RU2778401C2 - Surface-acting disinfectant with residual biocide property - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: invention relates to disinfectants; it can be used in medicine, food industry, agriculture, and in everyday life. A disinfectant composition contains: a polymer binder in the range from 0.1% to 10% by wt. or from 0.1% to 155 by wt., while the polymer binder is oxazoline homopolymer, a biocide compound in the range from 0.05% to 10% by wt., surfactant in the range from 0.01% to 10% by wt., pH-regulating substance in the range from 0.01% to 10% by wt. or from 0.01% to 30% by wt., glycolic ether in the range from 1% to 10% by wt. or to 30% by wt., and the rest up to 100% by wt. is water. The biocide compound is a quaternary ammonium compound or a mixture of quaternary ammonium compounds, where the quaternary ammonium compound has a structure:

,

and it can be selected, in particular, from n-alkyldimethylbenzyl ammonium chloride, di-n-octyl dimethylammonium chloride, dodecyldimethyl ammonium chloride, n-alkyl dimethylbenzyl ammonium saccharinate, 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride.

EFFECT: disinfectant composition is used for the surface treatment in order to form film with the capability of fast destruction of bacteria and other microorganisms during at least 24 hours after the application of film to the treated surface.

9 cl, 11 tbl

Description

FIELD OF THE INVENTION

[0002] The present invention relates to the field of disinfectant compositions, and more specifically, to a composition of a disinfectant that imparts a residual effect to a biocidal property.

BACKGROUND OF THE INVENTION

[0003] Microorganisms are everywhere in today's world. Some of them are beneficial to humans and the environment, but at the same time, some microorganisms can cause significant negative effects on contaminated objects, as well as on people, animals and members of environmental groups that come into contact with them. There are a number of industries and environments in which such microorganisms are particularly prevalent.

[0004] Healthcare

[0005] A nosocomial infection (HAI, otherwise referred to as "nosocomial infection") is an infection that is favored by the environment of a hospital or healthcare facility. Such diseases are usually fungal or bacterial infections that can cause local or systemic damage to the infected organism. Nosocomial infections can cause severe pneumonia, as well as infections of the urinary tract, bloodstream, and other organs and systems of the body.

[0006] Nosocomial infections have serious medical implications for patients and health care providers. According to data from the United States of America, there are approximately 1,700,000 nosocomial infections each year, causing approximately 100,000 deaths. According to European data and research results, it is shown that the annual number of deaths due to gram-negative bacterial infections is from 8000 to 10000 cases.

[0007] There are a number of aggravating factors contributing to the high incidence of HAI. Hospitals, emergency centres, nursing homes and other similar facilities focus on dealing with severe illness and injury. As a result, these institutions present an abnormally high concentration of immunocompromised patient populations.

[0008] The following are a trio of pathogens commonly found in healthcare settings that collectively cause approximately one-third of all hospital-acquired infections: coagulase-negative Staphylococci (15%), Candida spp . (11%), and Escherichia coli (10%).

[0009] Moreover, more resistant disease-causing pathogens are present in healthcare settings. Six so-called "ESKAPE pathogens" - Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa and Enterobacter species - are resistant to antibiotics and are present in nosocomial infections in almost half of cases. Their resistance to one or more biocidal substances results in a particular risk of such infections.

[0010] In particular, the broad food versatility of Pseudomonas allows them to survive under extreme conditions, including surviving on surfaces that are not very thoroughly cleaned and sterilized. The prevalence of this pathogen in the hospital setting makes it the leading cause of Gram-negative nosocomial infections. Immunocompromised patients (eg, those with burns, cystic fibrosis, or cancer) are especially vulnerable.

[0011] The spread and transmission of nosocomial infections most often occurs through direct or indirect contact. Transmission by direct contact involves patient contact with either an infected patient or a worker. As health care workers move within a healthcare facility, they come into contact with many patients. These workers unwittingly act in the same way as the bees in the garden, "pollinating" rooms and wards during the provision of medical care.

[0012] Transmission of infection by indirect contact occurs when a patient comes into contact with a contaminated object or surface. In the environment of medical institutions, there are many items that can passively carry pathogens.

[0013] Additionally, nosocomial infections deal a severe blow to the volume, quality, and cost of care provided by hospitals and other institutions. Approximately 100,000 nosocomial deaths occur each year in the United States, and an additional two million people are estimated to suffer from hospital-acquired infections and endure the physical and emotional suffering associated with these serious and preventable diseases.

[0014] The response of health care institutions has been to develop a policy of introducing more stringent requirements for cleanliness and disinfection in relation to personnel and the patient's environment. These programs typically include frequent hand washing and frequent surface disinfection. Despite the implementation of programs to limit nosocomial infections, an unacceptably high frequency of such infections is still detected.

[0015] Home Care and Furnishings

[0016] Microorganisms are also found in the domestic environment. Despite the effectiveness of consumer disinfectants and disinfectants in terms of initial destruction of microorganisms, their main disadvantage is that surfaces are easily and quickly re-contaminated by contact, airborne and remaining microorganisms not killed during processing. Although some of the disinfectants continue to work simply when they are left on the surface, in this case, greasy or sticky residues are formed, which are easily removed by accidental contact with the surface. Thus, there is a need for a cleaning agent for domestic and household use that quickly destroys microorganisms on contact and then continues to act as a residual disinfectant, but does not have the undesirable tacky or sticky effect mentioned. Such cleaners may be useful as general household cleaners, bathroom cleaners, and as aerosol protectants.

[0017] The difference between cleaning products used in hospitals and medical institutions from household products lies in the acceptable content of volatile organic substances (VOC). The rule of thumb for most non-aerosol household consumer disinfectants is no more than 1% VOC.

[0018] Catering

[0019] In the food service industry, there are also cases of infection of industrial premises with pathogens and the spread of the disease among consumers. Despite the fact that food manufacturers are taking active measures to maintain hygiene and comply with strict state sanitary and hygienic standards, large outbreaks of microbial nature are still occasionally observed, causing serious illness among consumers. Residual disinfectants should effectively reduce this problem.

[0020] Biofilms

[0021] A biofilm is generally referred to as a layer of microorganisms adhesively adhered to the surface of an organic or inorganic construct that secrete a protective coating of biological origin. Biofilms represent a major public health problem due to the increased resistance of biofilm-associated microorganisms to antimicrobial agents, as well as the possibility of infection by biofilm microorganisms. Thus, there is a need to solve disinfection problems with respect to biofilms. Current disinfectants do not have the ability to destroy biofilms, or isolate or block biofilms on surfaces to prevent cross-infection and prevent their growth. There are limited solutions to the problems of surface biofilms. For example, there is some evidence that surface biofilms are a significant problem in healthcare settings for the reasons outlined above. Additionally, biofilms are a recognized problem of possible microbial contamination in the food industry. Other industries face similar problems. Thus, there is a need to solve the potential problems associated with biofilms, with the ability to apply such a solution to the destruction of biofilms.

