JP2020516692A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020516692A5 JP2020516692A5 JP2020506139A JP2020506139A JP2020516692A5 JP 2020516692 A5 JP2020516692 A5 JP 2020516692A5 JP 2020506139 A JP2020506139 A JP 2020506139A JP 2020506139 A JP2020506139 A JP 2020506139A JP 2020516692 A5 JP2020516692 A5 JP 2020516692A5
- Authority
- JP
- Japan
- Prior art keywords
- wavelengths
- tissues
- dye
- light
- fluorescent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 anthracylin Chemical compound 0.000 description 5
- 239000007850 fluorescent dye Substances 0.000 description 4
- 210000001519 tissues Anatomy 0.000 description 3
- UJOBWOGCFQCDNV-UHFFFAOYSA-N Carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N Coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N Imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- FRASJONUBLZVQX-UHFFFAOYSA-N 1,4-Naphthoquinone Chemical compound C1=CC=C2C(=O)C=CC(=O)C2=C1 FRASJONUBLZVQX-UHFFFAOYSA-N 0.000 description 1
- AIQCTYVNRWYDIF-UHFFFAOYSA-N 1-phenyl-9H-xanthene Chemical compound C=12CC3=CC=CC=C3OC2=CC=CC=1C1=CC=CC=C1 AIQCTYVNRWYDIF-UHFFFAOYSA-N 0.000 description 1
- ILFYOWGJBKEMSK-UHFFFAOYSA-N 10H-phenoselenazine Chemical compound C1=CC=C2NC3=CC=CC=C3[Se]C2=C1 ILFYOWGJBKEMSK-UHFFFAOYSA-N 0.000 description 1
- HIYWOHBEPVGIQN-UHFFFAOYSA-N 1H-benzo[g]indole Chemical compound C1=CC=CC2=C(NC=C3)C3=CC=C21 HIYWOHBEPVGIQN-UHFFFAOYSA-N 0.000 description 1
- VHMICKWLTGFITH-UHFFFAOYSA-N 2H-isoindole Chemical compound C1=CC=CC2=CNC=C21 VHMICKWLTGFITH-UHFFFAOYSA-N 0.000 description 1
- FZEYVTFCMJSGMP-UHFFFAOYSA-N Acridone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 description 1
- MWPLVEDNUUSJAV-UHFFFAOYSA-N Anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 1
- RZVHIXYEVGDQDX-UHFFFAOYSA-N Anthraquinone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3C(=O)C2=C1 RZVHIXYEVGDQDX-UHFFFAOYSA-N 0.000 description 1
- JYZIHLWOWKMNNX-UHFFFAOYSA-N Benzimidazole Chemical compound C1=C[CH]C2=NC=NC2=C1 JYZIHLWOWKMNNX-UHFFFAOYSA-N 0.000 description 1
- IANQTJSKSUMEQM-UHFFFAOYSA-N Benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 description 1
- FCEHBMOGCRZNNI-UHFFFAOYSA-N Benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M CHEMBL593252 Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
- TXCDCPKCNAJMEE-UHFFFAOYSA-N Dibenzofuran Chemical compound C1=CC=C2C3=CC=CC=C3OC2=C1 TXCDCPKCNAJMEE-UHFFFAOYSA-N 0.000 description 1
- IYYZUPMFVPLQIF-UHFFFAOYSA-N Dibenzothiophene Chemical compound C1=CC=C2C3=CC=CC=C3SC2=C1 IYYZUPMFVPLQIF-UHFFFAOYSA-N 0.000 description 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-N Isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 1
- YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 1
- RDOWQLZANAYVLL-UHFFFAOYSA-N Phenanthridine Chemical compound C1=CC=C2C3=CC=CC=C3C=NC2=C1 RDOWQLZANAYVLL-UHFFFAOYSA-N 0.000 description 1
- WJFKNYWRSNBZNX-UHFFFAOYSA-N Phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 description 1
- 229950000688 Phenothiazine Drugs 0.000 description 1
