JP2020510668A5 - - Google Patents
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- Publication number
- JP2020510668A5 JP2020510668A5 JP2019547579A JP2019547579A JP2020510668A5 JP 2020510668 A5 JP2020510668 A5 JP 2020510668A5 JP 2019547579 A JP2019547579 A JP 2019547579A JP 2019547579 A JP2019547579 A JP 2019547579A JP 2020510668 A5 JP2020510668 A5 JP 2020510668A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonitrile
- pyrrolo
- pyrazol
- pyrimidin
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LSTMAJPRFFZYIT-UHFFFAOYSA-N 4-amino-7-[[1-(2-fluorophenyl)pyrazol-4-yl]methyl]-5-[2-(trifluoromethyl)pyrimidin-5-yl]pyrrolo[2,3-d]pyrimidine-6-carbonitrile Chemical compound NC=1C2=C(N=CN=1)N(C(=C2C=1C=NC(=NC=1)C(F)(F)F)C#N)CC=1C=NN(C=1)C1=C(C=CC=C1)F LSTMAJPRFFZYIT-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021183048A JP7360434B2 (ja) | 2016-11-18 | 2021-11-10 | Ｃｆｔｒ増強物質としてのピロロピリミジン |
| JP2023169299A JP7592814B2 (ja) | 2016-11-18 | 2023-09-29 | Ｃｆｔｒ増強物質としてのピロロピリミジン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662423919P | 2016-11-18 | 2016-11-18 | |
| US62/423,919 | 2016-11-18 | ||
| PCT/US2017/062148 WO2018094137A1 (en) | 2016-11-18 | 2017-11-17 | Pyrrolopyrimidines as cftr potentiators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021183048A Division JP7360434B2 (ja) | 2016-11-18 | 2021-11-10 | Ｃｆｔｒ増強物質としてのピロロピリミジン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510668A JP2020510668A (ja) | 2020-04-09 |
| JP2020510668A5 true JP2020510668A5 (enExample) | 2020-12-17 |
| JP6978507B2 JP6978507B2 (ja) | 2021-12-08 |
Family
ID=62144793
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019547579A Active JP6978507B2 (ja) | 2016-11-18 | 2017-11-17 | Ｃｆｔｒ増強物質としてのピロロピリミジン |
| JP2021183048A Active JP7360434B2 (ja) | 2016-11-18 | 2021-11-10 | Ｃｆｔｒ増強物質としてのピロロピリミジン |
| JP2023169299A Active JP7592814B2 (ja) | 2016-11-18 | 2023-09-29 | Ｃｆｔｒ増強物質としてのピロロピリミジン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021183048A Active JP7360434B2 (ja) | 2016-11-18 | 2021-11-10 | Ｃｆｔｒ増強物質としてのピロロピリミジン |
| JP2023169299A Active JP7592814B2 (ja) | 2016-11-18 | 2023-09-29 | Ｃｆｔｒ増強物質としてのピロロピリミジン |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US10301315B2 (enExample) |
| EP (2) | EP3541390B1 (enExample) |
| JP (3) | JP6978507B2 (enExample) |
| KR (2) | KR102824092B1 (enExample) |
| CN (2) | CN110337294B (enExample) |
| AU (2) | AU2017362350B2 (enExample) |
| CA (1) | CA3044050A1 (enExample) |
| CL (1) | CL2019001334A1 (enExample) |
| CO (1) | CO2019005993A2 (enExample) |
| CR (1) | CR20190292A (enExample) |
| DO (1) | DOP2019000126A (enExample) |
| EC (1) | ECSP19043120A (enExample) |
| ES (1) | ES2983686T3 (enExample) |
| IL (3) | IL314404B1 (enExample) |
| MX (2) | MX2021012639A (enExample) |
| PE (1) | PE20200739A1 (enExample) |
| PH (1) | PH12019501098A1 (enExample) |
| PL (1) | PL3541390T3 (enExample) |
| RU (2) | RU2021129721A (enExample) |
| SG (1) | SG10202106949XA (enExample) |
| UA (1) | UA125400C2 (enExample) |
| WO (1) | WO2018094137A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX350788B (es) | 2012-01-06 | 2017-09-13 | Abide Therapeutics Inc | Compuestos de carbamato y preparación y uso de los mismos. |
| SG10201902963PA (en) | 2014-10-06 | 2019-05-30 | Vertex Pharma | Modulators of cystic fibrosis transmembrane conductance regulator |
| CA3009339A1 (en) * | 2015-12-22 | 2017-06-29 | Proteostasis Therapeutics, Inc. | Methods of treating pulmonary diseases and disorders |
