JP2020521817A5 - - Google Patents
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- Publication number
- JP2020521817A5 JP2020521817A5 JP2020516962A JP2020516962A JP2020521817A5 JP 2020521817 A5 JP2020521817 A5 JP 2020521817A5 JP 2020516962 A JP2020516962 A JP 2020516962A JP 2020516962 A JP2020516962 A JP 2020516962A JP 2020521817 A5 JP2020521817 A5 JP 2020521817A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- quinazoline
- carboxamide
- oxo
- branched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 201000004384 Alopecia Diseases 0.000 claims 3
- 208000019838 Blood disease Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 3
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 3
- 206010046851 Uveitis Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 231100000360 alopecia Toxicity 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 208000014951 hematologic disease Diseases 0.000 claims 3
- 208000018706 hematopoietic system disease Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 2
- 206010013774 Dry eye Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 2
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 230000002489 hematologic effect Effects 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- JXPVWJOKXDUSLJ-JKSUJKDBSA-N 2-bromo-N-[(1S,2R)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound BrC=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@@H]1[C@@H](CCCC1)O)=O JXPVWJOKXDUSLJ-JKSUJKDBSA-N 0.000 claims 1
- RQUOUHPZMZVZGL-UHFFFAOYSA-N 2-bromo-N-cyclohexyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound BrC=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCCCC1)=O RQUOUHPZMZVZGL-UHFFFAOYSA-N 0.000 claims 1
- GHBYQVNMUFILIA-UHFFFAOYSA-N 2-bromo-N-cyclopentyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound BrC=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCCC1)=O GHBYQVNMUFILIA-UHFFFAOYSA-N 0.000 claims 1
- NYWQWNVWBKDBBS-UHFFFAOYSA-N 2-cyano-N-cyclohexyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C(#N)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCCCC1)=O NYWQWNVWBKDBBS-UHFFFAOYSA-N 0.000 claims 1
- LVHASCJIJRLCRT-UHFFFAOYSA-N 2-cyclopropyl-11-oxo-N-(oxolan-3-yl)pyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1COCC1)=O LVHASCJIJRLCRT-UHFFFAOYSA-N 0.000 claims 1
- QREIFIKQJUGJBT-UHFFFAOYSA-N 2-cyclopropyl-N-(1-methylpiperidin-4-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCN(CC1)C)=O QREIFIKQJUGJBT-UHFFFAOYSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-UHFFFAOYSA-N 2-cyclopropyl-N-(2-hydroxycyclohexyl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1C(CCCC1)O)=O XWTSGDSYCDKUNY-UHFFFAOYSA-N 0.000 claims 1
- XSKMMXUMCQXLDO-UHFFFAOYSA-N 2-cyclopropyl-N-(3-methyloxan-4-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1C(COCC1)C)=O XSKMMXUMCQXLDO-UHFFFAOYSA-N 0.000 claims 1
- MTDAHYCAQCESTK-UHFFFAOYSA-N 2-cyclopropyl-N-(4,4-difluorocyclohexyl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCC(CC1)(F)F)=O MTDAHYCAQCESTK-UHFFFAOYSA-N 0.000 claims 1
- FVODTXIMSAHXIU-UHFFFAOYSA-N 2-cyclopropyl-N-(oxan-4-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)NC1CCOCC1)=O FVODTXIMSAHXIU-UHFFFAOYSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-RTBURBONSA-N 2-cyclopropyl-N-[(1R,2R)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@H]1[C@@H](CCCC1)O)=O XWTSGDSYCDKUNY-RTBURBONSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-MOPGFXCFSA-N 2-cyclopropyl-N-[(1R,2S)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@H]1[C@H](CCCC1)O)=O XWTSGDSYCDKUNY-MOPGFXCFSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-RBUKOAKNSA-N 2-cyclopropyl-N-[(1S,2R)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@@H]1[C@@H](CCCC1)O)=O XWTSGDSYCDKUNY-RBUKOAKNSA-N 0.000 claims 1
- XWTSGDSYCDKUNY-OALUTQOASA-N 2-cyclopropyl-N-[(1S,2S)-2-hydroxycyclohexyl]-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CC1)C=1C=C2C(N3C(=NC2=CC=1)C(=CC=C3)C(=O)N[C@@H]1[C@H](CCCC1)O)=O XWTSGDSYCDKUNY-OALUTQOASA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 101000970023 Homo sapiens NUAK family SNF1-like kinase 1 Proteins 0.000 claims 1
