However, R ₁ , R ₂ , R ₅ and R ₆ independently include, but are not limited to, hydrogen, methyl, ethyl, propyl, or other longer carbon alkyl groups.

R ₃ and R ₄ are independently selected from, including, but not limited to, methylene, ethylene, propylene, or other longer alkylene linking groups.

n is the degree of polymerization, and n is an integer in the range of 2 to 10,000.

Examples of cationic polymers having the above structure include, but are not limited to, polyamines derived from dimethylamine and epichlorohydrin (eg, Superfloc C-572, commercially available from Kemira Chemicals).

Yet another polymeric QAC suitable for the present invention is polydiallyldimethylammonium chloride or polyDADMAC.

Yet another class of QACs useful for the present invention are chemical compounds having a biguanide moiety in the molecule. Examples of this type of cationic antimicrobial agent include, but are not limited to, PHMB and chlorhexidine.

Examples of commercially available quaternary ammonium compounds include, but are not limited to, Bardac 205M and 208M from Lonza, and BTC885 from Stepan Company.

The germicidal compound can be a weak acid, which has been shown to be particularly effective in bath cleaning agents. In these types of products, citric acid, sulfamic acid (also known as amidosulfonic acid, amidosulfuric acid, aminosulfonic acid, and sulfamic acid), glycolic acid, lactic acid, lauric acid, and capric acid are effective. It is useful both as a general fungicide and as a cleaner for bath stains and hard water deposits.

Another compound that may be useful is a silane quaternary salt such as 3(trihydroxysilyl)propyldimethyloctadecyl ammonium chloride. These can have the added benefit of reacting to the surface being treated for enhanced residual properties.

Additional bactericidal compounds suitable for use in the liquid formulations of the present invention cover a wide range of antibacterial, biocide, bactericidal, and antiseptic agents. Water-soluble or water-dispersible germicidal compounds are preferred, but alcohol-soluble germicides can alternatively be used.

A non-exhaustive list of suitable fungicidal compounds for use in the formulations of the present invention is triclosan, zinc pyrithione, metal salts and oxides, phenols, botanicals, halogens, peroxides, heterocyclic antimicrobial agents. , Aldehydes, and alcohols.

The concentration of the bactericidal compound in the formulation can range from 0.05% to 20%, based on the weight of the liquid composition. For liquid formulations for health care applications, it is preferably in the range 0.1% to 20%, more preferably 0.5% to 3%. For liquid formulations for all purposes and bath cleaning agents, it is preferably in the range of 0.05% to 10%. For formulations for protectants, it is preferably in the range 0.05% to 2%.

Career

The carrier or solvent for the liquid formulations of the present invention can be any solvent that is volatile, allowing easy evaporation at ambient conditions. Examples of liquid carriers include, but are not limited to, water and low molecular weight alcohols (eg C1-C8 alkanols). Specific examples include, but are not limited to, ethanol, isopropyl alcohol, butanol, pentanol, and combinations thereof.

Another type of solvent for use in the present invention comprises alkylene glycol ethers. Examples include ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monohexyl ether, ethylene glycol monohexyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monohexyl ether, triethylene glycol monomethyl ether. , Triethylene glycol monoethyl ether, triethylene glycol monobutyl ether, propylene glycol methyl ether, propylene glycol methyl ether acetate, propylene glycol n-butyl ether, dipropylene glycol n-butyl ether, dipropylene glycol methyl ether, dipropylene glycol methyl ether acetate , Propylene glycol n-propyl ether, dipropylene glycol n-propyl ether, and tripropylene glycol methyl ether, but are not limited thereto.

Another class of solvents for use in the present invention is based on terpenes and their derivatives such as terpene alcohols, terpene esters, terpene ethers or terpene aldehydes. Examples of solvents include, but are not limited to, pine leaf oil, lemon oil, limonene, pinene, cymene, myrcene, fencon, borneol, nopol, cineol, ionone and the like.

The preferred carrier in liquid formulations for home care cleaning applications is water.

