JP2020510014A5 - - Google Patents
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- Publication number
- JP2020510014A5 JP2020510014A5 JP2019548431A JP2019548431A JP2020510014A5 JP 2020510014 A5 JP2020510014 A5 JP 2020510014A5 JP 2019548431 A JP2019548431 A JP 2019548431A JP 2019548431 A JP2019548431 A JP 2019548431A JP 2020510014 A5 JP2020510014 A5 JP 2020510014A5
- Authority
- JP
- Japan
- Prior art keywords
- dialysate
- spiked
- pharmaceutical composition
- nitrite
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 104
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 94
- 229940005654 nitrite ion Drugs 0.000 claims description 91
- 238000000502 dialysis Methods 0.000 claims description 57
- 235000010288 sodium nitrite Nutrition 0.000 claims description 52
- 239000007864 aqueous solution Substances 0.000 claims description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 18
- 239000012141 concentrate Substances 0.000 claims description 16
- 239000012528 membrane Substances 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 210000004369 blood Anatomy 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 239000000243 solution Substances 0.000 claims description 11
- -1 nitrite ions Chemical class 0.000 claims description 9
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 7
- 208000033626 Renal failure acute Diseases 0.000 claims description 7
- 201000011040 acute kidney failure Diseases 0.000 claims description 7
- 208000012998 acute renal failure Diseases 0.000 claims description 7
- 208000020832 chronic kidney disease Diseases 0.000 claims description 7
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 7
- 206010002383 Angina Pectoris Diseases 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 206010059109 Cerebral vasoconstriction Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 2
- 208000001286 intracranial vasospasm Diseases 0.000 claims description 2
- 208000028867 ischemia Diseases 0.000 claims description 2
- 230000000302 ischemic effect Effects 0.000 claims description 2
- 208000030175 lameness Diseases 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims description 2
- 206010038464 renal hypertension Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 35
- 230000002265 prevention Effects 0.000 claims 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 206010049993 Cardiac death Diseases 0.000 claims 1
- 206010011906 Death Diseases 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 238000001631 haemodialysis Methods 0.000 claims 1
- 230000000322 hemodialysis Effects 0.000 claims 1
- 150000002826 nitrites Chemical class 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 description 120
- 206010049418 Sudden Cardiac Death Diseases 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 230000000925 erythroid effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023114331A JP7551858B2 (ja) | 2017-03-08 | 2023-07-12 | 亜硝酸ナトリウムの透析中の使用 |
| JP2024152352A JP7765687B2 (ja) | 2017-03-08 | 2024-09-04 | 亜硝酸ナトリウムの透析中の使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762468857P | 2017-03-08 | 2017-03-08 | |
| US62/468,857 | 2017-03-08 | ||
| PCT/US2018/021053 WO2018165098A1 (en) | 2017-03-08 | 2018-03-06 | Intradialytic use of sodium nitrite |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023114331A Division JP7551858B2 (ja) | 2017-03-08 | 2023-07-12 | 亜硝酸ナトリウムの透析中の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510014A JP2020510014A (ja) | 2020-04-02 |
| JP2020510014A5 true JP2020510014A5 (enExample) | 2021-04-22 |
| JP7314050B2 JP7314050B2 (ja) | 2023-07-25 |
Family
ID=63445965
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548431A Active JP7314050B2 (ja) | 2017-03-08 | 2018-03-06 | 亜硝酸ナトリウムの透析中の使用 |
| JP2023114331A Active JP7551858B2 (ja) | 2017-03-08 | 2023-07-12 | 亜硝酸ナトリウムの透析中の使用 |
| JP2024152352A Active JP7765687B2 (ja) | 2017-03-08 | 2024-09-04 | 亜硝酸ナトリウムの透析中の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023114331A Active JP7551858B2 (ja) | 2017-03-08 | 2023-07-12 | 亜硝酸ナトリウムの透析中の使用 |
| JP2024152352A Active JP7765687B2 (ja) | 2017-03-08 | 2024-09-04 | 亜硝酸ナトリウムの透析中の使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US10328099B2 (enExample) |
| EP (2) | EP3592342B1 (enExample) |
| JP (3) | JP7314050B2 (enExample) |
| KR (4) | KR102647803B1 (enExample) |
| AR (1) | AR111166A1 (enExample) |
| AU (2) | AU2018231016B2 (enExample) |
| BR (1) | BR112019018861A2 (enExample) |
| CA (1) | CA3055105A1 (enExample) |
| ES (1) | ES2986444T3 (enExample) |
| IL (4) | IL301302B2 (enExample) |
| NZ (1) | NZ756701A (enExample) |
| PH (1) | PH12019501950A1 (enExample) |
| TW (3) | TWI798203B (enExample) |
| WO (1) | WO2018165098A1 (enExample) |
| ZA (3) | ZA201905679B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL301302B2 (en) | 2017-03-08 | 2024-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium nitrite |