[0022] Thus, there remains a need for a composition capable of conferring a residual biocidal effect on the treated surface. Additionally, it is preferable to combine the composition with a surface disinfectant, which will allow a single cleaning to be carried out both for disinfection and for imparting a residual biocidal effect.

[0023] It will also be advantageous if the residual biocidal action is stably retained on the treated surface, so that the destruction of microorganisms continues for a long period of time after application.

[0024] An additional benefit would be the effectiveness of the composition(s) for a wide range of industries and applications.

The essence of the invention

[0025] The present invention relates to a disinfectant composition imparting a residual biocidal property. The disinfectant composition contains a polymeric binder, wherein said polymeric binder is an oxazoline homopolymer or an elongated or modified polymer based on an oxazoline homopolymer, and a biocidal compound. The disinfectant composition further comprises a carrier.

[0026] In one aspect of the present invention, the oxazoline homopolymer has the following structure:

in which R ₁ represents groups such as hydrogen, alkyl, alkenyl, alkoxy, alkylamino, alkynyl, allyl, amino, anilino, aryl, benzyl, carboxyl, carboxyalkyl, carboxyalkenyl, cyano, glycosyl, halogen, hydroxyl, oxazoline mesylate, oxazoline tosylate , oxazoline triflate, oxazoline silyl, phenol, polyalkoxy, quaternary ammonium, thiol or thioether; R ₂ represents groups such as hydrogen, alkyl, alkenyl, alkoxy, alkylamino, alkynyl, allyl, amino, anilino, aryl, benzyl, carboxyl, carboxyalkyl, carboxyalkenyl, cyano, glycosyl, halogen, hydroxyl, oxazoline mesylate, oxazoline tosylate, oxazoline triflate, oxazoline silyl, phenol, polyalkoxy, quaternary ammonium, thiol or thioether, or a macrocyclic structure; R ₃ is hydrogen, an alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxyalkyl or perfluoroalkyl group; and n is in the range from 1 to 1000000.

[0027] In another aspect of the invention, other properties of the disinfectant composition(s) are provided.

[0028] In another aspect, the present invention relates to an article of manufacture, which includes a disinfectant composition(s), as well as methods of making, using and using the disinfectant composition(s).

[0029] Additional fields of application of the present invention will become apparent from the detailed description below. It should be understood that the detailed description and specific examples indicating preferred embodiments of the invention are for purposes of illustration only and are not intended to limit the scope of the present invention.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0030] The following description of the embodiments of the present invention is for illustrative purposes only and is not intended to limit the scope of the invention, its applications or uses in any way. The present invention has a wide potential application and usefulness, which can be expected to be suitable for a wide range of industries. The following description is presented by way of example only, in order to enable the disclosure of the invention, and does not limit the scope or essence of the present invention.

[0031] As used herein, the terms "microorganism" or "microbial" should be understood to refer to any of the microscopic organisms studied by microbiologists or found under conditions of use of a treated article. Such organisms include, without limitation, bacteria and fungi, as well as other unicellular organisms such as molds, powdery mildew (mildew) and algae. The term "microorganism" also includes viral particles and other infectious agents.

[0032] As used herein, the term "antimicrobial" should be understood to encompass both microbicidal and microbostatic properties. That is, the term includes the killing of microorganisms, resulting in a reduction in their number, as well as the effect of inhibiting the growth of microorganisms, when their number can remain more or less constant (but still allowing a slight increase / decrease).

[0033] For ease of discussion, the term "antimicrobial" as used herein refers to broad spectrum activity (eg, against bacteria and fungi). When referring to efficacy against a particular microorganism or taxonomic rank, a more specific term should be used (eg, antifungal to indicate efficacy specifically against fungal growth).

[0034] In light of the above example, it should be understood that efficacy against fungi in no way precludes the possibility that the same antimicrobial composition may be effective against another class of microorganisms.

[0035] For example, the discussion of the potent antibacterial effect demonstrated in the described embodiment should not be considered to exclude this embodiment from those in which antifungal activity has been demonstrated. This mode of presentation should not be construed as limiting the scope of the invention in any way.

[0036] Disinfectant composition

[0037] The present invention relates to a disinfectant composition. In one aspect of the present invention, the disinfectant composition is in liquid form. The formulation of the disinfectant composition contains a biocidal compound and a polymeric binder. In addition to other components, the composition may contain a solvent (such as water or a low molecular weight alcohol), a surfactant, a coloring agent, and a fragrance.

[0038] The liquid composition is designed with surface disinfection properties and residual biocidal action. The composition can be applied to the surface by spraying, rolling, condensing, wiping, or other means. The composition acts as a surface disinfectant, destroying infectious microorganisms present on the surface.

[0039] After drying, the liquid composition leaves a residual protective film on the surface. The residual film has a biocidal property, which makes it possible to maintain the surface in a state of protection from microbial contamination for a long period of time after application of the composition.

[0040] In a preferred embodiment, the surface disinfectant composition creates a film that has the ability to quickly kill bacteria and other microorganisms, at least 24 hours after the formation of the film on the treated surface. In one aspect of the present invention, a quick kill generally refers to a period of time from about 30 seconds to about 5 minutes. The film remains on the surface and is resistant to repeated contact and abrasion of the surface.

[0041] In another embodiment of the present invention, the disinfectant composition is a liquid composition containing a polymeric binder, a biocidal compound, a carrier such as a solvent, and other optional components such as fragrances.

[0042] Biofilm isolation agent

[0043] In one embodiment of the present invention, the disinfectant composition is a biofilm isolation agent. The biofilm isolation agent forms a polymeric film after application to the surface. The polymer film is applied wet and dries as a film layer to seal and prevent subsequent growth of microorganisms from the biofilm. The biofilm isolation agent is preferably in the form of a liquid, but may also be in the form of a gel or other forms. After application of the biofilm isolation agent, the access of biofilm microorganisms to oxygen and exogenous substances is limited. The biofilm isolation agent is capable of sealing bacteria as well as providing sustained release of antimicrobial agents into the film to kill biofilm microorganisms.

[0044] In one embodiment of the present invention, the biofilm isolation agent comprises a polymeric binder and a biocidal compound. Biocidal compounds include, without limitation, any biocidal compound mentioned in the invention.

[0045] In one embodiment of the present invention, the biofilm isolation agent comprises an oxazoline homopolymer as a polymeric binder. The oxazoline homopolymer may have any of the structures mentioned in the invention.

[0046] In one embodiment of the present invention, the biofilm isolation agent comprises a polymeric binder, a biocidal compound, and an enzyme(s). The presence of the enzyme contributes to the destruction of the biofilm and provides improved antimicrobial penetration of the biocidal substance, and, ultimately, the removal of the biofilm. Examples of enzymes include, without limitation, proteinases, DNases, RNases, and carbohydrate-specific enzymes that are capable of degrading biofilm-associated extracellular matrix.

