JP2020522246A5 - - Google Patents
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- Publication number
- JP2020522246A5 JP2020522246A5 JP2019565853A JP2019565853A JP2020522246A5 JP 2020522246 A5 JP2020522246 A5 JP 2020522246A5 JP 2019565853 A JP2019565853 A JP 2019565853A JP 2019565853 A JP2019565853 A JP 2019565853A JP 2020522246 A5 JP2020522246 A5 JP 2020522246A5
- Authority
- JP
- Japan
- Prior art keywords
- catalyst
- sample
- bismuth
- iii
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003054 catalyst Substances 0.000 claims 16
- 238000000034 method Methods 0.000 claims 14
- 239000000523 sample Substances 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 6
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- ILOJFJBXXANEQW-UHFFFAOYSA-N aminooxy(phenyl)borinic acid Chemical group NOB(O)C1=CC=CC=C1 ILOJFJBXXANEQW-UHFFFAOYSA-N 0.000 claims 3
- 150000001621 bismuth Chemical class 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 150000003008 phosphonic acid esters Chemical class 0.000 claims 3
- ISZXCHNOGDNZSI-UHFFFAOYSA-N (2-amino-5-fluorophenyl)boronic acid Chemical compound NC1=CC=C(F)C=C1B(O)O ISZXCHNOGDNZSI-UHFFFAOYSA-N 0.000 claims 2
- JHMCGZZYTNWAQS-UHFFFAOYSA-N (2-amino-5-methylphenyl)boronic acid Chemical compound CC1=CC=C(N)C(B(O)O)=C1 JHMCGZZYTNWAQS-UHFFFAOYSA-N 0.000 claims 2
- DIRRKLFMHQUJCM-UHFFFAOYSA-N (2-aminophenyl)boronic acid Chemical compound NC1=CC=CC=C1B(O)O DIRRKLFMHQUJCM-UHFFFAOYSA-N 0.000 claims 2
- KKMOSYLWYLMHAL-UHFFFAOYSA-N 2-bromo-6-nitroaniline Chemical compound NC1=C(Br)C=CC=C1[N+]([O-])=O KKMOSYLWYLMHAL-UHFFFAOYSA-N 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- TXKAQZRUJUNDHI-UHFFFAOYSA-K bismuth tribromide Chemical compound Br[Bi](Br)Br TXKAQZRUJUNDHI-UHFFFAOYSA-K 0.000 claims 2
- REKWPXFKNZERAA-UHFFFAOYSA-K bismuth;2-carboxyphenolate Chemical compound [Bi+3].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O REKWPXFKNZERAA-UHFFFAOYSA-K 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- KVEBNTWOYMYORY-UHFFFAOYSA-N diethoxyphosphoryl(phenyl)methanamine Chemical compound CCOP(=O)(OCC)C(N)C1=CC=CC=C1 KVEBNTWOYMYORY-UHFFFAOYSA-N 0.000 claims 2
- 239000011541 reaction mixture Substances 0.000 claims 2
- KOECRLKKXSXCPB-UHFFFAOYSA-K triiodobismuthane Chemical compound I[Bi](I)I KOECRLKKXSXCPB-UHFFFAOYSA-K 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762512324P | 2017-05-30 | 2017-05-30 | |
| US62/512,324 | 2017-05-30 | ||
| PCT/EP2018/064161 WO2018219997A1 (en) | 2017-05-30 | 2018-05-30 | Catalysts for reversing formaldehyde adducts and crosslinks |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020522246A JP2020522246A (ja) | 2020-07-30 |
| JP2020522246A5 true JP2020522246A5 (https=) | 2021-07-26 |
| JP7291081B2 JP7291081B2 (ja) | 2023-06-14 |
Family
ID=62486578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565853A Active JP7291081B2 (ja) | 2017-05-30 | 2018-05-30 | ホルムアルデヒド付加及び架橋を反転するための触媒 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10995104B2 (https=) |
| EP (1) | EP3631408A1 (https=) |
| JP (1) | JP7291081B2 (https=) |
| CN (1) | CN110678729B (https=) |
| CA (1) | CA3061863A1 (https=) |
| WO (1) | WO2018219997A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025014306A1 (ko) * | 2023-07-12 | 2025-01-16 | 연세대학교 산학협력단 | Pfa 고정 또는 ffpe 처리된 생물학적 샘플의 고정액 교환용 조성물 및 이의 방법 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4786600A (en) | 1984-05-25 | 1988-11-22 | The Trustees Of Columbia University In The City Of New York | Autocatalytic replication of recombinant RNA |