If the method of applying the liquid formulations of the present invention is a pressurized aerosol, propellants may be required in the composition. Various propellants or mixtures can be used for the present invention and should be familiar to those skilled in the art. C1-C10 hydrocarbons or halogenated hydrocarbons are typical propellants in aerosol compositions known in the industry. Examples of such propellants include, but are not limited to, pentane, butane, propane, and methane. Other types of propellants that can be used for the present invention also include pressurized air, nitrogen, or carbon dioxide. Alternatively, a bag on the valve package can be used to aerosolize the product instead of adding the propellant gas directly to the composition.

Either a single solvent or a mixture of the above solvents can be used for the present invention. The type of solvent used for the present invention may depend on the intended use of the residual germicide composition. For example, if the compositions of the present invention are intended for home care applications, cleaning contaminated surfaces free of any type of dust or dirt can be a major concern. Liquid carriers or media that assist in and enhance soil removal can be included in the formulations of the invention. For example, it may be desirable for the residual fungicide formulation or composition of the present invention to include an alkyl or multi-alkyl glycol ether for good cleaning performance in home care versions of the formulation of the present invention. On the other hand, if the primary purpose of the residual fungicide composition is to be used in health care facilities where the main concern is nosocomial infections, then quick drying of the liquid composition of the present invention results in surface dust. Or it may be more desirable than cleaning dirt. Low molecular weight alcohols should be considered to help dry the liquid formulations of the present invention quickly after application. Also, low molecular weight alcohols in the liquid formulation will enhance the bactericidal activity of the liquid composition.

For health care applications of residual fungicides, mixtures of water and low molecular weight alcohols are preferred. The amount of alcohol present in the liquid formulation is preferably such that the liquid formulation is capable of forming a non-azeotrope between the alcohol and water. The minimum amount of alcohol (if present) in the liquid composition is 10%. Preferably, for health care applications of residual fungicides, the alcohol concentration is 30%, most preferably the alcohol concentration is based on the weight of the liquid composition for health care applications of the compositions of the present invention. It is at least 50%.

Surfactant

Surfactants or wetting agents can be used. Surfactants help to disperse and uniformly coat the liquid formulation on the treated surface. Surfactants further contribute to the formation of a non-azeotrope between alcohol and water, thus facilitating rapid and uniform drying of the liquid formulation once applied onto the surface. Surfactants also play an important role in the residual disinfectant liquid formulations of the present invention for home care applications if soil remediation performance is an important feature that the product is designed to have.

Suitable surfactants for the liquid formulations of the present invention include, but are not limited to, nonionic, anionic, or amphoteric in nature. Commercially available humectants include, but are not limited to, Ecosurf SA-4 or Tergitol TMN-3 from Dow Chemical, and Q2-5211 from Dow Corning.

Amine oxide surfactants are especially preferred when QACs are used as germicidal compounds in formulations.

In the nonionic surfactant category, different amounts of ethylene oxide or ethoxylated alcohols with HLB values can be used. Examples of ethoxylated alcohols are Triton X-100 (Dow Chemical, Midland MI), Ecosurf EH nonionic surfactant series from Dow Chemical, Tergitol nonionic surfactant series from Dow Chemical, Huntsman Corp. From Sulfone Surfactant Series, Neodol Surfactant Series from Shell, Ethox Surfactant Series from Ethox Chemicals, and Air Products and Chemicals, Inc. From Tomadol surfactant series, including but not limited to:

Another class of nonionic surfactant comprises alkyl polyglucosides. Examples include the Glucopon series from BASF and the Ecoteric series from Huntsman.

An alternative class of preferred surfactants for liquid formulations are silane-based surfactants. Examples include, but are not limited to, silicone polyether organofunctional or reactive silane wetting agents, and fluorochemical based wetting agents.

The content of surfactant in the liquid formulation is in the range 0% to 10%, preferably 0.01% to 5%.