| GEP20217329B (en) | 2016-09-30 | 2021-12-10 | Vertex Pharma | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| PE20200739A1 (es) * | 2016-11-18 | 2020-07-24 | Cystic Fibrosis Found Therapeutics Inc | Pirrolopirimidinas como potenciadores de cftr |
| HUE052205T2 (hu) | 2016-12-09 | 2021-04-28 | Vertex Pharma | Cisztás fibrózis transzmembrán vezetõképesség szabályzó modulátora, gyógyszerészeti készítmények, kezelési eljárások és eljárás a modulátor elõállítására |
| SG10201911076QA (en) | 2016-12-16 | 2020-01-30 | Cystic Fibrosis Found | Bycyclic heteroaryl derivatives as cftr potentiators |
| BR112019025801A2 (pt) | 2017-06-08 | 2020-07-07 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
| BR112020000941A2 (pt) | 2017-07-17 | 2020-07-21 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
| US11434201B2 (en) | 2017-08-02 | 2022-09-06 | Vertex Pharmaceuticals Incorporated | Processes for preparing pyrrolidine compounds |
| CA3078893A1 (en) | 2017-10-19 | 2019-04-25 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of cftr modulators |
| CA3085006A1 (en) | 2017-12-08 | 2019-06-13 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| HRP20230030T1 (hr) | 2018-02-15 | 2023-03-03 | Vertex Pharmaceuticals Incorporated | Makrocikli kao modulatori regulatora provodljivosti transmembrane cistične fibroze, njihovi farmaceutski pripravci, njihova uporaba u liječenju cistične fibroze, i postupak za njihovu proizvodnju |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| AR118555A1 (es) | 2019-04-03 | 2021-10-20 | Vertex Pharma | Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| BR112021024668A2 (pt) * | 2019-06-10 | 2022-05-31 | Novartis Ag | Derivado de piridina e pirazina para o tratamento de fc, dpoc e bronquiectasia |
| JP2022541178A (ja) | 2019-07-15 | 2022-09-22 | ノバルティス アーゲー | （ｓ）－３－アミノ－６－メトキシ－ｎ－（３，３，３－トリフルオロ－２－ヒドロキシ－２－メチルプロピル）－５－（トリフルオロメチル）ピコリンアミド製剤 |
| HUE066896T2 (hu) | 2019-08-14 | 2024-09-28 | Vertex Pharma | Eljárás CFTR modulátorok elõállítására |
| CA3150162A1 (en) | 2019-08-14 | 2021-02-18 | Vertex Pharmaceuticals Incorporated | Crystalline forms of cftr modulators |
| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| CN111138439B (zh) * | 2020-01-17 | 2021-06-25 | 厦门大学 | 氟代吡咯并嘧啶类化合物及其制备方法和应用 |
| US20230192700A1 (en) | 2020-03-06 | 2023-06-22 | Bayer Aktiengesellschaft | Pyrazolopyrazines acting on cancers via inhibition of cdk12 |
| CN116033895A (zh) | 2020-08-20 | 2023-04-28 | 小利兰·斯坦福大学托管委员会 | 用于治疗以黏液分泌过多为特征的呼吸系统疾病的方法 |
| WO2022125826A1 (en) | 2020-12-10 | 2022-06-16 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| WO2024096629A1 (ko) * | 2022-11-02 | 2024-05-10 | 일동제약 주식회사 | Cftr 조절제 화합물을 포함하는 점안용 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994013676A1 (en) * | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Pyrrolopyrimidines as crf antagonists |
| NZ518726A (en) | 2001-05-09 | 2004-06-25 | Warner Lambert Co | Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor |
| JP2004534779A (ja) | 2001-05-30 | 2004-11-18 | エルジー ライフサイエンス リミテッド | 疾病治療用プロテインキナーゼ阻害剤 |
| US20050008640A1 (en) * | 2003-04-23 | 2005-01-13 | Wendy Waegell | Method of treating transplant rejection |
| CA2553724A1 (en) * | 2004-02-03 | 2005-08-18 | Abbott Laboratories | Aminobenzoxazoles as therapeutic agents |
| ES2545907T3 (es) | 2005-12-29 | 2015-09-16 | Abbvie Inc. | Inhibidores de proteína quinasa |
| KR20090007319A (ko) * | 2006-03-11 | 2009-01-16 | 베르날리스 (알 앤드 디) 리미티드 | Ｈｓｐ90 억제제로서 사용되는 피롤로피리미딘 유도체 |
