JP2018515567A5 - - Google Patents
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- JP2018515567A5 JP2018515567A5 JP2017560686A JP2017560686A JP2018515567A5 JP 2018515567 A5 JP2018515567 A5 JP 2018515567A5 JP 2017560686 A JP2017560686 A JP 2017560686A JP 2017560686 A JP2017560686 A JP 2017560686A JP 2018515567 A5 JP2018515567 A5 JP 2018515567A5
- Authority
- JP
- Japan
- Prior art keywords
- particles
- ligands
- surrounding
- particle
- core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 26
- 239000003446 ligand Substances 0.000 claims 16
- 239000000463 material Substances 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 210000000605 viral structure Anatomy 0.000 claims 10
- 230000003612 virological effect Effects 0.000 claims 10
- 229960005520 bryostatin Drugs 0.000 claims 9
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 9
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 9
- 102000003964 Histone deacetylase Human genes 0.000 claims 6
- 108090000353 Histone deacetylase Proteins 0.000 claims 6
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical group CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 6
- MJQUEDHRCUIRLF-TVIXENOKSA-N bryostatin 1 Chemical compound C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(C)=O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 MJQUEDHRCUIRLF-TVIXENOKSA-N 0.000 claims 6
- MJQUEDHRCUIRLF-YCVQJEHTSA-N bryostatins Chemical compound C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)=C\C(=O)OC)C([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(C)=O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 MJQUEDHRCUIRLF-YCVQJEHTSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 230000037396 body weight Effects 0.000 claims 4
- 229960005539 bryostatin 1 Drugs 0.000 claims 3
- MUIWQCKLQMOUAT-AKUNNTHJSA-N bryostatin 20 Natural products COC(=O)C=C1C[C@@]2(C)C[C@]3(O)O[C@](C)(C[C@@H](O)CC(=O)O[C@](C)(C[C@@]4(C)O[C@](O)(CC5=CC(=O)O[C@]45C)C(C)(C)C=C[C@@](C)(C1)O2)[C@@H](C)O)C[C@H](OC(=O)C(C)(C)C)C3(C)C MUIWQCKLQMOUAT-AKUNNTHJSA-N 0.000 claims 3
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 3
- 229960005184 panobinostat Drugs 0.000 claims 3
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims 3
- 229960003452 romidepsin Drugs 0.000 claims 3
- OHRURASPPZQGQM-UHFFFAOYSA-N romidepsin Natural products O1C(=O)C(C(C)C)NC(=O)C(=CC)NC(=O)C2CSSCCC=CC1CC(=O)NC(C(C)C)C(=O)N2 OHRURASPPZQGQM-UHFFFAOYSA-N 0.000 claims 3
- 108010091666 romidepsin Proteins 0.000 claims 3
- 229960000604 valproic acid Drugs 0.000 claims 3
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 3
- 229960000237 vorinostat Drugs 0.000 claims 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562165444P | 2015-05-22 | 2015-05-22 | |
| US62/165,444 | 2015-05-22 | ||
| PCT/US2016/033766 WO2016191363A1 (en) | 2015-05-22 | 2016-05-23 | Combination hiv therapeutic |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020212055A Division JP7111795B2 (ja) | 2015-05-22 | 2020-12-22 | 組合せｈｉｖ治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515567A JP2018515567A (ja) | 2018-06-14 |
| JP2018515567A5 true JP2018515567A5 (https=) | 2019-06-27 |
| JP6816030B2 JP6816030B2 (ja) | 2021-01-20 |
Family
ID=57394156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560686A Active JP6816030B2 (ja) | 2015-05-22 | 2016-05-23 | 組合せｈｉｖ治療薬 |
| JP2020212055A Active JP7111795B2 (ja) | 2015-05-22 | 2020-12-22 | 組合せｈｉｖ治療薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020212055A Active JP7111795B2 (ja) | 2015-05-22 | 2020-12-22 | 組合せｈｉｖ治療薬 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10493030B2 (https=) |
| EP (1) | EP3297608B1 (https=) |
| JP (2) | JP6816030B2 (https=) |
| CN (1) | CN107708674A (https=) |
| WO (1) | WO2016191363A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| EP3560492B1 (en) * | 2016-12-26 | 2023-11-29 | FUJIFILM Corporation | Lipid particle composition and pharmaceutical composition |
| US11234932B2 (en) * | 2017-11-21 | 2022-02-01 | Aphios Corporation | Combination HIV therapeutic |
| US20210163935A1 (en) * | 2019-09-05 | 2021-06-03 | Trevor P. Castor | Targeted Critical Fluid Nanoparticles Platform for Delivery of Nucleic Acids for Treatment of HIV-1 and Other Diseases |
| WO2021183131A1 (en) * | 2020-03-12 | 2021-09-16 | Aphios Corporation | Dosage forms for improving organ transplantation, graft versus host disease and stem cells transplants |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007345319B2 (en) * | 2006-07-13 | 2012-09-06 | Institute For Advanced Study | Viral inhibitory nucleotide sequences and vaccines |
| WO2008108890A2 (en) * | 2006-10-18 | 2008-09-12 | University Of Rochester | Conditionally replicating viruses for cancer therapy |
| AT509277A1 (de) * | 2008-03-05 | 2011-07-15 | Moeller Gebaeudeautomation Gmbh | Schaltgerät |
| US20100166806A1 (en) * | 2008-12-29 | 2010-07-01 | Aphios Corporation | Combination therapy comprising the use of protein kinase C modulators and Histone Deacetylase inhibitors for treating HIV-1 latency |
| US8637074B2 (en) * | 2009-03-31 | 2014-01-28 | Aphios Corporation | Methods for co-encapsulation of combination drugs and co-encapsulated combination drug product |
| ES2618380T3 (es) * | 2010-09-24 | 2017-06-21 | International Aids Vaccine Initiative | Novedosos anticuerpos con amplio poder neutralizante de VIH-1 |
| US9034347B2 (en) * | 2011-12-19 | 2015-05-19 | Arphios Corporation | Drug delivery system and method for the treatment of neuro-degenerative disease |
| US20150320893A1 (en) * | 2012-05-03 | 2015-11-12 | Joseph M VOLPE | Treatment of latent hiv infection |
| KR102460800B1 (ko) * | 2013-11-01 | 2022-10-31 | 예일 유니버시티 | 면역요법용 모듈러 입자 |
| US11234932B2 (en) * | 2017-11-21 | 2022-02-01 | Aphios Corporation | Combination HIV therapeutic |
-
2016
- 2016-05-23 US US15/576,190 patent/US10493030B2/en active Active
- 2016-05-23 WO PCT/US2016/033766 patent/WO2016191363A1/en not_active Ceased
- 2016-05-23 CN CN201680029646.XA patent/CN107708674A/zh active Pending
- 2016-05-23 JP JP2017560686A patent/JP6816030B2/ja active Active
- 2016-05-23 EP EP16800598.1A patent/EP3297608B1/en active Active
-
2020
- 2020-12-22 JP JP2020212055A patent/JP7111795B2/ja active Active
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