Depending on the targeted application, liquid formulations of the present invention for home care applications may require suitable pH conditions. For example, if a liquid product is used in the kitchen area, a high pH product may be desirable to effectively remove the grease oil commonly found in that area. If the product is used in the bathroom area, bath dirt and hard water deposits may be a major concern. In such cases, low pH products may be more suitable for such purposes. There is no limitation as to the type of pH adjusting agent that can be added in the liquid composition of the present invention. Examples of pH adjusters that can be used are triethanolamine, diethanolamine, monoethanolamine, sodium hydroxide, sodium carbonate, potassium hydroxide, potassium carbonate, calcium carbonate, citric acid, acetic acid, hydrochloric acid, sulfamine. Including but not limited to acids, sulfuric acid, and the like.

Additional functional ingredients other than those mentioned above may be included in the liquid composition of the present invention. Additional ingredients include chelating agents, compatibilizers, coupling agents, anticorrosion agents, rheology modifiers, fragrances, colorants, preservatives, UV stabilizers, optical brighteners, and active ingredient indicators. Not limited to.

In an embodiment of the invention, the liquid solution comprises a polymeric binder, a quaternary ammonium compound, a silicone-based surfactant, and ethanol. Liquid formulations can be made or mixed by any conventional method known to those of ordinary skill in the art. As long as the formulation is ultimately homogeneous, compatible and stable, there is no preferred method of addition for the formulation of the present invention. For example, if the polymeric binder is a solid, it is preferred to first dissolve or disperse the polymer in a carrier such as water or alcohol to make a storage polymeric binder liquid dispersion. The storage polymer binder liquid dispersion can be easily added into the formulations of the present invention during the mixing procedure.

Application of liquid formulation

Liquid formulations can be applied by various means. If sprayed, the liquid formulation may advantageously be supplied in a conventional bottle with a sprayer. The sprayer can be a trigger sprayer. Aerosols can also be used to deliver the liquid formulation onto a surface as an option for a trigger sprayer. Additional application means include, but are not limited to, fogging, rolling, brushing, mopping, and the use of wipes with various application devices. It is within the scope of this invention that it is also possible to make wipe products which are pre-treated with or with the fungicide formulation of the invention, for example for off-the-shelf sails or applications.

Embodiments of the present invention provide wipes having residual sanitization activity up to 24 hours. Wipes can protect hard surfaces from microbial growth without leaving significant residues or accumulations and can provide protection against bacteria.

In an embodiment of the invention, the wipe consists of a substrate and a formulation applied to or present in the substrate of the wipe.

The wipe formulation provides a solid transparent film that is sufficiently water soluble to be easily removed with additional cleaning, yet durable enough to remain on the surface even after contact. ..

The substrate may be any fibrous material capable of absorbing and/or adsorbing water, preferably at least 3 times its weight in water. The substrate comprises synthetic material, natural material, or a combination thereof. Examples of synthetic materials include, but are not limited to, polypropylene, polystyrene, polyester, nylon, rayon, acrylic, spandex, and combinations thereof. Examples of natural materials include, but are not limited to, cotton, linen, silk, wool, hemp, flax, and combinations thereof.

The substrate can be woven or non-woven. The non-woven substrate can be made by any manufacturing method. The resulting non-woven substrate can be, but is not limited to, meltblown, conform, spunbond, air lay, hydroentangle, spunlace, bond, card, laminate, or combinations thereof. For example, the substrate can include a meltblown polymeric material.

In an embodiment of the invention, the wipe formulation comprises a germicidal compound, a polymeric binder, and a lubricant/surfactant.

For substrates containing natural materials, the wipe formulation can include a cation containing compound designed to compete with the quaternary ammonium compound for sites of anionic species on the substrate. Salts with high ionic strength can also be used. Examples of salts for use in wipe formulations include, but are not limited to, potassium citrate, sodium citrate, magnesium sulfate, sodium chloride, ammonium chloride, potassium chloride, and combinations thereof.