[0047] In one embodiment of the present invention, the biofilm isolation agent comprises a polymeric binder and an antibody as biological material for sustained release into the film. Functional antibodies bind to the biofilm microorganism to prevent cross-infection.

[0048] In one embodiment of the present invention, the biofilm isolation agent comprises a polymeric binder and a bacteriophage or mixture of bacteriophages as biological material for sustained release into the film. The bacteriophage acts as a targeted antimicrobial agent to kill biofilm-associated microorganisms.

[0049] In one embodiment of the present invention, the biofilm isolation agent comprises a polymeric binder and a mixture of bacteriophages, antimicrobials, enzymes, and antibodies as biological material for sustained release into the film.

[0050] Polymer binder

[0051] In one aspect of the present invention, the polymeric binder is an oxazoline homopolymer. As an additional feature of the invention, the oxazoline homopolymer has the following structure:

[0052] in which

[0053] R ₁ and R ₂ are end groups determined by the polymerization methods used to synthesize the oxazoline homopolymer. R ₁ and R ₂ are independently selected from each other and include, without limitation, groups such as hydrogen, alkyl, alkenyl, alkoxy, alkylamino, alkynyl, allyl, amino, anilino, aryl, benzyl, carboxyl, carboxyalkyl, carboxyalkenyl, cyano, glycosyl, halogen , hydroxyl, oxazoline mesylate, oxazoline tosylate, oxazoline triflate, oxazoline silyl, phenol, polyalkoxy, quaternary ammonium, thiol or thioether. Alternatively, R ₂ may include a macrocyclic structure formed during synthesis as a consequence of an intramolecular attack.

[0054] For example, if methyl tosylate is used as the initiator for the cation-initiated polymerization of oxazoline, then R ₁ is a methyl group and R ₂ is oxazoline tosylate.

[0055] R ₃ is an end group defined by the type of oxazoline that was used in the preparation of the polymeric binder of the invention. R ₃ includes, without limitation, hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxyalkyl, or perfluoroalkyl. For example, R ₃ represents an ethyl group if ethyloxazoline is the monomer used to prepare the polymeric binder of the invention.

[0056] The letter n denotes the degree of polymerization of oxazoline in the homopolymer. The value of n is in the range of 1 to 1000000. Preferably the value of n is in the range of 500 to 250000, most preferably the value of n is in the range of 2500 to 100000.

[0057] Elongated or modified polymers with some variations based on oxazoline homopolymer, which are similar to oxazoline homopolymer, are also suitable for the present invention. Techniques and options for making variations or modifications to the chemical or molecular structure of oxazoline will be known to those skilled in the art. The class of elongated or modified oxazoline homopolymer based polymers can be represented by the following molecular structure:

[0058] in which

[0059] The R ₁ and R ₃ groups have the same definition as above for the oxazoline homopolymer.

[0060] The designation B refers to the additional monomeric repeat unit associated with the oxazoline in the copolymer. The types of arrangement of repeating units between B and oxazoline in the copolymer may include, without limitation, blocks, alternation, periodic arrangement, or combinations thereof. There are no restrictions on the types B that can be used for copolymerization with oxazoline or modification of oxazoline according to the invention.

[0061] The letter n denotes the degree of polymerization for the oxazoline repeat unit; the value of n in the copolymer ranges from 1 to 1,000,000. The letter m denotes the degree of polymerization for the B repeating unit in the copolymer; m is in the range of 0 to 500000. Preferably, n is in the range of 500 to 250000 and m is in the range of 20 to 10000, and most preferably n is in the range of 2500 to 100000 and m is in the range of 50 to 5000 In addition to attaching a B unit to ethyloxazoline via copolymerization, B can also be linked to an oxazoline as an end group in a cationic polymerization using B as a cationic initiator if B itself is a quaternary ammonium compound.

[0062] Without being an exhaustive definition, B may be, for example, ethyleneimine with the following molecular structure:

[0063] in which

[0064] R ₁ and R ₂ are end groups having the same definition as specified for the oxazoline homopolymer.

[0065] R ₃ includes, without limitation, hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxyalkyl, or perfluoroalkyl.

[0066] R ₄ includes, without limitation, hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxyalkyl, or perfluoroalkyl.

[0067] The value of m is in the range of 0 to 500,000, preferably in the range of 20 to 10,000, and most preferably in the range of 50 to 5,000.

[0068] The value of n is in the range from 1 to 1000000, preferably from 500 to 250000, and most preferably in the range from 2500 to 100000.

[0069] Synthesis of the copolymer of oxazoline and ethyleneimine can be carried out in two stages. For example, in the first step, cationic ring-opening polymerization technology can be used to produce polyoxazoline homopolymer. In a second step, the polyoxazoline obtained in the first step can be hydrolyzed to convert a portion of the polyoxazoline repeat units to polyethyleneimine. Alternatively, the oxazoline-ethyleneimine copolymer can be prepared with suitable appropriate monomers such as oxazoline and aziridine. As a result, a cationic polymer having the above structure will be obtained.

[0070] The degree of polymerization n for the oxazoline repeating unit in the copolymer is in the range from 1 to 1000000, and the degree of polymerization m for the ethyleneimine repeating unit in the copolymer is in the range from 0 to 500000. Preferably, the value of n is in the range from 500 to 250000, the value of m is in the range of 20 to 10000 and most preferably the value of n is in the range of 2500 to 100000 and the value of m is in the range of 50 to 5000.

[0071] Alternatively, the nitrogen in the ethyleneimine repeat unit can be further quaternized to provide the following cationic copolymer:

Any quaternization method known to those skilled in the art can be used to quaternize the polymer of this example. The groups R ₁ , R ₂ , R ₃ and R ₄ have the same definition as the groups defined above for the oxazoline-ethyleneimine copolymer. R ₅ includes, without limitation, hydrogen, methyl, ethyl, propyl, or other types of alkyl group. The corresponding anion X ^- is a halogen, sulfonate, sulfate, phosphonate, phosphate, carbonate/bicarbonate, hydroxy or carboxylate.

[0072] The ranges of n and m are also similar to those given for the oxazoline-ethyleneimine copolymer.

[0073] Another example of a B unit that can be used in the present invention is polydiallyldimethylammonium chloride. Polyethyloxazoline modified with polydiallyldimethylammonium chloride has the following structure:

[0074] in which

[0075] R ₁ and R ₄ have the same meaning as indicated in the previous example for the quaternized oxazoline-ethyleneimine copolymer.

[0076] R ₂ and R ₃ independently of each other include, without limitation, short chain alkyl groups such as C ₁ - C ₆ . The corresponding anion X ^- is a halogen, sulfonate, sulfate, phosphonate, phosphate, carbonate/bicarbonate, hydroxy or carboxylate.

[0077] The definition and ranges of n and m are the same as in the previous examples.