- TZMSYXZUNZXBOL-UHFFFAOYSA-N Phenoxazine Chemical compound C1=CC=C2NC3=CC=CC=C3OC2=C1 TZMSYXZUNZXBOL-UHFFFAOYSA-N 0.000 description 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N Rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- IFLREYGFSNHWGE-UHFFFAOYSA-N Tetracene Chemical compound C1=CC=CC2=CC3=CC4=CC=CC=C4C=C3C=C21 IFLREYGFSNHWGE-UHFFFAOYSA-N 0.000 description 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N Triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N flavone Chemical compound O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 229930003944 flavones Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 1
- KAESVJOAVNADME-UHFFFAOYSA-N pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2(1H)-one Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 1
- 230000003595 spectral Effects 0.000 description 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 1
Description
蛍光化合物は、蛍光色素であり得る。本開示の蛍光色素は、その吸収波長、励起波長、及び発光波長の全てが、約３５０ｎｍまたはそれ以上の近赤外（ＮＩＲ）または可視光のスペクトル範囲内に収まる傾向がある。このことは、診断処置に有益である。可視光及びＮＩＲ光は組織を損傷する恐れが低いためである。約３５０ｎｍまたはそれ以上の波長を有する光は、組織に浸透する傾向があり、これにより、約３５０ｎｍ未満のＵＶ波長を使用した場合には到達できない可能性がある関心組織において診断処置を実施することが可能になる。適切な蛍光染料としては、アクリジン、アクリドン、アントラセン、アントラサイクリン、アントラキノン、アザアズレン、アゾアズレン、ベンゼン、ベンゾイミダゾール、ベンゾフラン、ベンゾインドカルボシアニン、ベンゾインドール、ベンゾチオフェン、カルバゾール、クマリン、シアニン、ジベンゾフラン、ジベンゾチオフェン、ジピロロ染料、フラボン、フルオレセイン、イミダゾール、インドカルボシアニン、インドシアニン、インドール、イソインドール、イソキノリン、ナフタセンジオン、ナフタレン、ナフトキノン、フェナントレン、フェナントリジン、フェナントリジン、フェノセレナジン、フェノチアジン、フェノキサジン、フェニルキサンテン、ポリフルオロベンゼン、プリン、ピラジン、ピラゾール、ピリジン、ピリミドン、ピロール、量子ドット、キノリン、キノロン、ローダミン、スクアライン、テトラセン、チオフェン、トリフェニルメタン染料、キサンテン、キサントン、及びそれらの誘導体が挙げられる。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762588606P | 2017-11-20 | 2017-11-20 | |
| US62/588,606 | 2017-11-20 | ||
| PCT/US2018/061282 WO2019099672A1 (en) | 2017-11-20 | 2018-11-15 | Method for preparing and analyzing fluorescent compounds in plasma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020516692A JP2020516692A (ja) | 2020-06-11 |
| JP2020516692A5 true JP2020516692A5 (ja) | 2021-03-11 |
Family
ID=66532776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506139A Pending JP2020516692A (ja) | 2017-11-20 | 2018-11-15 | 血漿中の蛍光化合物を調製及び分析する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11674965B2 (ja) |
| EP (1) | EP3713577A4 (ja) |
| JP (1) | JP2020516692A (ja) |
| KR (2) | KR20200007778A (ja) |
| CN (1) | CN110461332A (ja) |
| AU (1) | AU2018369913B2 (ja) |
| BR (1) | BR112019021044A2 (ja) |
| CA (1) | CA3058762A1 (ja) |
| IL (1) | IL269611A (ja) |
| MX (1) | MX2019011901A (ja) |
| MY (1) | MY188418A (ja) |
| PH (1) | PH12019502373A1 (ja) |
| RU (1) | RU2746503C1 (ja) |
| SG (1) | SG11201909366XA (ja) |
| WO (1) | WO2019099672A1 (ja) |
| ZA (1) | ZA201906445B (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113109491A (zh) * | 2020-01-13 | 2021-07-13 | 四川基因格司法鉴定中心 | 从生物样本中检测毒药物的通用方法 |
| TW202233586A (zh) * | 2020-11-10 | 2022-09-01 | 美商麥迪貝肯有限公司 | 吡𠯤化合物的皮下與肌內注射 |
| US20220324818A1 (en) * | 2021-03-31 | 2022-10-13 | Medibeacon Inc. | Preparation of substituted diaminopyrazine dicarboxylic acids |