The wipe formulation provides initial disinfection, which then leaves a residual protective film on the surface once dried. The film has bactericidal properties with the ability to kill bacteria, for example up to 24 hours after initial application within a contact time of 5 minutes.

In a preferred embodiment, the wipe formulation comprises poly(2-ethyl-2-oxazoline), a quaternary ammonium compound or a combination of quaternary ammonium compounds, alcohol ethoxylates, water, and optional perfume.

Quaternary ammonium compounds (QACs) are particularly suitable for this wipe application. Because they provide protection against a wide range of microorganisms. Examples of such compounds are commercially available from Stepan Chemical under the trade name BTC885. BTC885 contains 50% of the blend of quaternary ammonium compounds. Similar materials are also commercially available from Lonza under the trade name Bardac 205M.

Preferably, the quaternary ammonium compound and binder are in a ratio of 1:4 to 1:1 quaternary ammonium compound to binder.

Preferably, the wipe formulation comprises poly(2-ethyl-2-oxazoline) in an amount of 1-5% by weight, the weight% being based on the total weight of the wipe formulation.

Preferably, the wipe formulation comprises the quaternary ammonium compound in an amount of at least 0.2% by weight, preferably 0.2-2% by weight, the weight% being based on the total weight of the wipe formulation.

Preferably, the wipe formulation comprises a nonionic surfactant.

In an embodiment of the invention, the nonionic surfactant is an alcohol ethoxylate. Preferably, the wipe formulation comprises alcohol ethoxylates in an amount of 0.05 to 0.5% by weight, the weight% being based on the total weight of the wipe formulation. Preferred alcohol ethoxylates are linear alcohol ethoxylates having at least 9 moles ethylene oxide, more preferably at least 12 moles ethylene oxide. Alcohol ethoxylates such as this group surprisingly and preferably, when used in the formulations of the present invention, dry hard clear films (as opposed to tacky and hazy films). It was unexpected to maintain sufficient water solubility to allow release of the quaternary ammonium compound due to its bactericidal effect, while contributing to the aesthetics of the resulting film.

Weak acids, including but not limited to citric acid, lactic acid, sulfamic acid, glycolic acid, or combinations thereof, may be added to the formulation to increase efficacy against Gram-negative bacteria and help remove scale or soap residue. it can.

Ethylenediaminetetraacetic acid disodium salt or EDTA disodium salt can be added to the formulation to enhance antimicrobial efficacy in the presence of hard water.

The wipe formulation optionally includes a fragrance. If a fragrance is present, the wipe formulation preferably comprises the fragrance in an amount of 0 to 0.5% by weight, said weight% being based on the total weight of the wipe formulation.

Water is a suitable carrier for inert and active materials. A solvent such as ethanol or isopropanol is optionally added to reduce the drying time.

The wipe formulations of the present invention are effective for the purposes described above without requiring the presence of other ingredients in the formulation, although other ingredients may be present. For example, the wipe formulations of the present invention are effective against their residual bactericidal activity without hydrogen peroxide as a component of the formulation.

To disinfect the contaminated surface, spray the liquid formulation until the area is completely covered. The wet formulation may subsequently be wiped dry with a dry cloth or paper towel.

The invention also relates to articles treated with the fungicide formulation according to aspects of the invention.

The following example illustrates liquid formulations made in accordance with aspects of the invention. The test results for these formulations show desirable residual disinfecting or sterilizing performance once applied on the surface and dried. Clarifying performance is also tested for those formulations that provide not only residual bactericidal efficacy but also cleaning characteristics.

The formulations were tested for residual effect using the EPA01-1A protocol. Briefly, bacteria were added to glass slides and allowed to dry on the surface. The formulation was then sprayed onto the surface and dried to form a clear film. Once the film was formed, the glass slides were subjected to alternating wet and dry cycles using the Gardner abrasion tester described in the protocol. Between each cycle, slides were re-inoculated with bacteria. After an appropriate number of abrasions and revaccinations (48 abrasions and 11 revaccinations for health care formulations, 24 abrasions and 5 revaccinations for home care formulations) Slides were exposed to bacteria for the indicated time frame (ie 5 minutes) and then harvested in an appropriate neutralization solution.