| US4876187A (en) | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US5455170A (en) | 1986-08-22 | 1995-10-03 | Hoffmann-La Roche Inc. | Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05 |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| AU3539089A (en) | 1988-04-08 | 1989-11-03 | Salk Institute For Biological Studies, The | Ligase-based amplification method |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| ATE144556T1 (de) | 1988-06-24 | 1996-11-15 | Amgen Inc | Verfahren und mittel zum nachweis von nukleinsäuresequenzen |
| ATE138106T1 (de) | 1988-07-20 | 1996-06-15 | David Segev | Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5573907A (en) | 1990-01-26 | 1996-11-12 | Abbott Laboratories | Detecting and amplifying target nucleic acids using exonucleolytic activity |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US6033854A (en) | 1991-12-16 | 2000-03-07 | Biotronics Corporation | Quantitative PCR using blocking oligonucleotides |
| US5541311A (en) | 1992-12-07 | 1996-07-30 | Third Wave Technologies, Inc. | Nucleic acid encoding synthesis-deficient thermostable DNA polymerase |
| US5614402A (en) | 1992-12-07 | 1997-03-25 | Third Wave Technologies, Inc. | 5' nucleases derived from thermostable DNA polymerase |
| US5719028A (en) | 1992-12-07 | 1998-02-17 | Third Wave Technologies Inc. | Cleavase fragment length polymorphism |
| WO1995000667A1 (en) | 1993-06-17 | 1995-01-05 | The Research Foundation Of State University Of New York | Improved methods for detecting nucleic acid sequences |
| CA2169837A1 (en) | 1993-08-18 | 1995-02-23 | Peter D. Duck | Compositions and methods for detecting target nucleic acid sequences utilizing adjacent sequence-enzyme molecules |
| WO1995006137A1 (en) | 1993-08-27 | 1995-03-02 | Australian Red Cross Society | Detection of genes |
| WO1995014106A2 (en) | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| DE4400927A1 (de) | 1994-01-14 | 1995-07-20 | Henkel Kgaa | Wäßrige Lösungen von quaternierten Fettsäuretriethanolaminester-Salze |
| WO1995021271A1 (en) | 1994-02-07 | 1995-08-10 | Molecular Tool, Inc. | Ligase/polymerase-mediated genetic bit analysistm of single nucleotide polymorphisms and its use in genetic analysis |
| US5705365A (en) | 1995-06-07 | 1998-01-06 | Gen-Probe Incorporated | Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| US5710029A (en) | 1995-06-07 | 1998-01-20 | Gen-Probe Incorporated | Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| US6180349B1 (en) | 1999-05-18 | 2001-01-30 | The Regents Of The University Of California | Quantitative PCR method to enumerate DNA copy number |
| CN105441549A (zh) | 2007-03-30 | 2016-03-30 | 霍夫曼-拉罗奇有限公司 | 烷基胺改进甲醛固定的生物样品组分的检测 |
| US20170283860A1 (en) | 2014-09-16 | 2017-10-05 | The Board Of Trustees Of The Leland Stanford Junio University | Methods and compositions for the removal of aldehyde adducts and crosslinks from biomolecules |
-
2018
- 2018-05-29 US US15/991,087 patent/US10995104B2/en active Active
- 2018-05-30 CN CN201880034973.3A patent/CN110678729B/zh active Active
- 2018-05-30 EP EP18728362.7A patent/EP3631408A1/en active Pending
- 2018-05-30 WO PCT/EP2018/064161 patent/WO2018219997A1/en not_active Ceased
- 2018-05-30 CA CA3061863A patent/CA3061863A1/en active Pending
- 2018-05-30 JP JP2019565853A patent/JP7291081B2/ja active Active
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