JP2020521790A5 - - Google Patents

Info

Publication number

JP2020521790A5

JP2020521790A5 JP2019566112A JP2019566112A JP2020521790A5 JP 2020521790 A5 JP2020521790 A5 JP 2020521790A5 JP 2019566112 A JP2019566112 A JP 2019566112A JP 2019566112 A JP2019566112 A JP 2019566112A JP 2020521790 A5 JP2020521790 A5 JP 2020521790A5

Authority

JP

Japan

Prior art keywords

composition according

activator

effective amount

composition

weight

Prior art date

2018-05-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000012190 activator Substances 0.000 claims 14
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 3
• 229960001967 tacrolimus Drugs 0.000 claims 3
• QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 3
• 241000239290 Araneae Species 0.000 claims 2
• 239000004593 Epoxy Substances 0.000 claims 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
• 230000002745 absorbent Effects 0.000 claims 2
• 239000002250 absorbent Substances 0.000 claims 2
• 239000011230 binding agent Substances 0.000 claims 2
• 239000000835 fiber Substances 0.000 claims 2
• 229910021485 fumed silica Inorganic materials 0.000 claims 2
• 239000000463 material Substances 0.000 claims 2
• 239000005995 Aluminium silicate Substances 0.000 claims 1
• 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
• 206010013774 Dry eye Diseases 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 235000012211 aluminium silicate Nutrition 0.000 claims 1
• 239000004067 bulking agent Substances 0.000 claims 1
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 1
• 238000013268 sustained release Methods 0.000 claims 1
• 239000012730 sustained-release form Substances 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1