| WO2022212080A1 (en) * | 2021-03-31 | 2022-10-06 | Medibeacon Inc. | Purification of substituted diaminopyrazine dicarboxylic acids |
| CN117769543A (zh) * | 2021-08-11 | 2024-03-26 | 杭州中美华东制药有限公司 | 制备作为荧光示踪剂的吡嗪羧酸类衍生物的方法 |
| WO2023025271A1 (zh) * | 2021-08-27 | 2023-03-02 | 杭州中美华东制药有限公司 | 吡嗪类衍生物的晶型及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4647742B2 (ja) * | 2000-03-13 | 2011-03-09 | 三菱化学メディエンス株式会社 | アスコルビン酸の分析方法及び分析用試薬 |
| US6969592B2 (en) * | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
| US6909912B2 (en) | 2002-06-20 | 2005-06-21 | University Of Florida | Non-invasive perfusion monitor and system, specially configured oximeter probes, methods of using same, and covers for probes |
| EP1620002B1 (en) | 2003-04-24 | 2012-01-04 | The Board Of Regents, The University Of Texas System | Noninvasive blood analysis by optical probing of the veins under the tongue |
| US20060095102A1 (en) | 2003-09-17 | 2006-05-04 | Thomas Perez | Method and apparatus for sublingual application of light to blood |
| JP4214109B2 (ja) * | 2004-12-16 | 2009-01-28 | 日本ハム株式会社 | 畜水産物中の残留動物用薬剤の抽出液 |
| EP2039688A1 (en) | 2004-12-23 | 2009-03-25 | Mallinckrodt, Inc. | Fluorescent pyrazine derivatives and methods of using the same in assessing renal function |
| CA2628661A1 (en) | 2006-06-22 | 2007-12-27 | Mallinckrodt Inc. | Pyrazine derivatives and uses thereof in renal monitoring |
| DK2545939T3 (da) * | 2007-04-11 | 2021-02-15 | Biomarin Pharm Inc | Tetrahydrobiopterin til behandling af tilstande associeret med forhøjede phenylalaninniveauer |
| ES2923630T3 (es) | 2010-02-23 | 2022-09-29 | Brahms Gmbh | Un método para determinar un rendimiento correcto de la prueba para un elemento de prueba de flujo |
| US20120172679A1 (en) | 2010-12-30 | 2012-07-05 | Logan Robert J | Systems and methods for monitoring and processing biometric data |
| WO2012149227A2 (en) | 2011-04-26 | 2012-11-01 | Incube Labs, Llc | Mouthpiece for measurement of biometric data of a diver and underwater communication |
| EP3294296A4 (en) * | 2015-05-12 | 2018-12-26 | Medibeacon Inc. | Compositions and methods for assessing eye vasculature |
-
2018
- 2018-11-15 CN CN201880007191.0A patent/CN110461332A/zh active Pending
- 2018-11-15 RU RU2019132947A patent/RU2746503C1/ru active
- 2018-11-15 JP JP2020506139A patent/JP2020516692A/ja active Pending
- 2018-11-15 MY MYPI2019006109A patent/MY188418A/en unknown
- 2018-11-15 AU AU2018369913A patent/AU2018369913B2/en active Active
- 2018-11-15 MX MX2019011901A patent/MX2019011901A/es unknown
- 2018-11-15 EP EP18879660.1A patent/EP3713577A4/en active Pending
- 2018-11-15 KR KR1020197030774A patent/KR20200007778A/ko not_active IP Right Cessation
- 2018-11-15 US US16/192,113 patent/US11674965B2/en active Active
- 2018-11-15 BR BR112019021044-0A patent/BR112019021044A2/pt not_active Application Discontinuation
- 2018-11-15 SG SG11201909366X patent/SG11201909366XA/en unknown
- 2018-11-15 CA CA3058762A patent/CA3058762A1/en not_active Abandoned
- 2018-11-15 WO PCT/US2018/061282 patent/WO2019099672A1/en unknown
