JP7314050B2 - 亜硝酸ナトリウムの透析中の使用 - Google Patents
亜硝酸ナトリウムの透析中の使用 Download PDFInfo
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- JP7314050B2 JP7314050B2 JP2019548431A JP2019548431A JP7314050B2 JP 7314050 B2 JP7314050 B2 JP 7314050B2 JP 2019548431 A JP2019548431 A JP 2019548431A JP 2019548431 A JP2019548431 A JP 2019548431A JP 7314050 B2 JP7314050 B2 JP 7314050B2
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- JP
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- Prior art keywords
- dialysate
- nitrite
- spiked
- pharmaceutical
- dialyzer
- Prior art date
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- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 82
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| IL301302B2 (en) | 2017-03-08 | 2024-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium nitrite |
| ES2992792T3 (en) | 2017-03-08 | 2024-12-18 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Intradialytic use of sodium thiosulfate |
| KR102875863B1 (ko) * | 2019-07-22 | 2025-10-23 | 스쿨 주리디칼 퍼슨 키타사토 인스티튜트 | 투석 장치 |
| US20230149732A1 (en) * | 2021-11-17 | 2023-05-18 | Wake Forest University Health Sciences | Combined nitrite and light treatment to prevent device thrombosis |
| US12128166B2 (en) | 2022-12-16 | 2024-10-29 | Fresenius Medical Care Holdings, Inc. | Systems and methods for using nitric oxide in dialysis |
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| JP2015003871A (ja) | 2013-06-19 | 2015-01-08 | 扶桑薬品工業株式会社 | 酸化ストレス抑制型透析用剤およびその調製方法 |
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| CA1341151C (en) | 1985-09-10 | 2000-12-05 | Elias Klein | Osmotic agents form peritoneal dialysis |
| US6380163B1 (en) | 1992-12-22 | 2002-04-30 | Baxter International Inc. | Peritoneal dialysis solutions with polypeptides |
| FI98538C (fi) | 1993-10-20 | 1997-07-10 | Enso Gutzeit Oy | Menetelmä natriumhydroksidin valmistamiseksi valkolipeästä |
| US6306836B1 (en) | 1994-01-21 | 2001-10-23 | Baxter International Inc. | Peritoneal dialysis solutions containing maltodextrins and amino acids |
| US6436969B1 (en) | 1995-09-12 | 2002-08-20 | Kansas University Medical Center Research Institute Inc. | Dialysis solutions and methods |
| JP4882054B2 (ja) | 2000-09-13 | 2012-02-22 | 独立行政法人科学技術振興機構 | 腹膜透析液およびその調製法 |
| CA2537222A1 (en) * | 2003-07-09 | 2005-01-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
| US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
| US20070154570A1 (en) * | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
| US7547637B2 (en) * | 2005-06-21 | 2009-06-16 | Intel Corporation | Methods for patterning a semiconductor film |
| US20090304600A1 (en) | 2008-06-09 | 2009-12-10 | Anupkumar Shetty | Intradialytic administration of sodium thiosulfate |
| US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
| DK2451435T4 (da) | 2009-07-08 | 2022-02-28 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Natriumthiosulfat-indeholdende farmaceutiske sammensætninger |
| WO2013023217A1 (en) * | 2011-08-11 | 2013-02-14 | Board Of Regents, The University Of Texas System | Method of measuring and monitoring in vivo nitrite levels |
| AU2013212264B2 (en) | 2012-01-23 | 2017-05-18 | Santalis Pharmaceuticals Inc. | Sandalwood oil and its uses related to clostridium infections |
| JP5486069B1 (ja) | 2012-11-05 | 2014-05-07 | 旭 酒井 | 透析装置 |
| US20140350097A1 (en) | 2013-05-23 | 2014-11-27 | Medinox,Inc. | Treatment of hypotension associated with hemodialysis |
| IL301302B2 (en) | 2017-03-08 | 2024-09-01 | Hope Medical Entpr Inc Dba Hope Pharmaceuticals | Intradialytic use of sodium nitrite |
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| JP2015003871A (ja) | 2013-06-19 | 2015-01-08 | 扶桑薬品工業株式会社 | 酸化ストレス抑制型透析用剤およびその調製方法 |
Non-Patent Citations (3)
| Title |
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| Free Radical Biology and Medicine，2013年，Vol.58，pp.46-51 |
| Nitric Oxide，2016年，Vol.58，pp.1-9 |
| 化学工学論文集，1989年，Vol.15, No.6，pp.1102-1108 |
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