JP2020514258A5 - - Google Patents
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- Publication number
- JP2020514258A5 JP2020514258A5 JP2019532804A JP2019532804A JP2020514258A5 JP 2020514258 A5 JP2020514258 A5 JP 2020514258A5 JP 2019532804 A JP2019532804 A JP 2019532804A JP 2019532804 A JP2019532804 A JP 2019532804A JP 2020514258 A5 JP2020514258 A5 JP 2020514258A5
- Authority
- JP
- Japan
- Prior art keywords
- pna
- group
- conjugate
- antibody
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 15
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108090000790 Enzymes Chemical group 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021200641A JP7280339B2 (ja) | 2016-12-19 | 2021-12-10 | ペプチド核酸コンジュゲート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662436189P | 2016-12-19 | 2016-12-19 | |
| US62/436,189 | 2016-12-19 | ||
| PCT/US2017/066976 WO2018118759A1 (en) | 2016-12-19 | 2017-12-18 | Peptide nucleic acid conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021200641A Division JP7280339B2 (ja) | 2016-12-19 | 2021-12-10 | ペプチド核酸コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020514258A JP2020514258A (ja) | 2020-05-21 |
| JP2020514258A5 true JP2020514258A5 (https=) | 2021-01-21 |
| JP7048617B2 JP7048617B2 (ja) | 2022-04-05 |
Family
ID=61028174
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019532804A Active JP7048617B2 (ja) | 2016-12-19 | 2017-12-18 | ペプチド核酸コンジュゲート |
| JP2021200641A Active JP7280339B2 (ja) | 2016-12-19 | 2021-12-10 | ペプチド核酸コンジュゲート |
| JP2023078305A Pending JP2023113659A (ja) | 2016-12-19 | 2023-05-11 | ペプチド核酸コンジュゲート |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021200641A Active JP7280339B2 (ja) | 2016-12-19 | 2021-12-10 | ペプチド核酸コンジュゲート |
| JP2023078305A Pending JP2023113659A (ja) | 2016-12-19 | 2023-05-11 | ペプチド核酸コンジュゲート |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11597925B2 (https=) |
| EP (2) | EP3554556B1 (https=) |
| JP (3) | JP7048617B2 (https=) |
| CN (1) | CN110121364A (https=) |
| WO (1) | WO2018118759A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3195446A1 (en) * | 2020-10-16 | 2022-04-21 | Amelie Eriksson Karlstrom | Pna probes for pretargeted imaging and therapy |
| WO2025240810A1 (en) * | 2024-05-17 | 2025-11-20 | Siemens Healthcare Diagnostics Inc. | Sensitivity improvement of an immunoassay via branched dna |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1564604A (en) | 1925-06-12 | 1925-12-08 | Chas S Hodges | Water wheel |
| US5646265A (en) | 1990-01-11 | 1997-07-08 | Isis Pharmceuticals, Inc. | Process for the preparation of 2'-O-alkyl purine phosphoramidites |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US5786571A (en) | 1997-05-09 | 1998-07-28 | Lexmark International, Inc. | Wrapped temperature sensing assembly |
| CA2320390C (en) | 1998-02-11 | 2010-06-08 | Applied Biosystems, Llc | Pna and dna conjugates and methods for preparation thereof |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| JP3847559B2 (ja) | 1998-02-27 | 2006-11-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 独立スライド加熱器を有する自動化分子病理学装置 |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| EP1372741B1 (en) * | 2001-03-30 | 2006-08-09 | University of Massachusetts | Morpholino imaging and therapy |
| US6670113B2 (en) | 2001-03-30 | 2003-12-30 | Nanoprobes | Enzymatic deposition and alteration of metals |
| US7280812B2 (en) | 2003-06-06 | 2007-10-09 | Interdigital Technology Corporation | Digital baseband receiver with DC discharge and gain control circuits |