| ES2992792T3 (en) | 2017-03-08 | 2024-12-18 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| KR102875863B1 (ko) * | 2019-07-22 | 2025-10-23 | 스쿨 주리디칼 퍼슨 키타사토 인스티튜트 | 투석 장치 |
| US20230149732A1 (en) * | 2021-11-17 | 2023-05-18 | Wake Forest University Health Sciences | Combined nitrite and light treatment to prevent device thrombosis |
| US12128166B2 (en) | 2022-12-16 | 2024-10-29 | Fresenius Medical Care Holdings, Inc. | Systems and methods for using nitric oxide in dialysis |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341151C (en) | 1985-09-10 | 2000-12-05 | Elias Klein | Osmotic agents form peritoneal dialysis |
| US6380163B1 (en) | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| FI98538C (fi) | 1993-10-20 | 1997-07-10 | Enso Gutzeit Oy | Menetelmä natriumhydroksidin valmistamiseksi valkolipeästä |
| US6306836B1 (en) | 1994-01-21 | 2001-10-23 | Baxter International Inc. | Peritoneal dialysis solutions containing maltodextrins and amino acids |
| US6436969B1 (en) | 1995-09-12 | 2002-08-20 | Kansas University Medical Center Research Institute Inc. | Dialysis solutions and methods |
| JP4882054B2 (ja) | 2000-09-13 | 2012-02-22 | 独立行政法人科学技術振興機構 | 腹膜透析液およびその調製法 |
| CA2537222A1 (en) * | 2003-07-09 | 2005-01-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
| US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
| US20070154570A1 (en) * | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
| US7547637B2 (en) * | 2005-06-21 | 2009-06-16 | Intel Corporation | Methods for patterning a semiconductor film |
| US20090304600A1 (en) | 2008-06-09 | 2009-12-10 | Anupkumar Shetty | Intradialytic administration of sodium thiosulfate |
| US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| DK2451435T4 (da) | 2009-07-08 | 2022-02-28 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Natriumthiosulfat-indeholdende farmaceutiske sammensætninger |
| WO2013023217A1 (en) * | 2011-08-11 | 2013-02-14 | Board Of Regents, The University Of Texas System | Method of measuring and monitoring in vivo nitrite levels |
| AU2013212264B2 (en) | 2012-01-23 | 2017-05-18 | Santalis Pharmaceuticals Inc. | Sandalwood oil and its uses related to clostridium infections |
| JP5486069B1 (ja) | 2012-11-05 | 2014-05-07 | 旭 酒井 | 透析装置 |
| US20140350097A1 (en) | 2013-05-23 | 2014-11-27 | Medinox,Inc. | Treatment of hypotension associated with hemodialysis |
| JP6183832B2 (ja) | 2013-06-19 | 2017-08-23 | 扶桑薬品工業株式会社 | 酸化ストレス抑制型透析用剤およびその調製方法 |
| IL301302B2 (en) | 2017-03-08 | 2024-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium nitrite |
-
2018
- 2018-03-06 IL IL301302A patent/IL301302B2/en unknown
- 2018-03-06 EP EP18763384.7A patent/EP3592342B1/en active Active
- 2018-03-06 CA CA3055105A patent/CA3055105A1/en active Pending
- 2018-03-06 KR KR1020197029157A patent/KR102647803B1/ko active Active
- 2018-03-06 BR BR112019018861A patent/BR112019018861A2/pt unknown
- 2018-03-06 EP EP24182318.6A patent/EP4406595A3/en active Pending
- 2018-03-06 IL IL312092A patent/IL312092B2/en unknown
- 2018-03-06 AU AU2018231016A patent/AU2018231016B2/en active Active
- 2018-03-06 KR KR1020247008154A patent/KR102706379B1/ko active Active
- 2018-03-06 KR KR1020257002477A patent/KR20250017763A/ko active Pending
- 2018-03-06 JP JP2019548431A patent/JP7314050B2/ja active Active
- 2018-03-06 KR KR1020247030224A patent/KR102760913B1/ko active Active
- 2018-03-06 ES ES18763384T patent/ES2986444T3/es active Active
- 2018-03-06 WO PCT/US2018/021053 patent/WO2018165098A1/en not_active Ceased
- 2018-03-06 NZ NZ756701A patent/NZ756701A/en unknown
- 2018-03-07 US US15/914,353 patent/US10328099B2/en active Active
- 2018-03-07 TW TW107107745A patent/TWI798203B/zh active
- 2018-03-07 TW TW113105276A patent/TWI888012B/zh active
- 2018-03-07 AR ARP180100529A patent/AR111166A1/es not_active Application Discontinuation
- 2018-03-07 TW TW112109906A patent/TWI835595B/zh active
-
2019
- 2019-05-03 US US16/403,428 patent/US10898512B2/en active Active
- 2019-08-23 IL IL268882A patent/IL268882B/en unknown
- 2019-08-23 PH PH12019501950A patent/PH12019501950A1/en unknown
- 2019-08-28 ZA ZA2019/05679A patent/ZA201905679B/en unknown
-
2020
- 2020-11-23 US US17/102,411 patent/US11564938B2/en active Active
-
2021
- 2021-07-07 IL IL284684A patent/IL284684B2/en unknown
-
2022
- 2022-07-29 ZA ZA2022/08504A patent/ZA202208504B/en unknown
-
2023
- 2023-01-03 US US18/092,569 patent/US12011456B2/en active Active
- 2023-07-12 JP JP2023114331A patent/JP7551858B2/ja active Active
- 2023-07-25 ZA ZA2023/07367A patent/ZA202307367B/en unknown
-
2024
- 2024-05-08 US US18/658,338 patent/US20240285677A1/en active Pending
- 2024-05-28 AU AU2024203535A patent/AU2024203535A1/en active Pending
- 2024-09-04 JP JP2024152352A patent/JP7765687B2/ja active Active
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