- 101000844245 Homo sapiens Non-receptor tyrosine-protein kinase TYK2 Proteins 0.000 claims 1
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 claims 1
- CEXAGGOVTBATNW-UHFFFAOYSA-N N-(4,4-difluorocyclohexyl)-2-fluoro-8-methyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound FC1(CCC(CC1)NC(=O)C1=CC(=CN2C1=NC1=CC=C(C=C1C2=O)F)C)F CEXAGGOVTBATNW-UHFFFAOYSA-N 0.000 claims 1
- QXOHLSLHTKNUBT-LEWJYISDSA-N N-[(1S,2R)-2-hydroxycyclohexyl]-11-oxo-2-pyridin-4-ylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound O[C@H]1[C@H](CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=NC=C1 QXOHLSLHTKNUBT-LEWJYISDSA-N 0.000 claims 1
- CWDONLQVGHHKDP-LEWJYISDSA-N N-[(1S,2R)-2-hydroxycyclohexyl]-2-(4-methylpiperazin-1-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound O[C@H]1[C@H](CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)N1CCN(CC1)C CWDONLQVGHHKDP-LEWJYISDSA-N 0.000 claims 1
- BUQVOMJSBHFNOL-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-(trifluoromethoxy)pyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)OC(F)(F)F BUQVOMJSBHFNOL-UHFFFAOYSA-N 0.000 claims 1
- FJBTUIMJJJCNRZ-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-(trifluoromethyl)pyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C(F)(F)F FJBTUIMJJJCNRZ-UHFFFAOYSA-N 0.000 claims 1
- IYQDXNGDJCBVDZ-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-phenylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=CC=C1 IYQDXNGDJCBVDZ-UHFFFAOYSA-N 0.000 claims 1
- GUWULDWWZFEBMG-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-pyridin-4-ylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=NC=C1 GUWULDWWZFEBMG-UHFFFAOYSA-N 0.000 claims 1
- IKOANHRJTRKQAF-UHFFFAOYSA-N N-cyclohexyl-11-oxo-2-thiophen-2-ylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C=1SC=CC=1 IKOANHRJTRKQAF-UHFFFAOYSA-N 0.000 claims 1
- GESCXFZABJFAKQ-UHFFFAOYSA-N N-cyclohexyl-2-(4-fluorophenyl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=C(C=C1)F GESCXFZABJFAKQ-UHFFFAOYSA-N 0.000 claims 1
- HWPLAPKOYVXNOJ-UHFFFAOYSA-N N-cyclohexyl-2-(4-methylpiperazin-1-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)N1CCN(CC1)C HWPLAPKOYVXNOJ-UHFFFAOYSA-N 0.000 claims 1
- FYQHQBSVPAYETJ-UHFFFAOYSA-N N-cyclohexyl-2-cyclopropyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1CC1 FYQHQBSVPAYETJ-UHFFFAOYSA-N 0.000 claims 1
- AUKKKXYRYHJYGX-UHFFFAOYSA-N N-cyclohexyl-2-cyclopropyl-8-methyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC(=CN2C1=NC1=CC=C(C=C1C2=O)C1CC1)C AUKKKXYRYHJYGX-UHFFFAOYSA-N 0.000 claims 1
- ANUBZHMGCRHWQV-UHFFFAOYSA-N N-cyclohexyl-2-hydroxy-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)O ANUBZHMGCRHWQV-UHFFFAOYSA-N 0.000 claims 1
- JAEARRRCUGRDJR-UHFFFAOYSA-N N-cyclohexyl-2-methoxy-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)OC JAEARRRCUGRDJR-UHFFFAOYSA-N 0.000 claims 1
- VHIYDUCRIGCKTQ-UHFFFAOYSA-N N-cyclohexyl-2-methyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C VHIYDUCRIGCKTQ-UHFFFAOYSA-N 0.000 claims 1
- XAFMNQLWPHEYRJ-UHFFFAOYSA-N N-cyclohexyl-2-morpholin-4-yl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)N1CCOCC1 XAFMNQLWPHEYRJ-UHFFFAOYSA-N 0.000 claims 1
- VZKBWAZISLJGJE-UHFFFAOYSA-N N-cyclopentyl-11-oxo-2-pyridin-4-ylpyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1=CC=NC=C1 VZKBWAZISLJGJE-UHFFFAOYSA-N 0.000 claims 1
- QRWVAHABHPOCIO-UHFFFAOYSA-N N-cyclopentyl-2-(4-methylpiperazin-1-yl)-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)N1CCN(CC1)C QRWVAHABHPOCIO-UHFFFAOYSA-N 0.000 claims 1
- QDEFFAKLENOJFJ-UHFFFAOYSA-N N-cyclopentyl-2-cyclopropyl-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)C1CC1 QDEFFAKLENOJFJ-UHFFFAOYSA-N 0.000 claims 1
- MYPLVFXZZARGCE-UHFFFAOYSA-N N-cyclopentyl-2-hydroxy-11-oxopyrido[2,1-b]quinazoline-6-carboxamide Chemical compound C1(CCCC1)NC(=O)C1=CC=CN2C1=NC1=CC=C(C=C1C2=O)O MYPLVFXZZARGCE-UHFFFAOYSA-N 0.000 claims 1
- 102100021732 NUAK family SNF1-like kinase 1 Human genes 0.000 claims 1