In addition to the residual effect, the initial effect of the composition of the invention was also tested according to ASTM E 1153.

A modified ASTM D4488 was used to evaluate hard surface cleaning performance for home care compositions of the present invention. The stains of the following compositions were used for evaluation.

About 2 grams of liquid soil was placed on the aluminum foil in the process of making soiled ceramic tiles for cleaning tests. Rolls were used to roll and spread the stains on the foil, and the rollers picked up as much stain as possible. The dirt on the rollers was transferred evenly to the glass side of the ceramic tile by rolling the dirty roller over the ceramic surface. The soiled ceramic tile was then baked for 45 minutes in an oven set at 180°C. The baked tiles were conditioned at room temperature for 24 hours before being used for cleaning tests.

A Gardner abrasion tester was used in the cleaning test. An approximately 1 cm wide polishing pad was attached to the abrasion boat for abrasion. About 4 grams of test formulation was placed on a weighing boat. The attached polishing pad was dipped into a weighing boat to pick up the test formulation.

The cleaning process was started immediately after the pad was wetted with the cleaning formulation. Seven wear cycles (reciprocating) were used in the test.

Examples of residual fungicides for health care

The following formulations in the examples use alcohol as the primary carrier to give the liquid formulations fast drying properties.

Residual effect testing was performed using the EP01-1A protocol and the results are listed in the table below.

These formulations show excellent residual effect results based on the EP01-1A test.

The initial bactericidal properties of HE2 were also evaluated according to the ASTM E 1153 test protocol. These results are given in the table below.

These data clearly demonstrate that sample surfaces treated with the exemplary liquid formulations disclosed herein have demonstrable bactericidal activity in the time frames indicated.

Examples of residual disinfectant cleaners for home care

These compositions are formulated using water as a carrier. They are intended for home care applications, where VOC regulations prohibit high levels of heavy use of organic solvents such as alcohols.

Residual effects of these formulations were evaluated using the EP01-1A protocol and the results are listed in the table below.

Enterobacter aerogenes is the bacterium for the test of H1 and Staphylococcus aureus is the bacterium used for the rest of the formulation.

The test results show that all of H1-H5 give a residual effect on the treated surface. Purification performance was also evaluated using the modified ASTM D4488 test method.

The test results also clearly showed visually that the formulations of the invention not only provided a residual effect on bacteria, but also provided good cleaning performance on soiled surfaces.

The additional formulations described in the table below were tested for home care and home cleaning applications. To dissolve the perfume, a premix was made containing the perfume, the quaternary ammonium compound, the surfactant, and the glycol ether (if present).

Water-based formulation concentrates are made by removing some of the water from the formulation and concentrating the remaining raw materials. The concentrate obtained can then be diluted back to the working concentration before use. 5x and 10x concentrates are commonly used in the customer cleaning and hygiene industry in the hospitality area. Concentrates can be made at levels 15 times, 20 times, or higher, if desired, and can be within the scope of the invention. Concentrates are desired in these industries. Because it reduces transportation costs and saves storage space. Table 10 shows an exemplary concentrate formulation in one embodiment of the invention.

Comparative Example 1

A number of polymeric compounds have been used for their ability to provide sustained biofouling reduction using the EPA 01-1A protocol for Enterobacter aerogenes. Fifty microliters of each formulation was dried on a glass carrier prior to testing. Each test was conducted in the presence of 5% FBS. As shown in Table 11, the combination of polyoxazoline and quaternary ammonium compound provided a synergistic residual hygiene effect.

Example-Wipe Formulation Wipe formulations AI were made and tested on various substrates.

In testing Formulations AF, 8 grams of formulation was added to a 7 inch by 8 inch size substrate consisting of 100% PP at a rate of 34 grams per square meter substrate. The substrate obtained from Rockline Industries was a meltblown product of Kimberly Clark. The results are shown in Table 12 below.