[0078] Unit B may be other olefins including, but not limited to, diallyldimethylammonium chloride, styrene, methoxystyrene, and methoxyethene. Ethyloxazoline can also be copolymerized with heterocyclic monomers such as oxirane, thiethane, 1,3-dioxepan, oxetan-2-one and tetrahydrofuran to increase the activity of the polymer of the invention. The binder used in the invention can also use pendant oxazoline groups on the backbone of the polymer, for example an acrylic or styrene based polymer or an acrylic or styrene containing copolymer.

[0079] Examples of commercially available polyethyloxazolines include, without limitation, Aquazol 500 from Polymer Chemistry Innovations, Inc.

[0080] The amount of polymeric binder that can be used in the liquid composition may vary slightly depending on the desired duration of residual activity of the composition and the nature of all other components in the composition. The preferred amount of polymeric binder in the liquid composition is in the range of 0.1% to 20%, based on the weight of the liquid composition. In a liquid composition for medical use, the more preferred amount of polymeric binder in the liquid composition is 0.5% to 10%, and the most preferred amount is 0.8% to 5%. In general purpose liquid compositions and bathroom cleaners, the amount of polymeric binder in the liquid composition is more preferably 0.1% to 10%, and most preferably 0.1% to 5%.

[0081] The polymeric binder is preferably water-soluble and can be easily removed from the surface when any noticeable build-up is formed. The polymeric binder is present in small amounts, but is nevertheless able to provide a strong bond between the biocidal compound and the surface to be treated, which contributes to residual effectiveness.

[0082] Biocidal compound

[0083] The biocidal compound may be a quaternary ammonium compound (QAC) with the following molecular structure:

[0084] in which

[0085] R ₁ , R ₂ , R ₃ and R ₄ are independently selected and include, without limitation, alkyl, alkoxy, or aryl, and may or may not have a heteroatom, and be saturated or unsaturated. Some or all of the functional groups may be the same.

[0086] The corresponding anion X ^- includes, without limitation, halogen, sulfonate, sulfate, phosphate, phosphonate, carbonate/bicarbonate, hydroxy, or carboxylate.

[0087] Quaternary ammonium compounds include, but are not limited to, N-alkyl dimethyl benzyl ammonium chloride, di-n-octyl dimethyl ammonium chloride, dodecyl dimethyl ammonium chloride, n-alkyl dimethyl benzyl ammonium saccharinate, and 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride.

[0088] Preferred quaternary ammonium compounds are combinations of monomeric QACs that will be used to carry out the invention. Specific examples of the QAC combination are N-alkyl dimethyl benzyl ammonium chloride (40%), n-octyl chloride decyl dimethyl ammonium chloride (30%), di-n-decyl dimethyl ammonium chloride (15%) and di-n-dioctyl dimethyl ammonium chloride (15%). The indicated percentages are the weight percentages of a particular QAC, based on the total weight of the QAC mixture composition.

[0089] A quaternary ammonium polymer variation having the following structures can also be used in the invention:

или

or

[0090] in which

[0091] R ₁ , R ₂ , R ₅ and R ₆ , independently of each other, include, without limitation, hydrogen, methyl, ethyl, propyl, or other longer carbon alkyl groups.

[0092] R ₃ and R ₄ are independently selected and include, without limitation, methylene, ethylene, propylene, or other longer alkylene linking groups.

[0093] The letter n means the degree of polymerization; n is an integer in the range 2 to 10000.

[0094] Examples of cationic polymers with the above structure include, without limitation, polyamines derived from dimethylamine and epichlorohydrin, such as Superfloc C-572, commercially available from Kemira Chemicals.

[0095] Another polymer QAC suitable for the present invention is polydiallyldimethyl ammonium chloride or polyDADMAC.

[0096] Another class of suitable quaternary ammonium compounds of the invention are those with a biguanide moiety in the molecule. Examples of this class of cationic antimicrobials include, without limitation, PHMB (polyhexamethylene biguanide) and chlorhexidine.

[0097] Examples of commercially available quaternary ammonium compounds include, without limitation, Bardac 205M and 208M from Lonza and BTC885 from Stepan Company.

[0098] The biocidal compound may be a weak acid that has shown particular effectiveness in bathroom cleaners. These types of products use citric, sulfamic acids (also known as amidosulphonic acid, amidosulfuric acid, aminosulphonic acid, and sulfamic acid), glycolic, lactic, lauric, and capric acids, which are useful as both an effective biocide and soap remover. and hard deposits.

[0099] Other useful compounds are silane quaternary salts such as 3(trihydroxysilyl)propyldimethyloctadecyl ammonium chloride. They may have the added benefit of acting on the treated surface to enhance residual properties.

[00100] Additional biocidal compounds suitable for use in the liquid composition of the invention include a wide range of antimicrobial, biocidal, disinfectant, and disinfectant agents. A water-soluble or dispersible biocidal compound is preferred, although alcohol-soluble biocides may alternatively be used.

[00101] A non-exhaustive list of biocidal compounds suitable for use in the present composition includes triclosan, zinc pyrithione, metal salts and oxides, phenols, botanicals, halogens, peroxides, heterocyclic antimicrobials, aldehydes, and alcohols.

[00102] The concentration of the biocidal compound in the composition may range from 0.05% to 20% based on the weight of the liquid composition. To obtain a liquid composition for medical use, the preferred concentration is from 0.1% to 20%, and more preferably, is in the range from 0.5% to 3%. For general purpose liquid composition and bathroom cleaners, the preferred concentration is from 0.05% to 10%. For the composition of the protective agent, the preferred concentration is from 0.05% to 2%.

[00103] Carrier

[00104] The carrier or medium for the liquid composition of the invention can be any solvent that is volatile and can readily evaporate under ambient conditions. Examples of liquid carriers include, without limitation, water and low molecular weight alcohols such as C1-C8 alkanols. Specific examples include, without limitation, ethanol, isopropyl alcohol, butanol, pentanol, and combinations thereof.

[00105] Another class of solvents for use in the present invention includes alkylene glycol ether. Examples include, without limitation, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monohexyl ether, ethylene glycol monohexyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, triethylene glycol monohexyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, monobutyl ether, propylene glycol propylene glycol methyl ether acetate, propylene glycol n-butyl ether, dipropylene glycol n-butyl ether, dipropylene glycol methyl ether, dipropylene glycol methyl ether acetate, propylene glycol n-propyl ether, dipropylene glycol n-propyl ether and tripropylene glycol methyl ether.

[00106] Another class of solvents used in the present invention is based on terpenes and their derivatives, such as terpene alcohols, terpene esters, terpene esters, or terpene aldehydes. Examples of solvents include, without limitation, pine oil, lemon oil, limonene, pinene, cymene, myrcene, fenchone, borneol, cineole, nopol, ionone, and the like.

[00107] A preferred carrier in a liquid composition for use in household cleaners is water.