- 102100032028 Non-receptor tyrosine-protein kinase TYK2 Human genes 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 201000008100 Vaginitis Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000013066 combination product Substances 0.000 claims 1
- 229940127555 combination product Drugs 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP201730759 | 2017-06-01 | ||
| ES201730759 | 2017-06-01 | ||
| PCT/ES2018/070396 WO2018220252A1 (es) | 2017-06-01 | 2018-05-31 | Derivados de piridoquinazolina eficaces como inhibidores de proteína quinasa |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020521817A JP2020521817A (ja) | 2020-07-27 |
| JP2020521817A5 true JP2020521817A5 (https=) | 2021-07-26 |
| JP7110335B2 JP7110335B2 (ja) | 2022-08-01 |
Family
ID=61569288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020516962A Active JP7110335B2 (ja) | 2017-06-01 | 2018-05-31 | プロテインキナーゼ阻害剤として有用なピリドキナゾリン誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US11021479B2 (https=) |
| EP (1) | EP3632912B1 (https=) |
| JP (1) | JP7110335B2 (https=) |
| KR (1) | KR102629854B1 (https=) |
| CN (1) | CN111247143B (https=) |
| AU (1) | AU2018278283B2 (https=) |
| CA (1) | CA3066009A1 (https=) |
| CY (1) | CY1124087T1 (https=) |
| DK (1) | DK3632912T3 (https=) |
| EA (1) | EA037384B1 (https=) |
| ES (1) | ES2881960T3 (https=) |
| HR (1) | HRP20210814T1 (https=) |
| HU (1) | HUE054792T2 (https=) |
| LT (1) | LT3632912T (https=) |
| MX (1) | MX385475B (https=) |
| PL (1) | PL3632912T3 (https=) |
| PT (1) | PT3632912T (https=) |
| RS (1) | RS61833B1 (https=) |
| SI (1) | SI3632912T1 (https=) |
| SM (1) | SMT202100312T1 (https=) |
| WO (1) | WO2018220252A1 (https=) |
| ZA (1) | ZA201908372B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7525609B2 (ja) | 2020-01-31 | 2024-07-30 | エルジー エナジー ソリューション リミテッド | 多層構造の無機物層を含む分離膜一体型電極の製造方法及びそれによる分離膜一体型電極 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4551460A (en) | 1982-05-10 | 1985-11-05 | Hoffmann-La Roche Inc. | Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis |
| DE69713139T2 (de) * | 1996-11-26 | 2002-12-19 | American Cyanamid Co., Madison | Hetero-biaryl-pyridochinazolinonderivate als antikrebsmittel |
| US20050192314A1 (en) * | 2003-11-13 | 2005-09-01 | Ambit Biosciences Corporation | Urea derivatives as C-kit modulators |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2010061971A1 (ja) | 2008-11-28 | 2010-06-03 | 興和株式会社 | ピリジン－３－カルボキシアミド誘導体 |
| EP3119781B1 (en) * | 2014-03-20 | 2020-09-16 | The Johns Hopkins University | Compounds which inhibit rna polymerase, compositions including such compounds, and their use |
-
2018
- 2018-05-31 MX MX2019014436A patent/MX385475B/es unknown
- 2018-05-31 HR HRP20210814TT patent/HRP20210814T1/hr unknown
- 2018-05-31 AU AU2018278283A patent/AU2018278283B2/en active Active
- 2018-05-31 CN CN201880048531.4A patent/CN111247143B/zh active Active
- 2018-05-31 EP EP18759146.6A patent/EP3632912B1/en active Active
- 2018-05-31 HU HUE18759146A patent/HUE054792T2/hu unknown
- 2018-05-31 RS RS20210545A patent/RS61833B1/sr unknown
- 2018-05-31 US US16/615,867 patent/US11021479B2/en active Active
- 2018-05-31 JP JP2020516962A patent/JP7110335B2/ja active Active
- 2018-05-31 SI SI201830289T patent/SI3632912T1/sl unknown
- 2018-05-31 EA EA201992793A patent/EA037384B1/ru unknown
- 2018-05-31 CA CA3066009A patent/CA3066009A1/en active Pending
- 2018-05-31 LT LTEP18759146.6T patent/LT3632912T/lt unknown
- 2018-05-31 WO PCT/ES2018/070396 patent/WO2018220252A1/es not_active Ceased
- 2018-05-31 PT PT187591466T patent/PT3632912T/pt unknown
- 2018-05-31 DK DK18759146.6T patent/DK3632912T3/da active
- 2018-05-31 PL PL18759146T patent/PL3632912T3/pl unknown
- 2018-05-31 KR KR1020197038842A patent/KR102629854B1/ko active Active
- 2018-05-31 ES ES18759146T patent/ES2881960T3/es active Active
- 2018-05-31 SM SM20210312T patent/SMT202100312T1/it unknown
-
2019
- 2019-12-13 ZA ZA2019/08372A patent/ZA201908372B/en unknown
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2021
- 2021-05-20 CY CY20211100437T patent/CY1124087T1/el unknown
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