JP2020519250A5 - - Google Patents
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- Publication number
- JP2020519250A5 JP2020519250A5 JP2019558571A JP2019558571A JP2020519250A5 JP 2020519250 A5 JP2020519250 A5 JP 2020519250A5 JP 2019558571 A JP2019558571 A JP 2019558571A JP 2019558571 A JP2019558571 A JP 2019558571A JP 2020519250 A5 JP2020519250 A5 JP 2020519250A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion polypeptide
- amino acid
- seq
- leu
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 45
- 102000004196 processed proteins & peptides Human genes 0.000 claims 44
- 229920001184 polypeptide Polymers 0.000 claims 43
- 230000004927 fusion Effects 0.000 claims 38
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 102000003982 Parathyroid hormone Human genes 0.000 claims 11
- 108090000445 Parathyroid hormone Proteins 0.000 claims 11
- 239000000199 parathyroid hormone Substances 0.000 claims 11
- 229960001319 parathyroid hormone Drugs 0.000 claims 11
- 102000018997 Growth Hormone Human genes 0.000 claims 9
- 108010051696 Growth Hormone Proteins 0.000 claims 9
- 230000027455 binding Effects 0.000 claims 9
- 239000000122 growth hormone Substances 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102100020948 Growth hormone receptor Human genes 0.000 claims 2
- 108010068542 Somatotropin Receptors Proteins 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 208000000038 Hypoparathyroidism Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 102000043299 Parathyroid hormone-related Human genes 0.000 claims 1
- 101710123753 Parathyroid hormone-related protein Proteins 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 108010005905 delta-hGHR Proteins 0.000 claims 1
- 230000003054 hormonal effect Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022202078A JP2023027315A (ja) | 2017-04-28 | 2022-12-19 | 副甲状腺ホルモン融合ポリペプチド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1706781.0A GB201706781D0 (en) | 2017-04-28 | 2017-04-28 | Parathyroid hormone fusion polypeptide |
| GB1706781.0 | 2017-04-28 | ||
| PCT/GB2018/051120 WO2018197895A2 (en) | 2017-04-28 | 2018-04-27 | Parathyroid hormone fusion polypeptide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022202078A Division JP2023027315A (ja) | 2017-04-28 | 2022-12-19 | 副甲状腺ホルモン融合ポリペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020519250A JP2020519250A (ja) | 2020-07-02 |
| JP2020519250A5 true JP2020519250A5 (https=) | 2021-06-10 |
Family
ID=59011076
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558571A Pending JP2020519250A (ja) | 2017-04-28 | 2018-04-27 | 副甲状腺ホルモン融合ポリペプチド |
| JP2022202078A Pending JP2023027315A (ja) | 2017-04-28 | 2022-12-19 | 副甲状腺ホルモン融合ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022202078A Pending JP2023027315A (ja) | 2017-04-28 | 2022-12-19 | 副甲状腺ホルモン融合ポリペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11344606B2 (https=) |
| EP (1) | EP3609913A2 (https=) |
| JP (2) | JP2020519250A (https=) |
| CN (1) | CN110546159B (https=) |
| CA (1) | CA3061088A1 (https=) |
| GB (1) | GB201706781D0 (https=) |
| WO (1) | WO2018197895A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201706781D0 (en) * | 2017-04-28 | 2017-06-14 | Univ Sheffield | Parathyroid hormone fusion polypeptide |
| SG11202106223RA (en) * | 2019-01-11 | 2021-07-29 | Radius Health Inc | Methods for detecting neutralizing antibodies to parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp) analog |
| CN111876388A (zh) * | 2020-07-24 | 2020-11-03 | 赛瑞诚(苏州)生物科技有限公司 | 一种骨和骨组织靶向外泌体及其制备方法和应用 |
| CN118126197B (zh) * | 2024-03-19 | 2025-02-25 | 康众(广东)生物医药有限公司 | 一种重组pth融合蛋白及其构建方法与应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770623B1 (en) | 1997-12-09 | 2004-08-03 | Eli Lilly And Company | Stabilized teriparatide solutions |
| JPH11285388A (ja) | 1998-04-03 | 1999-10-19 | Jcr Pharmaceuticals Co Ltd | キメラレセプター発現細胞とその用途 |
| AU2001257169C1 (en) | 2000-04-21 | 2011-06-16 | Tufts Medical Center, Inc. | G-protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same |
| EP1771467A2 (en) | 2004-07-26 | 2007-04-11 | Asterion Limited | Linkers |
| KR100700869B1 (ko) | 2005-06-03 | 2007-03-29 | 재단법인 목암생명공학연구소 | Ｐｔｈ, 완충제 및 안정제를 포함하는 안정한 ｐｔｈ조성물 |
| WO2008124166A2 (en) | 2007-04-09 | 2008-10-16 | The Board Of Trustees Of The University Of Arkansas | Fusion proteins of collagen-binding domain and parathyroid hormone |
| GB0717985D0 (en) | 2007-07-20 | 2007-10-24 | Asterion Ltd | Growth hormone fusion proteins |
| EP2411038B1 (en) | 2009-03-27 | 2016-12-28 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
| CN105153313A (zh) | 2010-02-16 | 2015-12-16 | 诺沃—诺迪斯克有限公司 | 因子viii融合蛋白 |
| WO2011143406A2 (en) | 2010-05-13 | 2011-11-17 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
| GB201104285D0 (en) * | 2011-03-15 | 2011-04-27 | Asterion Ltd | Modified receptor fusion proteins |
| WO2013120060A1 (en) | 2012-02-09 | 2013-08-15 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents by a collagen binding protein |
| ES2695161T3 (es) | 2011-12-14 | 2019-01-02 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| WO2013108235A1 (en) | 2012-01-20 | 2013-07-25 | Lupin Limited | Stabilized pth formulation |
| CA2919477A1 (en) * | 2013-07-31 | 2015-02-05 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating thermogenesis using pth-related and egf-related molecules |
| JP6805174B2 (ja) | 2015-05-12 | 2020-12-23 | アメリカ合衆国 | 神経成長因子シグナルペプチド及び副甲状腺ホルモンを含むａａｖ分離株及び融合タンパク質 |
| GB201706781D0 (en) * | 2017-04-28 | 2017-06-14 | Univ Sheffield | Parathyroid hormone fusion polypeptide |
-
2017
- 2017-04-28 GB GBGB1706781.0A patent/GB201706781D0/en not_active Ceased
-
2018
- 2018-04-27 EP EP18782783.7A patent/EP3609913A2/en not_active Withdrawn
- 2018-04-27 CA CA3061088A patent/CA3061088A1/en active Pending
- 2018-04-27 WO PCT/GB2018/051120 patent/WO2018197895A2/en not_active Ceased
- 2018-04-27 CN CN201880027437.0A patent/CN110546159B/zh not_active Expired - Fee Related
- 2018-04-27 JP JP2019558571A patent/JP2020519250A/ja active Pending
- 2018-04-27 US US16/608,611 patent/US11344606B2/en active Active
-
2022
- 2022-03-30 US US17/708,394 patent/US20220218790A1/en not_active Abandoned
- 2022-12-19 JP JP2022202078A patent/JP2023027315A/ja active Pending
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