＊Ｃｌｏｒｏｘ法０１−１Ａ結果−この方法は、基体を長さ方向に１回折りたたみ、次いで折りたたまれた基体ストリップを、中指、薬指、小指を横切って巻き付けることによってワイプに適応された。一回の通過は、ガラスキャリアを横切ってなされた。合格と考えられるためには、３．０より大きいｌｏｇ減少が要求された。

* Clorox Method 01-1A Results-This method was applied to a wipe by folding the substrate one lengthwise and then wrapping the folded substrate strip around the middle, ring, and little fingers. One pass was made across the glass carrier. A log reduction of greater than 3.0 was required to be considered a pass.

In each of the tests for Formulations G and H, 11 grams of the formulation was added to a 7″×8″ size substrate made of 100% polyester from US Nonwovens (Item # XNW-8045). The results are shown in Table 13 below.

＊Ｃｌｏｒｏｘ法０１−１Ａ結果−この方法は、基体を長さ方向に１回折りたたみ、次いで折りたたまれた基体ストリップを、中指、薬指、小指を横切って巻き付けることによってワイプに適応された。一回の通過は、ガラスキャリアを横切ってなされた。合格と考えられるためには、３．０より大きいｌｏｇ減少が要求された。

* Clorox Method 01-1A Results-This method was applied to a wipe by folding the substrate one lengthwise and then wrapping the folded substrate strip around the middle, ring, and little fingers. One pass was made across the glass carrier. A log reduction of greater than 3.0 was required to be considered a pass.

In the test for Formulation I, 8 grams of the formulation was added to a 7 inch by 8 inch size substrate of 100% polypropylene (PP) at a rate of 35 grams per square meter substrate. The substrate was from Diamond wipes (item name #P50535). The results are shown in Table 14 below.

＊Ｃｌｏｒｏｘ法０１−１Ａ結果−この方法は、基体を長さ方向に１回折りたたみ、次いで折りたたまれた基体ストリップを、中指、薬指、小指を横切って巻き付けることによってワイプに適応された。一回の通過は、ガラスキャリアを横切ってなされた。合格と考えられるためには、３．０より大きいｌｏｇ減少が要求された。

* Clorox Method 01-1A Results-This method was applied to a wipe by folding the substrate one lengthwise and then wrapping the folded substrate strip around the middle, ring, and little fingers. One pass was made across the glass carrier. A log reduction of greater than 3.0 was required to be considered a pass.

Therefore, it will be readily appreciated by those skilled in the art that the compositions and methods of the present invention are open to a wide range of utilities and applications. Many embodiments and adaptations other than those described herein, as well as many variations, modifications, and equivalent arrangements, will be apparent from this disclosure and the foregoing description without departing from its substance or scope. Or, as would be reasonably suggested to one of ordinary skill in the art.

Thus, although the compositions and methods of the present invention have been described in detail herein with respect to their preferred embodiments, this disclosure is merely an illustration and illustration and is intended only for the purpose of providing a complete and feasible disclosure. It should be understood that

The above disclosure is not intended to limit or otherwise exclude such other embodiments, adaptations, variations, modifications and equivalent arrangements and should not be construed as such. ..

Claims (25)