[00108] If the method of applying the liquid composition of the invention is a pressurized aerosol, a propellant may be required in the composition. Various propellants or mixtures can be used in the present invention, which should be known to those skilled in the art. Typical propellants in aerosol compositions known in the industry are C1-C10 hydrocarbons or halogenated hydrocarbons. Examples of such propellants include, without limitation, pentane, butane, propane, and methane. Other types of propellants that can be used in the present invention also include compressed air, nitrogen or carbon dioxide. Alternatively, for an aerosol product, a bag-valve package may be used without the propellant being directly added to the composition.

[00109] In the present invention, either a single solvent or a mixture of the above solvents can be used. The types of solvents used in the present invention may depend on the intended use of the residual disinfectant composition. For example, if the composition according to the invention is intended for use in home care products, the main task may be to clean contaminated surfaces with the removal of all types of dirt or soil. The formulation of the invention may be a liquid carrier or carriers which aid and improve the removal of contaminants. Thus, for example, it may be desirable for a residual disinfectant formulation or composition of the present invention to include alkyl or polyalkyl glycol ethers to enhance cleaning performance in a home care formulation of the invention. On the other hand, if the primary purpose of a residual disinfectant composition is to be used in a medical facility where nosocomial infections are a major concern, then a quick drying liquid composition of the invention may be a more desirable property than cleaning surfaces of dirt or soil. It should be considered that low molecular weight alcohols contribute to the rapid drying of the liquid composition according to the invention after its application. Also, low molecular weight alcohol in the liquid composition enhances the disinfecting effect of the liquid composition.

[00110] In residual disinfectants for medical use, a mixture of water and low molecular weight alcohol is preferred. Preferably, an amount of alcohol is present in the liquid composition such that a non-azeotropic mixture between the alcohol and water can form in the liquid composition. The minimum amount of alcohol in the liquid composition, if present, is 10%. Preferably, in residual disinfectants for medical use, the alcohol concentration is 30%, and the most preferred alcohol concentration is at least 50%, based on the weight of the liquid composition for medical use in the composition of the present invention.

[00111] Surfactant

[00112] A surfactant or wetting agent may be used in the composition. The surfactant promotes the distribution of the liquid composition and its uniform application to the surface to be treated. The surfactant further promotes the formation of non-azeotropic mixtures between the alcohol and water, thereby facilitating rapid and uniform drying of the liquid composition after application to the surface. The surfactant also plays an important role in formulating the residual disinfectant liquid of the invention for home use, if cleaning efficiency is a key attribute of the product in terms of its intended use.

[00113] Surfactants suitable for the liquid composition of the invention include, without limitation, those that are non-ionic, anionic, or amphoteric in nature. Examples of commercially available wetting agents include, but are not limited to, Ecosurf CA-4 or Tergitol TMN-3 from Dow Chemical, and Q2-5211 from Dow Corning.

[00114] An amine oxide surfactant is preferred, particularly when using QAC as the biocidal compound in the composition.

[00115] In the category of non-ionic surfactants, ethoxylated alcohols with different amounts of ethylene oxides or different hydrophilic-lipophilic balance (HLB) values can be used. Examples of ethoxylated alcohols include, but are not limited to, Triton X-100 (Dow Chemical, Midland MI), Dow Chemical's Ecosurf EH non-ionic surfactants, Dow Chemical's Tergitol non-ionic surfactants, Huntsman's Surfonic range of surfactants. Corp., the Neodol range of surfactants from Shell, the Ethox range of surfactants from Ethox Chemicals, and the Tomadol range of surfactants from Air Products and Chemicals, Inc.

[00116] Another class of non-ionic surfactants includes alkyl polyglucosides. Examples include the Glucopon series from BASF and the Ecoteric series from Huntsman.

[00117] An alternative class of surfactants preferred for the liquid composition are silane-based surfactants. Examples include, without limitation, silicone polyesters of organofunctional or reactive silane wetting agents, and wetting agents based on fluorine compounds.

[00118] The content of surfactant in the liquid composition is in the range from 0% to 10%, preferably in the range from 0.01% to 5%.

[00119] Depending on the purpose of use, the liquid composition of the present invention, intended for home care, may require a suitable pH level. For example, if a liquid product is being used in a kitchen area, a high pH product may be desirable to effectively remove the grease found in that area. If the product is used in the bathroom area, soap scum and hard deposits from the water may be the main problem. In this case, a low pH product may be more suitable for these purposes. There are no restrictions on the types of pH adjusting agents that can be added to the liquid composition of the present invention. Examples of possible pH adjusting agents include, without limitation, triethanolamine, diethanolamine, monoethanolamine, sodium hydroxide, sodium carbonate, potassium hydroxide, potassium carbonate, calcium carbonate, citric acid, acetic acid, hydrochloric acid, sulfamic acid, sulfuric acid, and the like.

[00120] In addition to the components mentioned above, additional functional components may be included in the liquid composition of the present invention. Additional components include, without limitation, chelating agents, compatibilizers, binders, corrosion inhibitors, rheology modifiers, fragrances, colorants, preservatives, UV stabilizers, optical brighteners, and indicators of active ingredients.

[00121] In one embodiment of the present invention, the liquid solution contains a polymeric binder, a quaternary ammonium compound, a silicone-based surfactant, and ethanol. The liquid composition may be prepared or mixed by any conventional method known to the person skilled in the art. There are no preferred addition procedures for the composition of the present invention, provided that the composition is ultimately homogeneous, compatible and stable. For example, if the polymeric binder is a solid, it may be preferable to first dissolve or disperse the polymer in a carrier, such as water or alcohol, to obtain a stock liquid dispersion of the polymeric binder. Stock liquid dispersion of polymeric binder can be easily added to the composition of the present invention during mixing.

[00122] Application of the liquid composition

[00123] The liquid composition can be applied in a variety of ways. The sprayable liquid composition can preferably be supplied in a conventional spray bottle. The atomizer may be a trigger atomizer. Optionally, an aerosol can also be used in the trigger sprayer to deliver the liquid composition to the surface. Additional application methods include, but are not limited to, condensation, rolling, brushing, brushing, and wiping with various applicators. It is within the scope of the present invention to make wiping products (wipes) containing or pre-treated with the disinfectant composition(s) of the present invention, for example, for sale or use of ready-to-use products.

[00124] To disinfect a contaminated surface, a liquid composition should be sprayed until the surface area is completely covered. Moisture from the composition can subsequently be wiped dry with a dry cloth or paper towel.

[00125] The present invention also relates to an article treated with a disinfectant composition in accordance with aspects of the present invention.

[00126] EXAMPLES

[00127] The following examples show liquid compositions made in accordance with aspects of the present invention. The test results of these compositions demonstrate the desired properties of residual disinfectant or decontamination effectiveness after application to the surface and drying of the compositions. Those compositions that not only have the benefit of residual disinfection but also cleansing properties were also tested for cleansing efficacy.

