JP2020519895A5 - - Google Patents
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- Publication number
- JP2020519895A5 JP2020519895A5 JP2019562415A JP2019562415A JP2020519895A5 JP 2020519895 A5 JP2020519895 A5 JP 2020519895A5 JP 2019562415 A JP2019562415 A JP 2019562415A JP 2019562415 A JP2019562415 A JP 2019562415A JP 2020519895 A5 JP2020519895 A5 JP 2020519895A5
- Authority
- JP
- Japan
- Prior art keywords
- autoantibody
- group
- subject
- autoantigen
- autoantibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 46
- 201000006417 multiple sclerosis Diseases 0.000 claims description 31
- 239000011541 reaction mixture Substances 0.000 claims description 29
- 239000000758 substrate Substances 0.000 claims description 23
- 239000007787 solid Substances 0.000 claims description 21
- 239000012472 biological sample Substances 0.000 claims description 20
- 238000003018 immunoassay Methods 0.000 claims description 15
- 239000000523 sample Substances 0.000 claims description 13
- 108060003951 Immunoglobulin Proteins 0.000 claims description 11
- 102000018358 immunoglobulin Human genes 0.000 claims description 11
- 239000000020 Nitrocellulose Substances 0.000 claims description 10
- 229920001220 nitrocellulos Polymers 0.000 claims description 10
- 239000000427 antigen Substances 0.000 claims description 6
- 239000000104 diagnostic biomarker Substances 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 5
- 238000003745 diagnosis Methods 0.000 claims description 4
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 206010036790 Productive cough Diseases 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims description 3
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 238000012875 competitive assay Methods 0.000 claims description 3
- 238000003119 immunoblot Methods 0.000 claims description 3
- 238000001114 immunoprecipitation Methods 0.000 claims description 3
- 210000002381 plasma Anatomy 0.000 claims description 3
- 210000003296 saliva Anatomy 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 210000003802 sputum Anatomy 0.000 claims description 3
- 208000024794 sputum Diseases 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 2
- 239000007790 solid phase Substances 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 1
- 201000008628 secondary progressive multiple sclerosis Diseases 0.000 description 20
- 230000015572 biosynthetic process Effects 0.000 description 13
- 238000002493 microarray Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 230000000750 progressive effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 238000003491 array Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762504130P | 2017-05-10 | 2017-05-10 | |
| US62/504,130 | 2017-05-10 | ||
| PCT/US2018/032130 WO2018209126A1 (en) | 2017-05-10 | 2018-05-10 | Diagnostic biomarkers for detecting, subtyping, and/or assessing progression of multiple sclerosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519895A JP2020519895A (ja) | 2020-07-02 |
| JP2020519895A5 true JP2020519895A5 (enExample) | 2021-07-26 |
| JP7146286B2 JP7146286B2 (ja) | 2022-10-04 |
Family
ID=64104996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019562415A Active JP7146286B2 (ja) | 2017-05-10 | 2018-05-10 | 多発性硬化症の進行を検出する、サブタイプ分類する、および／または評価するための、診断用バイオマーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20210003570A1 (enExample) |
| EP (1) | EP3622291A4 (enExample) |
| JP (1) | JP7146286B2 (enExample) |
| CA (1) | CA3062763A1 (enExample) |
| WO (1) | WO2018209126A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110186962B (zh) * | 2019-05-10 | 2021-06-25 | 天津大学 | 一种用于电容层析成像的不完整测量数据成像方法 |
| MX2023001565A (es) * | 2020-08-03 | 2023-03-08 | Prevail Therapeutics Inc | Vectores aav que codifican parkin y usos de los mismos. |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US5856092A (en) | 1989-02-13 | 1999-01-05 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| EP0773227A1 (en) | 1991-09-18 | 1997-05-14 | Affymax Technologies N.V. | Diverse collections of oligomers in use to prepare drugs, diagnostic reagents, pesticides or herbicides |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| EP0916396B1 (en) | 1991-11-22 | 2005-04-13 | Affymetrix, Inc. (a Delaware Corporation) | Combinatorial strategies for polymer synthesis |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5861242A (en) | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
| US6027880A (en) | 1995-08-02 | 2000-02-22 | Affymetrix, Inc. | Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis |
| US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| US6090555A (en) | 1997-12-11 | 2000-07-18 | Affymetrix, Inc. | Scanned image alignment systems and methods |
| US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| WO1997043611A1 (en) | 1996-05-16 | 1997-11-20 | Affymetrix, Inc. | Systems and methods for detection of labeled materials |
| DE69830395T2 (de) | 1997-03-20 | 2006-01-26 | Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara | Iterative resequenzierung |
| US6201639B1 (en) | 1998-03-20 | 2001-03-13 | James W. Overbeck | Wide field of view and high speed scanning microscopy |
| US6185030B1 (en) | 1998-03-20 | 2001-02-06 | James W. Overbeck | Wide field of view and high speed scanning microscopy |
| US5936324A (en) | 1998-03-30 | 1999-08-10 | Genetic Microsystems Inc. | Moving magnet scanner |
| US6218803B1 (en) | 1999-06-04 | 2001-04-17 | Genetic Microsystems, Inc. | Position sensing with variable capacitance transducers |
| JP2004003989A (ja) | 2002-03-15 | 2004-01-08 | Affymetrix Inc | 生物学的物質の走査のためのシステム、方法、および製品 |
| US20050032074A1 (en) | 2002-09-09 | 2005-02-10 | Affymetrix, Inc. | Custom design method for resequencing arrays |
| US7300788B2 (en) | 2002-10-08 | 2007-11-27 | Affymetrix, Inc. | Method for genotyping polymorphisms in humans |
| NZ540219A (en) | 2002-11-07 | 2008-08-29 | Univ Erasmus | Fret probes and methods for detecting interacting molecules |
| US7317415B2 (en) | 2003-08-08 | 2008-01-08 | Affymetrix, Inc. | System, method, and product for scanning of biological materials employing dual analog integrators |
| CA2799309A1 (en) | 2010-05-13 | 2011-11-17 | University Of Medicine And Dentistry Of New Jersey | Diagnostic autoantibody profiles for the detection and diagnosis of neurodegenerative diseases |
| WO2013010003A1 (en) | 2011-07-12 | 2013-01-17 | University Of Medicine And Dentistry Of New Jersey | Diagnostic biomarker profiles for the detection and diagnosis of alzheimer's disease |
| US9746482B2 (en) | 2011-08-11 | 2017-08-29 | Rowan University | Diagnostic biomarker profiles for the detection and diagnosis of parkinsons disease |
-
2018
- 2018-05-10 EP EP18798139.4A patent/EP3622291A4/en not_active Withdrawn
- 2018-05-10 JP JP2019562415A patent/JP7146286B2/ja active Active
- 2018-05-10 CA CA3062763A patent/CA3062763A1/en active Pending
- 2018-05-10 US US16/611,951 patent/US20210003570A1/en not_active Abandoned
- 2018-05-10 WO PCT/US2018/032130 patent/WO2018209126A1/en not_active Ceased
-
2022
- 2022-08-18 US US17/820,815 patent/US20220390448A1/en active Pending
- 2022-08-18 US US17/820,803 patent/US12174187B2/en active Active
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