A wipe having residual bactericidal properties,
The wipe comprises a substrate of fibrous material and a formulation present on or in the substrate,
A wipe, wherein the formulation comprises poly(2-ethyl-2-oxazoline) and a quaternary ammonium compound or a combination of quaternary ammonium compounds, a surfactant, water, and an optional perfume. The wipe of claim 1 wherein the substrate is water absorbent, water absorbent, or both. The wipe of claim 1, wherein the substrate comprises a material selected from the group consisting of natural materials, synthetic materials, and combinations thereof. The wipe of claim 3, wherein the natural material is selected from the group consisting of cotton, linen, silk, wool, hemp, flax, and combinations thereof. The wipe of claim 3, wherein the synthetic material is selected from the group consisting of polypropylene, polystyrene, polyester, nylon, rayon, acrylic, spandex, and combinations thereof. The wipe according to claim 1, wherein the substrate is a woven or non-woven fabric. The wipe of claim 1, wherein the nonwoven substrate is selected from the group consisting of meltblown, conform, spunbond, air lay, hydroentangle, spunlace, bond, card, laminate, and combinations thereof. The wipe of claim 1, wherein the quaternary ammonium compound or combination of quaternary ammonium compounds is in a ratio of 1:4 to 1:1 with respect to poly(2-ethyl-2-oxazoline). The wipe of claim 1, wherein the poly(2-ethyl-2-oxazoline) is in an amount of 1-5% by weight, the weight% being based on the total weight of the formulation. The wipe of claim 1, wherein the quaternary ammonium compound is in an amount of at least 0.2% by weight, the weight% being based on the total weight of the formulation. The wipe of claim 10, wherein the quaternary ammonium compound is in an amount of 0.2-2% by weight, the weight% being based on the total weight of the formulation. The wipe of claim 1, wherein the surfactant is a nonionic surfactant. The wipe of claim 1, wherein the surfactant is an alcohol ethoxylate. 14. The wipe of claim 13, wherein the alcohol ethoxylate is in an amount of 0.05-0.5 wt%, the wt% being based on the total weight of the formulation. 14. The wipe of claim 13, wherein the alcohol ethoxylate is a linear alcohol ethoxylate with at least 9 moles of ethylene oxide. The wipe of claim 1, wherein the perfume is in an amount of 0-0.5% by weight, the weight% being based on the total weight of the formulation. The wipe of claim 1, wherein the formulation further comprises an alcohol, salt, acid, or combination thereof. A wipe having residual bactericidal properties,
The wipe comprises a substrate of fibrous material and a formulation present on or in the substrate,
The formulation comprises 1-2% by weight of poly(2-ethyl-2-oxazoline) and at least 0.4% by weight of a quaternary ammonium compound or a combination of quaternary ammonium compounds and 0.1-0.3% by weight. % Alcohol ethoxylates with at least 9 moles of ethylene oxide and the balance water,
Wipe, where wt% is based on the total weight of the formulation. 19. The wipe of claim 18, wherein the substrate comprises a material selected from the group consisting of natural materials, synthetic materials, and combinations thereof. 20. The wipe of claim 19, wherein the synthetic material is selected from the group consisting of polypropylene, polystyrene, polyester, nylon, rayon, acrylic, spandex, and combinations thereof. 19. The wipe of claim 18, wherein the alcohol ethoxylate has at least 12 moles of ethylene oxide. 19. The wipe of claim 18, further comprising 0.05-0.2 wt% fragrance. 1-2% by weight of poly(2-ethyl-2-oxazoline) and at least 0.4% by weight of a quaternary ammonium compound or a combination of quaternary ammonium compounds and 0.1-0.3% by weight of at least 9 A fungicide formulation comprising an alcohol ethoxylate with moles of ethylene oxide and the balance water,
Wt% is based on the total weight of the formulation,
A fungicide formulation, wherein the formulation provides residual fungicidal activity up to 24 hours. 24. The fungicide formulation of claim 23, wherein the alcohol ethoxylate has at least 12 moles of ethylene oxide. A germicide formulation,
A polymer binder in the range of 0.1 to 20%, based on the weight of the fungicide formulation, provided that the polymer binder is an oxazoline homopolymer, or an expanded or modified polymer based on the oxazoline homopolymer,
A bactericidal compound in the range of 0.05 to 20% based on the weight of the bactericide formulation,
A surfactant in the range of 0.01 to 20% based on the weight of the fungicide formulation,
A pH adjusting agent in the range of 0.01 to 10% based on the weight of the germicide formulation,
A glycol ether in the range of 1 to 50%, based on the weight of the fungicide formulation,
A germicide formulation comprising water in the range of 0 to 99.9%, based on the weight of the germicide formulation.