[00128] The compositions were tested for residual potency using EPA protocol 01-1A. Briefly, bacteria were applied to a glass slide and left to dry on the surface. The composition was then sprayed onto the surface and dried to obtain a transparent film. After film formation, the slide was subjected to alternating cycles of wetting and drying using a Gardner stability tester as described in the protocol. Bacteria were re-inoculated on the glass between each cycle. After performing a suitable number of resistance test cycles and re-inoculations (48 passages and 11 re-inoculations for the medical formulation and 24 passages and 5 re-inoculations for the home formulation), the slide was exposed to the bacteria for the specified time period (i.e. 5 minutes) followed by reconstitution in a suitable neutralizing solution.

[00129] In addition to residual efficacy, the composition of the present invention was also tested for initial efficacy according to the ASTM E 1153 protocol.

[00130] A modified ASTM D4488 protocol was used to evaluate hard surface cleaning performance for a home use composition of the present invention. For the evaluation, the mud of the following composition was used:

[00131] Table 1

Components Mass of each component (%) Pure vegetable oil 75 Carpet Dirt TM-122 AATCC 25

*TM-122 AATCC Carpet Dirt was obtained from Textile Innovators.

[00132] During the preparation of the soiled ceramic tile cleaning test, approximately 2 g of liquid soil was placed on aluminum foil. A roller was used to roll the dirt over the foil so that as much dirt as possible was collected on the roller. The dirt from the roller was transferred to the glazed surface of the ceramic tile uniformly by rolling the soiled roller over the ceramic surface. The contaminated ceramic tile was then fired in a kiln at 180°C for 45 minutes. After firing, the tile was left at room temperature for 24 hours before being used for the peel test.

[00133] To evaluate cleanliness, use the Gardner Abrasion Tester. Abrasive sponges about 1 cm wide were attached to an abrasive boat for abrasion. Approximately 4 g of the test composition was placed in a weighing bowl. The attached abrasive sponge was dipped into the weighing cup to collect the test composition.

[00134] The cleansing manipulation was started immediately after wetting the sponge with the cleaning composition. The test used seven cycles of abrasion (sponge back and forth).

[00135] Examples of Residual Disinfectants for Medical Use

[00136] In this example, this composition uses alcohol as the main carrier to achieve fast drying properties of liquid compositions.

[00137] Table 2

Components Composition HE1 (wt %) Composition HE2 (wt %) Composition HE3 (wt %) Water up to 100 up to 100 up to 100 Ethanol 70 70 0 2-propanol 0 0 70 Polyethyloxazoline 2 2 2 Quaternary ammonium compound 0.8 1.2 1.2 Wetting agent/surfactant 0.1 0.1 0.1

[00138] Residual potency testing was conducted using the results of the EP01-1A protocol shown in the following table.

[00139] Table 3

Composition EP01-1A (medium log of bacteria kill) HE1 3.53 HE2 5.50 HE3 4.50

[00140] These compositions showed an excellent residual potency result based on the EP01-1A test.

[00141] The ASTM E 1153 test protocol was also used to evaluate the initial biocidal property of HE2. The test results are presented in the following table.

[00142] Table 4

Initial efficiency Time Way Against bacteria 3 log destruction Complete destruction (<10 CFU/PFU) Klebsiella pneumoniae 30 seconds 1 minute ASTM E 1153 Pseudomonas aerugniosa 30 seconds 30 seconds ASTM E 1153 Staphylococcus aureus 30 seconds 30 seconds ASTM E 1153 MRSA 30 seconds 30 seconds ASTM E 1153 VRE 30 seconds 30 seconds ASTM E 1153 Enterobacter aerogenes 30 seconds 30 seconds ASTM E 1153 Enterococcus faecalis 30 seconds 1 minute ASTM E 1153 Against fungi Aspergillus niger 1 minute 5 minutes ASTM E 1153 Tricophyton mentagrophytes 1 minute 5 minutes ASTM E 1153 Against viruses H1N1
(with shell) 30 seconds 30 seconds ASTM E 1153 MS2
(no shell) 30 seconds 5 minutes ASTM E 1153 Residual efficiency Exposure period log destruction Pseudomonas aerugniosa 5 minutes > 3 EPA 01-1A Enterobacter aerogenes 5 minutes > 3 EPA 01-1A Staphylococcus aureus 5 minutes > 3 EPA 01-1A

CFU/PFU (CFU/PFU - colony forming unit/plaque forming unit)

[00143] It is clear from these data that surface samples treated with an exemplary liquid composition of the invention have a demonstrable biocidal effect in a given period of time.

[00144] Examples of Residual Disinfectants for Home Use

[00145] These compositions use water as a carrier. They are intended for use in home care, in which case VOC regulations prohibit the use of large amounts of organic solvents such as alcohols.

[00146] Table 5

Components Composition HE1 (wt%) Composition HE2 (wt%) Composition HE3 (wt%) Composition HE4 (wt%) Composition HE5 (wt%) Water up to 100 up to 100 up to 100 up to 100 up to 100 EDTA tetra sodium 0 0 0 0 0.4 Polyethyloxazoline one one one 0.5 0.5 Ethoxylated alcohol #1 0.33 0 0 0 0 Ethoxylated alcohol #2 0 0 0.2 0.2 0.2 Quaternary ammonium compound 0.4 0.4 0.4 0.4 0.4 ethanolamine 0.2 0.2 0.2 0.2 0.2 wetting agent 0.1 0.1 0.1 0.1 0.1

[00147] The residual efficacy of these compositions was evaluated using the EP01-1A protocol and the results are shown in the following table.

[00148] Table 6

Composition EP01-1A (medium log of bacteria kill) HE1 3.53 HE2 5.50 HE3 5.50 HE4 4.90 HE5 3.80

[00149] Enterobacter aerogenes bacteria was used to test H1 and Staphylococcus aureus bacteria was used to test the remaining compositions.

[00150] The test results showed that in all compositions from H1 to H5 revealed residual effectiveness on the treated surface. Cleaning performance was also evaluated using a modified ASTM D4488 test method.

[00151] It was also clearly visually shown from the test results that the compositions of the present invention not only provide residual efficacy against bacteria, but also have good cleaning properties on contaminated surfaces.

[00152] The additional compositions indicated in the tables below were tested as home care and home cleaning products. To dissolve the flavor, a premix was prepared containing the flavor, quaternary ammonium compound, surfactant, and glycol ether, if present.