| DK1636586T3 (da) | 2003-06-24 | 2009-11-23 | Ventana Med Syst Inc | Enzymkatalyseret metaldeponering til foröget in situ-detektion af immunhistokemisker epitoper og nucleinsyresekvenser |
| US8592219B2 (en) | 2005-01-17 | 2013-11-26 | Gyros Patent Ab | Protecting agent |
| SE0400181D0 (sv) | 2004-01-29 | 2004-01-29 | Gyros Ab | Segmented porous and preloaded microscale devices |
| US7244665B2 (en) | 2004-04-29 | 2007-07-17 | Micron Technology, Inc. | Wafer edge ring structures and methods of formation |
| WO2006022639A1 (en) | 2004-07-21 | 2006-03-02 | Applera Corporation | Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof |
| CA2606018A1 (en) | 2005-04-28 | 2006-11-02 | Ventana Medical Systems, Inc. | Nanoparticle conjugates |
| DE602006020577D1 (de) | 2005-07-01 | 2011-04-21 | Dako Denmark As | Monomere und polymere linker zur konjugierung von biologischen molekülen und anderen stoffen |
| US20070010014A1 (en) | 2005-07-06 | 2007-01-11 | General Electric Company | Compositions and methods for enhanced delivery to target sites |
| US20070134739A1 (en) | 2005-12-12 | 2007-06-14 | Gyros Patent Ab | Microfluidic assays and microfluidic devices |
| DK2444807T3 (da) | 2006-11-01 | 2014-08-11 | Ventana Med Syst Inc | Mono- og dinitropyrazolhaptenkonjugater |
| US9371348B2 (en) * | 2006-11-27 | 2016-06-21 | The Trustees Of The University Of Pennsylvania | Photocleavable oligonucleotide and uses thereof |
| EP2167963B1 (en) | 2007-05-23 | 2019-04-17 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
| CN101868728A (zh) | 2007-11-21 | 2010-10-20 | 鹿特丹伊拉斯姆斯大学医疗中心 | 改进的fret探针及其应用 |
| EP2334827B1 (en) | 2008-08-22 | 2015-03-11 | Ventana Medical Systems, Inc. | Method for chromogenic detection of two or more target molecules in a single sample |
| JP5634405B2 (ja) | 2008-10-07 | 2014-12-03 | ユィロス・パテント・アクチボラグＧｙｒｏｓ Ｐａｔｅｎｔ ＡＢ | 試料中のアナライトの検出のための半逐次アッセイ |
| CA2842661C (en) | 2009-10-19 | 2016-02-23 | Ventana Medical Systems, Inc. | Imaging system and techniques |
| CN105204152B (zh) | 2011-09-09 | 2018-10-26 | 文塔纳医疗系统公司 | 成像系统、盒和使用其的方法 |
| ES2678211T3 (es) | 2012-03-27 | 2018-08-09 | Ventana Medical Systems, Inc. | Conjugados de señalización y procedimientos de uso |
| ES2754177T3 (es) * | 2013-06-12 | 2020-04-16 | Massachusetts Gen Hospital | Métodos para la detección multiplexada de moléculas diana y sus usos |
| EP3096796A1 (en) | 2014-01-21 | 2016-11-30 | The United States of America, as represented by The Secretary, Department of Health and Human Services | cGAP-PNA MULTIVALENT PEPTIDE NUCLEIC ACID LIGAND DISPLAY |
| CN104031129A (zh) | 2014-07-07 | 2014-09-10 | 玉峰惠仁生物医药科技（北京）有限公司 | 用于检测金黄色葡萄球菌和/或表皮葡萄球菌的肽核酸探针组及其试剂盒、使用方法、用途 |
| MA42157A (fr) | 2015-04-23 | 2018-02-28 | Geron Corp | Procédés de préparation de polynucléotides à l'aide de compositions de sel cationique multivalent |
| JP7727385B2 (ja) * | 2017-12-18 | 2025-08-21 | ヴェンタナ メディカル システムズ， インク． | ペプチド核酸コンジュゲート |
-
2017
- 2017-12-18 EP EP17835751.3A patent/EP3554556B1/en active Active
- 2017-12-18 EP EP22152062.0A patent/EP4060345A1/en active Pending
- 2017-12-18 JP JP2019532804A patent/JP7048617B2/ja active Active
- 2017-12-18 CN CN201780078348.4A patent/CN110121364A/zh active Pending
- 2017-12-18 WO PCT/US2017/066976 patent/WO2018118759A1/en not_active Ceased
-
2019
- 2019-06-11 US US16/438,088 patent/US11597925B2/en active Active
-
2021
- 2021-12-10 JP JP2021200641A patent/JP7280339B2/ja active Active
-
2022
- 2022-10-17 US US17/966,904 patent/US20230151361A1/en active Pending
-
2023
- 2023-05-11 JP JP2023078305A patent/JP2023113659A/ja active Pending
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