| KR20150038395A (ko) * | 2006-04-04 | 2015-04-08 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 키나제 길항물질 |
| CA2705303A1 (en) * | 2007-11-07 | 2009-05-14 | Foldrx Pharmaceuticals, Inc. | Modulation of protein trafficking |
| EA024252B1 (ru) | 2009-01-08 | 2016-08-31 | Кьюрис, Инк. | Ингибиторы фосфоинозитид-3-киназ с цинксвязывающей группой |
| US20130123281A1 (en) | 2011-11-11 | 2013-05-16 | Beta Cat Pharmaceuticals, Llc | Compositions and Methods for Inhibition of TBL-1 Binding to Disease-Associated Molecules |
| US8828998B2 (en) * | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| WO2014060431A1 (en) * | 2012-10-16 | 2014-04-24 | Almirall, S.A. | Pyrrolotriazinone derivatives as pi3k inhibitors |
| WO2015091532A1 (en) | 2013-12-19 | 2015-06-25 | Almirall, S.A. | Pyrrolopyrimidine derivatives as pi3k inhibitors |
| PE20200739A1 (es) | 2016-11-18 | 2020-07-24 | Cystic Fibrosis Found Therapeutics Inc | Pirrolopirimidinas como potenciadores de cftr |
-
2017
- 2017-11-17 PE PE2019001045A patent/PE20200739A1/es unknown
- 2017-11-17 WO PCT/US2017/062148 patent/WO2018094137A1/en not_active Ceased
- 2017-11-17 RU RU2021129721A patent/RU2021129721A/ru unknown
- 2017-11-17 ES ES17872726T patent/ES2983686T3/es active Active
- 2017-11-17 MX MX2021012639A patent/MX2021012639A/es unknown
- 2017-11-17 CN CN201780083801.0A patent/CN110337294B/zh active Active
- 2017-11-17 IL IL314404A patent/IL314404B1/en unknown
- 2017-11-17 RU RU2019118623A patent/RU2757457C2/ru active
- 2017-11-17 EP EP17872726.9A patent/EP3541390B1/en active Active
- 2017-11-17 JP JP2019547579A patent/JP6978507B2/ja active Active
- 2017-11-17 US US15/815,809 patent/US10301315B2/en active Active
- 2017-11-17 EP EP24170395.8A patent/EP4424311A3/en active Pending
- 2017-11-17 UA UAA201906838A patent/UA125400C2/uk unknown
- 2017-11-17 IL IL296279A patent/IL296279A/en unknown
- 2017-11-17 PL PL17872726.9T patent/PL3541390T3/pl unknown
- 2017-11-17 CA CA3044050A patent/CA3044050A1/en active Pending
- 2017-11-17 MX MX2019005822A patent/MX387203B/es unknown
- 2017-11-17 AU AU2017362350A patent/AU2017362350B2/en active Active
- 2017-11-17 KR KR1020237033420A patent/KR102824092B1/ko active Active
- 2017-11-17 CN CN202211239693.0A patent/CN115850268B/zh active Active
- 2017-11-17 CR CR20190292A patent/CR20190292A/es unknown
- 2017-11-17 KR KR1020197017510A patent/KR102585398B1/ko active Active
- 2017-11-17 SG SG10202106949XA patent/SG10202106949XA/en unknown
-
2019
- 2019-04-05 US US16/377,005 patent/US10494374B2/en active Active
- 2019-05-15 IL IL266668A patent/IL266668B2/en unknown
- 2019-05-16 PH PH12019501098A patent/PH12019501098A1/en unknown
- 2019-05-16 CL CL2019001334A patent/CL2019001334A1/es unknown
- 2019-05-17 DO DO2019000126A patent/DOP2019000126A/es unknown
- 2019-06-07 CO CONC2019/0005993A patent/CO2019005993A2/es unknown
- 2019-06-17 EC ECSENADI201943120A patent/ECSP19043120A/es unknown
- 2019-09-20 US US16/578,277 patent/US20200017512A1/en not_active Abandoned
-
2021
- 2021-02-18 US US17/179,062 patent/US20210171534A1/en not_active Abandoned
- 2021-11-10 JP JP2021183048A patent/JP7360434B2/ja active Active
-
2022
- 2022-03-16 AU AU2022201816A patent/AU2022201816B2/en active Active
-
2023
- 2023-04-13 US US18/134,455 patent/US20230250100A1/en active Pending
- 2023-09-29 JP JP2023169299A patent/JP7592814B2/ja active Active
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