JP2020518629A5 - - Google Patents
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- JP2020518629A5 JP2020518629A5 JP2019560313A JP2019560313A JP2020518629A5 JP 2020518629 A5 JP2020518629 A5 JP 2020518629A5 JP 2019560313 A JP2019560313 A JP 2019560313A JP 2019560313 A JP2019560313 A JP 2019560313A JP 2020518629 A5 JP2020518629 A5 JP 2020518629A5
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- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims description 9
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims description 8
- 230000001684 chronic effect Effects 0.000 claims description 5
- 208000017733 acquired polycythemia vera Diseases 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 206010028537 myelofibrosis Diseases 0.000 claims description 4
- 208000037244 polycythemia vera Diseases 0.000 claims description 4
- 208000003476 primary myelofibrosis Diseases 0.000 claims description 4
- 210000000440 neutrophil Anatomy 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 30
- 108700028369 Alleles Proteins 0.000 claims 7
- 229940125904 compound 1 Drugs 0.000 claims 7
- 230000035772 mutation Effects 0.000 claims 7
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 claims 5
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 claims 5
- 239000002144 L01XE18 - Ruxolitinib Substances 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical group C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 claims 4
- 229960000215 ruxolitinib Drugs 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 206010014950 Eosinophilia Diseases 0.000 claims 2
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 229940121730 Janus kinase 2 inhibitor Drugs 0.000 claims 2
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000037538 Myelomonocytic Juvenile Leukemia Diseases 0.000 claims 1
- 201000005992 juvenile myelomonocytic leukemia Diseases 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 description 2
- 206010072206 Janus kinase 2 mutation Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000010437 erythropoiesis Effects 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 208000025113 myeloid leukemia Diseases 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
Images
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762502456P | 2017-05-05 | 2017-05-05 | |
| US62/502,456 | 2017-05-05 | ||
| US201762535146P | 2017-07-20 | 2017-07-20 | |
| US62/535,146 | 2017-07-20 | ||
| PCT/US2018/031090 WO2018204787A1 (en) | 2017-05-05 | 2018-05-04 | Methods of treatment of myeloproliferative neoplasm |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020518629A JP2020518629A (ja) | 2020-06-25 |
| JP2020518629A5 true JP2020518629A5 (enExample) | 2021-07-01 |
Family
ID=62245425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019560313A Pending JP2020518629A (ja) | 2017-05-05 | 2018-05-04 | 骨髄増殖性腫瘍の治療方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11229653B2 (enExample) |
| EP (1) | EP3618828B1 (enExample) |
| JP (1) | JP2020518629A (enExample) |
| ES (1) | ES2968376T3 (enExample) |
| WO (1) | WO2018204787A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018204787A1 (en) * | 2017-05-05 | 2018-11-08 | Memorial Sloan Kettering Cancer Center | Methods of treatment of myeloproliferative neoplasm |
| WO2020092894A1 (en) | 2018-11-02 | 2020-05-07 | Celgene Corporation | Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol |
| CN116473973A (zh) * | 2018-12-24 | 2023-07-25 | 正大天晴药业集团股份有限公司 | 吡咯并嘧啶化合物的治疗用途及其固体药物组合物 |
| US20220401450A1 (en) | 2019-11-14 | 2022-12-22 | Celgene Corporation | Pediatric formulations for treatment of cancer |
| CN111814193B (zh) * | 2020-08-31 | 2021-03-19 | 支付宝(杭州)信息技术有限公司 | 一种信息共享方法、装置及设备 |
| JP2024504367A (ja) * | 2021-01-22 | 2024-01-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | がんを治療及び改善するための方法 |
| WO2024031406A1 (en) * | 2022-08-10 | 2024-02-15 | Xiang Li | Idh mutations as biomarkers for zotiraciclib therapy |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2913401A (en) | 1957-04-19 | 1959-11-17 | Exxon Research Engineering Co | Hydrogen production and hydroforming |
| DE3307071C2 (de) | 1983-03-01 | 1986-05-22 | Joachim Dr.-Ing. 7250 Leonberg Wünning | Durchlaufofen für die Wärmbehandlung von metallischen Werkstücken |
| US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
| ATE302597T1 (de) | 1997-06-06 | 2005-09-15 | Depomed Inc | Im magen verweilende orale dosierungsformen von wasserlöslichen arzneistoffen mit kontrollierter freisetzung |
| MXPA02007254A (es) | 2000-02-04 | 2002-12-09 | Depomed Inc | Forma de dosis de cubierta-y-nucleo que se aproxima a liberacion de droga de orden cero. |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| CN102985557B (zh) | 2009-03-13 | 2018-06-15 | 安吉奥斯医药品有限公司 | 用于细胞增殖相关病症的方法和组合物 |
| WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| SMT201800334T1 (it) | 2012-01-06 | 2018-09-13 | Agios Pharmaceuticals Inc | Composti terapeuticamente attivi e loro metodi di utilizzo |
| MX375030B (es) | 2013-07-11 | 2025-03-06 | Agios Pharmaceuticals Inc | Compuestos de n,6-bis(aril o heteroaril)-1,3,5-triazin-2,4-diamina como inhibidores de idh2 mutantes para el tratamiento de cancer. |
| CN105916507A (zh) * | 2013-08-02 | 2016-08-31 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
| WO2015018060A1 (en) | 2013-08-09 | 2015-02-12 | Agios Pharmaceuticals, Inc. | Crystalline forms of therapeutically active compounds and use thereof |
| AU2015324158A1 (en) | 2014-09-29 | 2017-04-13 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| EP3253746A1 (en) | 2015-02-04 | 2017-12-13 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CN108349933A (zh) | 2015-08-05 | 2018-07-31 | 安吉奥斯医药品有限公司 | 制备6-(芳基或杂芳基)-1,3,5-三嗪-2,4-二醇和6-(芳基或杂芳基)-1,3,5-三嗪-2,4-二胺的方法 |
| JP2018534288A (ja) | 2015-10-15 | 2018-11-22 | アジオス ファーマシューティカルズ， インコーポレイテッド | 悪性腫瘍の治療のための併用療法 |
| CA3002029A1 (en) | 2015-10-15 | 2017-04-20 | Celgene Corporation | Combination therapy for treating malignancies |
| MA43374A (fr) | 2015-12-04 | 2018-10-10 | Agios Pharmaceuticals Inc | Méthodes de traitement de tumeurs malignes |
| CA3015753A1 (en) * | 2016-02-26 | 2017-08-31 | Celgene Corporation | Idh2 inhibitors for the treatment of haematological maligancies and solid tumours |
| WO2018204787A1 (en) * | 2017-05-05 | 2018-11-08 | Memorial Sloan Kettering Cancer Center | Methods of treatment of myeloproliferative neoplasm |
-
2018
- 2018-05-04 WO PCT/US2018/031090 patent/WO2018204787A1/en not_active Ceased
- 2018-05-04 ES ES18727499T patent/ES2968376T3/es active Active
- 2018-05-04 JP JP2019560313A patent/JP2020518629A/ja active Pending
- 2018-05-04 US US16/615,115 patent/US11229653B2/en active Active
- 2018-05-04 EP EP18727499.8A patent/EP3618828B1/en active Active
-
2021
- 2021-12-16 US US17/553,588 patent/US11833154B2/en active Active
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