- 2018-11-15 KR KR1020227003663A patent/KR20220021024A/ko not_active Application Discontinuation
-
2019
- 2019-09-24 IL IL26961119A patent/IL269611A/en unknown
- 2019-09-30 ZA ZA2019/06445A patent/ZA201906445B/en unknown
- 2019-10-18 PH PH12019502373A patent/PH12019502373A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020516692A5 (ja) | ||
| Luo et al. | A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes | |
| Cosco et al. | Flavylium polymethine fluorophores for near‐and shortwave infrared imaging | |
| Qin et al. | Facile synthesis of efficient luminogens with AIE features for three‐photon fluorescence imaging of the brain through the intact skull | |
| Jiang et al. | A simple mitochondrial targeting AIEgen for image-guided two-photon excited photodynamic therapy | |
| Mellish et al. | In Vitro Photodynamic Activity of a Series of Methylene Blue Analogues¶ | |
| Ciubini et al. | Design and synthesis of symmetrical pentamethine cyanine dyes as NIR photosensitizers for PDT | |
| Vankayala et al. | Gold nanoshells-mediated bimodal photodynamic and photothermal cancer treatment using ultra-low doses of near infra-red light | |
| He et al. | Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties | |
| Jagtap et al. | The synthesis and characterization of novel coumarin dyes derived from 1, 4-diethyl-1, 2, 3, 4-tetrahydro-7-hydroxyquinoxalin-6-carboxaldehyde | |
| Owens et al. | Correlating molecular character of NIR imaging agents with tissue-specific uptake | |
| JP2015528473A5 (ja) | ||
| Shen et al. | The first silicon (IV) phthalocyanine–nucleoside conjugates with high photodynamic activity | |
| Kee et al. | Examination of Chlorin–Bacteriochlorin Energy‐transfer Dyads as Prototypes for Near‐infrared Molecular Imaging Probes | |
| Shaw et al. | Two-photon absorption: an open door to the NIR-II biological window? | |
| Das et al. | Solid phase synthesis of ultra-photostable cyanine NIR dye library | |
| Chernonosov et al. | Effect of some substituents increasing the solubility of Zn (II) and Al (III) phthalocyanines on their photophysical properties | |
| Huang et al. | NIR aza-pentamethine dyes as photosensitizers for photodynamic therapy | |
| Linares et al. | Chlorin derivatives sterically-prevented from self-aggregation with high antitumor activity for photodynamic therapy | |
| Deckers et al. | Near‐Infrared BODIPY‐Acridine Dyads Acting as Heavy‐Atom‐Free Dual‐Functioning Photosensitizers | |
| EP3606927A1 (en) | Near and shortwave infrared polymethine dyes | |
| Deng et al. | Synthesis and bio-evaluation of novel hypocrellin derivatives: Potential photosensitizers for photodynamic therapy of age-related macular degeneration | |
| Lu et al. | Thiophene aromatic amine derivatives with two-photon activities as probes for the detection of picric acid and pH | |
| Yakubovskaya et al. | Photophysical properties and in vitro and in vivo photoinduced antitumor activity of cationic salts of meso-tetrakis (N-alkyl-3-pyridyl) bacteriochlorins | |
| Song et al. | The synthesis and photostability of novel squarylium indocyanine dyes |