[00153] Table 7 - Light Protective Compositions

Component P1
the weight% P2
the weight% P3
the weight% P4
the weight% P5
the weight% P6
the weight% P7
the weight% P8
the weight% P9
the weight% P10
the weight% P11
the weight% P12
the weight% P13
the weight% P14
the weight% P15
the weight% Polyethyloxazoline 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 0.50 1.00 0.50 1.00 0.50 Quaternary ammonium compound 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.20 0.20 0.10 0.10 flavoring 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 wetting agent 0.30 0.10 0.10 0.10 0.10 0.10 0.10 Aminoxide 0.30 0.30 0.30 0.30 0.30 Ethoxylated cationic surfactant 0.30 Dicoco Quat 0.30 Ethoxylated alcohol 0.30 Triethanolamine 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Sodium EDTA 0.10 Sodium metasilicate pentahydrate 0.10 sodium carbonate 0.10 Water* up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100

Component P16
the weight% P17
the weight% P18
the weight% P19
the weight% P20
the weight% P21
the weight% P22
the weight% P23
the weight% P24
the weight% P25
the weight% P26
the weight% P27
the weight% P28
the weight% P29
the weight% Polyethyloxazoline 1.00 0.50 1.00 0.50 1.00 0.50 1.00 0.50 1.00 1.00 1.00 0.50 0.50 0.50 Quaternary ammonium compound 0.20 0.20 0.10 0.10 0.20 0.20 0.10 0.10 0.20 0.20 0.20 0.20 0.20 0.20 flavoring 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 wetting agent Aminoxide 0.30 0.30 0.30 0.30 Ethoxylated cationic surfactant Dicoco Quat Ethoxylated alcohol 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Triethanolamine 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Sodium EDTA 0.10 0.10 Sodium metasilicate pentahydrate 0.10 0.10 sodium carbonate 0.10 0.10 Water* up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100

[00154] Table 8 - All Purpose Cleaner Composition

Component A1
the weight% A2
the weight% A3
the weight% A4
the weight% A5
the weight% A6
the weight% A7
the weight% A8
the weight% A9
the weight% A10
the weight% A11
the weight% A12
the weight% A13
the weight% A14
the weight% A15
the weight% Polyethyloxazoline 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.20 1.00 1.20 1.00 Quaternary ammonium compound 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.50 0.50 0.40 0.80 0.40 flavoring 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Aminoxide 0.90 0.90 0.90 0.90 0.90 0.90 0.90 0.60 0.45 0.45 0.60 0.60 0.60 0.45 Ethoxylated alcohol #1 0.50 Ethoxylated alcohol #2 Alkylpolyglucoside Triethanolamine 1.0 Glycol ether 1 5.00 Glycol ether 2 Sodium EDTA 0.40 Sodium metasilicate pentahydrate 0.10 0.25 0.25 0.25 0.10 0.10 0.10 0.10 sodium carbonate 0.10 STPP (sodium tripolyphosphate) 0.10 TKPP (tetrapotassium pyrophosphate) 0.10 Water* up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100

Component A16
the weight% A17
the weight% A18
the weight% A19
the weight% A20
the weight% A21
the weight% A22
the weight% A23
the weight% Polyethyloxazoline 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Quaternary ammonium compound 0.80 0.50 0.50 0.50 0.50 0.50 0.50 0.50 flavoring 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Aminoxide 0.60 0.60 0.60 1.50 1.20 0.60 Ethoxylated alcohol #1 0.50 1.0 Ethoxylated alcohol #2 Alkylpolyglucoside 0.60 0.50 Triethanolamine 0.50 Glycol ether 1 5.0 Glycol ether 2 Sodium EDTA Sodium metasilicate pentahydrate 0.10 0.10 0.05 0.05 sodium carbonate STPP (sodium tripolyphosphate) TKPP (tetrapotassium pyrophosphate) Water* up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100

Component A24
the weight% A25
the weight% A26
the weight% A27
the weight% A28
the weight% A29
the weight% A30
the weight% A31
the weight% A32
the weight% Polyethyloxazoline 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Quaternary ammonium compound 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 flavoring 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Aminoxide 0.60 Ethoxylated alcohol #1 0.20 0.60 0.60 0.80 Ethoxylated alcohol #2 0.10 0.20 0.20 0.80 Alkylpolyglucoside 0.50 0.40 0.40 0.40 Triethanolamine 0.50 0.50 0.50 0.50 0.50 0.50 Glycol ether 1 2.40 2.40 Glycol ether 2 2.40 2.40 2.40 Sodium EDTA Sodium metasilicate pentahydrate 0.05 0.05 0.05 sodium carbonate STPP (sodium tripolyphosphate) TKPP (tetrapotassium pyrophosphate) Water* up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100

[00155] Table 9 - Bathroom Cleaner Compositions

Component IN 1
the weight% IN 2
the weight% AT 3
the weight% AT 4
the weight% AT 5
the weight% AT 6
the weight% AT 7
the weight% AT 8
the weight% AT 9
the weight% AT 10 O'CLOCK
the weight% AT 11
the weight% AT 12
the weight% B13
the weight% B14
the weight% Polyethyloxazoline 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Quaternary ammonium compound 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 flavoring 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Aminoxide 0.84 0.42 0.84 0.42 0.84 0.42 0.84 0.42 0.84 0.84 Ethoxylated alcohol #1 0.84 0.84 0.84 0.84 0.84 Ethoxylated alcohol #2 0.50 0.50 0.50 0.50 glycol ether 4.00 4.00 4.00 4.00 4.00 4.00 4.00 4.00 Sodium EDTA 2.90 2.90 2.90 2.90 2.90 2.90 Lemon acid 2.50 2.50 2.50 2.50 2.50 2.50 Sulfamic acid 2.50 2.50 Water* up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100

Component B15
the weight% B16
the weight% B17
the weight% B18
the weight% B19
the weight% IN 20
the weight% AT 21
the weight% B22
the weight% B23
the weight% B24
the weight% Polyethyloxazoline 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Quaternary ammonium compound 0.20 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 flavoring 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Aminoxide 0.42 0.80 0.40 0.80 0.40 0.80 0.40 Ethoxylated alcohol #1 0.80 0.80 0.80 Ethoxylated alcohol #2 0.50 0.50 0.50 0.50 glycol ether 4.00 4.0 4.0 4.0 4.0 Sodium EDTA Lemon acid 2.50 2.50 2.50 2.50 2.50 2.50 Sulfamic acid 2.50 2.50 2.50 2.50 Water* up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100

[00156] A concentrate from a water-based composition is obtained by removing some of the water from the composition, increasing the concentration of the remaining raw materials. The resulting concentrate can then be back-diluted to work with the concentrate prior to use. Solutions at 5x and 10x concentrations are commonly used by cleaning and sanitizing industries and hospitality consumers. In these industries it is desirable to use concentrates as it reduces transport costs and saves storage space. Table 10 shows examples of concentrate compositions in one embodiment of the present invention.

[00157] Table 10 - Compositions of concentrates

Component Protective agent 5x Protective agent 10x All-purpose cleaner 5x All-purpose cleaner 10x Bathroom cleaner 5x Bathroom cleaner 10x Polyethyloxazoline 5.0 ten 5.0 ten 5.0 ten Quaternary ammonium compound 1.0 2.0 2.5 5.0 1.6 3.2 flavoring 0.25 0.50 0.5 1.0 0.75 1.5 surfactant 0.50 1.0 4.0 8.0 3.0 6.0 glycol ether 12.5 25 TEA (triethanolamine) 2.5 5.0 Lemon acid 12.5 25 Water* up to 100 up to 100 up to 100 up to 100 up to 100 up to 100

[00158] Comparative example

[00159] Various polymeric compounds were tested for the ability to provide a permanent reduction in the bioburden of Enterobacter aerogenes using the protocol EPA 01-1A. Before the test, each composition in a volume of 50 μl was left to dry on glass carriers. Each test was performed with the addition of 5% fetal bovine serum (FBS). As noted in Table 11, the combination of polyoxazoline and quaternary ammonium provides a synergistic advantage in terms of residual disinfection.

[00160] Table 11

Recipe 1 Recipe 2 Recipe 3 Recipe 4 Recipe 5 Active Ingredient Quaternary Ammonium Blend Quaternary Ammonium Blend Quaternary Ammonium Blend Quaternary Ammonium Blend Quaternary Ammonium Blend Polymer 3 glycidoxy-propyl-trimethoxy-silane Trimethoxy-silyl-propyl (polyethyleneimine SSP-060) acrylic emulsion Polyamide resin Polioxazoline Organyleptic properties cloudy film Sticky film after drying Transparent, non-tacky film Transparent, non-tacky film Transparent, non-tacky film Associated log kill NI* NI* Destruction 0.5 log Destruction 1.8 log Destruction of 5 logs

* Indicates that the study was not conducted due to poor organoleptic properties.

[00161] Thus, it will be apparent to those skilled in the art that the composition and methods of the present invention are useful and suitable for general use. Many embodiments and variations other than those described herein, as well as numerous variations, modifications, and equivalents, will be apparent or reasonably suggested to the person of ordinary skill in the art from the present invention and its foregoing description, without departing from the spirit or scope of the invention.

[00162] Thus, the composition and methods of the present invention have been described in detail with respect to its preferred embodiment, but at the same time, it should be understood that this description is purely illustrative, given by way of example and solely for the purpose of providing a complete and sufficient disclosure.

[00163] The foregoing description is not intended or should be construed as limiting in any way, and does not exclude any such other embodiments, changes, variations, modifications, and equivalents.

Claims (43)

1. Composition of a disinfectant containing: polymeric binder in the range from 0.1% to 10% wt. disinfectant compositions, wherein the polymeric binder is an oxazoline homopolymer, biocidal compound in the range from 0.05% to 10% wt. disinfectant compositions, surfactant in the range from 0.01% to 10% wt. disinfectant compositions, pH-regulating substance in the range from 0.01% to 10% wt. in the composition of the disinfectant, glycol ether in the range from 1% to 10% wt. disinfectant compositions, and the rest up to 100% wt. makes up water where the biocidal compound is a quaternary ammonium compound or a mixture of quaternary ammonium compounds, where the quaternary ammonium compound has the structure:

wherein R ₁ is alkyl, alkoxy or aryl, with or without a heteroatom and being saturated or unsaturated; R ₂ is alkyl, alkoxy or aryl with or without a heteroatom and is saturated or unsaturated; R ₃ is alkyl, alkoxy or aryl with or without a heteroatom and is saturated or unsaturated; R ₄ is alkyl, alkoxy or aryl with or without a heteroatom and is saturated or unsaturated; X ^- is an anion representing a halogen, sulfonate, sulfate, phosphonate, phosphate, carbonate, bicarbonate, hydroxy or carboxylate. 2. The disinfectant composition according to claim 1, in which the oxazoline homopolymer has the structure:

wherein R ₁ is hydrogen, alkyl, alkenyl, alkoxy, alkylamino, alkynyl, allyl, amino, anilino, aryl, benzyl, carboxyl, carboxyalkyl, carboxyalkenyl, cyano, glycosyl, halogen, hydroxyl, oxazoline mesylate, oxazoline tosylate, oxazoline triflate, oxazoline silyl, phenol, polyalkoxy, quaternary ammonium, thiol or thioether; R ₂ is hydrogen, alkyl, alkenyl, alkoxy, alkylamino, alkynyl, allyl, amino, anilino, aryl, benzyl, carboxyl, carboxyalkyl, carboxyalkenyl, cyano, glycosyl, halogen, hydroxyl, oxazoline mesylate, oxazoline tosylate, oxazoline triflate, oxazoline silyl, phenol, polyalkoxy, quaternary ammonium, thiol or thioether, or a macrocyclic structure; R ₃ is hydrogen, alkyl, alkenyl, alkoxy, aryl, benzyl, hydroxyalkyl or perfluoroalkyl; and the value of n is in the range from 1 to 1000000. 3. The disinfectant composition according to claim 1, wherein the polymeric binder is made with an ethyloxazoline monomer. 4. The disinfectant composition of claim 1, wherein the surfactant is non-ionic. 5. The disinfectant composition of claim 4, wherein the non-ionic surfactant is an ethoxylated alcohol. 6. The disinfectant composition of claim 1, wherein the surfactant is an amine oxide. 7. The composition of the disinfectant, containing: polymeric binder in the range from 0.1% to 15% wt. disinfectant compositions, wherein the polymeric binder is an oxazoline homopolymer, biocidal compound in the range from 0.05% to 10% wt. disinfectant compositions, surfactant in the range from 0.01% to 10% wt. disinfectant compositions, pH-regulating substance in the range from 0.01% to 30% wt. disinfectant compositions, glycol ether in the range from 0% to 30% wt. disinfectant compositions, and the rest up to 100% wt. makes up water where the biocidal compound is a quaternary ammonium compound or a mixture of quaternary ammonium compounds, where the quaternary ammonium compound has the structure:

wherein R ₁ is alkyl, alkoxy or aryl, with or without a heteroatom and being saturated or unsaturated; R ₂ is alkyl, alkoxy or aryl with or without a heteroatom and is saturated or unsaturated; R ₃ is alkyl, alkoxy or aryl with or without a heteroatom and is saturated or unsaturated; R ₄ is alkyl, alkoxy or aryl with or without a heteroatom and is saturated or unsaturated; X ^- is an anion representing a halogen, sulfonate, sulfate, phosphonate, phosphate, carbonate, bicarbonate, hydroxy or carboxylate. 8. The disinfectant composition according to claim 7, wherein the composition further comprises a biocidal compound selected from the group consisting of citric acid, sulfamic acid, glycolic acid, lactic acid, lauric acid and capric acid, quaternary silane salt, triclosan, zinc pyrithione , metal salt, metal oxide, phenol, vegetable matter, halogen, peroxide, heterocyclic antimicrobial agent, aldehyde, alcohol, and combinations thereof. 9. The disinfectant composition of claim 7, wherein the quaternary ammonium compound is selected from the group consisting of n-alkyldimethylbenzyl ammonium chloride, di-n-octyl dimethylammonium chloride, dodecyldimethyl ammonium chloride, n-alkyldimethylbenzyl ammonium saccharinate, 3-(trimethoxysilyl ) propyldimethyloctadecyl ammonium chloride and combinations thereof.